{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:51:08Z","timestamp":1792525868043,"version":"4.5.0"},"reference-count":229,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["24KJB180015"],"award-info":[{"award-number":["24KJB180015"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20250952"],"award-info":[{"award-number":["BK20250952"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bcp.2025.117359","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T03:38:42Z","timestamp":1758685122000},"page":"117359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"P3","title":["Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenation"],"prefix":"10.1016","volume":"242","author":[{"given":"Di","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinzheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem Ahmed","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuruliarizki Shinta","family":"Pandupuspitasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2025.117359_b0005","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.arr.2018.05.001","article-title":"Anti-senescence compounds: a potential nutraceutical approach to healthy aging","volume":"46","author":"Gur\u0103u","year":"2018","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0015","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1038\/s41467-025-57203-z","article-title":"Translational error in mice increases with ageing in an organ-dependent manner","volume":"16","author":"B\u00f6ttger","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0020","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/stcltm\/szac004","article-title":"Mesenchymal stem\/stromal cell senescence: hallmarks, mechanisms, and combating strategies","volume":"11","author":"Weng","year":"2022","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bcp.2025.117359_b0025","article-title":"Multi-omics approach reveals TGF-\u03b2 signaling-driven senescence in periodontium stem cells","author":"Li","year":"2024","journal-title":"J. Adv. Res."},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0030","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glae037","article-title":"The potential role and therapeutic relevance of cellular senescence in skeletal pathophysiology","volume":"79","author":"Li","year":"2024","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bcp.2025.117359_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107897","article-title":"Patchouli alcohol ameliorates acute liver injury via inhibiting oxidative stress and gut-origin LPS leakage in rats","volume":"98","author":"Xu","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117359_b0040","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","article-title":"The senescence-associated secretory phenotype and its physiological and pathological implications","volume":"25","author":"Wang","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.bcp.2025.117359_b0045","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13980","article-title":"A single-cell transcriptomic atlas characterizes age-related changes of murine cranial stem cell niches","volume":"22","author":"Li","year":"2023","journal-title":"Aging Cell"},{"issue":"6","key":"10.1016\/j.bcp.2025.117359_b0050","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1111\/odi.15291","article-title":"Dasatinib and quercetin mitigate age-related alveolar bone inflammaging and neutrophil infiltration","volume":"31","author":"Tang","year":"2025","journal-title":"Oral Dis."},{"issue":"8","key":"10.1016\/j.bcp.2025.117359_b0055","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117359_b0060","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in health and disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bcp.2025.117359_b0065","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/s42255-021-00491-8","article-title":"The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice","volume":"3","author":"Xu","year":"2021","journal-title":"Nat. Metab."},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0070","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"issue":"8","key":"10.1016\/j.bcp.2025.117359_b0075","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b0080","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12945","article-title":"Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction","volume":"18","author":"Walaszczyk","year":"2019","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0085","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1038\/s41467-025-57632-w","article-title":"Senescent-like microglia limit remyelination through the senescence associated secretory phenotype","volume":"16","author":"Gross","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2025.117359_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105612","article-title":"A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer\u2019s disease","volume":"113","author":"Millar","year":"2025","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0095","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1038\/s41598-017-01964-1","article-title":"A novel indication for panobinostat as a senolytic drug in NSCLC and HNSCC","volume":"7","author":"Samaraweera","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bcp.2025.117359_b0100","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.biotechadv.2018.03.012","article-title":"Natural products with anti-aging potential: affected targets and molecular mechanisms","volume":"36","author":"C\u0103tan\u0103","year":"2018","journal-title":"Biotechnol. Adv."},{"issue":"10","key":"10.1016\/j.bcp.2025.117359_b0105","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s43587-021-00121-8","article-title":"Strategies for targeting senescent cells in human disease","volume":"1","author":"Gasek","year":"2021","journal-title":"Nat. Aging"},{"issue":"12","key":"10.1016\/j.bcp.2025.117359_b0110","article-title":"The effective role of natural product berberine in modulating oxidative stress and inflammation related atherosclerosis: novel insights into the gut-heart axis evidenced by genetic sequencing analysis","volume":"22","author":"Cao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117359_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153412","article-title":"Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe\u2212\/\u2212 mice: role of SIRT1","volume":"81","author":"Hua","year":"2021","journal-title":"Phytomedicine"},{"issue":"13","key":"10.1016\/j.bcp.2025.117359_b0120","article-title":"A review for the pharmacological effects of paeoniflorin in the nervous system","volume":"15","author":"Hong","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"13","key":"10.1016\/j.bcp.2025.117359_b0125","article-title":"Yi-Shen-Hua-Shi granule alleviates adriamycin-induced glomerular fibrosis by suppressing the BMP2\/Smad signaling pathway","volume":"15","author":"Tan","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117359_b0130","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1002\/ptr.7499","article-title":"Resveratrol ameliorates muscle atrophy in chronic kidney disease via the axis of SIRT1\/FoxO1","volume":"36","author":"Wang","year":"2022","journal-title":"Phytother. Res."