{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:40:52Z","timestamp":1793126452622,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018551","name":"Science and Technology Innovation Talents in Universities of Henan Province","doi-asserted-by":"publisher","award":["24HASTIT068"],"award-info":[{"award-number":["24HASTIT068"]}],"id":[{"id":"10.13039\/501100018551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273927"],"award-info":[{"award-number":["82273927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018607","name":"Henan Province Science and Technology Innovation Talent Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bcp.2025.117150","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T07:55:15Z","timestamp":1752566115000},"page":"117150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["BCAA exaggerated acute and chronic ischemic heart disease through promotion of NLRP3 via Sirt1"],"prefix":"10.1016","volume":"241","author":[{"given":"Yajie","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusen","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyue","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bcp.2025.117150_b0005","doi-asserted-by":"crossref","first-page":"492","DOI":"10.4070\/kcj.2017.0128","article-title":"Risk scoring system to assess outcomes in patients treated with contemporary guideline-adherent optimal therapies after acute myocardial infarction","volume":"48","author":"Song","year":"2018","journal-title":"Korean Circ. J."},{"issue":"6","key":"10.1016\/j.bcp.2025.117150_b0010","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3892\/etm.2022.11357","article-title":"Myocardial ischemia\/reperfusion injury: Mechanisms of injury and implications for management (Review)","volume":"23","author":"He","year":"2022","journal-title":"Exp. Ther. Med."},{"issue":"7","key":"10.1016\/j.bcp.2025.117150_b0015","doi-asserted-by":"crossref","first-page":"165768","DOI":"10.1016\/j.bbadis.2020.165768","article-title":"Mitochondrial ROS in myocardial ischemia reperfusion and remodeling","volume":"1866","author":"Bugger","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"8","key":"10.1016\/j.bcp.2025.117150_b0020","first-page":"1111","article-title":"Left ventricular remodeling after myocardial infarction: from physiopathology to treatment","volume":"12","author":"Leanc\u0103","year":"2022","journal-title":"Life (Basel)"},{"issue":"10","key":"10.1016\/j.bcp.2025.117150_b0025","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s11886-022-01766-6","article-title":"Ischemic cardiomyopathy and heart failure after acute myocardial infarction","volume":"24","author":"Del Buono","year":"2022","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.bcp.2025.117150_b0030","doi-asserted-by":"crossref","first-page":"70016","DOI":"10.1111\/cpr.70016","article-title":"Elevated COMMD1 contributes to cardiomyocyte copper efflux in chronic myocardial ischemia: insights from rhesus monkey","author":"Li","year":"2025","journal-title":"Cell Prolif."},{"issue":"12","key":"10.1016\/j.bcp.2025.117150_b0035","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1016\/j.bbadis.2016.09.009","article-title":"Branched chain amino acid metabolic reprogramming in heart failure","volume":"1862","author":"Sun","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.bcp.2025.117150_b0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41569-022-00760-3","article-title":"Branched-chain amino acids in cardiovascular disease","volume":"20","author":"McGarrah","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bcp.2025.117150_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106815","article-title":"Review: acetylation mechanisms and targeted therapies in cardiac fibrosis","volume":"193","author":"Liu","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"17","key":"10.1016\/j.bcp.2025.117150_b0050","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.7150\/thno.100667","article-title":"Targeting sirtuins for cancer therapy: epigenetics modifications and beyond","volume":"14","author":"Shen","year":"2024","journal-title":"Theranostics"},{"issue":"Pt 1","key":"10.1016\/j.bcp.2025.117150_b0055","article-title":"Sirtuins in macrophage immune metabolism: a novel target for cardiovascular disorders","volume":"256","author":"Xu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117150_b0060","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.7150\/thno.44836","article-title":"Branched chain amino acids exacerbate myocardial ischemia\/reperfusion vulnerability via enhancing GCN2\/ATF6\/PPAR-\u03b1 pathway-dependent fatty acid oxidation","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"issue":"12","key":"10.1016\/j.bcp.2025.117150_b0065","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/CIRCRESAHA.110.223925","article-title":"A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse","volume":"107","author":"Gao","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2025.117150_b0070","doi-asserted-by":"crossref","first-page":"172587","DOI":"10.1016\/j.ejphar.2019.172587","article-title":"Beneficial