{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:29:45Z","timestamp":1789730985446,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KJQN202200458"],"award-info":[{"award-number":["KJQN202200458"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["CSTB2022NSCO-MSX1097"],"award-info":[{"award-number":["CSTB2022NSCO-MSX1097"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011786","name":"Chongqing Municipal Human Resources and Social Security Bureau","doi-asserted-by":"publisher","award":["2021XM3063"],"award-info":[{"award-number":["2021XM3063"]}],"id":[{"id":"10.13039\/501100011786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022MD713710"],"award-info":[{"award-number":["2022MD713710"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bcp.2025.117054","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T19:23:30Z","timestamp":1750447410000},"page":"117054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Cuproptosis involvement in neonatal ischemic-hypoxic encephalopathy through the COMMD1\/ATP7A signaling axis"],"prefix":"10.1016","volume":"239","author":[{"given":"Jingjing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxman","family":"Bharati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5872-8174","authenticated-orcid":false,"given":"Zhi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bcp.2025.117054_b0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamapediatrics.2014.3269","article-title":"Hypoxic-ischemic encephalopathy: a review for the clinician","volume":"169","author":"Douglas-Escobar","year":"2015","journal-title":"JAMA Pediatr."},{"issue":"6","key":"10.1016\/j.bcp.2025.117054_b0010","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum. Dev."},{"issue":"3","key":"10.1016\/j.bcp.2025.117054_b0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1053\/j.nainr.2011.07.004","article-title":"Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments","volume":"11","author":"Allen","year":"2011","journal-title":"Newborn Infant Nurs Rev"},{"issue":"4","key":"10.1016\/j.bcp.2025.117054_b0020","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1474-4422(11)70016-3","article-title":"Treatment advances in neonatal neuroprotection and neurointensive care","volume":"10","author":"Johnston","year":"2011","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/1673-5374.199008","article-title":"Molecular chaperones and hypoxic-ischemic encephalopathy","volume":"12","author":"Hua","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bcp.2025.117054_b0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.earlhumdev.2018.02.007","article-title":"Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - a systematic review","volume":"120","author":"Conway","year":"2018","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.bcp.2025.117054_b0035","doi-asserted-by":"crossref","unstructured":"P. Tsvetkov, S. Coy, B. Petrova, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins [published correction appears in Science. 2022 Apr 22;376(6591):eabq4855. doi: 10.1126\/science.abq4855.]. Science. 2022;375(6586):1254-1261. doi:10.1126\/science.abf0529.","DOI":"10.1126\/science.abf0529"},{"issue":"7","key":"10.1016\/j.bcp.2025.117054_b0040","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41589-018-0062-z","article-title":"Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system","volume":"14","author":"Xiao","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2025.117054_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.101018","article-title":"Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance","volume":"72","author":"Wang","year":"2024","journal-title":"Drug Resist. Updat."},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0050","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12967-025-06121-1","article-title":"Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications","volume":"23","author":"Cong","year":"2025","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.bcp.2025.117054_b0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cbpa.2010.01.003","article-title":"Human copper homeostasis: a network of interconnected pathways","volume":"14","author":"Lutsenko","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"9","key":"10.1016\/j.bcp.2025.117054_b0060","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1039\/c0mt00006j","article-title":"Copper handling machinery of the brain","volume":"2","author":"Lutsenko","year":"2010","journal-title":"Metallomics"},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0065","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct Target Ther."},{"issue":"20","key":"10.1016\/j.bcp.2025.117054_b0070","doi-asserted-by":"crossref","first-page":"20654","DOI":"10.1007\/s11356-019-05345-1","article-title":"Copper(II) generates ROS and RNS, impairs antioxidant system and damages membrane and DNA in human blood cells","volume":"26","author":"Husain","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118867","article-title":"Getting out what you put in: Copper in mitochondria and its impacts on human disease","volume":"1868","author":"Cobine","year":"2021","journal-title":"Biochim Biophys. Acta Mol. Cell. Res."},{"issue":"3","key":"10.1016\/j.bcp.2025.117054_b0080","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nchembio.72","article-title":"Mechanisms for copper acquisition, distribution and regulation","volume":"4","author":"Kim","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrneurol.2010.180","article-title":"ATP7A-related copper transport diseases-emerging concepts and future trends","volume":"7","author":"Kaler","year":"2011","journal-title":"Nat. Rev. Neurol."