{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:49:31Z","timestamp":1790401771840,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20221277"],"award-info":[{"award-number":["20221277"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014857","name":"National Natural Science Foundation of China-Guangdong Joint Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2022YFE0209700"],"award-info":[{"award-number":["2022YFE0209700"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202201011248"],"award-info":[{"award-number":["202201011248"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A04J7996"],"award-info":[{"award-number":["2024A04J7996"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bcp.2025.117067","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T18:51:19Z","timestamp":1750704679000},"page":"117067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["AXL enhances the self-renewal of cancer stem-like cells and Osimertinib chemoresistance by regulating SCD1 in non-small cell lung cancer"],"prefix":"10.1016","volume":"240","author":[{"given":"Qianrong","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuowen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quidi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-0461","authenticated-orcid":false,"given":"Xueping","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0005","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bcp.2025.117067_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116378","article-title":"Antibody-drug conjugates for non-small cell lung cancer: advantages and challenges in clinical translation","volume":"226","author":"Zhao","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"23","key":"10.1016\/j.bcp.2025.117067_b0015","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1158\/0008-5472.CAN-22-1289","article-title":"MNX1-AS1 promotes phase separation of IGF2BP1 to Drive c-Myc-mediated cell-cycle progression and proliferation in lung cancer","volume":"82","author":"Zhu","year":"2022","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bcp.2025.117067_b0020","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ymthe.2022.11.011","article-title":"PROTAC therapy as a new targeted therapy for lung cancer","volume":"31","author":"Li","year":"2023","journal-title":"Mol. Ther."},{"issue":"23","key":"10.1016\/j.bcp.2025.117067_b0025","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1056\/NEJMra1804280","article-title":"Clinical and therapeutic implications of cancer stem cells","volume":"380","author":"Clarke","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1615\/CritRevOncog.2019029512","article-title":"Cancer stem cells: root of the evil","volume":"24","author":"Erkisa","year":"2019","journal-title":"Crit. Rev. Oncog."},{"issue":"10","key":"10.1016\/j.bcp.2025.117067_b0035","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151591","article-title":"FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway","volume":"132","author":"Zhang","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"16","key":"10.1016\/j.bcp.2025.117067_b0040","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1158\/0008-5472.CAN-19-3613","article-title":"HDAC10 regulates cancer stem-like cell properties in KRAS-driven lung adenocarcinoma","volume":"80","author":"Li","year":"2020","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41420-021-00480-6","article-title":"Apatinib suppresses lung cancer stem-like cells by complex interplay between \u03b2-catenin signaling and mitochondrial ROS accumulation","volume":"7","author":"Zhu","year":"2021","journal-title":"Cell Death Discov"},{"issue":"6","key":"10.1016\/j.bcp.2025.117067_b0050","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0055","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12964-023-01313-y","article-title":"AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling","volume":"21","author":"Mohammadzadeh","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13046-023-02726-w","article-title":"AXL in cancer: a modulator of drug resistance and therapeutic target","volume":"42","author":"Tang","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"28","key":"10.1016\/j.bcp.2025.117067_b0065","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2024596118","article-title":"The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion","volume":"118","author":"Zd\u017calik-Bielecka","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bcp.2025.117067_b0070","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.celrep.2018.04.019","article-title":"The receptor tyrosine kinase AXL is required at multiple steps of the metastatic cascade during HER2-positive breast cancer progression","volume":"23","author":"Goyette","year":"2018","journal-title":"Cell Rep."},{"issue":"26","key":"10.1016\/j.bcp.2025.117067_b0075","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1182\/blood.2020007651","article-title":"Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia","volume":"137","author":"Niu","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2025.117067_b0080","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ebiom.2018.02.001","article-title":"Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive non-smallcell lung cancer associated with poor prognosis","volume":"29","author":"Karachaliou","year":"2018","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.bcp.2025.117067_b0085","article-title":"A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib","volume":"5","author":"Simoni-Nieves","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0090","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1038\/s41598-020-59281-z","article-title":"(-)-Epigallocatechin gallate inhibits stemness and tumourigenicity stimulated by AXL receptor tyrosine kinase in human lung cancer cells","volume":"10","author":"Namiki","year":"2020","journal-title":"Sci. Rep."},{"issue":"42","key":"10.1016\/j.bcp.2025.117067_b0095","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1038\/s41388-021-02002-1","article-title":"LGR6 activates the Wnt\/\u03b2-catenin signaling pathway and forms a \u03b2-catenin\/TCF7L2\/LGR6 feedback loop in LGR6(high) cervical cancer stem cells","volume":"40","author":"Feng","year":"2021","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.bcp.2025.117067_b0100","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41571-021-00501-4","article-title":"Evolution of systemic therapy for stages I-III non-metastatic non-small-cell lung cancer","volume":"18","author":"Chaft","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bcp.2025.117067_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.103194","article-title":"Molecular testing and targeted therapy for non-small cell lung cancer: current status and perspectives","volume":"157","author":"Imyanitov","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117067_b0110","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1053\/j.gastro.2020.12.080","article-title":"Clinical implications of colorectal cancer stem cells in the age of single-cell omics and targeted therapies","volume":"160","author":"Frank","year":"2021","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.bcp.2025.117067_b0115","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41571-019-0293-2","article-title":"Targeting signalling pathways and the immune microenvironment of cancer stem cells \u2013 a clinical update","volume":"17","author":"Clara","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bcp.2025.117067_b0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bcp.2018.12.010","article-title":"Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting","volume":"160","author":"Heng","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"49","key":"10.1016\/j.bcp.2025.117067_b0125","doi-asserted-by":"crossref","first-page":"31189","DOI":"10.1073\/pnas.2017152117","article-title":"Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis","volume":"117","author":"Yi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bcp.2025.117067_b0130","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41419-022-05065-4","article-title":"Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis","volume":"13","author":"Cheng","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2025.117067_b0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molimm.2023.05.005","article-title":"AXL-Induced Autophagy mitigates experimental autoimmune encephalomyelitis by suppressing microglial inflammation via the PI3K\/AKT\/mTOR signaling pathway","volume":"159","author":"Sun","year":"2023","journal-title":"Mol. Immunol."