{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:59:28Z","timestamp":1785502768808,"version":"3.56.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018225","name":"EuroNanoMed III","doi-asserted-by":"publisher","award":["FRQ-S 294233"],"award-info":[{"award-number":["FRQ-S 294233"]}],"id":[{"id":"10.13039\/100018225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 2662"],"award-info":[{"award-number":["GRK 2662"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["434130070"],"award-info":[{"award-number":["434130070"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2020-07011"],"award-info":[{"award-number":["RGPIN-2020-07011"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Quebec Health Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008582","name":"McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007537","name":"Freie Universit\u00e4t Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bcp.2025.116969","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:12:18Z","timestamp":1746756738000},"page":"116969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Charged dendrimers reduce glioblastoma viability by modulating lysosomal activity and HMGB1-RAGE interaction"],"prefix":"10.1016","volume":"238","author":[{"given":"Natali","family":"Joma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten","family":"Kagelmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8914-4606","authenticated-orcid":false,"given":"Issan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Dernedde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Haag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0017-5201","authenticated-orcid":false,"given":"Dusica","family":"Maysinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2025.116969_b0005","unstructured":"Tamimi, A. F.; Juweid, M. Epidemiology and Outcome of Glioblastoma. In Glioblastoma; De Vleeschouwer, S., Ed.; Codon Publications: Brisbane (AU), 2017."},{"issue":"2","key":"10.1016\/j.bcp.2025.116969_b0010","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/neuonc\/noab199","article-title":"Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas","volume":"24","author":"Wang","year":"2021","journal-title":"Neuro-Oncol."},{"issue":"7","key":"10.1016\/j.bcp.2025.116969_b0015","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.3390\/cancers15072116","article-title":"Mechanisms of resistance and current treatment options for glioblastoma multiforme (GBM)","volume":"15","author":"Yalamarty","year":"2023","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.bcp.2025.116969_b0020","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.3390\/brainsci13111536","article-title":"Advances in glioblastoma therapy: an update on current approaches","volume":"13","author":"Angom","year":"2023","journal-title":"Brain Sci."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0025","first-page":"142","article-title":"Emerging therapies for glioblastoma: current state and future directions","volume":"41","author":"Rong","year":"2022","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"issue":"3\u20134","key":"10.1016\/j.bcp.2025.116969_b0030","first-page":"257","article-title":"Dendritic polyglycerol: A new versatile biocompatible-Material","volume":"90","author":"Frey","year":"2002","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.bcp.2025.116969_b0035","article-title":"Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: A PET imaging study","author":"Roussel","year":"2024","journal-title":"J. Mater. Chem. B"},{"issue":"9","key":"10.1016\/j.bcp.2025.116969_b0040","doi-asserted-by":"crossref","first-page":"708","DOI":"10.2174\/1389200223666220616125524","article-title":"Surface engineered dendrimers: A potential nanocarrier for the effective management of glioblastoma multiforme","volume":"23","author":"Sahoo","year":"2022","journal-title":"Curr. Drug Metab."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1295\/polymj.17.117","article-title":"A new class of polymers: starburst-dendritic macromolecules","volume":"17","author":"Tomalia","year":"1985","journal-title":"Polym. J."},{"issue":"12","key":"10.1016\/j.bcp.2025.116969_b0050","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1021\/acs.biomac.0c01270","article-title":"Dendrimer-mediated targeted delivery of rapamycin to tumor-associated macrophages improves systemic treatment of glioblastoma","volume":"21","author":"Sharma","year":"2020","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0055","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/bc034044j","article-title":"Dendritic polyglycerol sulfates as new heparin analogues and potent inhibitors of the complement system","volume":"15","author":"T\u00fcrk","year":"2004","journal-title":"Bioconjug. Chem."