{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T19:04:46Z","timestamp":1787339086178,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220818102605012"],"award-info":[{"award-number":["JCYJ20220818102605012"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001755"],"award-info":[{"award-number":["82001755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1104900"],"award-info":[{"award-number":["2022YFA1104900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bcp.2025.117068","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T19:07:03Z","timestamp":1750792023000},"page":"117068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["IRF8 and RUNX1 cooperatively regulate the senescence and damage of urine-derived renal progenitor cells by upregulating LINC01806"],"prefix":"10.1016","volume":"240","author":[{"given":"Jie","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Lin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Li","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Zhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7993-1133","authenticated-orcid":false,"given":"Fu-Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl. (2011)"},{"issue":"2","key":"10.1016\/j.bcp.2025.117068_b0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJMp2001794","article-title":"Ensuring choice for people with kidney failure \u2013 dialysis, supportive care, and hope","volume":"383","author":"Kalantar-Zadeh","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12014-022-09387-5","article-title":"LC-MS\/MS based metabolomics and proteomics reveal candidate biomarkers and molecular mechanism of early IgA nephropathy","volume":"19","author":"Zhang","year":"2022","journal-title":"Clin. Proteomics"},{"issue":"29","key":"10.1016\/j.bcp.2025.117068_b0020","doi-asserted-by":"crossref","first-page":"5520","DOI":"10.1039\/D2TB01044E","article-title":"Advances in hydrogels for stem cell therapy: regulation mechanisms and tissue engineering applications","volume":"10","author":"Liu","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13287-019-1165-5","article-title":"Stem cells: past, present, and future","volume":"10","author":"Zakrzewski","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"5","key":"10.1016\/j.bcp.2025.117068_b0030","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4252\/wjsc.v16.i5.525","article-title":"Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury: a comparative analysis with mesenchymal stem cells","volume":"16","author":"Li","year":"2024","journal-title":"World J. Stem Cells"},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0035","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41598-020-57723-2","article-title":"The FGF, TGFbeta and WNT axis modulate self-renewal of human SIX2(+) urine derived renal progenitor cells","volume":"10","author":"Rahman","year":"2020","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bcp.2025.117068_b0040","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1681\/ASN.2014010057","article-title":"Human urine-derived renal progenitors for personalized modeling of genetic kidney disorders","volume":"26","author":"Lazzeri","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13287-018-0932-z","article-title":"Urine-derived cells for human cell therapy","volume":"9","author":"Pavathuparambil Abdul Manaph","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"15\u201316","key":"10.1016\/j.bcp.2025.117068_b0050","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1089\/ten.tea.2010.0637","article-title":"Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering","volume":"17","author":"Bharadwaj","year":"2011","journal-title":"Tissue Eng. A"},{"issue":"21","key":"10.1016\/j.bcp.2025.117068_b0055","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1038\/sj.emboj.7601381","article-title":"Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney","volume":"25","author":"Self","year":"2006","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.bcp.2025.117068_b0060","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/stem.1424","article-title":"Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology","volume":"31","author":"Bharadwaj","year":"2013","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.bcp.2025.117068_b0065","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1089\/ten.teb.2021.0142","article-title":"Urine-derived stem cells for regenerative medicine: basic biology, applications, and challenges","volume":"28","author":"Huang","year":"2022","journal-title":"Tissue Eng. Part B-Rev."},{"key":"10.1016\/j.bcp.2025.117068_b0070","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-014-0274-2","article-title":"Human urine-derived stem cells in combination with polycaprolactone\/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis","volume":"12","author":"Fu","year":"2014","journal-title":"J. Transl. Med."},{"issue":"12","key":"10.1016\/j.bcp.2025.117068_b0075","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.3346\/jkms.2015.30.12.1754","article-title":"Human urine-derived stem cells seeded surface modified composite Scaffold grafts for bladder reconstruction in a rat model","volume":"30","author":"Lee","year":"2015","journal-title":"J. Korean Med. