{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:17:29Z","timestamp":1778541449797,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20365"],"award-info":[{"award-number":["U22A20365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830117"],"award-info":[{"award-number":["81830117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["2024SZYRC08"],"award-info":[{"award-number":["2024SZYRC08"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["20252D003"],"award-info":[{"award-number":["20252D003"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2021002"],"award-info":[{"award-number":["2021002"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012429"],"award-info":[{"award-number":["2023A1515012429"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2025A03J3427"],"award-info":[{"award-number":["2025A03J3427"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024B03J1343"],"award-info":[{"award-number":["2024B03J1343"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bcp.2025.117487","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T01:46:27Z","timestamp":1761788787000},"page":"117487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["Hyperuricemia exacerbates acetaminophen hepatotoxicity via JNK activation and mitophagy reduction"],"prefix":"10.1016","volume":"243","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baizhao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dexian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigui","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanting","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanghai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiu Yee","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daming","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoshan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bcp.2025.117487_b0005","article-title":"Prevalence of hyperuricemia among chinese adults: findings from two nationally representative cross-sectional surveys in 2015-16 and 2018-19","volume":"7","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117487_b0010","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/art.40807","article-title":"Contemporary prevalence of gout and hyperuricemia in the united states and decadal trends: the national health and nutrition examination survey, 2007-2016","volume":"71","author":"Chen-Xu","year":"2019","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117487_b0015","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/BOR.0b013e3282f4b1ed","article-title":"Hyperuricemia, gout and the metabolic syndrome","volume":"20","author":"Puig","year":"2008","journal-title":"Curr. Opin. Rheumatol."},{"issue":"17","key":"10.1016\/j.bcp.2025.117487_b0020","doi-asserted-by":"crossref","first-page":"9221","DOI":"10.3390\/ijms22179221","article-title":"Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease","volume":"22","author":"Yanai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2025.117487_b0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/diseases9030061","article-title":"A population based study of liver function amongst adults with hyperuricemia and gout in the United States","volume":"9","author":"Deb","year":"2021","journal-title":"Diseases"},{"issue":"2","key":"10.1016\/j.bcp.2025.117487_b0030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/MEG.0000000000000507","article-title":"Hyperuricemia and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"28","author":"Gong","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117487_b0035","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3390\/metabo12100893","article-title":"Clinical and metabolic characteristics of hyperuricemia with risk of liver fibrosis: a cross-sectional study","volume":"12","author":"Wang","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.bcp.2025.117487_b0040","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1403454","article-title":"Mechanism of PDZK1 in hepatocellular carcinoma complicated with hyperuricemia","author":"Guo","year":"2022","journal-title":"J. Oncol."},{"key":"10.1016\/j.bcp.2025.117487_b0045","doi-asserted-by":"crossref","unstructured":"Hayashi M, Yamada S, Tanabe H, akami H, Inokawa Y, Sonohara F, et al. High Serum Uric Acid Levels Could Be a Risk Factor of Hepatocellular Carcinoma Recurrences. Nutr Cancer. 2021;73(6):996-1003.","DOI":"10.1080\/01635581.2020.1779758"},{"issue":"12","key":"10.1016\/j.bcp.2025.117487_b0050","article-title":"Elevated serum uric acid is associated with poor survival in advanced HCC patients and febuxostat improves prognosis in HCC rats","volume":"11","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"26","key":"10.1016\/j.bcp.2025.117487_b0055","first-page":"77","article-title":"Joint pain epidemiology and analgesic usage in Madagascar","volume":"20","author":"Samison","year":"2017","journal-title":"Pan Afr. Med. J."},{"issue":"1","key":"10.1016\/j.bcp.2025.117487_b0060","first-page":"11","article-title":"Paracetamol: mechanism of action, applications and safety concern","volume":"71","author":"J\u00f3\u017awiak-Bebenista","year":"2014","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.bcp.2025.117487_b0065","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117487_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cld.2013.07.001","article-title":"Drug-induced acute liver failure","volume":"17","author":"Lee","year":"2013","journal-title":"Clin. Liver Dis."},{"issue":"2","key":"10.1016\/j.bcp.2025.117487_b0075","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cld.2018.01.007","article-title":"Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and acute liver failure","volume":"22","author":"Bunchorntavakul","year":"2018","journal-title":"Clin. Liver Dis."},{"issue":"2","key":"10.1016\/j.bcp.2025.117487_b0080","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jcmgh.2023.10.005","article-title":"Inhibiting hepatocyte uric acid synthesis and reabsorption ameliorates acetaminophen-induced acute liver injury in mice","volume":"17","author":"Tang","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"20","key":"10.1016\/j.bcp.2025.117487_b0085","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1177\/15353702231211862","article-title":"Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1\/Nrf2 and inhibiting TLR4\/NF-\u03baB p65 pathways","volume":"248","author":"Tian","year":"2023","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.bcp.2025.117487_b0090","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","article-title":"Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential","volume":"10","author":"Du","year":"2016","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117487_b0095","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab. Rev."