{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:27:47Z","timestamp":1785814067181,"version":"3.56.0"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bcp.2025.117461","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:38:34Z","timestamp":1761403114000},"page":"117461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["Progress of TRAF6 in the pathogenesis of depression: opportunities and challenges from molecular mechanisms to therapeutic targets"],"prefix":"10.1016","volume":"243","author":[{"given":"Xue-He","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-3456","authenticated-orcid":false,"given":"Wei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7526","key":"10.1016\/j.bcp.2025.117461_b0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/515180a","article-title":"Mental health: a world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0010","doi-asserted-by":"crossref","DOI":"10.7326\/AITC202105180","article-title":"Depression","volume":"174","author":"McCarron","year":"2021","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41392-023-01519-z","article-title":"Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential","volume":"8","author":"Yuan","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2025.117461_b0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2024.01.010","article-title":"Bavachin ameliorates neuroinflammation and depressive-like behaviors in streptozotocin-induced diabetic mice through the inhibition of PKC\u03b4","volume":"213","author":"Zhang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.117461_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110552","article-title":"Upregulation of A20 and TAX1BP1 contributes to the anti-neuroinflammatory and antidepressant effects of bavachalcone","volume":"122","author":"Wu","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"10371","key":"10.1016\/j.bcp.2025.117461_b0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0140-6736(22)02080-3","article-title":"Novel and emerging treatments for major depression","volume":"401","author":"Marwaha","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2025.117461_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122724","article-title":"Cell-liposome delivery system based on neuroinflammation to target the amygdala for ameliorating depressive-like behaviors","volume":"637","author":"Zhou","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bcp.2025.117461_b0040","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbrc.2023.06.004","article-title":"Sodium aescinate improve behavioral performance by inhibiting dorsal raphe nucleus NLRP3 inflammasome in Post-traumatic stress disorder Rat Model","volume":"671","author":"Mei","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.bcp.2025.117461_b0045","article-title":"Microglia-Derived Interleukin-6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression-Like Behavior","volume":"12","author":"Shen","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0050","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-2187-8-7","article-title":"TRAF molecules in cell signaling and in human diseases","volume":"8","author":"Xie","year":"2013","journal-title":"J. Mol. Signal."},{"key":"10.1016\/j.bcp.2025.117461_b0055","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.3389\/fimmu.2018.01999","article-title":"Structure of TRAF Family: Current Understanding of Receptor Recognition","volume":"9","author":"Park","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2025.117461_b0060","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/978-0-387-70630-6_7","article-title":"Ubiquitination and TRAF signaling","volume":"597","author":"Pineda","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0065","first-page":"61","article-title":"Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)","volume":"35","author":"Lee","year":"2002","journal-title":"J. Biochem. Mol. Biol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117461_b0070","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1073\/pnas.052124799","article-title":"Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice","volume":"99","author":"R\u00e9gnier","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0075","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41419-025-07609-w","article-title":"Inflammation and cancer cell survival: TRAF2 as a key player","volume":"16","author":"Albini","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2025.117461_b0080","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/978-0-387-70630-6_3","article-title":"Physiological roles and mechanisms of signaling by TRAF2 and TRAF5","volume":"597","author":"Au","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117461_b0085","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0092-8674(94)90532-0","article-title":"A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor","volume":"78","author":"Rothe","year":"1994","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bcp.2025.117461_b0090","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.1128\/MCB.16.12.7098","article-title":"Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation","volume":"16","author":"Devergne","year":"1996","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0095","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13046-025-03363-1","article-title":"TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence","volume":"44","author":"Chen","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0100","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41420-021-00749-w","article-title":"TRAF7 contributes to tumor progression by promoting ubiquitin-proteasome mediated degradation of P53 in hepatocellular carcinoma","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Death