{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T01:55:03Z","timestamp":1788054903664,"version":"build-2784847793"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["CZKYCMCB202215"],"award-info":[{"award-number":["CZKYCMCB202215"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bcp.2025.117450","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T19:51:47Z","timestamp":1761076307000},"page":"117450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P4","title":["FSTL1 promotes osteoclast differentiation and Accelerates periprosthetic osteolysis via PP2A C\u03b1-Mediated activation of the JNK signaling pathway"],"prefix":"10.1016","volume":"242","author":[{"given":"Maoyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangrong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1385-7217","authenticated-orcid":false,"given":"Yuji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9855","key":"10.1016\/j.bcp.2025.117450_b0005","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/S0140-6736(12)60607-2","article-title":"Hip arthroplasty","volume":"380","author":"Pivec","year":"2012","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.bcp.2025.117450_b0010","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.3899\/jrheum.170990","article-title":"Rates of Total Joint Replacement in the United States: Future Projections to 2020-2040 using the National Inpatient Sample","volume":"46","author":"Singh","year":"2019","journal-title":"J. Rheumatol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117450_b0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11420-006-9003-6","article-title":"The central role of wear debris in periprosthetic osteolysis","volume":"2","author":"Purdue","year":"2006","journal-title":"HSS J."},{"issue":"4","key":"10.1016\/j.bcp.2025.117450_b0020","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jama.292.4.490","article-title":"Clinical implications of the osteoprotegerin\/RANKL\/RANK system for bone and vascular diseases","volume":"292","author":"Hofbauer","year":"2004","journal-title":"JAMA"},{"issue":"6984","key":"10.1016\/j.bcp.2025.117450_b0025","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature02444","article-title":"Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis","volume":"428","author":"Koga","year":"2004","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.bcp.2025.117450_b0030","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1073\/pnas.130200197","article-title":"Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression","volume":"97","author":"Shevde","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.bcp.2025.117450_b0035","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1016\/j.actbio.2013.05.005","article-title":"Osteolysis around total knee arthroplasty: a review of pathogenetic mechanisms","volume":"9","author":"Gallo","year":"2013","journal-title":"Acta Biomater."},{"issue":"6937","key":"10.1016\/j.bcp.2025.117450_b0040","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bcp.2025.117450_b0045","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nrrheum.2011.128","article-title":"Mediators of the inflammatory response to joint replacement devices","volume":"7","author":"Cobelli","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117450_b0050","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1074\/jbc.M309318200","article-title":"Structural characterization of TSC-36\/Flik: analysis of two charge isoforms","volume":"279","author":"Hambrock","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bcp.2025.117450_b0055","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1136\/annrheumdis-2013-204822","article-title":"Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells","volume":"74","author":"Chaly","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2025.117450_b0060","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/carcin\/bgn215","article-title":"Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis","volume":"30","author":"Chan","year":"2009","journal-title":"Carcinogenesis"},{"issue":"20","key":"10.1016\/j.bcp.2025.117450_b0065","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1158\/0008-5472.CAN-13-1364","article-title":"Targeting FSTL1 prevents tumor bone metastasis and consequent immune dysfunction","volume":"73","author":"Kudo-Saito","year":"2013","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2025.117450_b0070","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.yexmp.2005.07.005","article-title":"TSC-36\/FRP inhibits vascular smooth muscle cell proliferation and migration","volume":"80","author":"Liu","year":"2006","journal-title":"Exp. Mol. Pathol."},{"issue":"24","key":"10.1016\/j.bcp.2025.117450_b0075","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1161\/CIRCULATIONAHA.108.767673","article-title":"Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart","volume":"117","author":"Oshima","year":"2008","journal-title":"Circulation"},{"issue":"47","key":"10.1016\/j.bcp.2025.117450_b0080","doi-asserted-by":"crossref","first-page":"32802","DOI":"10.1074\/jbc.M803440200","article-title":"Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism","volume":"283","author":"Ouchi","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2025.117450_b0085","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4049\/jimmunol.182.1.234","article-title":"Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma","volume":"182","author":"Clutter","year":"2009","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.bcp.2025.117450_b0090","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.4049\/jimmunol.177.7.4758","article-title":"Follistatin-like protein-1 is a novel proinflammatory molecule","volume":"177","author":"Miyamae","year":"2006","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117450_b0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13075-015-0605-6","article-title":"The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-\u03baB-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation","volume":"17","author":"Ni","year":"2015","journal-title":"Arthritis Res. Ther."