},{"issue":"8","key":"10.1016\/j.bcp.2025.116969_b0060","first-page":"1005","article-title":"Synthesis of laminarin sulfates with anticoagulant activity","volume":"42","author":"Alban","year":"1992","journal-title":"Arzneimittelforschung"},{"issue":"5","key":"10.1016\/j.bcp.2025.116969_b0065","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202100507","article-title":"Scaffold flexibility controls binding of herpes simplex virus type 1 with sulfated dendritic polyglycerol hydrogels fabricated by thiol-maleimide click reaction","volume":"22","author":"Thongrom","year":"2022","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.bcp.2025.116969_b0070","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25281","article-title":"Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome","volume":"6","author":"Ferber","year":"2017","journal-title":"eLife"},{"issue":"9","key":"10.1016\/j.bcp.2025.116969_b0075","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1039\/C4NR04428B","article-title":"Dendritic polyglycerol sulfate as a novel platform for paclitaxel delivery: pitfalls of ester linkage","volume":"7","author":"Sousa-Herves","year":"2015","journal-title":"Nanoscale"},{"issue":"16","key":"10.1016\/j.bcp.2025.116969_b0080","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","article-title":"A Versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine","volume":"92","author":"Boussif","year":"1995","journal-title":"PNAS"},{"issue":"7","key":"10.1016\/j.bcp.2025.116969_b0085","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0142-9612(02)00445-3","article-title":"In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis","volume":"24","author":"Fischer","year":"2003","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.bcp.2025.116969_b0090","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1039\/C5BM00187K","article-title":"Systematic adjustment of charge densities and size of polyglycerol amines reduces cytotoxic effects and enhances cellular uptake","volume":"3","author":"Hellmund","year":"2015","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bcp.2025.116969_b0095","doi-asserted-by":"crossref","DOI":"10.1177\/17590914211073276","article-title":"Dendritic polyglycerol amine: an enhanced substrate to support long-term neural cell culture","volume":"14","author":"Cl\u00e9ment","year":"2022","journal-title":"ASN Neuro"},{"key":"10.1016\/j.bcp.2025.116969_b0100","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.freeradbiomed.2018.12.011","article-title":"DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin","volume":"131","author":"Du","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.116969_b0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12974-015-0244-5","article-title":"Docosahexaenoic acid (DHA): A modulator of microglia activity and dendritic spine morphology","volume":"12","author":"Chang","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.bcp.2025.116969_b0110","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.arr.2013.01.007","article-title":"Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms","volume":"12","author":"Denis","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bcp.2025.116969_b0115","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jns.2018.11.027","article-title":"Whole transcriptome sequencing analyses of DHA treated glioblastoma cells","volume":"396","author":"Ruan","year":"2019","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-3084(03)00101-4","article-title":"Docosahexaenoic acid: membrane properties of a unique fatty acid","volume":"126","author":"Stillwell","year":"2003","journal-title":"Chem. Phys. Lipids"},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0125","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12974-017-0939-x","article-title":"Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro","volume":"14","author":"Fourrier","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0130","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12974-016-0580-0","article-title":"Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells","volume":"13","author":"Tremblay","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.bcp.2025.116969_b0135","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11864-017-0508-7","article-title":"Optimal therapies for newly diagnosed elderly patients with glioblastoma","volume":"18","author":"Ironside","year":"2017","journal-title":"Curr. Treat. Options Oncol."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0140","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1073\/pnas.1314469111","article-title":"mTOR Target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy","volume":"111","author":"Weiler","year":"2014","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0145","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1509421","article-title":"Docosahexaenoic acid-enhanced autophagic flux improves cardiac dysfunction after myocardial infarction by targeting the AMPK\/mTOR signaling pathway","volume":"2022","author":"Shi","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.bcp.2025.116969_b0150","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/neuonc\/not095","article-title":"Are we ready for a randomized trial of valproic acid in newly diagnosed glioblastoma?","volume":"15","author":"Weller","year":"2013","journal-title":"Neuro-Oncol."