Discov"},{"issue":"6","key":"10.1016\/j.bcp.2025.117461_b0105","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/jcp.25676","article-title":"The Emerging Role of TRAF7 in Tumor Development","volume":"232","author":"Zotti","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117461_b0110","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/jcp.24011","article-title":"The seventh ring: exploring TRAF7 functions","volume":"227","author":"Zotti","year":"2012","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0115","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1007\/s12035-023-03737-6","article-title":"Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress","volume":"61","author":"Jiang","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0120","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2023.13129","article-title":"MCPIP1 alleviates depressive\u2011like behaviors in mice by inhibiting the TLR4\/TRAF6\/NF\u2011\u03baB pathway to suppress neuroinflammation","volume":"29","author":"An","year":"2024","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2025.117461_b0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yexcr.2019.02.005","article-title":"TRAF6-p38\/JNK-ATF2 axis promotes microglial inflammatory activation","volume":"376","author":"Li","year":"2019","journal-title":"Exp. Cell Res."},{"issue":"7","key":"10.1016\/j.bcp.2025.117461_b0130","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1002\/ptr.8219","article-title":"Pomegranate polyphenol punicalin ameliorates lipopolysaccharide-induced memory impairment, behavioral disorders, oxidative stress, and neuroinflammation via inhibition of TLR4-NF-\u043aB pathway","volume":"38","author":"Chen","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.bcp.2025.117461_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155518","article-title":"Gastrodin regulates the TLR4\/TRAF6\/NF-\u03baB pathway to reduce neuroinflammation and microglial activation in an AD model","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"6599","key":"10.1016\/j.bcp.2025.117461_b0140","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/383443a0","article-title":"TRAF6 is a signal transducer for interleukin-1","volume":"383","author":"Cao","year":"1996","journal-title":"Nature"},{"issue":"46","key":"10.1016\/j.bcp.2025.117461_b0145","doi-asserted-by":"crossref","first-page":"28745","DOI":"10.1074\/jbc.271.46.28745","article-title":"Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region","volume":"271","author":"Ishida","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bcp.2025.117461_b0150","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/bies.10352","article-title":"TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology","volume":"25","author":"Wu","year":"2003","journal-title":"Bioessays"},{"issue":"2","key":"10.1016\/j.bcp.2025.117461_b0155","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0092-8674(00)00126-4","article-title":"Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain","volume":"103","author":"Deng","year":"2000","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bcp.2025.117461_b0160","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nsmb.1605","article-title":"E2 interaction and dimerization in the crystal structure of TRAF6","volume":"16","author":"Yin","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"6896","key":"10.1016\/j.bcp.2025.117461_b0165","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature00888","article-title":"Distinct molecular mechanism for initiating TRAF6 signalling","volume":"418","author":"Ye","year":"2002","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0170","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/imr.12302","article-title":"Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system","volume":"266","author":"Walsh","year":"2015","journal-title":"Immunol. Rev."},{"issue":"7237","key":"10.1016\/j.bcp.2025.117461_b0175","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature07959","article-title":"Ubiquitylation in innate and adaptive immunity","volume":"458","author":"Bhoj","year":"2009","journal-title":"Nature"},{"issue":"48","key":"10.1016\/j.bcp.2025.117461_b0180","doi-asserted-by":"crossref","first-page":"79557","DOI":"10.18632\/oncotarget.12836","article-title":"Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.bcp.2025.117461_b0185","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1002\/alz.14122","article-title":"Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta","volume":"20","author":"Zhang","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"34","key":"10.1016\/j.bcp.2025.117461_b0190","doi-asserted-by":"crossref","first-page":"13191","DOI":"10.1074\/jbc.RA118.002649","article-title":"Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity","volume":"293","author":"Brenke","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0195","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/ijo.2014.198","article-title":"Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice","volume":"39","author":"van den Berg","year":"2015","journal-title":"Int. J. Obes. (Lond)"},{"issue":"2","key":"10.1016\/j.bcp.2025.117461_b0200","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1021\/ci500631e","article-title":"Discovery of small molecule CD40-TRAF6 inhibitors","volume":"55","author":"Zarzycka","year":"2015","journal-title":"J. Chem. Inf. Model."