{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:18:32Z","timestamp":1778642312344,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000240","name":"New Brunswick Innovation Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2022-03950"],"award-info":[{"award-number":["RGPIN-2022-03950"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["NSERC-RGPIN-2019\\u201305740"],"award-info":[{"award-number":["NSERC-RGPIN-2019\\u201305740"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bcp.2025.117404","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:12:20Z","timestamp":1759536740000},"page":"117404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["Defining the role of 12-lipoxygenase in regulating platelet-derived extracellular vesicles"],"prefix":"10.1016","volume":"242","author":[{"given":"Alexis J.","family":"Matthew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja\u00ebl D.","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa L.","family":"Gauvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu P.A.","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Touaibia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric P.","family":"Allain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-5026","authenticated-orcid":false,"given":"Luc H.","family":"Boudreau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2025.117404_b0005","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1055\/s-0031-1300956","article-title":"Platelet-derived microvesicles: multitalented participants in intercellular communication","volume":"38","author":"Aatonen","year":"2012","journal-title":"Semin. Thromb. Hemost."},{"issue":"3","key":"10.1016\/j.bcp.2025.117404_b0010","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/09537104.2016.1257114","article-title":"The role of platelet microvesicles in intercellular communication","volume":"28","author":"Edelstein","year":"2017","journal-title":"Platelets"},{"issue":"24","key":"10.1016\/j.bcp.2025.117404_b0015","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMra071014","article-title":"Platelet activation and atherothrombosis","volume":"357","author":"Dav\u00ec","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117404_b0020","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1432-1033.1996.0647u.x","article-title":"Calcium influx is a determining factor of calpain activation and microparticle formation in platelets","volume":"239","author":"Pasquet","year":"1996","journal-title":"Eur. J. Biochem."},{"issue":"15","key":"10.1016\/j.bcp.2025.117404_b0025","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1073\/pnas.87.15.5638","article-title":"Molecular cloning, primary structure, and expression of the human platelet\/erythroleukemia cell 12-lipoxygenase","volume":"87","author":"Funk","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"27","key":"10.1016\/j.bcp.2025.117404_b0030","doi-asserted-by":"crossref","first-page":"E3564","DOI":"10.1073\/pnas.1507905112","article-title":"Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA","volume":"112","author":"Duchez","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.bcp.2025.117404_b0035","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1073\/pnas.71.9.3400","article-title":"Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets","volume":"71","author":"Hamberg","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2025.117404_b0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jchromb.2014.03.015","article-title":"Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product","volume":"964","author":"Porro","year":"2014","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"3","key":"10.1016\/j.bcp.2025.117404_b0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0925-4439(93)90045-3","article-title":"Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders","volume":"1180","author":"Matsuda","year":"1993","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"3","key":"10.1016\/j.bcp.2025.117404_b0050","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1160\/TH13-01-0014","article-title":"12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity","volume":"110","author":"Yeung","year":"2013","journal-title":"Thromb. Haemost."},{"issue":"10","key":"10.1016\/j.bcp.2025.117404_b0055","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/ATVBAHA.117.309868","article-title":"First selective 12-LOX inhibitor, ML355, impairs thrombus formation and vessel occlusion in vivo with minimal effects on hemostasis","volume":"37","author":"Adili","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"27","key":"10.1016\/j.bcp.2025.117404_b0060","doi-asserted-by":"crossref","first-page":"15790","DOI":"10.1016\/S0021-9258(18)71546-9","article-title":"Calcium induces membrane translocation of 12-lipoxygenase in rat platelets","volume":"264","author":"Baba","year":"1989","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2025.117404_b0065","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1046\/j.1537-2995.1986.26486262742.x","article-title":"Use of PGE1 for preparation of platelet concentrates","volume":"26","author":"Menitove","year":"1986","journal-title":"Transfusion"},{"issue":"2","key":"10.1016\/j.bcp.2025.117404_b0070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3835(00)00634-0","article-title":"Role of \u2018platelet-type\u2019 12-lipoxygenase in skin carcinogenesis","volume":"162","author":"Virmani","year":"2001","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.bcp.2025.117404_b0075","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1124\/mol.118.113480","article-title":"Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets","volume":"95","author":"Doucet","year":"2019","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117404_b0080","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1084\/jem.20072329","article-title":"12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2","volume":"205","author":"Okuno","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2025.117404_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110419","article-title":"Caffeic acid phenethyl ester analogues as selective inhibitors of 12-lipoxygenase product biosynthesis in human platelets","volume":"121","author":"H\u00e9bert","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117404_b0090","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1016\/j.bmc.2006.01.057","article-title":"Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases","volume":"14","author":"Deschamps","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"14","key":"10.1016\/j.bcp.2025.117404_b0095","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","article-title":"Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation","volume":"124","author":"Boudreau","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.bcp.2025.117404_b0100","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1158\/1541-7786.MCR-23-0329","article-title":"Mitochondria transfer by platelet-derived microparticles regulates breast cancer bioenergetic states and malignant features","volume":"22","author":"Veilleux","year":"2024","journal-title":"Mol. Cancer Res."},{"issue":"14","key":"10.1016\/j.bcp.2025.117404_b0105","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1182\/blood-2014-05-575878","article-title":"Platelet 12-LOX is essential for Fc\u03b3RIIa-mediated platelet activation","volume":"124","author":"Yeung","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2025.117404_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2025.109445","article-title":"The role of 12-lipoxygenase in regulating megakaryocyte maturation and platelet-like particles production","volume":"254","author":"Gauvin","year":"2025","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.bcp.2025.117404_b0115","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3390\/biom11050717","article-title":"Regulation of tissue inflammation by 12-lipoxygenases","volume":"11","author":"Kulkarni","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.bcp.2025.117404_b0120","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s13054-020-03082-3","article-title":"Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock","volume":"24","author":"Jiao","year":"2020","journal-title":"Crit. Care"},{"issue":"1","key":"10.1016\/j.bcp.2025.117404_b0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12865-023-00560-5","article-title":"Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps","volume":"24","author":"Jiang","year":"2023","journal-title":"BMC Immunol."},{"issue":"15","key":"10.1016\/j.bcp.2025.117404_b0130","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.7150\/ijbs.76162","article-title":"Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2025.117404_b0135","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12943-015-0327-z","article-title":"MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3","volume":"14","author":"Liang","year":"2015","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2025.117404_b0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12964-023-01066-8","article-title":"Platelet-derived microparticles stimulate the invasiveness of colorectal cancer cells via the p38MAPK-MMP-2\/MMP-9 axis","volume":"21","author":"Kassassir","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"10","key":"10.1016\/j.bcp.2025.117404_b0145","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1161\/ATVBAHA.123.319021","article-title":"Loss of 12-lipoxygenase improves the post-transfusion function of stored platelets","volume":"43","author":"Larsen","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117404_b0150","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/ATVBAHA.118.310224","article-title":"Platelet signaling pathways and new inhibitors","volume":"38","author":"Grover","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225006690?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225006690?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:54:14Z","timestamp":1778640854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225006690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":30,"alternative-id":["S0006295225006690"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117404","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defining the role of 12-lipoxygenase in regulating platelet-derived extracellular vesicles","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117404"}}