},{"issue":"13","key":"10.1016\/j.bcp.2025.117359_b0135","article-title":"Sinomenine confers protection against myocardial ischemia reperfusion injury by preventing oxidative stress, cellular apoptosis, and inflammation","volume":"28","author":"Xia","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117359_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109120","article-title":"Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-\u03baB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury","volume":"111","author":"Xia","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2025.117359_b0145","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1002\/ptr.7549","article-title":"Mangiferin prevents hepatocyte epithelial-mesenchymal transition in liver fibrosis via targeting HSP27-mediated JAK2\/STAT3 and TGF-\u03b21\/Smad pathway","volume":"36","author":"Zhang","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bcp.2025.117359_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115231","article-title":"Puerarin improves busulfan-induced disruption of spermatogenesis by inhibiting MAPK pathways","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2025.117359_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154732","article-title":"Active post-transcriptional regulation and ACLY-mediated acetyl-CoA synthesis as a pivotal target of Shuang-Huang-Sheng-Bai formula for lung adenocarcinoma treatment","volume":"113","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2025.117359_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154664","article-title":"Pushen capsule treatment promotes functional recovery after ischemic stroke","volume":"111","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0165","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/ptr.8176","article-title":"Therapeutic effects of resveratrol on epigenetic mechanisms in age-related diseases: a comprehensive review","volume":"38","author":"Zhang","year":"2024","journal-title":"Phytother. Res."},{"issue":"8","key":"10.1016\/j.bcp.2025.117359_b0170","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/jpp\/rgad053","article-title":"Naringenin ameliorates vascular senescence and atherosclerosis involving SIRT1 activation","volume":"75","author":"Wang","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0175","doi-asserted-by":"crossref","first-page":"10860","DOI":"10.1038\/s41467-024-55164-3","article-title":"Aging-induced immune microenvironment remodeling fosters melanoma in male mice via \u03b3\u03b417-Neutrophil-CD8 axis","volume":"15","author":"Duan","year":"2024","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.bcp.2025.117359_b0180","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.devcel.2024.04.020","article-title":"Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule","volume":"59","author":"Kelly","year":"2024","journal-title":"Dev. Cell"},{"issue":"36","key":"10.1016\/j.bcp.2025.117359_b0185","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"A senomorphlytic three-drug combination discovered in salsola collina for delaying aging phenotypes and extending healthspan","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinh)."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41538-024-00358-8","article-title":"Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance","volume":"8","author":"Wang","year":"2024","journal-title":"NPJ Sci. Food"},{"key":"10.1016\/j.bcp.2025.117359_b0195","article-title":"The impact of rosemary and ginger extracts on aging and healthspan in Drosophila","author":"Aparicio","year":"2025","journal-title":"Aging Dis."},{"key":"10.1016\/j.bcp.2025.117359_b0200","article-title":"Salidroside improves oocyte competence of reproductively old mice by enhancing mitophagy","volume":"9","author":"Gu","year":"2025","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0205","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cmet.2025.01.024","article-title":"Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST","volume":"37","author":"Sprenger","year":"2025","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.bcp.2025.117359_b0210","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s42255-019-0073-4","article-title":"The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans","volume":"1","author":"Andreux","year":"2019","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2025.117359_b0220","article-title":"Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance","author":"Gherardi","year":"2024","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.bcp.2025.117359_b0225","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41593-019-0491-3","article-title":"Single-cell transcriptomic profiling of the aging mouse brain","volume":"22","author":"Ximerakis","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"6728","key":"10.1016\/j.bcp.2025.117359_b0230","doi-asserted-by":"crossref","DOI":"10.1126\/science.adp6547","article-title":"Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice","volume":"386","author":"Li","year":"2024","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0235","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ng.2851","article-title":"Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling","volume":"46","author":"Logan","year":"2014","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.bcp.2025.117359_b0240","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12967-014-0219-9","article-title":"Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases","volume":"3","author":"Bulotta","year":"2014","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0245","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1038\/s41467-025-60196-4","article-title":"Restoring calcium crosstalk between ER and mitochondria promotes intestinal stem cell rejuvenation through autophagy in aged Drosophila","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0250","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/ijms22010091","article-title":"The interplay between mitochondrial morphology and myomitokines in aging sarcopenia","volume":"22","author":"Romanello","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2025.117359_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156316","article-title":"Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K\/Akt\/mTOR signaling pathway","volume":"136","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"issue":"Pt 1","key":"10.1016\/j.bcp.2025.117359_b0260","article-title":"Effects of different selenium biofortification methods on Pleurotus eryngii polysaccharides: Structural characteristics, antioxidant activity and binding capacity in vitro","volume":"275","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bcp.2025.117359_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155567","article-title":"Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging via mitochondria-associated membrane-mediated calcium homeostasis regulation","volume":"129","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0270","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1039\/C8FO02004C","article-title":"Betaine increases mitochondrial content and improves hepatic lipid metabolism","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct."},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0275","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1017\/S0007114520002433","article-title":"Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study","volume":"125","author":"Long","year":"2021","journal-title":"Br. J. Nutr."