},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0205","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jacc.2017.11.055","article-title":"Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis","volume":"71","author":"Seijkens","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12974-017-0875-9","article-title":"Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation","volume":"14","author":"Aarts","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"8","key":"10.1016\/j.bcp.2025.117461_b0215","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1172\/JCI65414","article-title":"Medullary thymic epithelial cell depletion leads to autoimmune hepatitis","volume":"123","author":"Bonito","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2025.117461_b0220","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fimmu.2012.00261","article-title":"Emerging Functions of RANKL in Lymphoid Tissues","volume":"3","author":"Mueller","year":"2012","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117461_b0225","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/jb\/mvp080","article-title":"TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions","volume":"146","author":"Matsumura","year":"2009","journal-title":"J. Biochem."},{"key":"10.1016\/j.bcp.2025.117461_b0230","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbrc.2023.05.059","article-title":"TRAF6 signaling in dendritic cells plays protective role against infectious colitis by limiting C.rodentium infection through the induction of Th1 and Th17 responses","volume":"669","author":"Chalalai","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2025.117461_b0235","doi-asserted-by":"crossref","DOI":"10.2991\/978-94-6463-932-2","article-title":"Senkyunolide A interrupts TRAF6-HDAC3 interaction to epigenetically suppress c-MYC and attenuate cholestatic liver injury","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"issue":"Pt A","key":"10.1016\/j.bcp.2025.117461_b0240","article-title":"USP25 ameliorates diabetic nephropathy by inhibiting TRAF6-mediated inflammatory responses","volume":"124","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"47","key":"10.1016\/j.bcp.2025.117461_b0245","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2405265121","article-title":"REG\u03b3 is essential to maintain bone homeostasis by degrading TRAF6, preventing osteoporosis","volume":"121","author":"Du","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0250","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s10020-024-00893-w","article-title":"Epimedin A inhibits the PI3K\/AKT\/NF-\u03baB signalling axis and osteoclast differentiation by negatively regulating TRAF6 expression","volume":"30","author":"Li","year":"2024","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0255","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000528502","article-title":"MiR-124 Reduced Neuroinflammation after Traumatic Brain Injury by Inhibiting TRAF6","volume":"30","author":"Yang","year":"2023","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.bcp.2025.117461_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114672","article-title":"Cornuside protects against ischemic stroke in rats by suppressing the IL-17F\/TRAF6\/NF-\u03baB pathway via the brain-gut axis","volume":"373","author":"Yan","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bcp.2025.117461_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.629910","article-title":"Pathogenic Functions of Tumor Necrosis Factor Receptor-Associated Factor 6 Signaling Following Traumatic Brain Injury","volume":"14","author":"Huang","year":"2021","journal-title":"Front. Mol. Neurosci."},{"issue":"9","key":"10.1016\/j.bcp.2025.117461_b0270","doi-asserted-by":"crossref","first-page":"e1406","DOI":"10.1002\/ctm2.1406","article-title":"Rnd3 suppresses endothelial cell pyroptosis in atherosclerosis through regulation of ubiquitination of TRAF6","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"8","key":"10.1016\/j.bcp.2025.117461_b0275","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1007\/s11427-021-2040-8","article-title":"Ubiquitin-specific protease 47 regulates intestinal inflammation through deubiquitination of TRAF6 in epithelial cells","volume":"65","author":"Lei","year":"2022","journal-title":"Sci. China Life Sci."},{"issue":"12","key":"10.1016\/j.bcp.2025.117461_b0280","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1161\/CIRCRESAHA.111.300119","article-title":"Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination","volume":"112","author":"A. Luong le, M. Fragiadaki, J. Smith, J. Boyle, J. Lutz, J.L. Dean, S. Harten, M. Ashcroft, S.R. Walmsley, D.O. Haskard, P.H. Maxwell, H. Walczak, C. Pusey, P.C. Evans","year":"2013","journal-title":"Circ. Res."},{"issue":"6844","key":"10.1016\/j.bcp.2025.117461_b0285","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35085597","article-title":"TAK1 is a ubiquitin-dependent kinase of MKK and IKK","volume":"412","author":"Wang","year":"2001","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bcp.2025.117461_b0290","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101438","article-title":"Morroniside Inhibits Inflammatory Bone Loss through the TRAF6-Mediated NF-\u03baB\/MAPK Signalling Pathway","volume":"16","author":"Xiao","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"issue":"4","key":"10.1016\/j.bcp.2025.117461_b0295","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.molcel.2004.08.008","article-title":"TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains","volume":"15","author":"Kanayama","year":"2004","journal-title":"Mol. Cell"},{"issue":"18","key":"10.1016\/j.bcp.2025.117461_b0300","doi-asserted-by":"crossref","first-page":"13552","DOI":"10.1074\/jbc.M700548200","article-title":"IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression","volume":"282","author":"Koziczak-Holbro","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2025.117461_b0305","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1074\/jbc.M609503200","article-title":"Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation","volume":"282","author":"Lamothe","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2025.117461_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216836","article-title":"Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer","volume":"589","author":"Zhou","year":"2024","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0315","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.32604\/or.2025.062767","article-title":"OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6","volume":"33","author":"Qiu","year":"2025","journal-title":"Oncol. Res."