{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:37:23Z","timestamp":1781649443778,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC0713"],"award-info":[{"award-number":["2022NSFSC0713"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002045"],"award-info":[{"award-number":["82002045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bcp.2025.117185","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T06:28:14Z","timestamp":1752906494000},"page":"117185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting YAP1-dependent aerobic glycolysis to mitigate fibrosis progression in morphea"],"prefix":"10.1016","volume":"241","author":[{"given":"Yiming","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-0193","authenticated-orcid":false,"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2025.117185_b0005","doi-asserted-by":"crossref","unstructured":"J. Liu, J. Wang, Q. Zhang, F. Lu, J. Cai, Clinical, Histologic, and Transcriptomic Evaluation of Sequential Fat Grafting for Morphea: A Nonrandomized Controlled Trial, JAMA Dermatol. 160 (2024) 425-433.","DOI":"10.1001\/jamadermatol.2023.5908"},{"key":"10.1016\/j.bcp.2025.117185_b0010","article-title":"Scleroderma and scleroderma-like syndromes","volume":"15","author":"Romanowska-Prochnicka","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2025.117185_b0015","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/bjd\/ljae286","article-title":"Atypical chemokine receptor 1-positive endothelial cells mediate leucocyte infiltration and synergize with secreted frizzled-related protein 2\/asporin-positive fibroblasts to promote skin fibrosis in systemic sclerosis","volume":"191","author":"Huang","year":"2024","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bcp.2025.117185_b0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jaad.2021.12.068","article-title":"Emerging therapeutics in the management of connective tissue disease. Part II: dermatomyositis and scleroderma","volume":"87","author":"Kodumudi","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.bcp.2025.117185_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102730","article-title":"Targeted delivery in scleroderma fibrosis","volume":"20","author":"Varrica","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.bcp.2025.117185_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2022.11.025","article-title":"CXCL9 links skin inflammation and fibrosis through CXCR3-dependent upregulation of Col1a1 in fibroblasts","author":"Richmond","year":"2023","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bcp.2025.117185_b0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s40257-023-00831-2","article-title":"Recent advances in treatment of systemic sclerosis and morphea","volume":"25","author":"Teske","year":"2024","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.bcp.2025.117185_b0040","first-page":"605","article-title":"S2k guideline: diagnosis and therapy of localized scleroderma","volume":"22","author":"Kreuter","year":"2024","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"10.1016\/j.bcp.2025.117185_b0045","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.actbio.2022.08.063","article-title":"Mechanosensor YAP cooperates with TGF-beta1 signaling to promote myofibroblast activation and matrix stiffening in a 3D model of human cardiac fibrosis","volume":"152","author":"Ragazzini","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bcp.2025.117185_b0050","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41580-023-00644-5","article-title":"Control of stem cell renewal and fate by YAP and TAZ","volume":"24","author":"Driskill","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2025.117185_b0055","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400813RR","article-title":"YAP activation in liver macrophages via depletion of MST1\/MST2 enhances liver inflammation and fibrosis in MASLD","volume":"38","author":"Zhang","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2025.117185_b0060","doi-asserted-by":"crossref","first-page":"F512","DOI":"10.1152\/ajprenal.00367.2021","article-title":"MST1\/2 in PDGFRalpha(+) cells negatively regulates TGF-beta-induced myofibroblast accumulation in renal fibrosis","volume":"322","author":"An","year":"2022","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bcp.2025.117185_b0065","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.3390\/cells11132065","article-title":"New insights into Hippo\/YAP signaling in fibrotic diseases","volume":"11","author":"Mia","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2025.117185_b0070","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41586-020-1998-1","article-title":"Mechanical regulation of glycolysis via cytoskeleton architecture","volume":"578","author":"Park","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2025.117185_b0075","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1038\/s41467-023-42093-w","article-title":"Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice","volume":"14","author":"Venit","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2025.117185_b0080","doi-asserted-by":"crossref","first-page":"14026","DOI":"10.1111\/jcmm.16013","article-title":"Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis","volume":"24","author":"Henderson","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2025.117185_b0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41573-019-0040-5","article-title":"Targeting metabolic dysregulation for fibrosis therapy","volume":"19","author":"Zhao","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bcp.2025.117185_b0090","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41392-022-01097-6","article-title":"Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response","volume":"7","author":"Zeng","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2025.117185_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119206","article-title":"3-Bromopyruvate decreased kidney fibrosis and fibroblast activation by suppressing aerobic glycolysis in unilateral ureteral obstruction mice model","volume":"272","author":"Yu","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117185_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116271","article-title":"Shen Shuai II recipe inhibits hypoxia-induced glycolysis by preserving mitochondrial dynamics to attenuate kidney fibrosis","volume":"308","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2025.117185_b0105","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.canlet.2021.07.025","article-title":"Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression","volume":"518","author":"Lin","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2025.117185_b0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bcp.2025.117185_b0115","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/jid.2014.90","article-title":"The nano-scale mechanical properties of the extracellular matrix regulate dermal fibroblast function","volume":"134","author":"Achterberg","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bcp.2025.117185_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1004949","article-title":"Exploring metabolism in scleroderma reveals opportunities for pharmacological intervention for therapy in