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0280","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002106RR","article-title":"Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy","volume":"35","author":"Rovira Gonzalez","year":"2021","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0285","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1002\/jcsm.13558","article-title":"Betaine delays age-related muscle loss by mitigating Mss51-induced impairment in mitochondrial respiration via Yin Yang1","volume":"15","author":"Chen","year":"2024","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"217","key":"10.1016\/j.bcp.2025.117359_b0290","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.freeradbiomed.2024.03.009","article-title":"Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine?","volume":"1","author":"Halliwell","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.117359_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2025.01.023","article-title":"Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation","author":"Petrovic","year":"2025","journal-title":"Cell Metab"},{"issue":"51","key":"10.1016\/j.bcp.2025.117359_b0300","doi-asserted-by":"crossref","first-page":"20618","DOI":"10.1073\/pnas.0710191104","article-title":"Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans","volume":"104","author":"Miller","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.bcp.2025.117359_b0305","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.cmet.2021.06.013","article-title":"Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease","volume":"33","author":"Liu","year":"2021","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0310","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/15548627.2024.2395797","article-title":"Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration","volume":"21","author":"Cheng","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2025.117359_b0315","doi-asserted-by":"crossref","DOI":"10.1038\/s43587-024-00799-6","article-title":"Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging","author":"Khawaja","year":"2025","journal-title":"Nat. Aging"},{"issue":"22","key":"10.1016\/j.bcp.2025.117359_b0320","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/j.devcel.2022.10.008","article-title":"Autophagy promotes cell survival by maintaining NAD levels","volume":"57","author":"Kataura","year":"2022","journal-title":"Dev. Cell"},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0325","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111372","article-title":"NDP52 acts as a redox sensor in PINK1\/Parkin-mediated mitophagy","volume":"42","author":"Kataura","year":"2023","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.bcp.2025.117359_b0330","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117359_b0335","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.4132","article-title":"Urolithin a induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents","volume":"22","author":"Ryu","year":"2016","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b0340","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s42255-024-01007-w","article-title":"Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons","volume":"6","author":"Hees","year":"2024","journal-title":"Nat. Metab."},{"issue":"7","key":"10.1016\/j.bcp.2025.117359_b0345","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.molmed.2021.04.009","article-title":"Impact of the natural compound urolithin a on health, disease, and aging","volume":"27","author":"D'Amico","year":"2021","journal-title":"Trends Mol. Med."},{"issue":"13","key":"10.1016\/j.bcp.2025.117359_b0350","article-title":"Gut metabolite urolithin a inhibits osteoclastogenesis and senile osteoporosis by enhancing the autophagy capacity of bone marrow macrophages","volume":"12","author":"Tao","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0355","article-title":"Urolithin a improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults","volume":"3","author":"Singh","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.bcp.2025.117359_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153088","article-title":"Novel steroidal saponin isolated from Trillium tschonoskii maxim. exhibits anti-oxidative effect via autophagy induction in cellular and Caenorhabditis elegans models","volume":"65","author":"Wu","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2025.117359_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2024.111901","article-title":"Novel 18-norspirostane steroidal saponins: Extending lifespan and mitigating neurodegeneration through promotion of mitophagy and mitochondrial biogenesis in Caenorhabditis elegans","volume":"218","author":"Wu","year":"2024","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bcp.2025.117359_b0370","doi-asserted-by":"crossref","unstructured":"Deepika, S. Yadav, P.K. Maurya. Anti-aging Therapeutics: From Nutraceuticals to Pharmaceuticals. In: Qamar, I., Maurya, P.K. (eds) Cellular Senescence, Age-Related Disorders, and Emerging Treatments. Springer, Singapore. 2025. https:\/\/doi.org\/10.1007\/978-981-96-1041-9_14.","DOI":"10.1007\/978-981-96-1041-9_14"},{"issue":"15","key":"10.1016\/j.bcp.2025.117359_b0375","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.18632\/aging.204210","article-title":"Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells","volume":"14","author":"Ho","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"10.1016\/j.bcp.2025.117359_b0380","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1002\/jsfa.13273","article-title":"Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster","volume":"104","author":"Yang","year":"2024","journal-title":"J. Sci. Food Agric."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0385","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41467-019-13931-7","article-title":"DAF-16\/FOXO requires protein phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes","volume":"11","author":"Sen","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0390","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3892\/etm.2023.12104","article-title":"Ethyl acetate extract of Gastrodia elata protects Caenorhabditis elegans from oxidative stress and amyloid \u03b2 peptide toxicity","volume":"26","author":"Shi","year":"2023","journal-title":"Exp. Ther. Med."},{"issue":"241","key":"10.1016\/j.bcp.2025.117359_b0395","article-title":"Aligned core-shell fibrous nerve wrap containing Bletilla striata polysaccharide improves functional outcomes of peripheral nerve repair","volume":"30","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"205","key":"10.1016\/j.bcp.2025.117359_b0400","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ijbiomac.2022.02.073","article-title":"Structural characterization of a low molecular weight Bletilla striata polysaccharide and antitumor activity on H22 tumor-bearing mice","volume":"30","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 2","key":"10.1016\/j.bcp.2025.117359_b0405","article-title":"Exploration of the anti-inflammatory, analgesic, and wound healing activities of Bletilla Striata polysaccharide","volume":"261","author":"He","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 3","key":"10.1016\/j.bcp.2025.117359_b0410","article-title":"Regulation and mechanism of Bletilla striata polysaccharide on delaying aging in Drosophila melanogaster","volume":"310","author":"Hafeez","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"360","key":"10.1016\/j.bcp.2025.117359_b0415","article-title":"Patchouli essential oil extends the lifespan and healthspan of Caenorhabditis elegans through JNK-1\/DAF-16","volume":"1","author":"Xu","year":"2025","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0420","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jep.2014.04.020","article-title":"Prevention of UV radiation-induced cutaneous photoaging in mice by topical administration of patchouli oil","volume":"154","author":"Lin","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2025.117359_b0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154441","article-title":"Patchouli alcohol ameliorates the learning and memory impairments in an animal model of Alzheimer\u2019s disease via modulating SIRT1","volume":"106","author":"Xu","year":"2022","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0430","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1038\/s41401-021-00857-4","article-title":"Patchouli alcohol as a selective estrogen receptor \u03b2 agonist ameliorates AD-like pathology of APP\/PS1 model mice","volume":"43","author":"Yan","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0435","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1039\/D5FO01157D","article-title":"Crocin extends lifespan by mitigating oxidative stress and regulating lipid metabolism through the DAF-16\/FOXO pathway","volume":"16","author":"Li","year":"2025","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0440","first-page":"956","article-title":"Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer\u2019s