},{"issue":"9","key":"10.1016\/j.bcp.2025.117461_b0320","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1134\/S0006297922090085","article-title":"Spata2L Suppresses TLR4 Signaling by Promoting CYLD-Mediated Deubiquitination of TRAF6 and TAK1","volume":"87","author":"Zhang","year":"2022","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.bcp.2025.117461_b0325","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbi.2019.02.005","article-title":"A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-\u03baB signaling pathway","volume":"79","author":"Li","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bcp.2025.117461_b0330","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1042\/BJ20111358","article-title":"Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNF\u03b1-induced cancer cell migration","volume":"441","author":"Xiao","year":"2012","journal-title":"Biochem. J"},{"key":"10.1016\/j.bcp.2025.117461_b0335","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bbi.2020.04.064","article-title":"PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6","volume":"88","author":"Han","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.bcp.2025.117461_b0340","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s10875-019-00695-4","article-title":"A De Novo Frameshift Mutation in TNFAIP3 Impairs A20 Deubiquitination Function to Cause Neuropsychiatric Systemic Lupus Erythematosus","volume":"39","author":"Duan","year":"2019","journal-title":"J. Clin. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0345","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00018-025-05755-0","article-title":"NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4\/TRAF6\/NF-\u03baB pathway inhibition","volume":"82","author":"Hu","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"issue":"3\u20134","key":"10.1016\/j.bcp.2025.117461_b0350","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bbrc.2010.11.029","article-title":"Glutaredoxin-1 regulates TRAF6 activation and the IL-1 receptor\/TLR4 signalling","volume":"403","author":"Chantzoura","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2025.117461_b0355","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/sj.cdd.4402304","article-title":"TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3beta","volume":"15","author":"Yoon","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2025.117461_b0360","doi-asserted-by":"crossref","unstructured":"C.A. Janeway, Jr., Pillars article: approaching the asymptote? Evolution and revolution in immunology. Cold spring harb symp quant biol. 1989. 54: 1-13, J Immunol 191(9) (2013) 4475-87.","DOI":"10.1093\/jimmunol\/191.9.4475"},{"key":"10.1016\/j.bcp.2025.117461_b0365","doi-asserted-by":"crossref","unstructured":"K. Ozato, H. Tsujimura, T. Tamura, Toll-like receptor signaling and regulation of cytokine gene expression in the immune system, Biotechniques Suppl (2002) 66-8, 70, 72 passim.","DOI":"10.2144\/Oct0208"},{"issue":"8","key":"10.1016\/j.bcp.2025.117461_b0370","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0375","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117461_b0380","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of Toll-like receptors - redefining innate immunity","volume":"13","author":"O'Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117461_b0385","first-page":"195","article-title":"Roles for accessory molecules in microbial recognition by Toll-like receptors","volume":"12","author":"Miyake","year":"2006","journal-title":"J. Endotoxin Res."},{"issue":"11","key":"10.1016\/j.bcp.2025.117461_b0390","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.189.11.1777","article-title":"MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4","volume":"189","author":"Shimazu","year":"1999","journal-title":"J. Exp. Med."},{"issue":"6640","key":"10.1016\/j.bcp.2025.117461_b0395","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0400","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cell.2007.08.002","article-title":"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran","volume":"130","author":"Kim","year":"2007","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bcp.2025.117461_b0405","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ni1207","article-title":"CD14 is required for MyD88-independent LPS signaling","volume":"6","author":"Jiang","year":"2005","journal-title":"Nat. Immunol."},{"issue":"6851","key":"10.1016\/j.bcp.2025.117461_b0410","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/35092578","article-title":"Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction","volume":"413","author":"Fitzgerald","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2025.117461_b0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154685","article-title":"Cinnamomum verum extract inhibits NOX2\/ROS and PKC\u03b4\/JNK\/AP-1\/NF-\u03baB pathway-mediated inflammatory response in PMA-stimulated THP-1 monocytes","volume":"112","author":"Kim","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0420","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbrc.2008.01.061","article-title":"Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling","volume":"368","author":"Tanimura","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"49","key":"10.1016\/j.bcp.2025.117461_b0425","doi-asserted-by":"crossref","first-page":"19908","DOI":"10.1073\/pnas.1222811110","article-title":"Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling","volume":"110","author":"Enokizono","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bcp.2025.117461_b0430","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.cell.2011.09.051","article-title":"CD14 