{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:29:24Z","timestamp":1766395764176,"version":"3.48.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202312384"],"award-info":[{"award-number":["tsqn202312384"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200981"],"award-info":[{"award-number":["82200981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2022QH358"],"award-info":[{"award-number":["ZR2022QH358"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR202111250163"],"award-info":[{"award-number":["ZR202111250163"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","award":["BY2021KYQD29"],"award-info":[{"award-number":["BY2021KYQD29"]}],"id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bcp.2025.117576","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:25:59Z","timestamp":1764390359000},"page":"117576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nuciferine suppresses adipogenesis and mitochondrial function in brown adipocytes"],"prefix":"10.1016","volume":"244","author":[{"given":"Mengxin","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangzhen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3152-2124","authenticated-orcid":false,"given":"Ting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bcp.2025.117576_b0005","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2021.12.016","article-title":"Adipose-tissue plasticity in health and disease","volume":"185","author":"Sakers","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2025.117576_b0010","doi-asserted-by":"crossref","unstructured":"W.D. van Marken Lichtenbelt, J.W. Vanhommerig, N.M. Smulders, J.M.A.F. Drossaerts, G.J. Kemerink, N.D. Bouvy, P. Schrauwen, G.J.J. Teule, Cold-activated brown adipose tissue in healthy men, N Engl J Med 360(15) (2009) 1500-1508.10.1056\/NEJMoa0808718.","DOI":"10.1056\/NEJMoa0808718"},{"issue":"15","key":"10.1016\/j.bcp.2025.117576_b0015","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117576_b0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41591-020-1126-7","article-title":"Brown adipose tissue is associated with cardiometabolic health","volume":"27","author":"Becher","year":"2021","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.bcp.2025.117576_b0025","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/bph.15364","article-title":"Nuciferine protects against folic acid\u2010induced acute kidney injury by inhibiting ferroptosis","volume":"178","author":"Li","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117576_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155312","article-title":"Nuciferine reduces inflammation induced by cerebral ischemia-reperfusion injury through the pi3k\/akt\/nf-\u03bab pathway","volume":"125","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"issue":"42","key":"10.1016\/j.bcp.2025.117576_b0035","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1021\/acs.jafc.6b03031","article-title":"Nuciferine alleviates renal injury by inhibiting inflammatory responses in fructose-fed rats","volume":"64","author":"Wang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bcp.2025.117576_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156829","article-title":"Nuciferine ameliorates blood-brain barrier disruption post-ischemic stroke via inhibiting the jak2\/stat3 pathway","volume":"143","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.bcp.2025.117576_b0045","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1021\/acs.jafc.1c08375","article-title":"Nuciferine inhibits tmem16a in dietary adjuvant therapy for lung cancer","volume":"70","author":"Bai","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.bcp.2025.117576_b0050","article-title":"Nuciferine attenuates cancer cachexia\u2010induced muscle wasting in mice via hsp90aa1, Journal of Cachexia","volume":"16","author":"An","year":"2025","journal-title":"Sarcopenia and Muscle"},{"issue":"6","key":"10.1016\/j.bcp.2025.117576_b0055","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/j.apsb.2021.12.012","article-title":"Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating tfeb-mediated autophagy\u2013lysosomal pathway","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"12","key":"10.1016\/j.bcp.2025.117576_b0060","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/s12276-020-00534-2","article-title":"Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats","volume":"52","author":"Wang","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"44","key":"10.1016\/j.bcp.2025.117576_b0065","doi-asserted-by":"crossref","first-page":"24417","DOI":"10.1021\/acs.jafc.4c04929","article-title":"Nuciferine alleviates high-fat diet- and apoe\u2013\/\u2013 -induced hepatic steatosis and ferroptosis in nafld mice via the ppar\u03b1 signaling pathway","volume":"72","author":"Qiu","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"22","key":"10.1016\/j.bcp.2025.117576_b0070","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1111\/bph.14482","article-title":"Nuciferine ameliorates hepatic steatosis in high\u2010fat diet\/streptozocin\u2010induced diabetic mice through a ppar\u03b1\/ppar\u03b3 coactivator\u20101\u03b1 pathway","volume":"175","author":"Zhang","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117576_b0075","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1039\/D3FO03632D","article-title":"Nuciferine prevents obesity by activating brown adipose tissue","volume":"15","author":"Yan","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.bcp.2025.117576_b0080","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.lfs.2015.07.001","article-title":"Pronuciferine and nuciferine inhibit lipogenesis in 3t3-l1 adipocytes by activating the ampk signaling pathway","volume":"136","author":"Ma","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117576_b0085","article-title":"Nuciferine inhibited the differentiation and lipid accumulation of 3t3-l1 preadipocytes by regulating the expression of lipogenic genes and adipokines","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117576_b0090","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cell.2009.01.051","article-title":"Twist-1 is a ppardelta-inducible, negative-feedback regulator of pgc-1alpha in brown fat metabolism","volume":"137","author":"Pan","year":"2009","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bcp.2025.117576_b0095","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/s42255-022-00644-3","article-title":"Cdo1 promotes ppargamma-mediated adipose tissue lipolysis in male mice","volume":"4","author":"Guo","year":"2022","journal-title":"Nat Metab"},{"issue":"2","key":"10.1016\/j.bcp.2025.117576_b0100","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"Autodock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bcp.2025.117576_b0105","unstructured":"D. Sacks, B. Baxter, B.C.V. Campbell, J.S. Carpenter, C. Cognard, D. Dippel, M. Eesa, U. Fischer, K. Hausegger, J.A. Hirsch, M. Shazam Hussain, O. Jansen, M.V. Jayaraman, A.A. Khalessi, B.W. Kluck, S. Lavine, P.M. Meyers, S. Ramee, D.A. Rufenacht, C.M. Schirmer, D. Vorwerk, Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke, Int J Stroke 13(6) (2018) 612-632.10.1177\/1747493018778713."