},{"key":"10.1016\/j.bcp.2025.116969_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1336191","article-title":"HMGB1\/RAGE Axis in tumor development: unraveling its significance","volume":"14","author":"Fan","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2025.116969_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00422","article-title":"DAMPs from cell death to new life","volume":"6","author":"V\u00e9n\u00e9reau","year":"2015","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0165","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1186\/s12967-024-05489-w","article-title":"HMGB1\/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4\/Akt signaling","volume":"22","author":"Qiu","year":"2024","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/cmi.2016.34","article-title":"HMGB1, IL-1\u03b1, IL-33 and S100 proteins: dual-function alarmins","volume":"14","author":"Bertheloot","year":"2017","journal-title":"Cell. Mol. Immunol."},{"issue":"9","key":"10.1016\/j.bcp.2025.116969_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104872","article-title":"Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE","volume":"25","author":"Ye","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.bcp.2025.116969_b0180","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cytogfr.2024.07.004","article-title":"Deciphering the roles of the HMGB family in cancer: insights from subcellular localization dynamics","volume":"78","author":"Jiang","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"10.1016\/j.bcp.2025.116969_b0185","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3892\/ijmm.2023.5272","article-title":"Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)","volume":"52","author":"Shao","year":"2023","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.116969_b0190","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1023\/B:NEON.0000024220.07063.70","article-title":"Spheroid preparation from hanging drops: characterization of a model of brain tumor invasion","volume":"67","author":"Del Duca","year":"2004","journal-title":"J. Neurooncol"},{"issue":"7","key":"10.1016\/j.bcp.2025.116969_b0195","doi-asserted-by":"crossref","DOI":"10.1002\/mame.202000688","article-title":"Automated solvent-free polymerization of hyperbranched polyglycerol with tailored molecular weight by online torque detection","volume":"306","author":"Wallert","year":"2021","journal-title":"Macromol. Mater. Eng."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0200","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/bc034044j","article-title":"Dendritic Polyglycerol sulfates as new heparin analogues and potent inhibitors of the complement system","volume":"15","author":"CccT\u00fcrk","year":"2004","journal-title":"Bioconjug. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2025.116969_b0205","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"issue":"8016","key":"10.1016\/j.bcp.2025.116969_b0210","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"27","key":"10.1016\/j.bcp.2025.116969_b0215","doi-asserted-by":"crossref","first-page":"10958","DOI":"10.1073\/pnas.1222308110","article-title":"Crystal Structure of the high-affinity Na+K+-ATPase-Ouabain complex with Mg2+ bound in the cation binding site","volume":"110","author":"Laursen","year":"2013","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.bcp.2025.116969_b0220","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1021\/acs.biochem.1c00684","article-title":"Molecular features of CA-074 pH-dependent inhibition of Cathepsin B","volume":"61","author":"Yoon","year":"2022","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.bcp.2025.116969_b0225","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.bbrc.2013.10.085","article-title":"Redox-sensitive structural change in the A-domain of HMGB1 and its implication for the binding to cisplatin modified DNA","volume":"441","author":"Wang","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"24","key":"10.1016\/j.bcp.2025.116969_b0230","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1111\/febs.12556","article-title":"Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products","volume":"280","author":"Yatime","year":"2013","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0235","first-page":"239","article-title":"\u03a93-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: in vitro and in vivo","volume":"39","author":"Kim","year":"2018","journal-title":"Oncol. Rep."},{"issue":"3","key":"10.1016\/j.bcp.2025.116969_b0240","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3390\/biomedicines11030779","article-title":"Effect of polyunsaturated fatty acids on temozolomide drug-sensitive and drug-resistant glioblastoma cells","volume":"11","author":"Silva","year":"2023","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.bcp.2025.116969_b0245","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2174\/156652411796268740","article-title":"Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis","volume":"11","author":"Wang","year":"2011","journal-title":"Curr. Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0250","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10555-021-09997-9","article-title":"Glioma: molecular signature and crossroads with tumor microenvironment","volume":"41","author":"Barthel","year":"2022","journal-title":"Cancer Metastasis Rev."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0255","article-title":"Tumor microenvironment in glioblastoma: current and emerging concepts","volume":"5","author":"Sharma","year":"2023","journal-title":"Neuro-Oncol. Adv."