{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:12:14Z","timestamp":1779297134945,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103275"],"award-info":[{"award-number":["82103275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100210"],"award-info":[{"award-number":["82100210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400269"],"award-info":[{"award-number":["82400269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013189"],"award-info":[{"award-number":["2024A1515013189"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20210324105802007"],"award-info":[{"award-number":["JCYJ20210324105802007"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813120110014"],"award-info":[{"award-number":["JCYJ20240813120110014"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bcp.2025.117447","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:54:18Z","timestamp":1761180858000},"page":"117447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["BDA-366 inhibits extra-nodal natural killer\/T-cell lymphoma by inducing mitochondria damage through NF-\u03baB pathway"],"prefix":"10.1016","volume":"243","author":[{"given":"Jiali","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunju","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimin","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0005","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13045-022-01293-5","article-title":"How we treat NK\/T-cell lymphomas","volume":"15","author":"Tse","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117447_b0010","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S1470-2045(19)30799-5","article-title":"Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations","volume":"21","author":"Lin","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bcp.2025.117447_b0015","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fonc.2018.00265","article-title":"Epstein-barr virus-associated malignancies: roles of viral oncoproteins in carcinogenesis","volume":"8","author":"El-Sharkawy","year":"2018","journal-title":"Front. Oncol."},{"issue":"15","key":"10.1016\/j.bcp.2025.117447_b0020","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1182\/blood-2012-05-431460","article-title":"SMILE for natural killer\/T-cell lymphoma: analysis of safety and efficacy from the Asia Lymphoma Study Group","volume":"120","author":"Kwong","year":"2012","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.bcp.2025.117447_b0025","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1182\/blood-2013-01-453233","article-title":"How I treat NK\/T-cell lymphomas","volume":"121","author":"Tse","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13045-023-01483-9","article-title":"Novel target and treatment agents for natural killer\/T-cell lymphoma","volume":"16","author":"Tian","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.20892\/j.issn.2095-3941.2020.0400","article-title":"Updating targets for natural killer\/T-cell lymphoma immunotherapy","volume":"18","author":"Xue","year":"2021","journal-title":"Cancer Biol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13045-019-0716-7","article-title":"Molecular pathogenic pathways in extranodal NK\/T cell lymphoma","volume":"12","author":"de Mel","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bcp.2025.117447_b0045","article-title":"Epigenetic aberrations in natural killer\/T-cell lymphoma: diagnostic, prognostic and therapeutic implications","volume":"12","author":"K\u00fc\u00e7\u00fck","year":"2020","journal-title":"Therapeutic Adv. Med. Oncol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0050","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41392-020-00331-3","article-title":"Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer\/T cell lymphoma","volume":"5","author":"Cai","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"19","key":"10.1016\/j.bcp.2025.117447_b0055","first-page":"4775","article-title":"BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus-associated T\/NK-cell lymphoma","volume":"4","author":"Sejic","year":"2020","journal-title":"Blood Adv."},{"issue":"5","key":"10.1016\/j.bcp.2025.117447_b0060","doi-asserted-by":"crossref","first-page":"793","DOI":"10.7150\/jca.17766","article-title":"Overexpression of MYC and BCL2 predicts poor prognosis in patients with extranodal NK\/T-cell Lymphoma, nasal type","volume":"8","author":"Wang","year":"2017","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0065","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.1038\/s41467-024-49106-2","article-title":"Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer","volume":"15","author":"Bai","year":"2024","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bcp.2025.117447_b0070","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ccr.2006.10.006","article-title":"Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia","volume":"10","author":"Konopleva","year":"2006","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.bcp.2025.117447_b0075","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","article-title":"ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor","volume":"68","author":"Tse","year":"2008","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0080","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/leu.2013.216","article-title":"The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma","volume":"28","author":"Touzeau","year":"2014","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.bcp.2025.117447_b0085","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJMoa1513257","article-title":"Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia","volume":"374","author":"Roberts","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.bcp.2025.117447_b0090","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1182\/blood-2011-04-347849","article-title":"Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets","volume":"118","author":"Schoenwaelder","year":"2011","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bcp.2025.117447_b0095","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/emboj\/17.4.1029","article-title":"The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4","volume":"17","author":"Huang","year":"1998","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.bcp.2025.117447_b0100","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.drudis.2015.11.008","article-title":"BH4 domain of Bcl-2 as a novel target for cancer therapy","volume":"21","author":"Liu","year":"2016","journal-title":"Drug Discov. Today"},{"issue":"6","key":"10.1016\/j.bcp.2025.117447_b0105","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.ccell.2015.04.010","article-title":"Small-molecule Bcl2 BH4 antagonist for lung cancer therapy","volume":"27","author":"Han","year":"2015","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.bcp.2025.117447_b0110","doi-asserted-by":"crossref","first-page":"27753","DOI":"10.18632\/oncotarget.8513","article-title":"BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth","volume":"7","author":"Deng","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.bcp.2025.117447_b0115","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41419-020-02944-6","article-title":"BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models","volume":"11","author":"Vervloessem","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41392-020-00376-4","article-title":"Targeting the signaling in Epstein-Barr virus-associated diseases: mechanism, regulation, and clinical study","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2025.117447_b0125","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1023\/A:1027344914565","article-title":"Membrane-linked systems preventing superoxide formation","volume":"17","author":"Skulachev","year":"1997","journal-title":"Biosci. Rep."