disease","volume":"43","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"263","key":"10.1016\/j.bcp.2025.117359_b0445","article-title":"Effect of short-term oral supplementation of crocin on age-related oxidative stress, cholinergic, and mitochondrial dysfunction in rat cerebral cortex","volume":"15","author":"Krishnaswamy","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117359_b0450","article-title":"Targeting senescence with apigenin improves chemotherapeutic efficacy and ameliorates age-related conditions in mice","volume":"23","author":"Zhang","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"issue":"33","key":"10.1016\/j.bcp.2025.117359_b0455","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023216118","article-title":"Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis","volume":"118","author":"Huang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.bcp.2025.117359_b0460","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s13238-021-00882-3","article-title":"Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice","volume":"13","author":"Li","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.bcp.2025.117359_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156787","article-title":"Procyanidin C1 ameliorates aging-related skin fibrosis through targeting EGFR to inhibit TGF\u03b2\/SMAD pathway","volume":"142","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0470","doi-asserted-by":"crossref","first-page":"89","DOI":"10.18632\/aging.202464","article-title":"Further assessment of Salvia haenkei as an innovative strategy to counteract skin photo-aging and restore the barrier integrity","volume":"13","author":"Cocetta","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0475","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/s43587-024-00663-7","article-title":"Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice","volume":"4","author":"Zumerle","year":"2024","journal-title":"Nat. Aging"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0480","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3892\/etm.2022.11396","article-title":"Luteolin suppresses TNF-\u03b1-induced inflammatory injury and senescence of nucleus pulposus cells via the Sirt6\/NF-\u03baB pathway","volume":"24","author":"Xie","year":"2022","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b0485","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1096\/fj.201902319RRR","article-title":"Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt\/\u03b2-catenin signaling pathways","volume":"34","author":"Yu","year":"2020","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0490","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s41467-022-28908-2","article-title":"The flavonoid corylin exhibits lifespan extension properties in mouse","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2025.117359_b0495","doi-asserted-by":"crossref","DOI":"10.1038\/s43587-024-00802-0","article-title":"Ginkgolide B increases healthspan and lifespan of female mice","author":"Lee","year":"2025","journal-title":"Nat. Aging"},{"issue":"7","key":"10.1016\/j.bcp.2025.117359_b0500","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/jnci\/djz210","article-title":"Molecular mechanism of telomere length dynamics and its prognostic value in pediatric cancers","volume":"112","author":"Wang","year":"2020","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b0505","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/bjp.2008.272","article-title":"Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms","volume":"155","author":"Xia","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"2\u20133","key":"10.1016\/j.bcp.2025.117359_b0510","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.vph.2008.07.002","article-title":"Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity","volume":"49","author":"Zhu","year":"2008","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117359_b0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153275","article-title":"Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence","volume":"77","author":"Tang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2025.117359_b0520","doi-asserted-by":"crossref","DOI":"10.1007\/s11357-025-01580-2","article-title":"Unveiling the geroprotective potential of Monarda didyma L.: insights from in vitro studies and a randomized clinical trial on slowing biological aging and improving quality of life","author":"Campisi","year":"2025","journal-title":"Geroscience"},{"key":"10.1016\/j.bcp.2025.117359_b0525","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-0-387-46401-5_3","article-title":"Antioxidant and anti-inflammatory properties of curcumin","volume":"595","author":"Menon","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0530","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3390\/ijms23042144","article-title":"Curcumin as an enhancer of therapeutic efficiency of chemotherapy drugs in breast cancer","volume":"23","author":"Farghadani","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0535","first-page":"73","article-title":"Cancer prevention with green tea and its principal constituent, EGCG: from early investigations to current focus on human cancer stem cells","volume":"41","author":"Fujiki","year":"2018","journal-title":"Mol. Cells"},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0540","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.phymed.2011.11.011","article-title":"Ginkgo biloba protects against intermittent hypoxia-induced memory deficits and hippocampal DNA damage in rats","volume":"19","author":"Abdel-Wahab","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2025.117359_b0545","doi-asserted-by":"crossref","unstructured":"D. Oliveira, B. Johansson, R. Oliveira. Ginkgo biloba, DNA Damage and DNA Repair: Overview. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. 2017. https:\/\/doi.org\/10.1007\/978-3-319-31143-2_11-1.","DOI":"10.1007\/978-3-319-31143-2_11-1"},{"issue":"34","key":"10.1016\/j.bcp.2025.117359_b0550","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.phymed.2017.07.001","article-title":"Neem (Azadirachta indica): an indian traditional panacea with modern molecular basis","volume":"15","author":"Gupta","year":"2017","journal-title":"Phytomedicine"},{"issue":"331","key":"10.1016\/j.bcp.2025.117359_b0555","article-title":"Molecular mechanisms of Asparagus racemosus willd. and Withania somnifera (L.) Dunal as chemotherapeutic adjuvants for breast cancer treatment","volume":"15","author":"Prasad","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"2021","key":"10.1016\/j.bcp.2025.117359_b0560","article-title":"Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study","volume":"30","author":"Gopukumar","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"12","key":"10.1016\/j.bcp.2025.117359_b0565","doi-asserted-by":"crossref","first-page":"29732","DOI":"10.3390\/ijms161226195","article-title":"The role of sulforaphane in epigenetic mechanisms, including interdependence between histone modification and DNA methylation","volume":"16","author":"Kaufman-Szymczyk","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0570","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac310","article-title":"Reprogramming of ovarian aging epigenome by resveratrol","volume":"2","author":"Gou","year":"2022","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.bcp.2025.117359_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116797","article-title":"Sulforaphane: an emerging star in neuroprotection and neurological disease prevention","volume":"233","author":"Wu","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117359_b0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107518","article-title":"Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis","volume":"210","author":"Wen","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0585","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13307","article-title":"Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells","volume":"20","author":"Zhang","year":"2021","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.bcp.2025.117359_b0590","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tig.2019.11.004","article-title":"The bivalent genome: characterization, structure, and regulation","volume":"36","author":"Blanco","year":"2020","journal-title":"Trends Genet."