},{"issue":"345","key":"10.1016\/j.bcp.2025.116969_b0260","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf7374","article-title":"P-selectin is a nanotherapeutic delivery target in the tumor microenvironment","volume":"8","author":"Shamay","year":"2016","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0265","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1038\/s41467-021-22186-0","article-title":"P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression","volume":"12","author":"Yeini","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0270","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/15419069409014198","article-title":"Expression of P-selectin on endothelial cells is upregulated by LPS and TNF-alpha in vivo","volume":"2","author":"Gotsch","year":"1994","journal-title":"Cell Adhes. Commun."},{"issue":"46","key":"10.1016\/j.bcp.2025.116969_b0275","doi-asserted-by":"crossref","first-page":"19679","DOI":"10.1073\/pnas.1003103107","article-title":"Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation","volume":"107","author":"Dernedde","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2025.116969_b0280","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11051-015-2927-3","article-title":"Biodistribution, cellular localization, and in vivo tolerability of 35S-labeled antiinflammatory dendritic polyglycerol sulfate amine","volume":"17","author":"Holzhausen","year":"2015","journal-title":"J. Nanoparticle Res."},{"issue":"6","key":"10.1016\/j.bcp.2025.116969_b0285","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1021\/acs.jproteome.9b00792","article-title":"Quantitative proteomics reveals docosahexaenoic acid-mediated neuroprotective effects in lipopolysaccharide-stimulated microglial cells","volume":"19","author":"Yang","year":"2020","journal-title":"J. Proteome Res."},{"issue":"8","key":"10.1016\/j.bcp.2025.116969_b0290","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/biom9080330","article-title":"Cytotoxicity of dendrimers","volume":"9","author":"Janaszewska","year":"2019","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.bcp.2025.116969_b0295","first-page":"1","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy","volume":"13","author":"Zhang","year":"2022","journal-title":"Metabolic Disorders. Cell Death Dis."},{"issue":"8","key":"10.1016\/j.bcp.2025.116969_b0300","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and autophagy-related pathways in cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0305","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tcb.2014.09.001","article-title":"Cellular and metabolic functions for autophagy in cancer cells","volume":"25","author":"Kenific","year":"2015","journal-title":"Trends Cell Biol."},{"issue":"4","key":"10.1016\/j.bcp.2025.116969_b0310","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/ijc.34991","article-title":"Autophagy in glioblastoma: A mechanistic perspective","volume":"155","author":"Meena","year":"2024","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.bcp.2025.116969_b0315","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41418-019-0474-7","article-title":"Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients","volume":"27","author":"Mulcahy Levy","year":"2020","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0320","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s43556-023-00155-x","article-title":"Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma","volume":"4","author":"Tang","year":"2023","journal-title":"Mol. Biomed."},{"issue":"8","key":"10.1016\/j.bcp.2025.116969_b0325","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.bcp.2025.116969_b0330","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bbadis.2013.01.020","article-title":"The Role of proton dynamics in the development and maintenance of multidrug resistance in cancer","volume":"1832","author":"Daniel","year":"2013","journal-title":"Biochim. Biophys. Acta BBA - Mol. Basis Dis."},{"issue":"12","key":"10.1016\/j.bcp.2025.116969_b0335","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41573-019-0036-1","article-title":"Lysosomes as a therapeutic target","volume":"18","author":"Bonam","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.bcp.2025.116969_b0340","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2025.116969_b0345","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1322746","article-title":"Lipid peroxidation of immune cells in cancer","volume":"14","author":"Xiao","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0350","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1038\/s41467-020-19193-y","article-title":"Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression","volume":"11","author":"Yee","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2025.116969_b0355","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejpb.2015.12.008","article-title":"Pharmacological inhibition of lipid droplet formation enhances the effectiveness of curcumin in glioblastoma","volume":"100","author":"Zhang","year":"2016","journal-title":"Eur. J. Pharm. Biopharm. off. J. Arbeitsgemeinschaft Pharm. Verfahrenstechnik