controls the LPS-induced endocytosis of Toll-like receptor 4","volume":"147","author":"Zanoni","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bcp.2025.117461_b0435","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.immuni.2008.03.001","article-title":"Th17 cell differentiation: the long and winding road","volume":"28","author":"McGeachy","year":"2008","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0440","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cyto.2008.12.024","article-title":"IL-17F: regulation, signaling and function in inflammation","volume":"46","author":"Chang","year":"2009","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0445","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.it.2017.01.006","article-title":"IL-17 Signaling: The Yin and the Yang","volume":"38","author":"Amatya","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bcp.2025.117461_b0450","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3389\/fimmu.2019.01293","article-title":"TRAF Regulation of IL-17 Cytokine Signaling","volume":"10","author":"Swaidani","year":"2019","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117461_b0455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110972","article-title":"Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging","volume":"9","author":"Primiani","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2025.117461_b0460","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bbi.2016.09.014","article-title":"TNFAIP3, a negative regulator of the TLR signaling pathway, is a potential predictive biomarker of response to antidepressant treatment in major depressive disorder","volume":"59","author":"Hung","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bcp.2025.117461_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106145","article-title":"Stress induced microglial activation contributes to depression","volume":"179","author":"Li","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0470","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12974-022-02492-0","article-title":"Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.bcp.2025.117461_b0475","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202402873R","article-title":"TRAF6 promotes abdominal aortic aneurysm development by activating macrophage pyroptosis via the NLRP3\/Caspase1\/GSDMD pathway","volume":"39","author":"Cai","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2025.117461_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155410","article-title":"Protopine ameliorates OVA-induced asthma through modulatingTLR4\/MyD88\/NF-\u03baB pathway and NLRP3 inflammasome-mediated pyroptosis","volume":"126","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.bcp.2025.117461_b0485","first-page":"486","article-title":"Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation","volume":"72","author":"Bharadwaj","year":"2020","journal-title":"Fibrosis, and Cancer: Rationale, Progress, and Caution, Pharmacol Rev"},{"issue":"2","key":"10.1016\/j.bcp.2025.117461_b0490","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2174\/187152710791012053","article-title":"Assessing activation states in microglia","volume":"9","author":"Colton","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.bcp.2025.117461_b0495","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6871089","article-title":"The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex","volume":"2017","author":"Liu","year":"2017","journal-title":"Neural Plast."},{"issue":"3","key":"10.1016\/j.bcp.2025.117461_b0500","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2025.117461_b0505","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbi.2020.11.007","article-title":"Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala","volume":"91","author":"Zheng","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bcp.2025.117461_b0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120242","article-title":"An integrated pharmacochemical analysis and investigation of the effects of Jingqianshu granules on premenstrual dysphoric disorder (PMDD)","volume":"352","author":"Cheng","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2025.117461_b0515","doi-asserted-by":"crossref","unstructured":"A.P. Association, Diagnostic and statistical manual of mental disorders, American psychiatric association2013.","DOI":"10.1176\/appi.books.9780890425596"},{"issue":"5","key":"10.1016\/j.bcp.2025.117461_b0520","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1176\/appi.ajp.2012.11081302","article-title":"Premenstrual dysphoric disorder: evidence for a new category for DSM-5","volume":"169","author":"Epperson","year":"2012","journal-title":"Am. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0525","first-page":"60","article-title":"The trends of mood disorders in ICD-11: bipolar and depressive disorders","volume":"115","author":"Kurumaji","year":"2013","journal-title":"Seishin Shinkeigaku Zasshi"},{"key":"10.1016\/j.bcp.2025.117461_b0530","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jpsychires.2022.06.026","article-title":"Gonadal hormone trigger the dynamic microglial alterations through Traf6\/TAK1 axis that correlate with depressive behaviors","volume":"152","author":"Peng","year":"2022","journal-title":"J. Psychiatr. Res."