{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:25:06Z","timestamp":1780395906722,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900633"],"award-info":[{"award-number":["31900633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bcp.2025.117045","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T11:27:41Z","timestamp":1749209261000},"page":"117045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["ALKBH7 mediates the mitigative effect of bismuth drug against cisplatin-induced acute kidney injury"],"prefix":"10.1016","volume":"239","author":[{"given":"Hui","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longpo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bcp.2025.117045_b0005","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11095-007-9254-z","article-title":"Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications","volume":"24","author":"Koepsell","year":"2007","journal-title":"Pharm Res"},{"issue":"1","key":"10.1016\/j.bcp.2025.117045_b0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41581-022-00631-7","article-title":"Cisplatin nephrotoxicity: new insights and therapeutic implications","volume":"19","author":"Tang","year":"2023","journal-title":"Nat Rev Nephrol"},{"issue":"9","key":"10.1016\/j.bcp.2025.117045_b0015","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s41581-022-00592-x","article-title":"Immunometabolic rewiring of tubular epithelial cells in kidney disease","volume":"18","author":"van der Rijt","year":"2022","journal-title":"Nat Rev Nephrol"},{"issue":"19","key":"10.1016\/j.bcp.2025.117045_b0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197416","article-title":"PPAR-alpha deletion attenuates cisplatin nephrotoxicity by modulating renal organic transporters MATE-1 and OCT-2","volume":"21","author":"Freitas-Lima","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.bcp.2025.117045_b0025","article-title":"Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia\/reperfusion injury in the rat","volume":"8","author":"Sivarajah","year":"2002","journal-title":"Med Sci Monit"},{"issue":"2","key":"10.1016\/j.bcp.2025.117045_b0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1188\/18.CJON.175-183","article-title":"Nephrotoxicity: evidence in patients receiving cisplatin therapy","volume":"22","author":"Duffy","year":"2018","journal-title":"Clin J Oncol Nurs"},{"issue":"11","key":"10.1016\/j.bcp.2025.117045_b0035","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Mechanisms of cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins (basel)"},{"issue":"6","key":"10.1016\/j.bcp.2025.117045_b0040","doi-asserted-by":"crossref","first-page":"F1582","DOI":"10.1152\/ajprenal.00385.2019","article-title":"Chronic effects of repeated low-dose cisplatin treatment in mouse kidneys and renal tubular cells","volume":"317","author":"Fu","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"10.1016\/j.bcp.2025.117045_b0045","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nchem.609","article-title":"Green bismuth","volume":"2","author":"Mohan and Ram","year":"2010","journal-title":"Nat. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2025.117045_b0050","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrgastro.2011.84","article-title":"Helicobacter pylori eradication: a new, single-capsule bismuth-containing quadruple therapy","volume":"8","author":"Gisbert","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.bcp.2025.117045_b0055","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1349-7006.1988.tb01605.x","article-title":"Specific reduction of toxic side effects of adriamycin by induction of metallothionein in mice","volume":"79","author":"Naganuma","year":"1988","journal-title":"Jpn J Cancer Res"},{"issue":"4","key":"10.1016\/j.bcp.2025.117045_b0060","first-page":"983","article-title":"Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(ii) by induction of metallothionein synthesis without compromising its antitumor-activity in mice","volume":"47","author":"Naganuma","year":"1987","journal-title":"Cancer Res."},{"issue":"7298","key":"10.1016\/j.bcp.2025.117045_b0065","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nature09018","article-title":"Affinity gradients drive copper to cellular destinations","volume":"465","author":"Banci","year":"2010","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.bcp.2025.117045_b0070","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1073\/pnas.1421002112","article-title":"Glutathione and multidrug resistance protein transporter mediate a self-propelled disposal of bismuth in human cells","volume":"112","author":"Hong","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bcp.2025.117045_b0075","article-title":"Bismuth reduces cisplatin-induced nephrotoxicity via enhancing Glutathione conjugation and Vesicular transport","volume":"13","author":"Jiang","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bcp.2025.117045_b0080","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/srep00999","article-title":"Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe","volume":"2","author":"Yang","year":"2012","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2025.117045_b0085","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0162-0134(02)00649-9","article-title":"Binding of bismuth to serum proteins: implication for targets of Bi(III) in blood plasma","volume":"94","author":"Sun","year":"2003","journal-title":"J Inorg Biochem"},{"issue":"5","key":"10.1016\/j.bcp.2025.117045_b0090","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41589-022-01223-z","article-title":"Co-evolution-based prediction of metal-binding sites in proteomes by machine learning","volume":"19","author":"Cheng","year":"2023","journal-title":"Nat Chem Biol"},{"issue":"5\u20136","key":"10.1016\/j.bcp.2025.117045_b0095","first-page":"551","article-title":"Carnitine: transport and physiological functions in the brain","volume":"25","author":"Nalecz","year":"2004","journal-title":"Mol Aspects Med"},{"issue":"1","key":"10.1016\/j.bcp.2025.117045_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(96)00603-5","article-title":"Palmitoylcarnitine, a surface-active metabolite","volume":"390","author":"Goni","year":"1996","journal-title":"FEBS Lett"},{"issue":"6141","key":"10.1016\/j.bcp.2025.117045_b0105","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez Molina","year":"2013","journal-title":"Science"},{"issue":"15","key":"10.1016\/j.bcp.2025.117045_b0110","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission","volume":"282","author":"Taguchi","year":"2007","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.bcp.2025.117045_b0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2014.04.084","article-title":"Functional