},{"issue":"4","key":"10.1016\/j.bcp.2025.117447_b0130","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1007\/s12015-020-10112-8","article-title":"Latent membrane protein 1 promotes tumorigenesis through upregulation of PGC1\u03b2 signaling pathway","volume":"17","author":"Feng","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"issue":"4","key":"10.1016\/j.bcp.2025.117447_b0135","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1016\/S2352-3026(19)30283-2","article-title":"Survival outcomes of patients with extranodal natural-killer T-cell lymphoma: a prospective cohort study from the international T-cell Project","volume":"7","author":"Fox","year":"2020","journal-title":"Lancet Haematol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0140","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12185-017-2324-z","article-title":"Autologous hematopoietic stem cell transplantation may improve long-term outcomes in patients with newly diagnosed extranodal natural killer\/T-cell lymphoma, nasal type: a retrospective controlled study in a single center","volume":"107","author":"Wang","year":"2018","journal-title":"Int. J. Hematol."},{"issue":"17","key":"10.1016\/j.bcp.2025.117447_b0145","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1182\/blood-2016-12-756841","article-title":"PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK\/T-cell lymphoma failing l-asparaginase","volume":"129","author":"Kwong","year":"2017","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bcp.2025.117447_b0150","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0962-8924(98)01321-X","article-title":"Bcl-2-family proteins: the role of the BH3 domain in apoptosis","volume":"8","author":"Kelekar","year":"1998","journal-title":"Trends Cell Biol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117447_b0155","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ceb.2006.10.004","article-title":"How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?","volume":"18","author":"Antignani","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117447_b0160","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tibs.2013.12.006","article-title":"Many players in BCL-2 family affairs","volume":"39","author":"Moldoveanu","year":"2014","journal-title":"Trends Biochem. Sci"},{"issue":"3","key":"10.1016\/j.bcp.2025.117447_b0165","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.leukres.2006.06.027","article-title":"Larger than life: mitochondria and the Bcl-2 family","volume":"31","author":"Skommer","year":"2007","journal-title":"Leuk. Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0170","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13046-018-0909-x","article-title":"The role of cellular reactive oxygen species in cancer chemotherapy","volume":"37","author":"Yang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res.: CR."},{"issue":"5","key":"10.1016\/j.bcp.2025.117447_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054487","article-title":"A brief review on chemoresistance; targeting cancer stem cells as an alternative approach","volume":"24","author":"Toledo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2025.117447_b0180","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3389\/fonc.2018.00679","article-title":"Aspirin inhibits natural killer\/T-Cell Lymphoma by modulation of VEGF expression and mitochondrial function","volume":"8","author":"Zhang","year":"2018","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117447_b0185","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1038\/s41375-020-0801-5","article-title":"HKDC1 C-terminal based peptides inhibit extranodal natural killer\/T-cell lymphoma by modulation of mitochondrial function and EBV suppression","volume":"34","author":"Chen","year":"2020","journal-title":"Leukemia"},{"issue":"34","key":"10.1016\/j.bcp.2025.117447_b0190","doi-asserted-by":"crossref","first-page":"14397","DOI":"10.1073\/pnas.0907555106","article-title":"The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor","volume":"106","author":"Rong","year":"2009","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.bcp.2025.117447_b0195","first-page":"167","article-title":"Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy","volume":"1805","author":"Li","year":"2010","journal-title":"BBA"},{"issue":"24","key":"10.1016\/j.bcp.2025.117447_b0200","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.0507809103","article-title":"The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas","volume":"103","author":"Bernal-Mizrachi","year":"2006","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.bcp.2025.117447_b0205","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2141.2005.05720.x","article-title":"Effects of nuclear factor-kappaB inhibitors and its implication on natural killer T-cell lymphoma cells","volume":"131","author":"Kim","year":"2005","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117447_b0210","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/febs.13175","article-title":"New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond","volume":"282","author":"Villena","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.bcp.2025.117447_b0215","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fonc.2019.00290","article-title":"PGC1\u03b2 Regulates breast tumor growth and metastasis by SREBP1-mediated HKDC1 expression","volume":"9","author":"Chen","year":"2019","journal-title":"Front. Oncol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225007129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225007129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:35:05Z","timestamp":1778636105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225007129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":43,"alternative-id":["S0006295225007129"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117447","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BDA-366 inhibits extra-nodal natural killer\/T-cell lymphoma by inducing mitochondria damage through NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117447"}}