},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0595","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/path.5925","article-title":"Epigenetic lockdown of CDKN1A (p21) and CDKN2A (p16) characterises the neoplastic spindle cell component of giant cell tumours of bone","volume":"257","author":"Giesche","year":"2022","journal-title":"J. Pathol."},{"issue":"21","key":"10.1016\/j.bcp.2025.117359_b0600","doi-asserted-by":"crossref","first-page":"11466","DOI":"10.3390\/ijms252111466","article-title":"The roles of H3K9me3 writers, readers, and erasers in cancer immunotherapy","volume":"25","author":"Oleksiewicz","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0605","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3892\/mmr.2022.12861","article-title":"Transcriptional regulation of CDKN2A\/p16 by sirtuin 7 in senescence","volume":"26","author":"Rodr\u00edguez","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0610","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41392-025-02157-3","article-title":"Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification","volume":"10","author":"Mao","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6675","key":"10.1016\/j.bcp.2025.117359_b0615","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf3208","article-title":"ROS-induced ribosome impairment underlies ZAK\u03b1-mediated metabolic decline in obesity and aging","volume":"382","author":"Snieckute","year":"2023","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0620","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1038\/s41467-024-49796-8","article-title":"Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging","volume":"15","author":"Fu","year":"2024","journal-title":"Nat. Commun."},{"issue":"7894","key":"10.1016\/j.bcp.2025.117359_b0625","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41586-021-04295-4","article-title":"Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis","volume":"601","author":"Stein","year":"2022","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bcp.2025.117359_b0630","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.molcel.2024.02.031","article-title":"Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice","volume":"84","author":"Sirozh","year":"2024","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0635","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1038\/s41467-025-58188-5","article-title":"High-content screening identifies ganoderic acid a as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.advnut.2025.100376","article-title":"Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals","volume":"16","author":"Beaver","year":"2025","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.bcp.2025.117359_b0645","first-page":"00416","article-title":"Global genetic diversity of human gut microbiome species is related to geographic location and host health","author":"Andreu-S\u00e1nchez","year":"2025","journal-title":"Cell"},{"issue":"7885","key":"10.1016\/j.bcp.2025.117359_b0650","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-021-03832-5","article-title":"Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians","volume":"599","author":"Sato","year":"2021","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bcp.2025.117359_b0655","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70064","article-title":"Aged gut microbiota contributes to cognitive impairment and hippocampal synapse loss in mice","volume":"24","author":"Li","year":"2025","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2025.117359_b0660","article-title":"Aging-induced alternation in the gut microbiota impairs host antibacterial defense","volume":"10","author":"Gu","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"issue":"8066","key":"10.1016\/j.bcp.2025.117359_b0665","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41586-025-08938-8","article-title":"Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1","volume":"642","author":"Agarwal","year":"2025","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0670","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41522-025-00677-y","article-title":"Age-related alterations in gut homeostasis are microbiota dependent","volume":"11","author":"Jing","year":"2025","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"6","key":"10.1016\/j.bcp.2025.117359_b0675","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134049","article-title":"Intestinal alkaline phosphatase targets the gut barrier to prevent aging","volume":"5","author":"K\u00fchn","year":"2020","journal-title":"JCI Insight"},{"issue":"10","key":"10.1016\/j.bcp.2025.117359_b0680","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.3390\/nu11102426","article-title":"Curcumin, gut microbiota, and neuroprotection","volume":"11","author":"Di Meo","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0685","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s40168-021-01115-9","article-title":"Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis","volume":"9","author":"Wu","year":"2021","journal-title":"Microbiome"},{"issue":"33","key":"10.1016\/j.bcp.2025.117359_b0690","doi-asserted-by":"crossref","first-page":"12018","DOI":"10.1080\/10408398.2022.2098246","article-title":"Effect of chicory-derived inulin-type fructans on abundance of Bifidobacterium and on bowel function: a systematic review with meta-analyses","volume":"63","author":"Nagy","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"Pt 1","key":"10.1016\/j.bcp.2025.117359_b0695","article-title":"A ginseng polysaccharide protects intestinal barrier integrity in high-fat diet-fed obese mice","volume":"277","author":"Gao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0700","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/gutjnl-2020-321031","article-title":"Ginseng polysaccharides alter the gut microbiota and kynurenine\/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1\/programmed cell death ligand 1 (anti-PD-1\/PD-L1) immunotherapy","volume":"71","author":"Huang","year":"2022","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.bcp.2025.117359_b0705","article-title":"Quercetin-driven akkermansia muciniphila alleviates obesity by modulating bile acid metabolism via an ILA\/m6A\/CYP8B1 signaling","volume":"12","author":"Liu","year":"2025","journal-title":"Adv Sci (weinh)."},{"key":"10.1016\/j.bcp.2025.117359_b0710","doi-asserted-by":"crossref","DOI":"10.4028\/b-XDTcg5","article-title":"Alistipes senegalensis is critically involved in gut barrier repair mediated by panax ginseng neutral polysaccharides in aged mice","volume":"3","author":"Wang","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0715","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2007.07.025","article-title":"Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts","volume":"130","author":"Nakamura","year":"2007","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.bcp.2025.117359_b0720","doi-asserted-by":"crossref","first-page":"e553","DOI":"10.1016\/S2468-2667(19)30155-0","article-title":"Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data","volume":"4","author":"Zhu","year":"2019","journal-title":"Lancet Public Health"},{"issue":"7901","key":"10.1016\/j.bcp.2025.117359_b0725","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41586-022-04463-0","article-title":"FSH blockade improves cognition in mice with Alzheimer\u2019s disease","volume":"603","author":"Xiong","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2025.117359_b0730","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112062","article-title":"Salidroside