EV"},{"issue":"8","key":"10.1016\/j.bcp.2025.116969_b0360","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cmet.2021.05.016","article-title":"Peroxidation of N-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects","volume":"33","author":"Dierge","year":"2021","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.bcp.2025.116969_b0365","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.bcp.2025.116969_b0370","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1038\/s44318-024-00130-4","article-title":"LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma","volume":"43","author":"Lu","year":"2024","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.bcp.2025.116969_b0375","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3892\/or.2023.8653","article-title":"Starvation insult induces the translocation of high mobility group box 1 to cytosolic compartments in glioma","volume":"50","author":"Cui","year":"2023","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bcp.2025.116969_b0380","article-title":"Temozolomide treatment induces HMGB1 to promote the formation of glioma stem cells via the TLR2\/NEAT1\/Wnt pathway in glioblastoma","volume":"9","author":"Gao","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0385","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13046-022-02291-8","article-title":"Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization","volume":"41","author":"Li","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2025.116969_b0390","first-page":"8916","article-title":"High mobility group box 1 (HMGB1) predicts invasion and poor prognosis of glioblastoma multiforme via activating AKT signaling in an autocrine pathway","volume":"24","author":"Cheng","year":"2018","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"issue":"6894","key":"10.1016\/j.bcp.2025.116969_b0395","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2025.116969_b0400","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2025.116969_b0405","first-page":"1","article-title":"Addicted to death: invasive cancer and the immune response to unscheduled cell death","volume":"28","author":"Zeh","year":"2005","journal-title":"J. Immunother. Hagerstown Md 1977"},{"issue":"9","key":"10.1016\/j.bcp.2025.116969_b0410","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1074\/jbc.M609554200","article-title":"Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1","volume":"282","author":"Tanno","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2025.116969_b0415","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1021\/acschemneuro.2c00558","article-title":"SulfaTED HYPERBRANCHED AND LINEAR POLYGLYCEROLS MODULATE HMGB1 and morphological plasticity in neural cells","volume":"14","author":"Maysinger","year":"2023","journal-title":"ACS Chem. Nerosci."},{"issue":"2","key":"10.1016\/j.bcp.2025.116969_b0420","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.intimp.2010.11.014","article-title":"Heparin changes the conformation of high-mobility group protein 1 and decreases its affinity toward receptor for advanced glycation endproducts in vitro","volume":"11","author":"Ling","year":"2011","journal-title":"Int. Immunopharmacol."},{"issue":"16","key":"10.1016\/j.bcp.2025.116969_b0425","first-page":"4805","article-title":"Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis","volume":"62","author":"Huttunen","year":"2002","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bcp.2025.116969_b0430","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1074\/jbc.M113.541474","article-title":"An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor","volume":"289","author":"LeBlanc","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2025.116969_b0435","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cis.2018.06.005","article-title":"PAMAM dendrimer - cell membrane interactions","volume":"257","author":"Fox","year":"2018","journal-title":"Adv. Colloid Interface Sci."},{"issue":"7948","key":"10.1016\/j.bcp.2025.116969_b0440","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41586-022-05682-1","article-title":"Aberrant phase separation and nucleolar dysfunction in rare genetic diseases","volume":"614","author":"Mensah","year":"2023","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.bcp.2025.116969_b0445","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/s41592-019-0586-5","article-title":"Engineering of human brain organoids with a functional vascular-like system","volume":"16","author":"Cakir","year":"2019","journal-title":"Nat. Methods"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522500231X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522500231X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:01:38Z","timestamp":1785499298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522500231X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":89,"alternative-id":["S000629522500231X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.116969","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Charged dendrimers reduce glioblastoma viability by modulating lysosomal activity and HMGB1-RAGE interaction","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.116969","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116969"}}