fibrosis","volume":"13","author":"Cantanhede","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2025.117185_b0125","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s42255-018-0008-5","article-title":"Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis","volume":"1","author":"Zhao","year":"2019","journal-title":"Nat. Metab"},{"key":"10.1016\/j.bcp.2025.117185_b0130","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.3390\/cells9102234","article-title":"PGC-1alpha in disease: recent renal insights into a versatile metabolic regulator","volume":"9","author":"Chambers","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2025.117185_b0135","article-title":"From metabolism to malignancy: the multifaceted role of PGC1alpha in cancer","volume":"14","author":"Wang","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2025.117185_b0140","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1007\/s12035-016-9944-9","article-title":"The interaction of mitochondrial biogenesis and fission\/fusion mediated by PGC-1alpha regulates rotenone-induced dopaminergic neurotoxicity","volume":"54","author":"Peng","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bcp.2025.117185_b0145","article-title":"Morphea: the 2023 update","volume":"10","author":"Papara","year":"2023","journal-title":"Front. Med (lausanne)"},{"key":"10.1016\/j.bcp.2025.117185_b0150","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11010-020-03866-9","article-title":"YAP\/TAZ affects the development of pulmonary fibrosis by regulating multiple signaling pathways","volume":"475","author":"Zhu","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bcp.2025.117185_b0155","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkac036","article-title":"Skin biomechanics: a potential therapeutic intervention target to reduce scarring","volume":"10","author":"Hosseini","year":"2022","journal-title":"Burns Trauma"},{"key":"10.1016\/j.bcp.2025.117185_b0160","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.jid.2016.02.005","article-title":"Yes-associated protein contributes to the development of human cutaneous squamous cell carcinoma via activation of RAS","volume":"136","author":"Jia","year":"2016","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bcp.2025.117185_b0165","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10456-020-09760-8","article-title":"YAP promotes ocular neovascularization by modifying PFKFB3-driven endothelial glycolysis","volume":"24","author":"Feng","year":"2021","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bcp.2025.117185_b0170","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jdermsci.2021.09.002","article-title":"Keloid fibroblasts have elevated and dysfunctional mechanotransduction signaling that is independent of TGF-beta","volume":"104","author":"Deng","year":"2021","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.bcp.2025.117185_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102709","article-title":"Mitochondrial fusion induced by transforming growth factor-beta1 serves as a switch that governs the metabolic reprogramming during differentiation of regulatory T cells","volume":"62","author":"Fang","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2025.117185_b0180","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.molcel.2016.04.010","article-title":"Activation of mitofusin2 by Smad2-RIN1 complex during mitochondrial fusion","volume":"62","author":"Kumar","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2025.117185_b0185","first-page":"871","article-title":"Impaired mitochondrial transcription factor a expression promotes mitochondrial damage to drive fibroblast activation and fibrosis in systemic sclerosis, arthritis","volume":"74","author":"Zhou","year":"2022","journal-title":"Rheumatol"},{"key":"10.1016\/j.bcp.2025.117185_b0190","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1089\/ars.2011.4243","article-title":"Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis","volume":"16","author":"Pavlides","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2025.117185_b0195","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1089\/ars.2020.8028","article-title":"Targeting evolutionary conserved oxidative stress and immunometabolic pathways for the treatment of respiratory infectious diseases","volume":"32","author":"Erlich","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2025.117185_b0200","doi-asserted-by":"crossref","first-page":"11384","DOI":"10.3390\/ijms222413384","article-title":"Mitochondrial oxidative stress-a causative factor and therapeutic target in many diseases","volume":"22","author":"Kowalczyk","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2025.117185_b0205","article-title":"Recent advances in mitochondria-targeting theranostic agents","volume":"4","author":"Qian","year":"2024","journal-title":"Exploration (beijing)"},{"key":"10.1016\/j.bcp.2025.117185_b0210","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.7150\/thno.74563","article-title":"Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload","volume":"12","author":"Yue","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2025.117185_b0215","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.freeradbiomed.2022.10.323","article-title":"YAP1 silencing attenuated lung injury\/fibrosis but worsened diaphragmatic function by regulating oxidative stress and inflammation response in mice","volume":"193","author":"Li","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"23","key":"10.1016\/j.bcp.2025.117185_b0220","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202214468","article-title":"YAP\u2010suppressive nanodrug crosslinked self\u2010immunoregulatory polysaccharide injectable hydrogel for attenuating cardiac fibrosis to treat myocardial infarction","volume":"33","author":"Sun","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bcp.2025.117185_b0225","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jconrel.2024.01.032","article-title":"Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling","volume":"366","author":"Han","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bcp.2025.117185_b0230","doi-asserted-by":"crossref","first-page":"F561","DOI":"10.1152\/ajprenal.00036.2017","article-title":"Inhibiting aerobic glycolysis suppresses renal interstitial fibroblast activation and renal fibrosis","volume":"313","author":"Ding","year":"2017","journal-title":"Am. J. Physiol \u3002 Renal Physiol"},{"key":"10.1016\/j.bcp.2025.117185_b0235","first-page":"448","article-title":"AMPK activation is indispensable for the protective effects of caloric restriction on left ventricular function in postinfarct myocardium","volume":"11","author":"Niemann","year":"2022","journal-title":"Biology (basel)"},{"key":"10.1016\/j.bcp.2025.117185_b0240","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.3390\/ijms25105236","article-title":"The effects of caloric restriction on inflammatory targets in the prostates of aged rats","volume":"25","author":"Rago","year":"2024","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225004502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225004502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T13:29:08Z","timestamp":1767360548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225004502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":48,"alternative-id":["S0006295225004502"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117185","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting YAP1-dependent aerobic glycolysis to mitigate fibrosis progression in morphea","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117185"}}