},{"issue":"8","key":"10.1016\/j.bcp.2025.117450_b0100","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.biomaterials.2009.11.069","article-title":"Protection against titanium particle induced osteolysis by cannabinoid receptor 2 selective antagonist","volume":"31","author":"Geng","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcp.2025.117450_b0105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biomaterials.2015.04.048","article-title":"Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model","volume":"60","author":"Shao","year":"2015","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.bcp.2025.117450_b0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.orthres.2003.08.013","article-title":"The effectiveness of polyethylene versus titanium particles in inducing osteolysis in vivo","volume":"22","author":"von Knoch","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bcp.2025.117450_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.11.046","article-title":"Inhibition of titanium-particle-induced inflammatory osteolysis after local administration of dopamine and suppression of osteoclastogenesis via D2-like receptor signaling pathway","volume":"80","author":"Yang","year":"2016","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.bcp.2025.117450_b0120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/10520290310001646668","article-title":"Quantification of tartrate resistant acid phosphatase distribution in mouse tibiae using image analysis","volume":"78","author":"Sawyer","year":"2003","journal-title":"Biotech. Histochem."},{"issue":"25","key":"10.1016\/j.bcp.2025.117450_b0125","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.7150\/thno.37717","article-title":"HBX-induced miR-5188 impairs FOXO1 to stimulate \u03b2-catenin nuclear translocation and promotes tumor stemness in hepatocellular carcinoma","volume":"9","author":"Lin","year":"2019","journal-title":"Theranostics"},{"issue":"30","key":"10.1016\/j.bcp.2025.117450_b0130","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1016\/j.biomaterials.2006.05.054","article-title":"The correlation of RANK, RANKL and TNFalpha expression with bone loss volume and polyethylene wear debris around hip implants","volume":"27","author":"Holding","year":"2006","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.bcp.2025.117450_b0135","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.cellsig.2016.05.018","article-title":"Follistatin-like 1 promotes osteoclast formation via RANKL-mediated NF-\u03baB activation and M-CSF-induced precursor proliferation","volume":"28","author":"Kim","year":"2016","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.bcp.2025.117450_b0140","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1186\/ar3241","article-title":"Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis","volume":"13","author":"Li","year":"2011","journal-title":"Arthritis Res. Ther."},{"issue":"36","key":"10.1016\/j.bcp.2025.117450_b0145","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1016\/j.biomaterials.2006.08.023","article-title":"Effects of orthopaedic wear particles on osteoprogenitor cells","volume":"27","author":"Goodman","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcp.2025.117450_b0150","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.actbio.2016.11.022","article-title":"Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathway","volume":"48","author":"Hu","year":"2017","journal-title":"Acta Biomater."},{"issue":"11","key":"10.1016\/j.bcp.2025.117450_b0155","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1210\/en.2009-0026","article-title":"Phosphatidylinositol 3 Kinase\/Akt Signal Relay Cooperates with Smad in Bone Morphogenetic Protein-2-Induced Colony Stimulating Factor-1 (CSF-1) Expression and Osteoclast Differentiation","volume":"150","author":"Mandal","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2025.117450_b0160","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.actbio.2018.04.013","article-title":"Protein phosphatase 2A as a new target for downregulating osteoclastogenesis and alleviating titanium particle-induced bone resorption","volume":"73","author":"Wang","year":"2018","journal-title":"Acta Biomater."},{"issue":"23","key":"10.1016\/j.bcp.2025.117450_b0165","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.4161\/15384101.2014.965068","article-title":"The role of Cullin3-mediated ubiquitination of the catalytic subunit of PP2A in TRAIL signaling","volume":"13","author":"Xu","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2025.117450_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113715","article-title":"Catalpol suppresses osteoclastogenesis and attenuates osteoclast-derived bone resorption by modulating PTEN activity","volume":"171","author":"Meng","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117450_b0175","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1038\/ncomms4773","article-title":"FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation","volume":"5","author":"Bartell","year":"2014","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.bcp.2025.117450_b0180","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat. Rev. Genet."