alleviates taurolithocholic acid 3-sulfate-induced AR42J cell injury","volume":"142","author":"Qian","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"339","key":"10.1016\/j.bcp.2025.117359_b0735","article-title":"Salidroside: a review of its recent advances in synthetic pathways and pharmacological properties","volume":"25","author":"Zhang","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bcp.2025.117359_b0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109123","article-title":"Salidroside alleviates severe acute pancreatitis-triggered pancreatic injury and inflammation by regulating miR-217-5p\/YAF2 axis","volume":"111","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"13","key":"10.1016\/j.bcp.2025.117359_b0745","article-title":"Salidroside ameliorates Alzheimer\u2019s disease by targeting NLRP3 inflammasome-mediated pyroptosis","volume":"21","author":"Cai","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0750","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and age-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bcp.2025.117359_b0755","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jare.2024.02.019","article-title":"Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch\/ITGB1 signal path in CSVD model","volume":"68","author":"Tu","year":"2025","journal-title":"J. Adv. Res."},{"issue":"2)","key":"10.1016\/j.bcp.2025.117359_b0760","article-title":"Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging","volume":"8","author":"Xu","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0765","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41467-024-55509-y","article-title":"Physiological premature aging of ovarian blood vessels leads to decline in fertility in middle-aged mice","volume":"16","author":"Mu","year":"2025","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.bcp.2025.117359_b0770","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1055\/s-0036-1584205","article-title":"Salidroside promotes random skin flap survival in rats by enhancing angiogenesis and inhibiting apoptosis","volume":"32","author":"Deheng","year":"2016","journal-title":"J. Reconstr. Microsurg."},{"issue":"7","key":"10.1016\/j.bcp.2025.117359_b0775","doi-asserted-by":"crossref","first-page":"44810","DOI":"10.1038\/srep44810","article-title":"CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions","volume":"23","author":"Feng","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b0780","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1530\/REP-16-0577","article-title":"Stimulation of ovarian follicle growth after AMPK inhibition","volume":"153","author":"Lu","year":"2017","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0785","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41467-025-55929-4","article-title":"Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0790","article-title":"Bacteroides fragilis transplantation reverses reproductive senescence by transporting extracellular vesicles through the gut-ovary axis","volume":"12","author":"Xiong","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"issue":"7942","key":"10.1016\/j.bcp.2025.117359_b0795","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41586-022-05535-x","article-title":"Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration","volume":"613","author":"Moiseeva","year":"2023","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.bcp.2025.117359_b0800","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.devcel.2023.05.012","article-title":"Restoration of CPEB4 prevents muscle stem cell senescence during aging","volume":"58","author":"Zeng","year":"2023","journal-title":"Dev. Cell"},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0805","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202050964","article-title":"Mitochondrial transplantation-a possible therapeutic for mitochondrial dysfunction?: mitochondrial transfer is a potential cure for many diseases but proof of efficacy and safety is still lacking","volume":"21","author":"Lightowlers","year":"2020","journal-title":"EMBO Rep."},{"issue":"7613","key":"10.1016\/j.bcp.2025.117359_b0810","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.bcp.2025.117359_b0815","article-title":"ROS-responsive exogenous functional mitochondria can rescue neural cells post-ischemic stroke","volume":"3","author":"Li","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0820","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","article-title":"A network of macrophages supports mitochondrial homeostasis in the heart","volume":"183","author":"Nicol\u00e1s-\u00c1vila","year":"2020","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0825","first-page":"994","article-title":"Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy","volume":"33","author":"Ahmad","year":"2014","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0830","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12929-018-0429-1","article-title":"Regenerative abilities of mesenchymal stem cells through mitochondrial transfer","volume":"25","author":"Paliwal","year":"2018","journal-title":"J. Biomed. Sci."},{"issue":"11","key":"10.1016\/j.bcp.2025.117359_b0835","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ni.3002","article-title":"Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications","volume":"15","author":"Wang","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bcp.2025.117359_b0840","unstructured":"J. Wang, J. Xia, R. Huang, Y. Hu, J. Fan, Q. Shu, J. Xu. Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization."},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b0845","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/stem.2779","article-title":"Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells","volume":"36","author":"de Witte","year":"2018","journal-title":"Stem Cells"},{"issue":"12","key":"10.1016\/j.bcp.2025.117359_b0850","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12938","article-title":"Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency","volume":"53","author":"Yan","year":"2020","journal-title":"Cell Prolif."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0855","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1186\/s13287-021-02486-4","article-title":"Bone marrow mesenchymal stem cells derived from juvenile macaques reversed ovarian ageing in elderly macaques","volume":"12","author":"Tian","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0860","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13287-022-02759-6","article-title":"Important role of the SDF-1\/CXCR4 axis in the homing of systemically transplanted human amnion-derived mesenchymal stem cells (hAD-MSCs) to ovaries in rats with chemotherapy-induced premature ovarian insufficiency (POI)","volume":"13","author":"Ling","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b0865","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s12015-022-10493-y","article-title":"The therapeutic potential of human umbilical cord derived mesenchymal stem cells for the treatment of premature Ovarian failure","volume":"19","author":"Umer","year":"2023","journal-title":"Stem Cell Rev. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0870","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s13287-023-03551-w","article-title":"Menstrual blood-derived endometrial stem cell, a unique and promising alternative in the stem cell-based therapy for chemotherapy-induced premature ovarian insufficiency","volume":"14","author":"Zhang","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bcp.2025.117359_b0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110025","article-title":"Bone marrow-derived mesenchymal stem cells accelerate angiogenesis in pregnant experimentally induced deep venous thrombosis rat model via up-regulation of pro-angiogenic secretogranin II","volume":"118","author":"Cheng","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0880","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s13287-024-03997-6","article-title":"Transplantation of human umbilical cord-derived mesenchymal stem cells improves age-related ovarian functional decline via regulating the local renin-angiotensin system on inflammation and oxidative stress","volume":"15","author":"Wei","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"220","key":"10.1016\/j.bcp.2025.117359_b0885","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.04.229","article-title":"Human umbilical cord mesenchymal stem cells alleviate chemotherapy-induced premature ovarian insufficiency mouse model by suppressing ferritinophagy-mediated ferroptosis in granulosa cells","volume":"1","author":"Dai","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0890","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13287-024-03660-0","article-title":"Transplantation of the LRP1high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice","volume":"15","author":"Shen","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0895","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s13287-019-1315-9","article-title":"Human amniotic mesenchymal stem cells improve the follicular microenvironment to recover ovarian function in premature ovarian failure mice","volume":"10","author":"Liu","year":"2019","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0900","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13287-019-1136-x","article-title":"Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism","volume":"10","author":"Ling","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0905","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13287-024-03709-0","article-title":"Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy","volume":"15","author":"Lu","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0910","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13287-024-03705-4","article-title":"Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1\/ATM\/p53 pathway","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0915","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13287-021-02382-x","article-title":"Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk\/FoxO3a signaling pathway","volume":"12","author":"Liu","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0920","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/s41422-020-0354-1","article-title":"Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis","volume":"30","author":"Wu","year":"2020","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b0925","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41421-024-00726-4","article-title":"Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys","volume":"10","author":"Yan","year":"2024","journal-title":"Cell Discov."},{"issue":"13","key":"10.1016\/j.bcp.2025.117359_b0930","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202403944","article-title":"Ovarian function restoration with biomimetic scaffold incorporating angiogenic molecules and antioxidant in chemotherapy-induced perimenopausal model","volume":"14","author":"Kim","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bcp.2025.117359_b0935","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.12.005","article-title":"Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis","volume":"318","author":"Zhao","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bcp.2025.117359_b0940","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113463","article-title":"Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization","volume":"153","author":"Shi","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b0945","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/CAD.0000000000001430","article-title":"Exosomal circ-ADRM1 promotes lung adenocarcinoma progression and induces macrophage M2 polarization through regulating MMP14 mRNA and protein","volume":"34","author":"Qian","year":"2023","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.bcp.2025.117359_b0950","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100915","article-title":"Exosomal LOC85009 inhibits docetaxel resistance in lung adenocarcinoma through regulating ATG5-induced autophagy","volume":"67","author":"Yu","year":"2023","journal-title":"Drug Resist. Updat."},{"issue":"15","key":"10.1016\/j.bcp.2025.117359_b0955","article-title":"Exosomes derived from HUVECs alleviate ischemia-reperfusion induced inflammation in neural cells by upregulating KLF14 expression","volume":"2","author":"Qin","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"Pt 3","key":"10.1016\/j.bcp.2025.117359_b0960","article-title":"Crosstalk between non-coding RNA and apoptotic signaling in diabetic nephropathy","volume":"230","author":"Zhang","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0965","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.3390\/pharmaceutics13091493","article-title":"M1 macrophage-derived exosomes loaded with gemcitabine and deferasirox against chemoresistant pancreatic cancer","volume":"13","author":"Zhao","year":"2021","journal-title":"Pharmaceutics"},{"issue":"7","key":"10.1016\/j.bcp.2025.117359_b0970","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12109","article-title":"Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes","volume":"10","author":"Zheng","year":"2021","journal-title":"J. Extracell Vesicles"},{"issue":"25","key":"10.1016\/j.bcp.2025.117359_b0975","first-page":"472","article-title":"Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling","volume":"9","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b0980","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41422-018-0070-2","article-title":"Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.bcp.2025.117359_b0985","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109066","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells regulate lymphangiogenesis via the miR-302d-3p\/VEGFR3\/AKT axis to ameliorate inflammatory bowel disease","volume":"110","author":"Zhang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2025.117359_b0990","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108910","article-title":"Mesenchymal stem cells-derived extracellular vesicles-shuttled microRNA-223-3p suppress lipopolysaccharide-induced cardiac inflammation, pyroptosis, and dysfunction","volume":"110","author":"Pan","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2025.117359_b0995","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108925","article-title":"HucMSC-Ex carrying miR-203a-3p.2 ameliorates colitis through the suppression of caspase11\/4-induced macrophage pyroptosis","volume":"110","author":"Xu","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"979","key":"10.1016\/j.bcp.2025.117359_b1000","article-title":"Overexpression of miR-20a-5p in mesenchymal stem cell derived-exosomes from systemic lupus erythematosus patients restored therapeutic effect and Treg immune regulation","volume":"15","author":"Ji","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b1005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3390\/ph17050607","article-title":"Therapeutic prospects of mesenchymal stem cell and their derived exosomes in the regulation of the gut microbiota in inflammatory bowel disease","volume":"17","author":"Qiao","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bcp.2025.117359_b1010","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116406","article-title":"Mechanistic and therapeutic perspectives of miRNA-PTEN signaling axis in cancer therapy resistance","volume":"226","author":"Wu","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117359_b1015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2024.11.013","article-title":"Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells","author":"Bi","year":"2025","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b1020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s13287-024-03926-7","article-title":"Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K\/AKT pathway","volume":"15","author":"He","year":"2024","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b1025","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13048-024-01536-8","article-title":"Human umbilical cord mesenchymal stem cell-derived extracellular vesicles harboring IGF-1 improve ovarian function of mice with premature ovarian insufficiency through the Nrf2\/HO-1 pathway","volume":"17","author":"Miao","year":"2024","journal-title":"J. Ovarian Res."