analysis of iPSC-derived myocytes from a patient with carnitine palmitoyltransferase II deficiency","volume":"448","author":"Yasuno","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.bcp.2025.117045_b0120","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s12276-022-00736-w","article-title":"The mechanism of HMGB1 secretion and release","volume":"54","author":"Chen","year":"2022","journal-title":"Exp Mol Med"},{"issue":"41","key":"10.1016\/j.bcp.2025.117045_b0125","doi-asserted-by":"crossref","first-page":"12408","DOI":"10.1021\/ja037019x","article-title":"Structure of colloidal bismuth subcitrate (CBS) in dilute HCl: unique assembly of bismuth citrate dinuclear units ([Bi(cit)(2)Bi](2-))","volume":"125","author":"Li","year":"2003","journal-title":"J Am Chem Soc"},{"issue":"40","key":"10.1016\/j.bcp.2025.117045_b0130","doi-asserted-by":"crossref","first-page":"27924","DOI":"10.1074\/jbc.M114.590505","article-title":"The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism","volume":"289","author":"Wang","year":"2014","journal-title":"J Biol Chem"},{"issue":"5855","key":"10.1016\/j.bcp.2025.117045_b0135","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.1151710","article-title":"The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase","volume":"318","author":"Gerken","year":"2007","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bcp.2025.117045_b0140","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1093\/jmcb\/mjt012","article-title":"Deletion of mouse Alkbh7 leads to obesity","volume":"5","author":"Solberg","year":"2013","journal-title":"J Mol Cell Biol"},{"issue":"5 Pt 2","key":"10.1016\/j.bcp.2025.117045_b0145","first-page":"F977","article-title":"Substrate specificity to maintain cellular ATP along the mouse nephron","volume":"255","author":"Uchida","year":"1988","journal-title":"Am J Physiol"},{"issue":"15","key":"10.1016\/j.bcp.2025.117045_b0150","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.1007\/s00018-021-03892-w","article-title":"The role of metabolic reprogramming in tubular epithelial cells during the progression of acute kidney injury","volume":"78","author":"Li","year":"2021","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.bcp.2025.117045_b0155","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41581-021-00488-2","article-title":"Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease","volume":"18","author":"Baek","year":"2022","journal-title":"Nat Rev Nephrol"},{"issue":"7","key":"10.1016\/j.bcp.2025.117045_b0160","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41556-021-00709-7","article-title":"ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing","volume":"23","author":"Zhang","year":"2021","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.bcp.2025.117045_b0165","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12953-019-0156-x","article-title":"The interactome and proteomic responses of ALKBH7 in cell lines by in-depth proteomics analysis","volume":"17","author":"Meng","year":"2019","journal-title":"Proteome Sci"},{"issue":"10","key":"10.1016\/j.bcp.2025.117045_b0170","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"640","key":"10.1016\/j.bcp.2025.117045_b0175","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abk2709","article-title":"Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms","volume":"14","author":"Wang","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bcp.2025.117045_b0180","article-title":"Alteration of N6-methyladenosine RNA profiles in cisplatin-induced acute kidney injury in mice","volume":"8","author":"Li","year":"2021","journal-title":"Front Mol Biosci"},{"issue":"10","key":"10.1016\/j.bcp.2025.117045_b0185","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/s41587-021-00915-6","article-title":"Quantitative profiling of pseudouridylation dynamics in native RNAs with nanopore sequencing","volume":"39","author":"Begik","year":"2021","journal-title":"Nat Biotechnol"},{"issue":"2","key":"10.1016\/j.bcp.2025.117045_b0190","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.1365-2125.1996.03929.x","article-title":"Pharmacokinetics of bismuth and ranitidine following single doses of ranitidine bismuth citrate","volume":"42","author":"Koch","year":"1996","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117045_b0195","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1365-2125.1996.39310.x","article-title":"Pharmacokinetics of bismuth and ranitidine following multiple doses of ranitidine bismuth citrate","volume":"42","author":"Koch","year":"1996","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117045_b0200","first-page":"53","article-title":"Bismuth ions are metabolized into autometallographic traceable bismuth-sulphur quantum dots","volume":"51","author":"Stoltenberg","year":"2007","journal-title":"Eur J Histochem"},{"issue":"3","key":"10.1016\/j.bcp.2025.117045_b0205","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0006-2952(91)90533-B","article-title":"The role of metallothionein in the reduction of cisplatin-induced nephrotoxicity by Bi3+-Pretreatment in the rat invivo and invitro - are antioxidant properties of metallothionein more relevant than platinum binding","volume":"41","author":"Boogaard","year":"1991","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117045_b0210","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1101\/gad.215533.113","article-title":"Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis","volume":"27","author":"Fu","year":"2013","journal-title":"Genes Dev"},{"key":"10.1016\/j.bcp.2025.117045_b0215","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58573","article-title":"ALKBH7 mediates necrosis via rewiring of glyoxal metabolism","volume":"9","author":"Kulkarni","year":"2020","journal-title":"Elife"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225003107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225003107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T06:54:49Z","timestamp":1752648889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225003107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":43,"alternative-id":["S0006295225003107"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117045","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ALKBH7 mediates the mitigative effect of bismuth drug against cisplatin-induced acute kidney injury","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117045"}}