{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:19:23Z","timestamp":1789676363576,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002836","name":"Chang Gung University","doi-asserted-by":"publisher","award":["ZRRPF3N0101"],"award-info":[{"award-number":["ZRRPF3N0101"]}],"id":[{"id":"10.13039\/501100002836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPF1J0051-3"],"award-info":[{"award-number":["CMRPF1J0051-3"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPF1P0051-3"],"award-info":[{"award-number":["CORPF1P0051-3"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPF1M0101-2"],"award-info":[{"award-number":["CMRPF1M0101-2"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPF1L0011"],"award-info":[{"award-number":["CORPF1L0011"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3J1001-3"],"award-info":[{"award-number":["CMRPG3J1001-3"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPF1L0071"],"award-info":[{"award-number":["CMRPF1L0071"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPF1N0021"],"award-info":[{"award-number":["CMRPF1N0021"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3K0921"],"award-info":[{"award-number":["CMRPG3K0921"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["BMRP450"],"award-info":[{"award-number":["BMRP450"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPF1P0071-3"],"award-info":[{"award-number":["CORPF1P0071-3"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPF1M0131-2"],"award-info":[{"award-number":["CMRPF1M0131-2"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["109-2327-B-255-001"],"award-info":[{"award-number":["109-2327-B-255-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2321-B-182-003"],"award-info":[{"award-number":["113-2321-B-182-003"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110-2320-B-182A-009"],"award-info":[{"award-number":["110-2320-B-182A-009"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["111-2320-B-255-006-MY3"],"award-info":[{"award-number":["111-2320-B-255-006-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2321-B-255-001"],"award-info":[{"award-number":["113-2321-B-255-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2321-B-255-001"],"award-info":[{"award-number":["112-2321-B-255-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Linkou Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017667","name":"Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CLRPG3D0048"],"award-info":[{"award-number":["CLRPG3D0048"]}],"id":[{"id":"10.13039\/100017667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bcp.2025.117348","type":"journal-article","created":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T05:32:55Z","timestamp":1758432775000},"page":"117348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P2","title":["Butyrolactone I from Aspergillus fungi blocks neutrophil FPR1 to alleviate acute respiratory distress syndrome"],"prefix":"10.1016","volume":"242","author":[{"given":"Chun-Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chuang","family":"Liaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Fong","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Cheng","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony Eight","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-3977","authenticated-orcid":false,"given":"Tsong-Long","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bcp.2025.117348_b0005","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41577-022-00787-0","article-title":"Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases","volume":"23","author":"Wigerblad","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117348_b0010","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41590-023-01452-x","article-title":"Strategies of neutrophil diversification","volume":"24","author":"Palomino-Segura","year":"2023","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117348_b0015","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1165\/rcmb.2018-0101PS","article-title":"The emerging role of neutrophils in repair after acute lung injury","volume":"59","author":"Blazquez-Prieto","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117348_b0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chest.2017.03.056","article-title":"The role of neutrophil elastase inhibitors in lung diseases","volume":"152","author":"Polverino","year":"2017","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12950-023-00333-2","article-title":"Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance","volume":"20","author":"Scaramuzzo","year":"2023","journal-title":"J. Inflamm. (Lond.)"},{"key":"10.1016\/j.bcp.2025.117348_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.572009","article-title":"Targeting neutrophils to treat acute respiratory distress syndrome in coronavirus disease","volume":"11","author":"Chiang","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117348_b0035","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bj.2020.09.001","article-title":"Understanding the role of neutrophils in acute respiratory distress syndrome","volume":"44","author":"Yang","year":"2021","journal-title":"Biomed J"},{"key":"10.1016\/j.bcp.2025.117348_b0040","doi-asserted-by":"crossref","unstructured":"R.D. Ye, F. Boulay, J.M. Wang, C. Dahlgren, C. Gerard, M. Parmentier, C.N. Serhan, P.M. Murphy, International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family, Pharmacol. Rev. 61(2) (2009) 119-61.","DOI":"10.1124\/pr.109.001578"},{"key":"10.1016\/j.bcp.2025.117348_b0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaut.2017.06.012","article-title":"Regulation of inflammation by members of the formyl-peptide receptor family","volume":"85","author":"Chen","year":"2017","journal-title":"J. Autoimmun."