},{"issue":"11","key":"10.1016\/j.bcp.2025.117067_b0140","doi-asserted-by":"crossref","first-page":"e357","DOI":"10.1097\/TP.0000000000005036","article-title":"Gas6\/AXL alleviates hepatic ischemia\/reperfusion injury by inhibiting ferroptosis via the PI3K\/AKT pathway","volume":"108","author":"Zhan","year":"2024","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0145","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41467-018-08074-0","article-title":"AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells","volume":"10","author":"Taniguchi","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bcp.2025.117067_b0150","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1158\/1541-7786.MCR-21-0444","article-title":"Bemcentinib and gilteritinib inhibit cell growth and impair the endo-lysosomal and autophagy systems in an AXL-independent manner","volume":"20","author":"Zd\u017calik-Bielecka","year":"2022","journal-title":"Mol. Cancer Res."},{"issue":"11","key":"10.1016\/j.bcp.2025.117067_b0155","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1158\/2159-8290.CD-22-0111","article-title":"AXL and error-prone DNA replication confer drug resistance and offer strategies to treat EGFR-mutant lung cancer","volume":"12","author":"Noronha","year":"2022","journal-title":"Cancer Discov."},{"issue":"2","key":"10.1016\/j.bcp.2025.117067_b0160","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/cas.15608","article-title":"High levels of AXL expression in untreated EGFR-mutated non-small cell lung cancer negatively impacts the use of osimertinib","volume":"114","author":"Yoshimura","year":"2023","journal-title":"Cancer Sci."},{"issue":"5","key":"10.1016\/j.bcp.2025.117067_b0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41419-019-1601-6","article-title":"AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells","volume":"10","author":"Kim","year":"2019","journal-title":"Cell Death Dis."},{"issue":"21","key":"10.1016\/j.bcp.2025.117067_b0170","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1056\/NEJMoa2306434","article-title":"Osimertinib with or without chemotherapy in EGFR-mutated advanced NSCLC","volume":"389","author":"Planchard","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bcp.2025.117067_b0175","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s10637-023-01341-y","article-title":"Evaluation of combination treatment with DS-1205c, an AXL kinase inhibitor, and osimertinib in metastatic or unresectable EGFR-mutant non-small cell lung cancer: results from a multicenter, open-label phase 1 study","volume":"41","author":"Yang","year":"2023","journal-title":"Invest. New Drugs"},{"issue":"12","key":"10.1016\/j.bcp.2025.117067_b0180","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1038\/s41416-020-0827-5","article-title":"Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo\/YAP pathway","volume":"122","author":"Gao","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"7","key":"10.1016\/j.bcp.2025.117067_b0185","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004616","article-title":"Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating \u03b2-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody","volume":"10","author":"Katoh","year":"2022","journal-title":"J. Immunother. Cancer"},{"issue":"20","key":"10.1016\/j.bcp.2025.117067_b0190","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1158\/0008-5472.CAN-19-0369","article-title":"Stearoyl-CoA desaturase 1 protects ovarian cancer cells from ferroptotic cell death","volume":"79","author":"Tesfay","year":"2019","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.bcp.2025.117067_b0195","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1016\/j.ymthe.2022.03.015","article-title":"An SCD1-dependent mechanoresponsive pathway promotes HCC invasion and metastasis through lipid metabolic reprogramming","volume":"30","author":"Liu","year":"2022","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0200","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1186\/s12885-019-5963-z","article-title":"Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic target","volume":"19","author":"Ma","year":"2019","journal-title":"BMC Cancer"},{"issue":"32","key":"10.1016\/j.bcp.2025.117067_b0205","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1038\/onc.2017.75","article-title":"Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP\/TAZ","volume":"36","author":"Noto","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2025.117067_b0210","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2017.07.027","article-title":"Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells","volume":"406","author":"Pisanu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2025.117067_b0215","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12935-019-0809-y","article-title":"SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR\/PI3K\/AKT signals","volume":"19","author":"She","year":"2019","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0220","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13046-019-1120-4","article-title":"Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer","volume":"38","author":"Huang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117067_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101294","article-title":"Chlorogenic acid: potential source of natural drugs for the therapeutics of fibrosis and cancer","volume":"15","author":"Nwafor","year":"2022","journal-title":"Transl. Oncol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117067_b0230","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jtho.2020.01.015","article-title":"AXL targeting abrogates autophagic flux and induces immunogenic cell death in drug-resistant cancer cells","volume":"15","author":"Lotsberg","year":"2020","journal-title":"J. Thorac. Oncol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117067_b0235","article-title":"AXL targeting restores PD-1 blockade sensitivity of STK11\/LKB1 mutant NSCLC through expansion of TCF1(+) CD8 Tcells","volume":"3","author":"Li","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.bcp.2025.117067_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2023.107291","article-title":"Phase 1 trial of bemcentinib (BGB324), a first-in-class, selective AXL inhibitor, with docetaxel in patients with previously treated advanced non-small cell lung cancer","volume":"182","author":"Bhalla","year":"2023","journal-title":"Lung Cancer"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225003326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225003326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:24:06Z","timestamp":1762097046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225003326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":48,"alternative-id":["S0006295225003326"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117067","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AXL enhances the self-renewal of cancer stem-like cells and Osimertinib chemoresistance by regulating SCD1 in non-small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117067"}}