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2025.117068_b0080","doi-asserted-by":"crossref","first-page":"p","DOI":"10.3892\/etm.2020.9240","article-title":"Pretreatment with human urine-derived stem cells protects neurological function in rats following cardiopulmonary resuscitation after cardiac arrest","volume":"20","author":"Pan","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"5","key":"10.1016\/j.bcp.2025.117068_b0085","first-page":"2222","article-title":"Autologous preconditioned mesenchymal stem cell sheets improve left ventricular function in a rabbit old myocardial infarction model","volume":"8","author":"Tanaka","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0090","doi-asserted-by":"crossref","first-page":"p","DOI":"10.1186\/s13287-021-02266-0","article-title":"Stem\/progenitor cell in kidney: characteristics, homing, coordination, and maintenance","volume":"12","author":"Huang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"12","key":"10.1016\/j.bcp.2025.117068_b0095","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/nprot.2012.115","article-title":"Generation of human induced pluripotent stem cells from urine samples","volume":"7","author":"Zhou","year":"2012","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.bcp.2025.117068_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2019.06.009","article-title":"Generation of human PSC-derived kidney organoids with patterned nephron segments and a De Novo vascular network","volume":"25","author":"Low","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.bcp.2025.117068_b0105","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41419-019-1569-2","article-title":"Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow","volume":"10","author":"Song","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0110","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1681\/ASN.2017030314","article-title":"Kidney proximal tubule lipoapoptosis is regulated by fatty acid transporter-2 (FATP2)","volume":"29","author":"Khan","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117068_b0115","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11357-020-00183-3","article-title":"Regulation of senescence traits by MAPKs","volume":"42","author":"Anerillas","year":"2020","journal-title":"Geroscience"},{"issue":"3","key":"10.1016\/j.bcp.2025.117068_b0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/MNH.0000000000000782","article-title":"Ageing, cellular senescence and chronic kidney disease: experimental evidence","volume":"31","author":"Tan","year":"2022","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bcp.2025.117068_b0125","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3389\/fphar.2020.00755","article-title":"Cellular senescence and senotherapies in the kidney: current evidence and future directions","volume":"11","author":"Docherty","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2025.117068_b0130","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.21037\/tau-21-506","article-title":"Functional characterization of the immunomodulatory properties of human urine-derived stem cells","volume":"10","author":"Wu","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"10.1016\/j.bcp.2025.117068_b0135","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4378947","article-title":"Urine-derived stem cells: the present and the future","volume":"2017","author":"Ji","year":"2017","journal-title":"Stem Cells Int."},{"issue":"5","key":"10.1016\/j.bcp.2025.117068_b0140","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/j.juro.2008.07.023","article-title":"Urine derived cells are a potential source for urological tissue reconstruction","volume":"180","author":"Zhang","year":"2008","journal-title":"J. Urol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117068_b0145","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.eururo.2017.03.026","article-title":"Tissue engineering of the urethra: a systematic review and meta-analysis of preclinical and clinical studies","volume":"72","author":"Versteegden","year":"2017","journal-title":"Eur. Urol."},{"key":"10.1016\/j.bcp.2025.117068_b0150","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8035076","article-title":"Therapeutic effects of human urine-derived stem cells in a rat model of cisplatin-induced acute kidney injury in vivo and in vitro","volume":"2019","author":"Sun","year":"2019","journal-title":"Stem Cells Int."},{"issue":"3","key":"10.1016\/j.bcp.2025.117068_b0155","doi-asserted-by":"crossref","first-page":"435","DOI":"10.7150\/ijbs.37550","article-title":"Reno-protection of urine-derived stem cells in a chronic kidney disease rat model induced by renal ischemia and nephrotoxicity","volume":"16","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2025.117068_b0160","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.3892\/mmr.2017.7240","article-title":"Human urine-derived stem cells contribute to the repair of ischemic acute kidney injury in rats","volume":"16","author":"Tian","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0165","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13287-018-1097-5","article-title":"Application potential of stem\/progenitor cell-derived extracellular vesicles in renal diseases","volume":"10","author":"Sun","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2025.117068_b0170","first-page":"1316","article-title":"Urine-derived stem cells for the therapy of diabetic nephropathy mouse model","volume":"24","author":"Xiong","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.bcp.2025.117068_b0175","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41580-024-00738-8","article-title":"SenNet recommendations for detecting senescent cells in different tissues","volume":"25","author":"Suryadevara","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117068_b0180","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13317","article-title":"Metformin inhibits chronic kidney disease-induced DNA damage and senescence of mesenchymal stem cells","volume":"20","author":"Kim","year":"2021","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0185","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1038\/s41467-024-51901-w","article-title":"P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance","volume":"15","author":"Jiang","year":"2024","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.bcp.2025.117068_b0190","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14184","article-title":"PAR2-mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease","volume":"23","author":"Ha","year":"2024","journal-title":"Aging Cell"},{"issue":"46","key":"10.1016\/j.bcp.2025.117068_b0195","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"PNAS"},{"issue":"10","key":"10.1016\/j.bcp.2025.117068_b0200","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.7150\/thno.55672","article-title":"Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2","volume":"11","author":"Xiang","year":"2021","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.bcp.2025.117068_b0205","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/s41418-019-0467-6","article-title":"A