},{"issue":"9","key":"10.1016\/j.bcp.2025.117450_b0185","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1136\/annrheumdis-2015-207593","article-title":"Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis","volume":"75","author":"Mediero","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.bcp.2025.117450_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061272","article-title":"Osteoblast Role in Rheumatic Diseases","volume":"18","author":"Corrado","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2025.117450_b0195","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.3892\/mmr.2017.7039","article-title":"Osteoclast regulation of osteoblasts via RANK\u2011RANKL reverse signal transduction invitro","volume":"16","author":"Zhang","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"14","key":"10.1016\/j.bcp.2025.117450_b0200","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.biomaterials.2004.05.017","article-title":"Expression of inflammatory cytokines, RANKL and OPG induced by titanium, cobalt-chromium and polyethylene particles","volume":"26","author":"Masui","year":"2005","journal-title":"Biomaterials"},{"issue":"18","key":"10.1016\/j.bcp.2025.117450_b0205","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1073\/pnas.1211383110","article-title":"C\/EBP\u03b1 regulates osteoclast lineage commitment","volume":"110","author":"Chen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2025.117450_b0210","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1749-6632.2009.05303.x","article-title":"New immune connections in osteoclast formation","volume":"1192","author":"Takayanagi","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"22","key":"10.1016\/j.bcp.2025.117450_b0215","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1016\/j.biomaterials.2014.04.006","article-title":"The effect of enoxacin on osteoclastogenesis and reduction of titanium particle-induced osteolysis via suppression of JNK signaling pathway","volume":"35","author":"Liu","year":"2014","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.bcp.2025.117450_b0220","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ptr.5565","article-title":"Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK\/c-Fos\/NFATc1 Signaling and Prevents Inflammatory Bone loss in mice","volume":"30","author":"Park","year":"2016","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117450_b0225","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbrc.2006.10.011","article-title":"Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway","volume":"351","author":"Huang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.bcp.2025.117450_b0230","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1172\/JCI35711","article-title":"NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism","volume":"118","author":"Aliprantis","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.bcp.2025.117450_b0235","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.20051150","article-title":"Autoamplification of NFATc1 expression determines its essential role in bone homeostasis","volume":"202","author":"Asagiri","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2025.117450_b0240","doi-asserted-by":"crossref","first-page":"13700","DOI":"10.1038\/ncomms13700","article-title":"G\u03b113 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3\u03b2-NFATc1 signalling pathway","volume":"8","author":"Wu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2025.117450_b0245","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00003086-200112000-00007","article-title":"Wear and periprosthetic osteolysis: the problem","volume":"393","author":"Harris","year":"2001","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"5","key":"10.1016\/j.bcp.2025.117450_b0250","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/eji.201344063","article-title":"Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1\u03b2 secretion from monocytes and macrophages","volume":"44","author":"Chaly","year":"2014","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117450_b0255","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.neuron.2011.01.022","article-title":"Follistatin-like 1 suppresses sensory afferent transmission by activating Na+,K+-ATPase","volume":"69","author":"Li","year":"2011","journal-title":"Neuron"},{"issue":"20","key":"10.1016\/j.bcp.2025.117450_b0260","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1111\/j.1742-4658.2010.07816.x","article-title":"DIP2 disco-interacting protein 2 homolog a (Drosophila) is a candidate receptor for follistatin-related protein\/follistatin-like 1\u2013analysis of their binding with TGF-\u03b2 superfamily proteins","volume":"277","author":"Tanaka","year":"2010","journal-title":"FEBS J."},{"issue":"10","key":"10.1016\/j.bcp.2025.117450_b0265","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1074\/jbc.M109.069468","article-title":"DIP2A functions as a FSTL1 Receptor*","volume":"285","author":"Ouchi","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2025.117450_b0270","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3390\/biology13090692","article-title":"Roles of Toll-like Receptor Signaling in Inflammatory Bone Resorption","volume":"13","author":"Tominari","year":"2024","journal-title":"Biology"},{"issue":"6","key":"10.1016\/j.bcp.2025.117450_b0275","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/jcp.25266","article-title":"Establishment of Immortalized BMP2\/4 double Knock-out Osteoblastic Cells is Essential for Study of Osteoblast Growth, Differentiation, and Osteogenesis","volume":"231","author":"Wu","year":"2016","journal-title":"J. Cell. Physiol."}],"updated-by":[{"DOI":"10.1016\/j.bcp.2025.117538","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000}}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225007154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225007154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T01:25:38Z","timestamp":1769477138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225007154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":55,"alternative-id":["S0006295225007154"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117450","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FSTL1 promotes osteoclast differentiation and Accelerates periprosthetic osteolysis via PP2A C\u03b1-Mediated activation of the JNK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117450","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117450"}}