{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:43:30Z","timestamp":1789494210327,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473980"],"award-info":[{"award-number":["82473980"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bcp.2025.116955","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:15:05Z","timestamp":1745450105000},"page":"116955","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["GSNO induced mitochondrial Cx43 nitrosylation in cardiomyocyte differentiation from mouse ES cells in vitro"],"prefix":"10.1016","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8030-9327","authenticated-orcid":false,"given":"Jiayu","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bcp.2025.116955_b0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3390\/antiox9030225","article-title":"An Update on Thiol Signaling: S-Nitrosothiols, Hydrogen Sulfide and a Putative Role for Thionitrous Acid","volume":"9","author":"Marozkina","year":"2020","journal-title":"Antioxidants (basel)"},{"issue":"1","key":"10.1016\/j.bcp.2025.116955_b0010","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1038\/s41598-019-41266-2","article-title":"Glutathione-related substances maintain cardiomyocyte contractile function in hypoxic conditions","volume":"9","author":"Poluektov","year":"2019","journal-title":"Scientific Reports (4.996)"},{"issue":"12","key":"10.1016\/j.bcp.2025.116955_b0015","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1161\/CIRCRESAHA.123.323571","article-title":"Nitric Oxide Modulates Ca2+ Leak and Arrhythmias via S-Nitrosylation of CaMKII","volume":"133","author":"Power","year":"2023","journal-title":"Circulation Research (23.213)"},{"issue":"9","key":"10.1016\/j.bcp.2025.116955_b0020","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3390\/antiox8090404","article-title":"S-Nitrosylation: An Emerging Paradigm of Redox Signaling","volume":"8","author":"Fernando","year":"2019","journal-title":"Antioxidants (basel)"},{"issue":"12","key":"10.1016\/j.bcp.2025.116955_b0025","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1089\/ars.2019.7872","article-title":"When S-nitrosylation gets to mitochondria: from signaling to age-related diseases","volume":"32","author":"Montagna","year":"2020","journal-title":"Antioxid. Redox Signal."},{"issue":"15","key":"10.1016\/j.bcp.2025.116955_b0030","doi-asserted-by":"crossref","first-page":"E3388","DOI":"10.1073\/pnas.1722452115","article-title":"S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy","volume":"115","author":"Rizza","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.bcp.2025.116955_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113869","article-title":"S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli","volume":"176","author":"Faienza","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2025.116955_b0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2016.05.025","article-title":"Peroxiredoxin-2 nitrosylation facilitates cardiomyogenesis of mouse embryonic stem cells via XBP-1s\/PI3K pathway","volume":"97","author":"Wu","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.116955_b0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41569-018-0074-0","article-title":"Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles","volume":"16","author":"Bonora","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"issue":"9","key":"10.1016\/j.bcp.2025.116955_b0050","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCRESAHA.118.313249","article-title":"Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1alpha and LDHA","volume":"123","author":"Hu","year":"2018","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.bcp.2025.116955_b0055","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"PNAS"},{"issue":"7","key":"10.1016\/j.bcp.2025.116955_b0060","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"12","key":"10.1016\/j.bcp.2025.116955_b0065","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.3390\/ijms19123893","article-title":"Mitochondrial Dynamics in Stem Cells and Differentiation","volume":"19","author":"Seo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2025.116955_b0070","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1161\/CIRCRESAHA.119.316502","article-title":"EHD1 Modulates Cx43 Gap Junction Remodeling Associated With Cardiac Diseases","volume":"126","author":"Martins-Marques","year":"2020","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.116955_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-019-0759-5","article-title":"Mitochondrial connexin 43 in sex-dependent myocardial responses and estrogen-mediated cardiac protection following acute ischemia\/reperfusion injury","volume":"115","author":"Wang","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bcp.2025.116955_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104926","article-title":"Trastuzumab-induced cardiotoxicity and role of mitochondrial connexin43 in the adaptive response","volume":"67","author":"Pecoraro","year":"2020","journal-title":"Toxicol. In Vitro"},{"issue":"3","key":"10.1016\/j.bcp.2025.116955_b0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-017-0618-1","article-title":"Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart","volume":"112","author":"Gadicherla","year":"2017","journal-title":"Basic Res. Cardiol."