},{"issue":"5","key":"10.1016\/j.bcp.2025.117348_b0050","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.ajpath.2015.01.020","article-title":"The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation","volume":"185","author":"Dorward","year":"2015","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117348_b0055","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125937","article-title":"FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis","volume":"5","author":"Leslie","year":"2020","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0060","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2020.1760061","article-title":"The ambiguous role of FPR1 in immunity and inflammation","volume":"9","author":"Vacchelli","year":"2020","journal-title":"Oncoimmunology"},{"issue":"10","key":"10.1016\/j.bcp.2025.117348_b0065","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1136\/thoraxjnl-2017-210030","article-title":"Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome","volume":"72","author":"Dorward","year":"2017","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.bcp.2025.117348_b0070","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41579-018-0121-1","article-title":"Fungal secondary metabolism: regulation, function and drug discovery","volume":"17","author":"Keller","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117348_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/md14080141","article-title":"Marine natural product inhibitors of neutrophil-associated inflammation","volume":"14","author":"Chen","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bcp.2025.117348_b0080","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.copbio.2021.02.004","article-title":"Aspergillus terreus as an industrial filamentous fungus for pharmaceutical biotechnology","volume":"69","author":"Huang","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.bcp.2025.117348_b0085","article-title":"Secondary metabolites from the deep-sea derived fungus Aspergillus terreus MCCC M28183","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0090","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12974-022-02403-3","article-title":"Marine fungal metabolite butyrolactone I prevents cognitive deficits by relieving inflammation and intestinal microbiota imbalance on aluminum trichloride-injured zebrafish","volume":"19","author":"Nie","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.bcp.2025.117348_b0095","first-page":"2425","article-title":"Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase","volume":"8","author":"Kitagawa","year":"1993","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.bcp.2025.117348_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/md16060202","article-title":"Butyrolactone-I from coral-derived fungus aspergillus terreus attenuates neuro-inflammatory response via suppression of NF-kappaB pathway in BV-2 cells","volume":"16","author":"Zhang","year":"2018","journal-title":"Mar. Drugs"},{"issue":"22","key":"10.1016\/j.bcp.2025.117348_b0105","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1080\/14786419.2017.1375924","article-title":"A new anti-inflammatory meroterpenoid from the fungus Aspergillus terreus H010","volume":"32","author":"Liu","year":"2018","journal-title":"Nat. Prod. Res."},{"issue":"11","key":"10.1016\/j.bcp.2025.117348_b0110","doi-asserted-by":"crossref","first-page":"12616","DOI":"10.1096\/fj.201901061R","article-title":"Butyrolactone-I, an efficient alpha-glucosidase inhibitor, improves type 2 diabetes with potent TNF-alpha-lowering properties through modulating gut microbiota in db\/db mice","volume":"33","author":"Wu","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2025.117348_b0115","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.freeradbiomed.2018.09.048","article-title":"Propofol inhibits endogenous formyl peptide-induced neutrophil activation and alleviates lung injury","volume":"129","author":"Chen","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.bcp.2025.117348_b0120","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.4049\/jimmunol.1202215","article-title":"Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1","volume":"190","author":"Yang","year":"2013","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117348_b0125","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bbrc.2006.02.173","article-title":"Simultaneous measurement of superoxide generation and intracellular Ca2+ concentration reveals the effect of extracellular Ca2+ on rapid and transient contents of superoxide generation in differentiated THP-1 cells","volume":"344","author":"Ishibashi","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2025.117348_b0130","doi-asserted-by":"crossref","first-page":"18204","DOI":"10.1038\/srep18204","article-title":"Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2025.117348_b0135","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1084\/jem.115.3.453","article-title":"The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes","volume":"115","author":"Boyden","year":"1962","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0140","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1038\/s41467-022-32822-y","article-title":"Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns","volume":"13","author":"Chen","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0145","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2025.117348_b0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2018.03.049","article-title":"Neutrophils and redox stress in the pathogenesis of autoimmune disease","volume":"125","author":"Glennon-Alty","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117348_b0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"Suppl 2","key":"10.1016\/j.bcp.2025.117348_b0160","article-title":"Intracellular beta2 integrin (CD11\/CD18) interacting partners in neutrophil trafficking","volume":"48","author":"Thome","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0165","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41467-020-14728-9","article-title":"Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling","volume":"11","author":"Zhuang","year":"2020","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bcp.2025.117348_b0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047114","article-title":"The role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulations","volume":"7","author":"Yuan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2025.117348_b0175","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fphys.2018.00477","article-title":"Role of ROS and nutritional antioxidants in human diseases","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bcp.2025.117348_b0180","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-319-63245-2_8","article-title":"ROS signaling in the pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)","volume":"967","author":"Kellner","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117348_b0185","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1271\/bbb.90918","article-title":"Soybean lipoxygenase inhibitory and DPPH radical-scavenging activities of aspernolide a and butyrolactones I and II","volume":"74","author":"Sugiyama","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0190","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s00044-013-0659-4","article-title":"Effect on \u03b1-glucosidase inhibition and antioxidant activities of butyrolactone derivatives from Aspergillus terreus MC751","volume":"23","author":"Dewi","year":"2014","journal-title":"Med. Chem. Res."