{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:15:44Z","timestamp":1793639744824,"version":"4.5.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016981","name":"Necmettin Erbakan \u00dcniversitesi","doi-asserted-by":"publisher","award":["08.02.2024"],"award-info":[{"award-number":["08.02.2024"]}],"id":[{"id":"10.13039\/501100016981","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016981","name":"Necmettin Erbakan \u00dcniversitesi","doi-asserted-by":"publisher","award":["2024-10"],"award-info":[{"award-number":["2024-10"]}],"id":[{"id":"10.13039\/501100016981","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bcp.2025.117131","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T10:54:34Z","timestamp":1751712874000},"page":"117131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Hesperidin ameliorates vancomycin-induced kidney injury via multipathway modulation: Nrf-2\/HO-1, Caspase-3\/Bax\/Bcl-2, ATF-4, KIM-1 and improved renal tissue function"],"prefix":"10.1016","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-4146","authenticated-orcid":false,"given":"Selman","family":"Gencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"\u015eim\u015fek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurhan","family":"Akaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u0130lerit\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"G\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefa","family":"K\u00fc\u00e7\u00fckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naz\u0131m Abd\u00fclkadir","family":"Kank\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2025.117131_b0005","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/pro.3819","article-title":"Molecular mechanisms of vancomycin resistance","volume":"29","author":"Stogios","year":"2020","journal-title":"Protein Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118382","article-title":"Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis","volume":"259","author":"Kucukler","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0015","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/jac\/dkz563","article-title":"Lack of synergistic nephrotoxicity between vancomycin and piperacillin\/tazobactam in a rat model and a confirmatory cellular model","volume":"75","author":"Pais","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bcp.2025.117131_b0020","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/ajhp\/zxaa128","article-title":"Towards precision medicine: Therapeutic drug monitoring\u2013guided dosing of vancomycin and \u03b2-lactam antibiotics to maximize effectiveness and minimize toxicity","volume":"77","author":"Cusumano","year":"2020","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.bcp.2025.117131_b0025","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/jac\/dkaa184","article-title":"Relationship of vancomycin trough levels with acute kidney injury risk: an exposure\u2013toxicity meta-analysis","volume":"75","author":"Bellos","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bcp.2025.117131_b0030","article-title":"Vancomycin nephrotoxicity: a comprehensive clinico-pathological study","volume":"19","author":"Ganesh","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2025.117131_b0035","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.21037\/atm-21-3294","article-title":"Vitamin C reduces vancomycin-related nephrotoxicity through the inhibition of oxidative stress, apoptosis, and inflammation in mice","volume":"9","author":"He","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bcp.2025.117131_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120098","article-title":"Anti-oxidant, anti-apoptotic, and mitochondrial regulatory effects of selenium nanoparticles against vancomycin induced nephrotoxicity in experimental rats","volume":"288","author":"Mehanna","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0045","first-page":"438","article-title":"Vancomycin-induced kidney injury: animal models of toxicodynamics, mechanisms of injury, human translation, and potential strategies for prevention. pharmacotherapy: the journal of human pharmacology and drug","volume":"40","author":"Pais","year":"2020","journal-title":"Therapy"},{"key":"10.1016\/j.bcp.2025.117131_b0050","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/01480545.2018.1512612","article-title":"Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats","volume":"43","author":"Uckun","year":"2020","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0055","article-title":"Rutin attenuates vancomycin-induced nephrotoxicity by ameliorating oxidative stress, apoptosis and inflammation in rats","volume":"63","author":"Qu","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2025.117131_b0060","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1007\/s11356-020-10999-3","article-title":"The efficiency of pomegranate (Punica granatum) peel ethanolic extract in attenuating the vancomycin-triggered liver and kidney tissues injury in rats","volume":"28","author":"El Bohi","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.bcp.2025.117131_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108369","article-title":"Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress","volume":"118","author":"Ileriturk","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0070","doi-asserted-by":"crossref","DOI":"10.1590\/acb391124","article-title":"Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats","volume":"39","author":"Ozyigit","year":"2024","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.bcp.2025.117131_b0075","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s12012-022-09751-9","article-title":"Hesperidin