effects of Oridonin on myocardial ischemia\/reperfusion injury: insight gained by metabolomic approaches","volume":"861","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"D1","key":"10.1016\/j.bcp.2025.117150_b0075","doi-asserted-by":"crossref","first-page":"D18","DOI":"10.1093\/nar\/gkad1078","article-title":"Database resources of the national genomics data center, China National Center for bioinformation in 2024","volume":"52","author":"Partners","year":"2024","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.bcp.2025.117150_b0080","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ebiom.2016.10.013","article-title":"Branched chain amino acids cause liver injury in obese\/diabetic mice by promoting adipocyte lipolysis and inhibiting hepatic autophagy","volume":"13","author":"Zhang","year":"2016","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.bcp.2025.117150_b0085","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.3892\/mmr.2017.7676","article-title":"Inhibition of cardiotrophin\u20111 overexpression is involved in the anti\u2011fibrotic effect of AstrogalosideIV","volume":"16","author":"Jia","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bcp.2025.117150_b0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2017.01.009","article-title":"High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation","volume":"104","author":"Zhenyukh","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117150_b0095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117150_b0100","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bcp.2025.117150_b0105","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1083\/jcb.201602089","article-title":"The cell biology of inflammasomes: mechanisms of inflammasome activation and regulation","volume":"213","author":"Sharma","year":"2016","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117150_b0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s43556-025-00249-8","article-title":"GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets","volume":"6","author":"Li","year":"2025","journal-title":"Mol. Biomed."},{"issue":"5","key":"10.1016\/j.bcp.2025.117150_b0115","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41422-025-01107-6","article-title":"Pyroptosis: molecular mechanisms and roles in disease","volume":"35","author":"Broz","year":"2025","journal-title":"Cell Res."},{"issue":"11","key":"10.1016\/j.bcp.2025.117150_b0120","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.cmet.2022.09.008","article-title":"Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure","volume":"34","author":"Murashige","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2025.117150_b0125","doi-asserted-by":"crossref","first-page":"1279066","DOI":"10.3389\/fnut.2023.1279066","article-title":"Branched chain amino acids metabolism in heart failure","volume":"10","author":"Gao","year":"2023","journal-title":"Front. Nutr."},{"issue":"12","key":"10.1016\/j.bcp.2025.117150_b0130","first-page":"12","article-title":"Levels of branched chain amino acid in patients with congestive heart failure and their relationship with cardiac function and major adverse cardiovascular events","volume":"31","author":"Fu","year":"2023","journal-title":"Pract. J. Cardiac Cereb. Pneumal Vasc. Disease"},{"issue":"5","key":"10.1016\/j.bcp.2025.117150_b0135","doi-asserted-by":"crossref","first-page":"H1160","DOI":"10.1152\/ajpheart.00114.2016","article-title":"Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction","volume":"311","author":"Wang","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2025.117150_b0140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cca.2016.02.020","article-title":"1H NMR-derived metabolomics of filtered serum of myocardial ischemia in unstable angina patients","volume":"456","author":"Ameta","year":"2016","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.bcp.2025.117150_b0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12933-022-01494-9","article-title":"Prognostic significance of metabolomic biomarkers in patients with diabetes mellitus and coronary artery disease","volume":"21","author":"Karagiannidis","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bcp.2025.117150_b0150","doi-asserted-by":"crossref","unstructured":"B. T, The conversion of valine to propionylcarnitine in isolated rat liver mitochondria, Biochim. Biophys. Acta 208(1) (1970) 167\u2013169. doi: 10.1016\/0304-4165(70)90067-X.","DOI":"10.1016\/0304-4165(70)90067-X"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2025.117150_b0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ymgme.2019.05.008","article-title":"Metabolic analysis reveals evidence for branched chain amino acid catabolism crosstalk and the potential for improved treatment of organic acidurias","volume":"128","author":"McCalley","year":"2019","journal-title":"Mol. Genet. Metab."