{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:26:33Z","timestamp":1781360793348,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","award":["2020ZSLC24"],"award-info":[{"award-number":["2020ZSLC24"]}],"id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21Y11921800"],"award-info":[{"award-number":["21Y11921800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bcp.2025.116915","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T03:41:41Z","timestamp":1743997301000},"page":"116915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Phosphocreatine alleviates monocrotaline-induced liver injury dependent on PSRC1-regulated endoplasmic reticulum stress"],"prefix":"10.1016","volume":"237","author":[{"given":"Sinuo","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2025.116915_b0005","first-page":"124","article-title":"Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids","volume":"38","author":"Song","year":"2020","journal-title":"J. Environ. Sci. Health C Toxicol. Carcinog."},{"key":"10.1016\/j.bcp.2025.116915_b0010","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.2147\/DDDT.S87858","article-title":"Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome","volume":"9","author":"Gao","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bcp.2025.116915_b0015","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00204-020-02921-0","article-title":"Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites","volume":"95","author":"He","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bcp.2025.116915_b0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.toxlet.2020.10.007","article-title":"Platelets prevent the development of monocrotaline-induced liver injury in mice","volume":"335","author":"Otaka","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bcp.2025.116915_b0025","doi-asserted-by":"crossref","DOI":"10.1177\/0300060519894448","article-title":"Aquaporin-2 expression in the kidney and urine is elevated in rats with monocrotaline-induced pulmonary heart disease","volume":"48","author":"Ouyang","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.bcp.2025.116915_b0030","doi-asserted-by":"crossref","first-page":"825","DOI":"10.18433\/J3BG7J","article-title":"Hepatotoxicity of pyrrolizidine alkaloids","volume":"18","author":"Neuman","year":"2015","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.bcp.2025.116915_b0035","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1002\/mrm.27655","article-title":"Chemical exchange saturation transfer imaging of phosphocreatine in the muscle","volume":"81","author":"Chung","year":"2019","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.bcp.2025.116915_b0040","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.2147\/DDDT.S203564","article-title":"Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway","volume":"13","author":"Li","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bcp.2025.116915_b0045","doi-asserted-by":"crossref","first-page":"e3081","DOI":"10.1038\/cddis.2017.453","article-title":"Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development","volume":"8","author":"Tang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2025.116915_b0050","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/jat.4004","article-title":"Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis","volume":"40","author":"Wang","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.bcp.2025.116915_b0055","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bcp.2025.116915_b0060","doi-asserted-by":"crossref","first-page":"17939","DOI":"10.1038\/s41598-018-36063-2","article-title":"HIF-1\u03b1 triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis","volume":"8","author":"Delbrel","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2025.116915_b0065","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/hep.30607","article-title":"Endoplasmic reticulum stress causes liver cancer cells to release exosomal miR-23a-3p and up-regulate programmed death ligand 1 expression in macrophages","volume":"70","author":"Liu","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.bcp.2025.116915_b0070","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1038\/s41467-020-19668-y","article-title":"AdipoR1\/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis","volume":"11","author":"Xu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2025.116915_b0075","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.116915_b0080","doi-asserted-by":"crossref","first-page":"e1879","DOI":"10.1038\/cddis.2015.248","article-title":"ER stress induces NLRP3 inflammasome activation and hepatocyte death","volume":"6","author":"Lebeaupin","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2025.116915_b0085","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1038\/sj.onc.1210304","article-title":"p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway","volume":"26","author":"Hsieh","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2025.116915_b0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.yjmcc.2018.01.013","article-title":"PSRC1 overexpression attenuates atherosclerosis progression in apoE(-\/-) mice by modulating cholesterol transportation and inflammation","volume":"116","author":"Guo","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bcp.2025.116915_b0095","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s12031-023-02133-y","article-title":"PSRC1 regulated by DNA methylation is a novel target for LGG immunotherapy","volume":"73","author":"Liu","year":"2023","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bcp.2025.116915_b0100","doi-asserted-by":"crossref","first-page":"e1220","DOI":"10.1002\/ctm2.1220","article-title":"Proline\/serine-rich