attenuates oxidative stress, inflammation, apoptosis, and cardiac dysfunction in sodium fluoride\u2010induced cardiotoxicity in rats","volume":"22","author":"Var\u0131\u015fl\u0131","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0080","first-page":"30","article-title":"Protective effect of hesperidin on oxidative stress, inflammation and apoptosis in abamectin-induced gastric toxicity","volume":"25","author":"Tuncer","year":"2024","journal-title":"Kocatepe Medical Journal"},{"key":"10.1016\/j.bcp.2025.117131_b0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neuro.2022.04.002","article-title":"Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy","volume":"90","author":"Y\u0131ld\u0131z","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bcp.2025.117131_b0090","doi-asserted-by":"crossref","first-page":"10818","DOI":"10.1007\/s11356-020-11327-5","article-title":"Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin","volume":"28","author":"Kuzu","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.bcp.2025.117131_b0095","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/1440-1681.13221","article-title":"Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat","volume":"47","author":"Kumar","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bcp.2025.117131_b0100","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1612348","article-title":"Protective effect of Natural Antioxidants on reducing Cisplatin-Induced Nephrotoxicity","volume":"2022","author":"Zhou","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bcp.2025.117131_b0105","doi-asserted-by":"crossref","unstructured":"Abd-Eldayem AM, Makram SM, Messiha BAS, Abd-Elhafeez HH, Abdel-Reheim MA. Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-\u03b1, NF-\u03baB, and Bax. Scientific Reports 2024 14:1 2024;14:1\u201321. https:\/\/doi.org\/10.1038\/s41598-024-57300-x.","DOI":"10.1038\/s41598-024-57300-x"},{"key":"10.1016\/j.bcp.2025.117131_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117657","article-title":"Protective effect of Urtica dioica in induced neurobehavioral changes, nephrotoxicity and hepatotoxicity after chronic exposure to potassium bromate in rats","volume":"287","author":"Dhouibi","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.bcp.2025.117131_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147502","article-title":"Beneficial effects of Chrysin on Cadmium\u2010induced nephrotoxicity in rats: Modulating the levels of Nrf2\/HO\u20101, RAGE\/NLRP3, and Caspase-3\/Bax\/Bcl-2 signaling pathways","volume":"875","author":"\u015eim\u015fek","year":"2023","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.bcp.2025.117131_b0120","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0003-2697(66)90167-9","article-title":"Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems","volume":"16","author":"Placer","year":"1966","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bcp.2025.117131_b0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"[13] Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117131_b0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clin. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2025.117131_b0135","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbrc.2012.08.016","article-title":"Glutathione peroxidase activity in selenium-deficient rat liver. 1976","volume":"425","author":"Lawrence","year":"2012","journal-title":"Biochem Biophys Res Commun."},{"issue":"1","key":"10.1016\/j.bcp.2025.117131_b0140","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2025.117131_b0145","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2025.117131_b0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bcp.2025.117131_b0155","doi-asserted-by":"crossref","unstructured":"M. Ileriturk, O. Kandemir, Fatih, M. Kandemir Evaluation of protective effects of quercetin against cypermethrin\u2010induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and. Wiley Online LibraryM Ileriturk, O Kandemir, FM KandemirEnvironmental Toxicology, 2022\u2022Wiley Online Library 2022;37:2639\u201350. https:\/\/doi.org\/10.1002\/tox.23624.","DOI":"10.1002\/tox.23624"},{"key":"10.1016\/j.bcp.2025.117131_b0160","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22201","article-title":"Improvement in colistin-induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin","volume":"32","author":"Aksu","year":"2018","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0165","doi-asserted-by":"crossref","first-page":"101208","DOI":"10.1007\/s11356-023-29410-y","article-title":"Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach","volume":"30","author":"\u015eim\u015fek","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.bcp.2025.117131_b0170","first-page":"13034","article-title":"Hyperbaric oxygen treatment ameliorates lung injury in paraquat intoxicated rats","volume":"8","author":"Akcilar","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bcp.2025.117131_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114791","article-title":"The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death","volume":"190","author":"Kank\u0131l\u0131\u00e7","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0180","first-page":"138","article-title":"Anti-oxidant, Anti-inflammatory, and Anti-apoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats","volume":"12","author":"Akaras","year":"2023","journal-title":"Tr J Nature Sci"},{"key":"10.1016\/j.bcp.2025.117131_b0185","first-page":"1098","article-title":"Protective effects of zingerone against sodium arsenite-induced lung toxicity: a multi-biomarker