{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:23:54Z","timestamp":1791260634249,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bcp.2025.117347","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T06:54:24Z","timestamp":1758178464000},"page":"117347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"P2","title":["The pregnane\u00a0X\u00a0receptor is a novel host target for dengue virus infection that reprograms lipid metabolism and suppresses the immune response"],"prefix":"10.1016","volume":"242","author":[{"given":"Carlos Daniel","family":"Bautista-Olivier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima E.","family":"Murillo-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Lim\u00f3n-Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Hern\u00e1ndez-C\u00e1zares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvin No\u00e9","family":"Palacios-R\u00e1palo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Daniel","family":"Cordero-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Noe","family":"Farfan-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"del \u00c1ngel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-9126","authenticated-orcid":false,"given":"Guillermo","family":"Elizondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.bcp.2025.117347_b0005","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.3201\/eid2808.220550","article-title":"Emergence of Dengue Virus Serotype 2 Cosmopolitan Genotype, Brazil","volume":"28","author":"Giovanetti","year":"2022","journal-title":"Emerg. Infect. Dis."},{"issue":"9","key":"10.1016\/j.bcp.2025.117347_b0010","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1073\/pnas.1806094116","article-title":"Climate-driven variation in mosquito density predicts the spatiotemporal dynamics of dengue","volume":"116","author":"Li","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bcp.2025.117347_b0015","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fphar.2016.00456","article-title":"Pregnane X receptor (PXR)-mediated gene repression and cross-talk of PXR with other nuclear receptors via coactivator interactions","volume":"7","author":"Pavek","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117347_b0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/138920008783571774","article-title":"Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues","volume":"9","author":"Pavek","year":"2008","journal-title":"Curr. Drug Metab."},{"issue":"1","key":"10.1016\/j.bcp.2025.117347_b0025","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1124\/jpet.118.255679","article-title":"Pregnane X receptor activation triggers rapid ATP release in primed macrophages that mediates NLRP3 inflammasome activation","volume":"370","author":"Hudson","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.bcp.2025.117347_b0030","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1124\/pr.55.4.2","article-title":"Induction of drug metabolism: the role of nuclear receptors","volume":"55","author":"Handschin","year":"2003","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2025.117347_b0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80900-9","article-title":"An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway","volume":"92","author":"Kliewer","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2025.117347_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115147","article-title":"PXR as the tipping point between innate immune response, microbial infections, and drug metabolism","volume":"202","author":"Bautista-Olivier","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"21","key":"10.1016\/j.bcp.2025.117347_b0045","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1074\/jbc.M511116200","article-title":"A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway","volume":"281","author":"Zhou","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2025.117347_b0050","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jhep.2018.12.038","article-title":"Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis","volume":"70","author":"Gwag","year":"2019","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117347_b0055","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1111\/bph.15433","article-title":"Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2\u2010mediated mechanism","volume":"178","author":"Karpale","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117347_b0060","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.dld.2013.06.004","article-title":"Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis","volume":"45","author":"Niu","year":"2013","journal-title":"Dig. Liver Dis."},{"issue":"12","key":"10.1016\/j.bcp.2025.117347_b0065","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/nchembio.2193","article-title":"Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection","volume":"12","author":"Levy","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117347_b0070","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1084\/jem.20060929","article-title":"A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections","volume":"203","author":"Chow","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2025.117347_b0075","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/1471-2334-12-274","article-title":"HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes","volume":"12","author":"Renga","year":"2012","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2025.117347_b0080","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2477647","article-title":"Dengue virus and lipid metabolism: unravelling the interplay for future therapeutic approaches","volume":"14","author":"Xie","year":"2025","journal-title":"Emerg Microbes Infect"},{"issue":"11","key":"10.1016\/j.bcp.2025.117347_b0085","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1128\/JVI.74.11.4957-4966.2000","article-title":"Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons","volume":"74","author":"Diamond","year":"2000","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.bcp.2025.117347_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004242","article-title":"G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA","volume":"10","author":"Bidet","year":"2014","journal-title":"PLoS Pathog."},{"issue":"51","key":"10.1016\/j.bcp.2025.117347_b0095","doi-asserted-by":"crossref","first-page":"49982","DOI":"10.1074\/jbc.M209649200","article-title":"Scavenger receptors class A-I\/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages","volume":"277","author":"Kunjathoor","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2025.117347_b0100","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cellsig.2018.10.020","article-title":"Sterol regulatory element binding protein (SREBP) -1 mediates oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation through NLRP3 inflammasome activation","volume":"53","author":"Varghese","year":"2019","journal-title":"Cell. Signal."