novel long noncoding RNA represses cellular senescence through multileveled reduction of p21 expression","volume":"27","author":"Lee","year":"2020","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.bcp.2025.117068_b0210","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1093\/stmcls\/sxac054","article-title":"The long non-coding RNA HOTAIR controls the self-renewal, cell senescence, and secretion of anti-aging protein alpha-klotho in human adult renal progenitor cells","volume":"40","author":"Picerno","year":"2022","journal-title":"Stem Cells"},{"issue":"8","key":"10.1016\/j.bcp.2025.117068_b0215","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1101\/gad.203984.112","article-title":"Tumor suppressor activity of the ERK\/MAPK pathway by promoting selective protein degradation","volume":"27","author":"Deschenes-Simard","year":"2013","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0220","doi-asserted-by":"crossref","first-page":"7712","DOI":"10.1038\/s41467-024-51746-3","article-title":"10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl beta hydroxylase and inhibiting chondrocyte senescence in male mice preclinically","volume":"15","author":"Geng","year":"2024","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bcp.2025.117068_b0225","article-title":"IRF8 maintains mononuclear phagocyte and neutrophil function in acute kidney injury","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bcp.2025.117068_b0230","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.932205","article-title":"Exploring the pathogenesis of diabetic kidney disease by microarray data analysis","volume":"13","author":"Cao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117068_b0235","article-title":"IRF8-dependent type I conventional dendritic cells (cDC1s) control post-ischemic inflammation and mildly protect against post-ischemic acute kidney injury and disease","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0240","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1038\/s41467-022-32401-1","article-title":"Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes","volume":"13","author":"Luo","year":"2022","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bcp.2025.117068_b0245","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.7150\/ijbs.90459","article-title":"WTAP mediated N6-methyladenosine RNA modification of ELF3 drives cellular senescence by upregulating IRF8","volume":"20","author":"Zhou","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"49","key":"10.1016\/j.bcp.2025.117068_b0250","doi-asserted-by":"crossref","first-page":"18807","DOI":"10.1074\/jbc.RA119.010648","article-title":"Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation","volume":"294","author":"Zhang","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2025.117068_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.02.055","article-title":"IRF8 regulates transcription of naips for NLRC4 inflammasome activation","volume":"173","author":"Karki","year":"2018","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bcp.2025.117068_b0260","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1182\/blood-2012-06-437863","article-title":"Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation","volume":"121","author":"Kurotaki","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bcp.2025.117068_b0265","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1038\/s41467-017-01070-w","article-title":"IRF8-dependent molecular complexes control the Th9 transcriptional program","volume":"8","author":"Humblin","year":"2017","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bcp.2025.117068_b0270","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s00109-019-01852-3","article-title":"Characterisation of transcription factor profiles in polycystic kidney disease (PKD): identification and validation of STAT3 and RUNX1 in the injury\/repair response and PKD progression","volume":"97","author":"Formica","year":"2019","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"11","key":"10.1016\/j.bcp.2025.117068_b0275","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1158\/0008-5472.CAN-19-3870","article-title":"RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome","volume":"80","author":"Rooney","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2025.117068_b0280","doi-asserted-by":"crossref","first-page":"p","DOI":"10.1093\/ndt\/gfae069.1106","article-title":"Runt-related transcription factor 1 (RUNX1) is a mediator of acute kidney injury","volume":"39","author":"G\u00f3mez","year":"2024","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bcp.2025.117068_b0285","doi-asserted-by":"crossref","first-page":"p","DOI":"10.1016\/j.metabol.2021.154916","article-title":"Brown adipose tissue transplantation ameliorates diabetic nephropathy through the miR-30b pathway by targeting Runx1","volume":"125","author":"Zhang","year":"2021","journal-title":"Metabolism-Clin. Exp."},{"issue":"4","key":"10.1016\/j.bcp.2025.117068_b0290","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13040764","article-title":"IRF8 is an AML-specific susceptibility factor that regulates signaling pathways and proliferation of AML cells","volume":"13","author":"Liss","year":"2021","journal-title":"Cancers (Basel)"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225003338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225003338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:22:37Z","timestamp":1762096957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225003338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":58,"alternative-id":["S0006295225003338"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117068","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IRF8 and RUNX1 cooperatively regulate the senescence and damage of urine-derived renal progenitor cells by upregulating LINC01806","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117068"}}