approach","volume":"26","author":"\u015eim\u015fek","year":"2023","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0190","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23604","article-title":"Naringin attenuates oxaliplatin-induced nephrotoxicity and hepatotoxicity: a molecular, biochemical, and histopathological approach in a rat model","volume":"38","author":"Ileriturk","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0195","doi-asserted-by":"crossref","DOI":"10.1111\/and.13353","article-title":"The antiapoptotic and antioxidant effects of eugenol against cisplatin-induced testicular damage in the experimental model","volume":"51","author":"Ekinci Akdemir","year":"2019","journal-title":"Andrologia"},{"key":"10.1016\/j.bcp.2025.117131_b0200","first-page":"1","article-title":"Carvacrol reduces mercuric chloride-induced testicular toxicity by regulating oxidative stress, inflammation, apoptosis, autophagy, and histopathological changes","author":"\u015eim\u015fek","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bcp.2025.117131_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120104","article-title":"The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats","volume":"287","author":"Semis","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0210","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/tox.23156","article-title":"Hesperidin protects against the chlorpyrifos-induced chronic hepato-renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up-regulation of PARP-1\/VEGF","volume":"36","author":"K\u00fc\u00e7\u00fckler","year":"2021","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0215","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.lfs.2016.01.038","article-title":"Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats","volume":"147","author":"Kocak","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0220","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/1440-1681.12511","article-title":"Effects of captopril, telmisartan and bardoxolone methyl (CDDO-Me) in ischemia-reperfusion-induced acute kidney injury in rats: an experimental comparative study","volume":"43","author":"Kocak","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bcp.2025.117131_b0225","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neuro.2020.10.009","article-title":"Neuroprotective effect of chrysin on isoniazid-induced neurotoxicity via suppression of oxidative stress, inflammation and apoptosis in rats","volume":"81","author":"\u00c7elik","year":"2020","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bcp.2025.117131_b0230","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jss.2016.03.027","article-title":"Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid\u2013induced gastric ulcer in rats","volume":"203","author":"Zeren","year":"2016","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bcp.2025.117131_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110073","article-title":"Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2\/HO-1 and caspase-3\/Bax\/Bcl-2 signaling pathways","volume":"365","author":"Gur","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bcp.2025.117131_b0240","first-page":"556","article-title":"Effects of quercetin on cypermethrin-induced stomach injury: the role of oxidative stress, inflammation, and apoptosis","volume":"12","author":"Akaras","year":"2023","journal-title":"GUJHS"},{"key":"10.1016\/j.bcp.2025.117131_b0245","doi-asserted-by":"crossref","first-page":"9641","DOI":"10.1007\/s11033-022-07873-5","article-title":"The impact of Nrf2\/HO-1, caspase-3\/Bax\/Bcl2 and ATF6\/IRE1\/PERK\/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats","volume":"49","author":"Var\u0131\u015fl\u0131","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bcp.2025.117131_b0250","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1007\/s11033-022-07395-0","article-title":"Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy","volume":"49","author":"Kandemir","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bcp.2025.117131_b0255","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/tox.23784","article-title":"Carvacrol protects against \u03bb-Cyhalothrin-induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy","volume":"38","author":"Ileriturk","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0260","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s11011-022-01027-z","article-title":"Neuroprotective effects of 18\u03b2-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1\/STAT1 signaling pathway","volume":"37","author":"Caglayan","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bcp.2025.117131_b0265","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1080\/15548627.2020.1827780","article-title":"ATF4 links ER stress with reticulophagy in glioblastoma cells","volume":"17","author":"Zielke","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2025.117131_b0270","doi-asserted-by":"crossref","unstructured":"Y. Goel, R. Fouda, K. Gupta. Endoplasmic Reticulum Stress in Chemotherapy-Induced Peripheral Neuropathy: Emerging Role of Phytochemicals. Antioxidants 2022, Vol 11, Page 265 2022;11:265. https:\/\/doi.org\/10.3390\/ANTIOX11020265.","DOI":"10.3390\/antiox11020265"},{"key":"10.1016\/j.bcp.2025.117131_b0275","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11255-015-1169-8","article-title":"The effects of ozone therapy on caspase pathways, TNF-\u03b1, and HIF-1\u03b1 in diabetic nephropathy","volume":"48","author":"G\u00fc\u00e7l\u00fc","year":"2016","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.bcp.2025.117131_b0280","first-page":"22158","article-title":"Effects of Ukrain on intestinal apoptosis caused by ischemia-reperfusion injury in rats","volume":"8","author":"Akc\u0131lar","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.bcp.2025.117131_b0285","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.transproceed.2013.10.036","article-title":"Effect of verapamil and lidocaine on TRPM and NaV1.9 gene expressions in renal ischemia-reperfusion","volume":"46","author":"Dusmez","year":"2014","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.bcp.2025.117131_b0290","first-page":"96","article-title":"Acacetin ameliorates acetylsalicylic acid-induced gastric ulcer in rats by interfering with oxidative stress, inflammation, and apoptosis","volume":"6","author":"Simsek","year":"2023","journal-title":"Int. J. Med. Biochem."