},{"issue":"10","key":"10.1016\/j.bcp.2025.117487_b0100","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1097\/TP.0b013e31816fefb5","article-title":"Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2","volume":"85","author":"Theruvath","year":"2008","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.bcp.2025.117487_b0105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hep.22578","article-title":"Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance","volume":"49","author":"Singh","year":"2009","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.bcp.2025.117487_b0110","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1002\/jcb.27724","article-title":"Hydrogen sulfide protects against acetaminophen-induced acute liver injury by inhibiting apoptosis via the JNK\/MAPK signaling pathway","volume":"120","author":"Li","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bcp.2025.117487_b0115","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/cdd.2014.150","article-title":"Oxidative stress and autophagy: the clash between damage and metabolic needs","volume":"22","author":"Filomeni","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2025.117487_b0120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-981-15-0602-4_9","article-title":"Oxidative stress and Autophagy","volume":"1206","author":"Gao","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117487_b0125","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/liv.13866","article-title":"Role and mechanisms of autophagy in acetaminophen-induced liver injury","volume":"38","author":"Chao","year":"2018","journal-title":"Liver Int."},{"issue":"7","key":"10.1016\/j.bcp.2025.117487_b0130","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s00204-018-2237-5","article-title":"Autophagy and acetaminophen-induced hepatotoxicity","volume":"92","author":"Shan","year":"2018","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117487_b0135","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jhep.2016.04.025","article-title":"Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice","volume":"65","author":"Ni","year":"2016","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117487_b0140","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00535-011-0500-0","article-title":"Loss of autophagy promotes murine acetaminophen hepatotoxicity","volume":"47","author":"Igusa","year":"2012","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bcp.2025.117487_b0145","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.048041","article-title":"Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency","author":"Wu","year":"2021","journal-title":"Dis. Model. Mech."},{"issue":"2022","key":"10.1016\/j.bcp.2025.117487_b0150","article-title":"High level of uric acid promotes atherosclerosis by targeting NRF2-mediated autophagy dysfunction and ferroptosis","volume":"18","author":"Yu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"277","key":"10.1016\/j.bcp.2025.117487_b0155","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cbi.2017.09.007","article-title":"Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes","volume":"1","author":"Nguyen","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bcp.2025.117487_b0160","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.gastro.2006.03.045","article-title":"c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity","volume":"131","author":"Gunawan","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcp.2025.117487_b0165","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/hep.29689","article-title":"New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases","volume":"67","author":"Win","year":"2018","journal-title":"Hepatology"},{"issue":"2021","key":"10.1016\/j.bcp.2025.117487_b0170","article-title":"The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors","volume":"26","author":"Liu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.bcp.2025.117487_b0175","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.3390\/ijms23063188","article-title":"Uric acid and oxidative stress-relationship with cardiovascular, metabolic, and renal impairment","volume":"23","author":"Gherghina","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2025.117487_b0180","doi-asserted-by":"crossref","first-page":"E1032","DOI":"10.1152\/ajpendo.00518.2020","article-title":"High uric acid induces liver fat accumulation via ROS\/JNK\/AP-1 signaling","volume":"320","author":"Xie","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"23","key":"10.1016\/j.bcp.2025.117487_b0185","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.21037\/atm-20-3105","article-title":"Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway","volume":"8","author":"Wang","year":"2020","journal-title":"Ann Transl Med."},{"issue":"6","key":"10.1016\/j.bcp.2025.117487_b0190","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/med.21574","article-title":"JNK signaling in cancer cell survival","volume":"39","author":"Wu","year":"2019","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2025.117487_b0195","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/15548627.2021.1888244","article-title":"Regulation of PRKN-independent mitophagy","volume":"18","author":"Tere\u0161ak","year":"2022","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.bcp.2025.117487_b0200","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7150\/thno.79876","article-title":"Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation","volume":"13","author":"Lu","year":"2023","journal-title":"Theranostics"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522500752X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522500752X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:01:12Z","timestamp":1775797272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522500752X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":40,"alternative-id":["S000629522500752X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117487","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperuricemia exacerbates acetaminophen hepatotoxicity via JNK activation and mitophagy reduction","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117487"}}