coiled-coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2","volume":"13","author":"Pan","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bcp.2025.116915_b0105","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2077602","article-title":"Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3","volume":"14","author":"Luo","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bcp.2025.116915_b0110","doi-asserted-by":"crossref","unstructured":"Y. Li, et al., (Apo)Lipoprotein profiling with multi-omics analysis identified medium-HDL-targeting PSRC1 with therapeutic potential for coronary artery disease. Adv. Sci. (Weinh), e2413491, doi:10.1002\/advs.202413491 (2025).","DOI":"10.1002\/advs.202413491"},{"key":"10.1016\/j.bcp.2025.116915_b0115","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100786RR","article-title":"CELSR2 deficiency suppresses lipid accumulation in hepatocyte by impairing the UPR and elevating ROS level","volume":"35","author":"Tan","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2025.116915_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152307","article-title":"Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury","volume":"428","author":"Huang","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.bcp.2025.116915_b0125","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.3748\/wjg.v25.i28.3753","article-title":"Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment, and outcomes","volume":"25","author":"Yang","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bcp.2025.116915_b0130","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1111\/liv.13684","article-title":"Clinical characteristics and treatment of pyrrolizidine alkaloid-related hepatic vein occlusive disease","volume":"38","author":"Zhuge","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.bcp.2025.116915_b0135","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12876-020-1180-0","article-title":"Clinical characteristics, CT signs, and pathological findings of Pyrrolizidine alkaloids-induced sinusoidal obstructive syndrome: a retrospective study","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.bcp.2025.116915_b0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.abb.2004.03.026","article-title":"5'-Heterogeneity of mouse Dda3 transcripts is attributed to differential initiation of transcription and alternative splicing","volume":"425","author":"Lo","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2025.116915_b0145","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s00726-016-2173-8","article-title":"Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease","volume":"48","author":"Balestrino","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.bcp.2025.116915_b0150","first-page":"L243","article-title":"Docosahexaenoic acid inhibits monocrotaline-induced pulmonary hypertension via attenuating endoplasmic reticulum stress and inflammation","volume":"314","author":"Chen","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bcp.2025.116915_b0155","article-title":"CHOP regulates endoplasmic reticulum stress-mediated hepatoxicity induced by monocrotaline","volume":"12","author":"Guo","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2025.116915_b0160","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41574-020-0365-5","article-title":"Creatine metabolism: energy homeostasis, immunity and cancer biology","volume":"16","author":"Kazak","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bcp.2025.116915_b0165","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/17474124.2016.1179575","article-title":"Targeting endoplasmic reticulum stress in liver disease","volume":"10","author":"Wu","year":"2016","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcp.2025.116915_b0170","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41419-019-1687-x","article-title":"The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK\/eIF2\u03b1 and IRE1\u03b1\/XBP-1 in colorectal cancer","volume":"10","author":"Chern","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2025.116915_b0175","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1111\/jcmm.17560","article-title":"CaMKII orchestrates endoplasmic reticulum stress and apoptosis in doxorubicin-induced cardiotoxicity by regulating the IRE1\u03b1\/XBP1s pathway","volume":"26","author":"Kong","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2025.116915_b0180","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1053\/j.gastro.2017.10.012","article-title":"Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models","volume":"154","author":"Biczo","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcp.2025.116915_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155080","article-title":"Asperosaponin VI protects alcohol-induced hepatic steatosis and injury via regulating lipid metabolism and ER stress","volume":"121","author":"Wei","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2025.116915_b0190","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41467-019-08591-6","article-title":"Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism","volume":"10","author":"Sasako","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225001777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225001777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:54:21Z","timestamp":1778622861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225001777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":38,"alternative-id":["S0006295225001777"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.116915","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphocreatine alleviates monocrotaline-induced liver injury dependent on PSRC1-regulated endoplasmic reticulum stress","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.116915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116915"}}