},{"issue":"7","key":"10.1016\/j.bcp.2025.117150_b0160","first-page":"667","article-title":"Effects and molecular mechanism of exogenous L-carnitine on excessive endoplasmic reticulum stress-mediated hepatic pyroptosis in severely scald rats","volume":"38","author":"Fan","year":"2022","journal-title":"Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi"},{"key":"10.1016\/j.bcp.2025.117150_b0165","doi-asserted-by":"crossref","first-page":"155111","DOI":"10.1016\/j.phymed.2023.155111","article-title":"Xie Zhuo Tiao Zhi formula modulates intestinal microbiota and liver purine metabolism to suppress hepatic steatosis and pyroptosis in NAFLD therapy","volume":"121","author":"Qiu","year":"2023","journal-title":"Phytomedicine"},{"issue":"7884","key":"10.1016\/j.bcp.2025.117150_b0170","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-021-04020-1","article-title":"Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11","volume":"599","author":"Li","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bcp.2025.117150_b0175","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.intimp.2015.06.011","article-title":"Fumaric acid esters prevent the NLRP3 inflammasome-mediated and ATP-triggered pyroptosis of differentiated THP-1 cells","volume":"28","author":"Miglio","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117150_b0180","first-page":"4069","article-title":"Tryptophan alleviates lipopolysaccharide-induced liver injury and inflammation by modulating necroptosis and pyroptosis signaling pathways in piglets","volume":"34","author":"Gu","year":"2023","journal-title":"Anim. Biotechnol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117150_b0185","doi-asserted-by":"crossref","first-page":"113700","DOI":"10.1016\/j.celrep.2024.113700","article-title":"Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting","volume":"43","author":"Pereira","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2025.117150_b0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.abb.2017.04.009","article-title":"Adrenic acid as an inflammation enhancer in non-alcoholic fatty liver disease","volume":"623\u2013624","author":"Horas","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2025.117150_b0195","doi-asserted-by":"crossref","first-page":"36949","DOI":"10.1038\/srep36949","article-title":"Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2025.117150_b0200","doi-asserted-by":"crossref","first-page":"259","DOI":"10.14348\/molcells.2023.2128","article-title":"The role of pyruvate metabolism in mitochondrial quality control and inflammation","volume":"46","author":"Kim","year":"2023","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bcp.2025.117150_b0205","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3389\/fendo.2019.00935","article-title":"Regulation of inflammation pathways and inflammasome by sex steroid hormones in endometriosis","volume":"10","author":"Garc\u00eda-G\u00f3mez","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.bcp.2025.117150_b0210","doi-asserted-by":"crossref","first-page":"e127801","DOI":"10.1172\/jci.insight.127801","article-title":"Arginine metabolic control of airway inflammation","volume":"5","author":"Asosingh","year":"2020","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.bcp.2025.117150_b0215","first-page":"4516","article-title":"Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury","volume":"18","author":"Niu","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2025.117150_b0220","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s10753-019-01021-1","article-title":"Co-nanoencapsulation of vitamin D(3) and curcumin regulates inflammation and purine metabolism in a model of arthritis","volume":"42","author":"da Silva","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.bcp.2025.117150_b0225","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.2147\/DDDT.S427837","article-title":"Mechanism of the effect of compound anoectochilus roxburghii (Wall.) Lindl. oral liquid in treating alcoholic rat liver injury by metabolomics","volume":"17","author":"Huang","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"issue":"5","key":"10.1016\/j.bcp.2025.117150_b0230","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3892\/mmr.2023.13098","article-title":"Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway","volume":"28","author":"Gao","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bcp.2025.117150_b0235","doi-asserted-by":"crossref","first-page":"45668514","DOI":"10.1155\/2022\/4566851","article-title":"The ROS\/GRK2\/HIF-1\u03b1\/NLRP3 pathway mediates pyroptosis of fibroblast-like synoviocytes and the regulation of monomer derivatives of