},{"issue":"4","key":"10.1016\/j.bcp.2025.117461_b0535","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1007\/s12035-016-9848-8","article-title":"Antidepressant-Like Effect of Ropren\u00ae in \u03b2-Amyloid-(25-35) Rat Model of Alzheimer's Disease with Altered Levels of Androgens","volume":"54","author":"Soultanov","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bcp.2025.117461_b0540","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yhbeh.2018.05.012","article-title":"Bisphenol-A inhibits improvement of testosterone in anxiety- and depression-like behaviors in gonadectomied male mice","volume":"102","author":"Liang","year":"2018","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bcp.2025.117461_b0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104527","article-title":"Gut microbiota and its metabolites in depression: from pathogenesis to treatment","volume":"90","author":"Liu","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bcp.2025.117461_b0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105840","article-title":"The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders","volume":"172","author":"Soca\u0142a","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2025.117461_b0555","article-title":"Xiaoyaosan Exerts Therapeutic Effects on the Colon of Chronic Restraint Stress Model Rats via the Regulation of Immunoinflammatory Activation Induced by the TLR4\/NLRP3 Inflammasome Signaling Pathway","volume":"2021","author":"Zhu","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117461_b0560","first-page":"2083","article-title":"Impact of chronic immobilization stress on parameters of colonic homeostasis in BALB\/c mice","volume":"20","author":"Machorro-Rojas","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2025.117461_b0565","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117461_b0570","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"Lu","year":"2014","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bcp.2025.117461_b0575","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2025.117461_b0580","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.12659\/MSM.908529","article-title":"NF-\u03baB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial Infarction","volume":"24","author":"Lei","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bcp.2025.117461_b0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119732","article-title":"Transcriptomic analysis and experiment to verify the mechanism of Xiaoyao san in the treatment of irritable bowel syndrome with depression","volume":"347","author":"Yu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"26","key":"10.1016\/j.bcp.2025.117461_b0590","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1056\/NEJMra1607547","article-title":"Irritable Bowel Syndrome","volume":"376","author":"Ford","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.bcp.2025.117461_b0595","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2169\/internalmedicine.55.5716","article-title":"The Colonic Tissue Levels of TLR2, TLR4 and Nitric Oxide in Patients with Irritable Bowel Syndrome","volume":"55","author":"Ko\u00e7ak","year":"2016","journal-title":"Intern. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0600","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2025.117461_b0605","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/978-0-387-70630-6_6","article-title":"Characteristics and biological functions of TRAF6","volume":"597","author":"Inoue","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117461_b0610","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41419-022-04808-7","article-title":"USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction","volume":"13","author":"Kim","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2025.117461_b0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110290","article-title":"Sennoside A restrains TRAF6 level to modulate ferroptosis, inflammation and cognitive impairment in aging mice with Alzheimer's Disease","volume":"120","author":"Li","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0620","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12883-022-02833-9","article-title":"Expression of TRAF6 in peripheral blood B cells of patients with myasthenia gravis","volume":"22","author":"Li","year":"2022","journal-title":"BMC Neurol."},{"issue":"19","key":"10.1016\/j.bcp.2025.117461_b0625","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1523\/JNEUROSCI.20-19-07384.2000","article-title":"Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS","volume":"20","author":"Lomaga","year":"2000","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bcp.2025.117461_b0630","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1186\/s12951-024-02941-3","article-title":"Magnetic targeting enhances the neuroprotective function of human mesenchymal stem cell-derived iron oxide exosomes by delivering miR-1228-5p","volume":"22","author":"Hu","year":"2024","journal-title":"J Nanobiotechnology"},{"issue":"8","key":"10.1016\/j.bcp.2025.117461_b0635","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1101\/gad.13.8.1015","article-title":"TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling","volume":"13","author":"Lomaga","year":"1999","journal-title":"Genes Dev."},{"issue":"7242","key":"10.1016\/j.bcp.2025.117461_b0640","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/nature07830","article-title":"The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex","volume":"458","author":"Park","year":"2009","journal-title":"Nature"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225007269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225007269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:57:34Z","timestamp":1775797054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225007269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":128,"alternative-id":["S0006295225007269"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117461","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progress of TRAF6 in the pathogenesis of depression: opportunities and challenges from molecular mechanisms to therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117461"}}