},{"issue":"Suppl 2","key":"10.1016\/j.bcp.2025.117348_b0195","article-title":"Calcium signalling and related ion channels in neutrophil recruitment and function","volume":"48","author":"Immler","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bcp.2025.117348_b0200","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.intimp.2013.11.010","article-title":"Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int. Immunopharmacol."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2025.117348_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.01.034","article-title":"Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils","volume":"534","author":"Selvatici","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117348_b0210","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s11606-020-05762-w","article-title":"Review of the clinical characteristics of coronavirus disease 2019 (COVID-19)","volume":"35","author":"Jiang","year":"2020","journal-title":"J. Gen. Intern. Med."},{"issue":"7","key":"10.1016\/j.bcp.2025.117348_b0215","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","article-title":"Extrapulmonary manifestations of COVID-19","volume":"26","author":"Gupta","year":"2020","journal-title":"Nat. Med."},{"issue":"4 Suppl","key":"10.1016\/j.bcp.2025.117348_b0220","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.1097\/01.CCM.0000057843.47705.E8","article-title":"Neutrophils and acute lung injury","volume":"31","author":"Abraham","year":"2003","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117348_b0225","doi-asserted-by":"crossref","first-page":"L217","DOI":"10.1152\/ajplung.00311.2013","article-title":"The mercurial nature of neutrophils: still an enigma in ARDS?","volume":"306","author":"Williams","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"7285","key":"10.1016\/j.bcp.2025.117348_b0230","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2025.117348_b0235","doi-asserted-by":"crossref","unstructured":"M. Raoof, Q. Zhang, K. Itagaki, C.J. Hauser, Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1, J. Trauma 68(6) (2010) 1328-32; discussion 1332-4.","DOI":"10.1097\/TA.0b013e3181dcd28d"},{"issue":"2","key":"10.1016\/j.bcp.2025.117348_b0240","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1124\/mol.112.081315","article-title":"Functional characterization of three mouse formyl peptide receptors","volume":"83","author":"He","year":"2013","journal-title":"Mol. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117348_b0245","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1002\/eji.200526338","article-title":"Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR","volume":"35","author":"Rabiet","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bcp.2025.117348_b0250","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pupt.2016.02.005","article-title":"Mitochondrial N-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation","volume":"37","author":"Wenceslau","year":"2016","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.bcp.2025.117348_b0255","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0260","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250010","article-title":"Neutrophil activation and neutrophil extracellular traps (NETs) in COVID-19 ARDS and immunothrombosis","volume":"53","author":"Cesta","year":"2023","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117348_b0265","doi-asserted-by":"crossref","first-page":"L1137","DOI":"10.1152\/ajplung.2000.279.6.L1137","article-title":"Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury","volume":"279","author":"Abraham","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0270","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1097\/CCM.0000000000004732","article-title":"Mitochondrial damage-associated molecular patterns exacerbate lung fluid imbalance via the formyl peptide receptor-1 signaling pathway in acute lung injury","volume":"49","author":"Yuan","year":"2021","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0275","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12931-024-02678-5","article-title":"Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)","volume":"25","author":"Huang","year":"2024","journal-title":"Respir. Res."},{"key":"10.1016\/j.bcp.2025.117348_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108516","article-title":"Neutrophil Extracellular Traps (NETs) and Covid-19: a new frontiers for therapeutic modality","volume":"104","author":"Al-Kuraishy","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117348_b0285","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/MOH.0b013e32835b06be","article-title":"Neutrophil apoptosis and its induction as a potential treatment for chronic inflammatory disease","volume":"20","author":"Hampson","year":"2013","journal-title":"Curr. Opin. Hematol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117348_b0290","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1038\/cdd.2012.80","article-title":"Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation","volume":"19","author":"Leitch","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2025.117348_b0295","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jare.2024.07.026","article-title":"Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis","volume":"72","author":"Chen","year":"2025","journal-title":"J. Adv. Res."},{"issue":"37","key":"10.1016\/j.bcp.2025.117348_b0300","doi-asserted-by":"crossref","first-page":"18561","DOI":"10.1073\/pnas.1905221116","article-title":"Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration","volume":"116","author":"Hsu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"16","key":"10.1016\/j.bcp.2025.117348_b0305","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1111\/bph.16080","article-title":"Palbociclib blocks neutrophilic phosphatidylinositol 3-kinase activity to alleviate psoriasiform dermatitis","volume":"180","author":"Chen","year":"2023","journal-title":"Br. J. Pharmacol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225006136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225006136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T05:16:36Z","timestamp":1761455796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225006136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":61,"alternative-id":["S0006295225006136"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117348","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Butyrolactone I from Aspergillus fungi blocks neutrophil FPR1 to alleviate acute respiratory distress syndrome","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117348"}}