},{"key":"10.1016\/j.bcp.2025.117131_b0295","first-page":"209","article-title":"Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-\u03b1, Smad1 and TGF-\u03b21 genes in a rat model of lung ischemia\/reperfusion","volume":"19","author":"\u015eim\u015fek","year":"2016","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0300","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23643","article-title":"Protective effects of naringin on colistin-induced damage in rat testicular tissue: Modulating the levels of Nrf-2\/HO-1, AKT-2\/FOXO1A, Bax\/Bcl2\/Caspase-3, and Beclin-1\/LC3A\/LC3B signaling pathways","volume":"38","author":"Kank\u0131l\u0131\u00e7","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bcp.2025.117131_b0305","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s11033-023-08286-8","article-title":"Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2\/HO-1 and Bax\/Bcl2\/Caspase-3 signaling pathways","volume":"50","author":"K\u0131z\u0131l","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bcp.2025.117131_b0310","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/10520295.2021.2021449","article-title":"Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB\/p53 and Bcl-2 expression","volume":"97","author":"\u00c7omakl\u0131","year":"2022","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.bcp.2025.117131_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118301","article-title":"Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-\u03baB, Bax\/Bcl-2 and PI3K\/Akt\/mTOR signaling pathways","volume":"261","author":"Kucukler","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119730","article-title":"Hesperidin protects liver and kidney against sodium fluoride-induced toxicity through anti-apoptotic and anti-autophagic mechanisms","volume":"281","author":"Caglayan","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117131_b0325","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00210-019-01741-z","article-title":"Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis","volume":"393","author":"Temel","year":"2020","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117131_b0330","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/15569543.2017.1364268","article-title":"Preventive effects of hesperidin on diabetic nephropathy induced by streptozotocin via modulating TGF-\u03b21 and oxidative DNA damage","volume":"37","author":"Kandemir","year":"2018","journal-title":"Toxin Rev."},{"key":"10.1016\/j.bcp.2025.117131_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2024.103288","article-title":"Narirutin ameliorates polystyrene microplastics induced nephrotoxicity by modulating oxidative stress, inflammation and Nrf2\/Keap1 pathway","author":"Umar Ijaz","year":"2024","journal-title":"J King Saud Univ Sci"},{"key":"10.1016\/j.bcp.2025.117131_b0340","first-page":"95","article-title":"Hesperidin Alleviates Malathion-Induced nephrotoxicity in Rats: Impact on Oxidative damage, Inflammation, Pyroptosis and Apoptosis","author":"Saati","year":"2024","journal-title":"Saati. Bull Egypt Soc Physiol Sci"},{"key":"10.1016\/j.bcp.2025.117131_b0345","article-title":"Irbesartan restored aquaporin-1 levels via inhibition of NF-kB expression in acute kidney injury model","author":"Candan","year":"2023","journal-title":"Nefrolog\u00eda"},{"key":"10.1016\/j.bcp.2025.117131_b0350","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.biopha.2018.06.048","article-title":"Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney","volume":"105","author":"Kandemir","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2025.117131_b0355","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s11255-015-0949-5","article-title":"Nephrotoxic effects of varenicline as the most effective drug used for smoking cessation: a preliminary experimental study","volume":"47","author":"Ko\u00e7","year":"2015","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.bcp.2025.117131_b0360","doi-asserted-by":"crossref","first-page":"46","DOI":"10.21608\/ajfm.2022.212379","article-title":"The possible ameliorative effect of hesperidin administration in aluminum phosphide induced acute nephrotoxicity in adult albino rats","volume":"38","author":"Mohamed Moustafa","year":"2022","journal-title":"Ain Shams Journal of Forensic Medicine and Clinical Toxicology"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522500396X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522500396X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T21:06:20Z","timestamp":1755810380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522500396X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":72,"alternative-id":["S000629522500396X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117131","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hesperidin ameliorates vancomycin-induced kidney injury via multipathway modulation: Nrf-2\/HO-1, Caspase-3\/Bax\/Bcl-2, ATF-4, KIM-1 and improved renal tissue function","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117131"}}