},{"issue":"6491","key":"10.1016\/j.bcp.2025.117054_b0090","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1126\/science.aaz8899","article-title":"Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice","volume":"368","author":"Guthrie","year":"2020","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.bcp.2025.117054_b0095","doi-asserted-by":"crossref","first-page":"13850","DOI":"10.3390\/ijms232213850","article-title":"The Role of Copper Homeostasis in Brain Disease","volume":"23","author":"An","year":"2022","journal-title":"Int J Mol Sci."},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40635-020-00300-8","article-title":"Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke","volume":"8","author":"Mendon\u00e7a","year":"2020","journal-title":"Intensive Care Med. Exp."},{"key":"10.1016\/j.bcp.2025.117054_b0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/nyas.12347","article-title":"Pathological mitochondrial copper overload in livers of Wilson's disease patients and related animal models","volume":"1315","author":"Zischka","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2025.117054_b0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092408","article-title":"The Copper Metabolism MURR1 domain protein 1 (COMMD1) modulates the aggregation of misfolded protein species in a client-specific manner","volume":"9","author":"Vonk","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1091\/mbc.e14-06-1073","article-title":"COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A","volume":"26","author":"Phillips-Krawczak","year":"2015","journal-title":"Mol. Biol. Cell"},{"issue":"12","key":"10.1016\/j.bcp.2025.117054_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029183","article-title":"Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation","volume":"6","author":"Vonk","year":"2011","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.bcp.2025.117054_b0125","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.bbadis.2013.09.014","article-title":"Tuning NF-\u03baB activity: a touch of COMMD proteins","volume":"1832","author":"Bartuzi","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.bcp.2025.117054_b0130","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1053\/j.gastro.2005.10.054","article-title":"ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion","volume":"130","author":"Cater","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcp.2025.117054_b0135","doi-asserted-by":"crossref","first-page":"10640","DOI":"10.1038\/ncomms10640","article-title":"Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway","volume":"7","author":"Hatori","year":"2016","journal-title":"Nat. Commun."},{"issue":"3\u20134","key":"10.1016\/j.bcp.2025.117054_b0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ceca.2004.02.016","article-title":"Metabolic stages, mitochondria and calcium in hypoxic\/ischemic brain damage","volume":"36","author":"Kristi\u00e1n","year":"2004","journal-title":"Cell Calcium"},{"issue":"8","key":"10.1016\/j.bcp.2025.117054_b0145","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.bcp.2025.117054_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090544","article-title":"Upregulated copper transporters in hypoxia-induced pulmonary hypertension","volume":"9","author":"Zimnicka","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2025.117054_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2025.105973","article-title":"Sp4\/HD11 and Sp1\/HAT-p300 complexes induce apoptotic cell death in CuCl2-treated neurons by modulating histone acetylation on BCL-W and BAX promoters","volume":"186","author":"Ruggiero","year":"2025","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0160","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41392-025-02192-0","article-title":"The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer","volume":"10","author":"Guo","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117054_b0165","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12974-021-02309-6","article-title":"The semantics of microglia activation: neuroinflammation, homeostasis, and stress","volume":"18","author":"Woodburn","year":"2021","journal-title":"J. Neuroinflammation."},{"issue":"9","key":"10.1016\/j.bcp.2025.117054_b0170","first-page":"1633","article-title":"Role of Serum Level of Neurometals; copper, Zinc and Magnesium in Neonates with Hypoxic Ischemic Encephalopathy","volume":"62","author":"Foley","year":"2016","journal-title":"Clin. Lab."},{"key":"10.1016\/j.bcp.2025.117054_b0175","doi-asserted-by":"crossref","unstructured":"K. Murata, C. Fang, C. Terao, et al. Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis [published correction appears in Immunity. 2022 Nov 8;55(11):2209. doi: 10.1016\/j.immuni.2022.10.007.]. Immunity. 2017;47(1):66-79.e5. doi:10.1016\/j.immuni.2017.06.018.","DOI":"10.1016\/j.immuni.2017.06.018"}],"updated-by":[{"DOI":"10.1016\/j.bcp.2026.118274","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000}}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225003193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225003193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:23:44Z","timestamp":1786083824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225003193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":35,"alternative-id":["S0006295225003193"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117054","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cuproptosis involvement in neonatal ischemic-hypoxic encephalopathy through the COMMD1\/ATP7A signaling axis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117054"}}