},{"issue":"11","key":"10.1016\/j.bcp.2025.116955_b0090","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/s41401-020-00591-3","article-title":"Rictor\/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43","volume":"42","author":"Wang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.bcp.2025.116955_b0095","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00395-021-00861-z","article-title":"Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning","volume":"116","author":"Hirschhauser","year":"2021","journal-title":"Basic Res. Cardiol."},{"issue":"24","key":"10.1016\/j.bcp.2025.116955_b0100","article-title":"S-nitrosylation of connexin43 hemichannels elicits cardiac stress-induced arrhythmias in Duchenne muscular dystrophy mice","volume":"4","author":"Lillo","year":"2019","journal-title":"JCI Insight (9.484)"},{"issue":"3","key":"10.1016\/j.bcp.2025.116955_b0105","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1124\/jpet.120.000427","article-title":"Novel Tocolytic Strategy: Modulating Cx43 Activity by S-Nitrosation","volume":"376","author":"Barnett","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"15","key":"10.1016\/j.bcp.2025.116955_b0110","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.3390\/ijms21155415","article-title":"Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice","volume":"21","author":"Vielma","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2025.116955_b0115","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/ATVBAHA.110.215939","article-title":"Compartmentalized connexin 43 s-nitrosylation\/denitrosylation regulates heterocellular communication in the vessel wall","volume":"31","author":"Straub","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.bcp.2025.116955_b0120","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00395-014-0433-x","article-title":"S-nitrosation of mitochondrial connexin 43 regulates mitochondrial function","volume":"109","author":"Soetkamp","year":"2014","journal-title":"Basic Res. Cardiol."},{"issue":"6","key":"10.1016\/j.bcp.2025.116955_b0125","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe3706","article-title":"Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling","volume":"7","author":"Majumdar","year":"2021","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.bcp.2025.116955_b0130","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3390\/biom10091225","article-title":"Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection","volume":"10","author":"Rusiecka","year":"2020","journal-title":"Biomolecules (6.064)"},{"issue":"5","key":"10.1016\/j.bcp.2025.116955_b0135","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.3390\/ijms19051428","article-title":"Protein(-)Protein Interactions with Connexin 43: Regulation and Function","volume":"19","author":"Sorgen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2025.116955_b0140","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.freeradbiomed.2017.02.032","article-title":"The role of mitochondria in cardiac development and protection","volume":"106","author":"Pohjoismaki","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.bcp.2025.116955_b0145","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.3390\/cells10092463","article-title":"Mitochondrial Biogenesis, Mitochondrial Dynamics, and Mitophagy in the Maturation of Cardiomyocytes","volume":"10","author":"Ding","year":"2021","journal-title":"Cells (7.666)"},{"issue":"1","key":"10.1016\/j.bcp.2025.116955_b0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00395-021-00889-1","article-title":"Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases","volume":"116","author":"Feng","year":"2021","journal-title":"Basic Res. Cardiol."},{"issue":"3","key":"10.1016\/j.bcp.2025.116955_b0155","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"issue":"15","key":"10.1016\/j.bcp.2025.116955_b0160","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1111\/bph.13891","article-title":"ZP1609\/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design","volume":"174","author":"DeLalio","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2025.116955_b0165","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1152\/physrev.00010.2019","article-title":"Connexins: Key Players in the Control of Vascular Plasticity and Function","volume":"100","author":"Pohl","year":"2020","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2025.116955_b0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00395-012-0309-x","article-title":"Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia\/reperfusion injury","volume":"108","author":"Wang","year":"2013","journal-title":"Basic Res. Cardiol."},{"issue":"2","key":"10.1016\/j.bcp.2025.116955_b0175","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11427-019-1706-1","article-title":"Cardiac Na(+)-Ca(2+) exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish","volume":"64","author":"Chu","year":"2021","journal-title":"Sci. China Life Sci."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225002175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225002175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T21:03:09Z","timestamp":1750280589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225002175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":35,"alternative-id":["S0006295225002175"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.116955","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GSNO induced mitochondrial Cx43 nitrosylation in cardiomyocyte differentiation from mouse ES cells in vitro","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.116955","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116955"}}