},{"issue":"21","key":"10.1016\/j.bcp.2025.117359_b1030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.omtn.2020.05.013","article-title":"Exosomal miRNA-320a is released from hAMSCs and regulates SIRT4 to prevent reactive oxygen species generation in POI","volume":"4","author":"Ding","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"8","key":"10.1016\/j.bcp.2025.117359_b1035","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.7150\/thno.94943","article-title":"Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling","volume":"14","author":"Fu","year":"2024","journal-title":"Theranostics"},{"issue":"199","key":"10.1016\/j.bcp.2025.117359_b1040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jconrel.2014.12.013","article-title":"Biodistribution and delivery efficiency of unmodified tumor-derived exosomes","volume":"10","author":"Smyth","year":"2015","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b1045","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12958-024-01299-3","article-title":"Intraovarian injection of 3D-MSC-EVs-ECM gel significantly improved rat ovarian function after chemotherapy","volume":"22","author":"Zhang","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b1050","doi-asserted-by":"crossref","first-page":"561.e1","DOI":"10.1016\/j.ajog.2023.01.018","article-title":"Single intraovarian dose of stem cell- and platelet-secreted factors mitigates age-related ovarian infertility in a murine model","volume":"228","author":"Marchante","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"21","key":"10.1016\/j.bcp.2025.117359_b1055","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba6357","article-title":"In situ repair abilities of human umbilical cord-derived mesenchymal stem cells and autocrosslinked hyaluronic acid gel complex in rhesus monkeys with intrauterine adhesion","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b1060","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1186\/s13287-021-02479-3","article-title":"Prevention of chemotherapy-induced premature ovarian insufficiency in mice by scaffold-based local delivery of human embryonic stem cell-derived mesenchymal progenitor cells","volume":"12","author":"Shin","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b1065","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13287-022-02724-3","article-title":"Mesenchymal stem cells combined with autocrosslinked hyaluronic acid improve mouse ovarian function by activating the PI3K-AKT pathway in a paracrine manner","volume":"13","author":"Jiao","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"15","key":"10.1016\/j.bcp.2025.117359_b1070","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1089\/scd.2021.0005","article-title":"Matrigel\/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure","volume":"30","author":"Zhou","year":"2021","journal-title":"Stem Cells Dev."},{"issue":"6315","key":"10.1016\/j.bcp.2025.117359_b1075","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf4445","article-title":"Tissue damage and senescence provide critical signals for cellular reprogramming in vivo","volume":"354","author":"Mosteiro","year":"2016","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b1080","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.stem.2016.11.020","article-title":"Injury-induced senescence enables in vivo reprogramming in skeletal muscle","volume":"20","author":"Chiche","year":"2017","journal-title":"Cell Stem Cell"},{"issue":"8044","key":"10.1016\/j.bcp.2025.117359_b1085","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41586-024-08285-0","article-title":"Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis","volume":"637","author":"Zhuang","year":"2025","journal-title":"Nature"},{"issue":"7686","key":"10.1016\/j.bcp.2025.117359_b1090","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature25167","article-title":"Senescence-associated reprogramming promotes cancer stemness","volume":"553","author":"Milanovic","year":"2018","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b1095","doi-asserted-by":"crossref","DOI":"10.1136\/esmoopen-2017-000250","article-title":"Biology of premature ageing in survivors of cancer","volume":"2","author":"Cupit-Link","year":"2017","journal-title":"ESMO Open"},{"key":"10.1016\/j.bcp.2025.117359_b1100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155629","article-title":"Rhizoma Alismatis Decoction improved mitochondrial dysfunction to alleviate SASP by enhancing autophagy flux and apoptosis in hyperlipidemia acute pancreatitis","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b1105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s43587-024-00747-4","article-title":"Generation of a selective senolytic platform using a micelle-encapsulated Sudan black B conjugated analog","volume":"5","author":"Magkouta","year":"2025","journal-title":"Nat. Aging"},{"issue":"4","key":"10.1016\/j.bcp.2025.117359_b1110","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1474-9726.2007.00315.x","article-title":"Regulation of replicative senescence by insulin-like growth factor-binding protein 3 in human umbilical vein endothelial cells","volume":"6","author":"Kim","year":"2007","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.bcp.2025.117359_b1115","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cmet.2020.09.006","article-title":"Generation of a p16 reporter mouse and its use to characterize and target p16high cells in vivo","volume":"32","author":"Omori","year":"2020","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.bcp.2025.117359_b1120","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cell.2007.12.033","article-title":"Visualizing spatiotemporal dynamics of multicellular cell-cycle progression","volume":"132","author":"Sakaue-Sawano","year":"2008","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bcp.2025.117359_b1125","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Copp\u00e9","year":"2008","journal-title":"PLoS Biol."},{"issue":"20","key":"10.1016\/j.bcp.2025.117359_b1130","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.bcp.2025.117359_b1135","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1038\/s41467-022-34801-9","article-title":"A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice","volume":"13","author":"Sun","year":"2022","journal-title":"Nat. Commun."},{"issue":"7589","key":"10.1016\/j.bcp.2025.117359_b1140","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.bcp.2025.117359_b1145","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1016\/j.ymthe.2024.04.002","article-title":"A p21-ATD mouse model for monitoring and eliminating senescent cells and its application in liver regeneration post injury","volume":"32","author":"Chen","year":"2024","journal-title":"Mol. Ther."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225006240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225006240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:25:38Z","timestamp":1777379138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225006240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":229,"alternative-id":["S0006295225006240"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117359","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pursuing healthy aging and longevity through natural product and stem cell-driven rejuvenation","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117359","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117359"}}