paeoniflorin","volume":"2022","author":"Hong","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2025.117150_b0240","doi-asserted-by":"crossref","first-page":"1095427","DOI":"10.3389\/fimmu.2022.1095427","article-title":"HIF-1\u03b1\/BNIP3L induced cognitive deficits in a mouse model of sepsis-associated encephalopathy","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117150_b0245","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/08923973.2021.1924194","article-title":"Anti-inflammatory effects of paeoniflorin caused by regulation of the hif1a\/miR-210\/caspase1\/GSDMD signaling pathway in astrocytes: a novel strategy for hypoxia-induced brain injury in rats","volume":"43","author":"Jiang","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117150_b0250","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1080\/15384101.2020.1743911","article-title":"Metformin activates AMPK\/SIRT1\/NF-\u03baB pathway and induces mitochondrial dysfunction to drive caspase3\/GSDME-mediated cancer cell pyroptosis","volume":"19","author":"Zheng","year":"2020","journal-title":"Cell Cycle"},{"issue":"5","key":"10.1016\/j.bcp.2025.117150_b0255","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.7150\/ijbs.29680","article-title":"Metformin inhibits the NLRP3 inflammasome via AMPK\/mTOR-dependent effects in diabetic cardiomyopathy","volume":"15","author":"Yang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2025.117150_b0260","doi-asserted-by":"crossref","first-page":"e13009","DOI":"10.1111\/jeu.13009","article-title":"Eimeria falciformis extracellular vesicles differentially express host cell lncRNAs","volume":"71","author":"Olajide","year":"2024","journal-title":"J. Eukaryot. Microbiol."},{"issue":"11","key":"10.1016\/j.bcp.2025.117150_b0265","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1002\/tox.23917","article-title":"N6-methyladenosine methylation regulator RBM15 promotes the progression of diabetic nephropathy by regulating cell proliferation, inflammation, oxidative stress, and pyroptosis through activating the AGE-RAGE pathway","volume":"38","author":"Qin","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117150_b0270","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13020-022-00671-y","article-title":"Nitidine chloride induces caspase 3\/GSDME-dependent pyroptosis by inhibting PI3K\/Akt pathway in lung cancer","volume":"17","author":"Yu","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.bcp.2025.117150_b0275","doi-asserted-by":"crossref","unstructured":"I. G, Pyroptosis in health and disease, Am. J. Physiol. Cell Physiol. 326(3) (2024) C784\u2013C794 doi: 10.1152\/ajpcell.00503.2023.","DOI":"10.1152\/ajpcell.00503.2023"},{"key":"10.1016\/j.bcp.2025.117150_b0280","doi-asserted-by":"crossref","first-page":"1128358","DOI":"10.3389\/fimmu.2023.1128358","article-title":"Uncoupled pyroptosis and IL-1\u03b2 secretion downstream of inflammasome signaling","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117150_b0285","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12563","article-title":"Role of pyroptosis in cardiovascular disease","volume":"52","author":"Zhaolin","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bcp.2025.117150_b0290","doi-asserted-by":"crossref","first-page":"149272","DOI":"10.1016\/j.bbrc.2023.149272","article-title":"Cardiac reprogramming reduces inflammatory macrophages and improves cardiac function in chronic myocardial infarction","volume":"690","author":"Abe","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2025.117150_b0295","first-page":"e934255","article-title":"Role of NLRP3 inflammasome in myocardial ischemia-reperfusion injury and ventricular remodeling","volume":"28","author":"Shen","year":"2022","journal-title":"Med. Sci. Monit."},{"issue":"1","key":"10.1016\/j.bcp.2025.117150_b0300","doi-asserted-by":"crossref","first-page":"8396","DOI":"10.1038\/s41467-023-44203-0","article-title":"Acetylation is required for full activation of the NLRP3 inflammasome","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bcp.2025.117150_b0305","doi-asserted-by":"crossref","first-page":"H1375","DOI":"10.1152\/ajpheart.00053.2015","article-title":"The role of sirtuins in cardiac disease","volume":"309","author":"Matsushima","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225004150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225004150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T13:27:03Z","timestamp":1767360423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225004150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":61,"alternative-id":["S0006295225004150"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117150","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BCAA exaggerated acute and chronic ischemic heart disease through promotion of NLRP3 via Sirt1","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117150","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117150"}}