},{"issue":"36","key":"10.1016\/j.bcp.2025.117347_b0105","doi-asserted-by":"crossref","first-page":"14610","DOI":"10.1073\/pnas.1212379109","article-title":"Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro","volume":"109","author":"Schoggins","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bcp.2025.117347_b0110","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4049\/jimmunol.1600203","article-title":"Human xenobiotic nuclear receptor PXR augments Mycobacterium tuberculosis survival","volume":"197","author":"Bhagyaraj","year":"2016","journal-title":"J. Immunol."},{"issue":"21","key":"10.1016\/j.bcp.2025.117347_b0115","doi-asserted-by":"crossref","first-page":"10832","DOI":"10.1128\/JVI.00883-08","article-title":"Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha","volume":"82","author":"Ramiere","year":"2008","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117347_b0120","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.biocel.2009.11.016","article-title":"Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development","volume":"43","author":"Reese","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"48","key":"10.1016\/j.bcp.2025.117347_b0125","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.3748\/wjg.v11.i48.7591","article-title":"Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A","volume":"11","author":"Cheng","year":"2005","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117347_b0130","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jhep.2007.09.015","article-title":"Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR","volume":"48","author":"Scholtes","year":"2008","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117347_b0135","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1097-2765(03)00384-8","article-title":"Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism","volume":"12","author":"Castrillo","year":"2003","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.bcp.2025.117347_b0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000632","article-title":"Dengue virus capsid protein usurps lipid droplets for viral particle formation","volume":"5","author":"Samsa","year":"2009","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.bcp.2025.117347_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002934","article-title":"DENV inhibits type I IFN production in infected cells by cleaving human STING","volume":"8","author":"Aguirre","year":"2012","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.bcp.2025.117347_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002780","article-title":"Dengue virus targets the adaptor protein MITA to subvert host innate immunity","volume":"8","author":"Yu","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bcp.2025.117347_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2023.03.016","article-title":"A cellular screening platform, stably expressing DENV2 NS5, defines a novel anti-DENV mechanism of action of Apigenin based on STAT2 activation","volume":"583","author":"Acchioni","year":"2023","journal-title":"Virology"},{"issue":"10","key":"10.1016\/j.bcp.2025.117347_b0160","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bbalip.2006.08.015","article-title":"Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y","volume":"1761","author":"Murphy","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2025.117347_b0165","doi-asserted-by":"crossref","unstructured":"S.N. Palacios-Rapalo, C.N. Farfan-Morales, C.D. Cordero-Rivera, L.A. De Jesus-Gonzalez, J.M. Reyes-Ruiz, M.A. Meraz-Rios, R.M. Del Angel, An ivermectin - atorvastatin combination impairs nuclear transport inhibiting dengue infection in vitro and in vivo, iScience 26(12) (2023) 108294.","DOI":"10.1016\/j.isci.2023.108294"},{"issue":"21","key":"10.1016\/j.bcp.2025.117347_b0170","doi-asserted-by":"crossref","first-page":"60009","DOI":"10.1007\/s11356-023-26736-5","article-title":"Effects of atorvastatin on the Sirtuin\/PXR signaling pathway in Mugilogobius chulae","volume":"30","author":"Zhao","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"9","key":"10.1016\/j.bcp.2025.117347_b0175","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/15287394.2017.1335258","article-title":"Simvastatin modulates gene expression of key receptors in zebrafish embryos","volume":"80","author":"Cunha","year":"2017","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"3","key":"10.1016\/j.bcp.2025.117347_b0180","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bcp.2014.01.031","article-title":"Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB\/c mouse","volume":"88","author":"Chuang","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117347_b0185","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/AAC.30.4.617","article-title":"Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide","volume":"30","author":"Iwen","year":"1986","journal-title":"Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.bcp.2025.117347_b0190","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.bcp.2011.08.023","article-title":"Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene","volume":"82","author":"Krausova","year":"2011","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117347_b0195","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1124\/mol.108.049437","article-title":"Computational discovery of novel low micromolar human pregnane X receptor antagonists","volume":"74","author":"Ekins","year":"2008","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117347_b0200","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.1038\/s41598-021-87707-9","article-title":"The antiviral effect of metformin on zika and dengue virus infection","volume":"11","author":"Farfan-Morales","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2025.117347_b0205","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1038\/s41598-018-21612-6","article-title":"Metformin use and severe dengue in diabetic adults","volume":"8","author":"Htun","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225006124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225006124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T05:19:36Z","timestamp":1761455976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225006124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":41,"alternative-id":["S0006295225006124"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117347","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pregnane\u00a0X\u00a0receptor is a novel host target for dengue virus infection that reprograms lipid metabolism and suppresses the immune response","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117347"}}