},{"issue":"3","key":"10.1016\/j.bcp.2025.117576_b0110","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2753.2004.00489.x","article-title":"can we smell the organizational coffee?' the gap between the theory and practice of 'learning practices","volume":"10","author":"Elwyn","year":"2004","journal-title":"J. Eval. Clin. Pract."},{"issue":"2","key":"10.1016\/j.bcp.2025.117576_b0115","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmgm.2005.12.005","article-title":"Automatic atom type and bond type perception in molecular mechanical calculations","volume":"25","author":"Wang","year":"2006","journal-title":"J. Mol. Graph. Model."},{"issue":"1","key":"10.1016\/j.bcp.2025.117576_b0120","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/1756-0500-5-367","article-title":"Acpype - antechamber python parser interface","volume":"5","author":"Sousa Da Silva","year":"2012","journal-title":"BMC. Res. Notes"},{"issue":"1","key":"10.1016\/j.bcp.2025.117576_b0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2014.04.049","article-title":"Irf4 is a key thermogenic transcriptional partner of pgc-1alpha","volume":"158","author":"Kong","year":"2014","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bcp.2025.117576_b0130","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.devcel.2015.11.002","article-title":"Jmjd3-mediated h3k27me3 dynamics orchestrate brown fat development and regulate white fat plasticity","volume":"35","author":"Pan","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bcp.2025.117576_b0135","doi-asserted-by":"crossref","unstructured":"C.L. Mattsson, R.I. Csikasz, E. Chernogubova, D.L. Yamamoto, H.T. Hogberg, E. Amri, D.S. Hutchinson, T. Bengtsson, Beta(1)-adrenergic receptors increase ucp1 in human mads brown adipocytes and rescue cold-acclimated beta(3)-adrenergic receptor-knockout mice via nonshivering thermogenesis, Am J Physiol Endocrinol Metab 301(6) (2011) E1108-E1118.10.1152\/ajpendo.00085.2011.","DOI":"10.1152\/ajpendo.00085.2011"},{"key":"10.1016\/j.bcp.2025.117576_b0140","doi-asserted-by":"crossref","unstructured":"M.J. Riis-Vestergaard, B. Richelsen, J.M. Bruun, W. Li, J.B. Hansen, S.B. Pedersen, Beta-1 and not beta-3 adrenergic receptors may be the primary regulator of human brown adipocyte metabolism, J Clin Endocrinol Metab 105(4) (2020).10.1210\/clinem\/dgz298.","DOI":"10.1210\/clinem\/dgz298"},{"issue":"1","key":"10.1016\/j.bcp.2025.117576_b0145","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1096\/fj.14-263038","article-title":"Cellular origins of cold-induced brown adipocytes in adult mice","volume":"29","author":"Lee","year":"2015","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.bcp.2025.117576_b0150","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cmet.2017.08.006","article-title":"Global analysis of plasma lipids identifies liver-derived acylcarnitines as a fuel source for brown fat thermogenesis","volume":"26","author":"Simcox","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2025.117576_b0155","doi-asserted-by":"crossref","unstructured":"H. Xu, X. Lyu, X. Guo, H. Yang, L. Duan, H. Zhu, H. Pan, F. Gong, L. Wang, Distinct ampk-mediated fas\/hsl pathway is implicated in the alleviating effect of nuciferine on obesity and hepatic steatosis in hfd-fed mice, Nutrients 14(9) (2022).10.3390\/nu14091898.","DOI":"10.3390\/nu14091898"},{"key":"10.1016\/j.bcp.2025.117576_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101241","article-title":"Dopamine d2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes","volume":"51","author":"Tavares","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bcp.2025.117576_b0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbrc.2021.12.040","article-title":"Dopamine receptor d1 signaling stimulates lipolysis and browning of white adipocytes","volume":"588","author":"Yu","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2025.117576_b0170","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1038\/ncomms7794","article-title":"Regulation of systemic energy homeostasis by serotonin in adipose tissues","volume":"6","author":"Oh","year":"2015","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bcp.2025.117576_b0175","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s12020-023-03525-1","article-title":"Subcutaneous adipose tissue dopamine d2 receptor is increased in prediabetes and t2d","volume":"83","author":"Vranic","year":"2024","journal-title":"Endocrine"},{"issue":"8","key":"10.1016\/j.bcp.2025.117576_b0180","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s42255-023-00839-2","article-title":"The serotonin transporter sustains human brown adipose tissue thermogenesis","volume":"5","author":"Suchacki","year":"2023","journal-title":"Nat Metab"},{"issue":"9","key":"10.1016\/j.bcp.2025.117576_b0185","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1210\/endo.140.9.6972","article-title":"Beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation","volume":"140","author":"Bronnikov","year":"1999","journal-title":"Endocrinology"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522500841X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522500841X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:25:04Z","timestamp":1766395504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522500841X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":37,"alternative-id":["S000629522500841X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117576","relation":{},"ISSN":["0006-2952"],"issn-type":[{"type":"print","value":"0006-2952"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuciferine suppresses adipogenesis and mitochondrial function in brown adipocytes","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117576","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117576"}}