{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:51:34Z","timestamp":1792842694359,"version":"4.5.0"},"reference-count":515,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SGL027\/1011"],"award-info":[{"award-number":["SGL027\/1011"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["CNPJ 43.828.151\/0001\\u201345"],"award-info":[{"award-number":["CNPJ 43.828.151\/0001\\u201345"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"publisher","award":["10666"],"award-info":[{"award-number":["10666"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["SFRH\/BD\/140283\/2018"],"award-info":[{"award-number":["SFRH\/BD\/140283\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019976","name":"Science and Technology Bureau of Jiaxing City","doi-asserted-by":"publisher","award":["2019AY32012"],"award-info":[{"award-number":["2019AY32012"]}],"id":[{"id":"10.13039\/501100019976","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202108330069"],"award-info":[{"award-number":["202108330069"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202308320054"],"award-info":[{"award-number":["202308320054"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["LGD21H300001"],"award-info":[{"award-number":["LGD21H300001"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bcp.2025.117620","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T19:45:16Z","timestamp":1767210316000},"page":"117620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Pharmacological targeting of nuclear factor (erythroid-derived 2)-like 2 (NRF2): a potential strategy to improve the efficacy of oncological photodynamic therapy"],"prefix":"10.1016","volume":"248","author":[{"given":"Daniel J.","family":"de Klerk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-9406","authenticated-orcid":false,"given":"Mark J.","family":"de Keijzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo P.","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim A.","family":"Gureev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingnan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Mesquita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon E.","family":"Saelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis","family":"Van herteryck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel M.","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne R.","family":"de Haan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka N.C.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa Y.S.","family":"Le Large","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Giovannetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Kazemier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry D.","family":"Moerland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Stubbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Devreese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri B.","family":"Porozov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Verheij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Twan","family":"Lammers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazan S.","family":"Khaled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-4465","authenticated-orcid":false,"given":"Michal","family":"Heger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0005","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10103-008-0539-1","article-title":"Photophysics and photochemistry of photodynamic therapy: fundamental aspects","volume":"24","author":"Plaetzer","year":"2009","journal-title":"Lasers Med. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0010","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1166\/jbn.2018.2558","article-title":"Combining photodynamic therapy and chemotherapy: improving breast cancer treatment with nanotechnology","volume":"14","author":"Candido","year":"2018","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.bcp.2025.117620_b0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pdpdt.2016.09.003","article-title":"In vitro effects of photodynamic therapy induced by chloroaluminum phthalocyanine nanoemulsion","volume":"16","author":"Franchi","year":"2016","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.bcp.2025.117620_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2020.111992","article-title":"The redox function of apurinic\/apyrimidinic endonuclease 1 as key modulator in photodynamic therapy","volume":"211","author":"Franchi","year":"2020","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bcp.2025.117620_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.111984","article-title":"Cholesterol-rich nanoemulsion (LDE) as a novel drug delivery system to diagnose, delineate, and treat human glioblastoma","volume":"123","author":"Tedesco","year":"2021","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"5074","key":"10.1016\/j.bcp.2025.117620_b0030","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1355616","article-title":"Protein oxidation and aging","volume":"257","author":"Stadtman","year":"1992","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0035","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF02536472","article-title":"The dual effect of oxidation on lipid bilayer structure","volume":"27","author":"Borchman","year":"1992","journal-title":"Lipids"},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0040","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00018-016-2401-0","article-title":"Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy","volume":"74","author":"Weijer","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2025.117620_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2021.112146","article-title":"Attritional evaluation of lipophilic and hydrophilic metallated phthalocyanines for oncological photodynamic therapy","volume":"216","author":"Dias","year":"2021","journal-title":"J. Photochem. Photobiol. B"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0050","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/php.12952","article-title":"Apoptosis, paraptosis and autophagy: death and survival pathways associated with photodynamic therapy","volume":"95","author":"Kessel","year":"2019","journal-title":"Photochem. Photobiol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/php.12857","article-title":"Cell death pathways associated with photodynamic therapy: an update","volume":"94","author":"Kessel","year":"2018","journal-title":"Photochem. Photobiol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0060","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/php.12256","article-title":"Measurement of intracellular oxygen concentration during photodynamic therapy in vitro","volume":"90","author":"Weston","year":"2014","journal-title":"Photochem. Photobiol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0065","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1089\/clm.1996.14.323","article-title":"Vascular effects of photodynamic therapy","volume":"14","author":"Fingar","year":"1996","journal-title":"J. Clin. Laser Med. Surg."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0070","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrc1894","article-title":"Photodynamic therapy and anti-tumour immunity","volume":"6","author":"Castano","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0075","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1039\/c0pp00294a","article-title":"DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown","volume":"10","author":"Garg","year":"2011","journal-title":"Photochem. Photobiol. Sci."},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b0080","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","article-title":"Immunogenic cell death and DAMPs in cancer therapy","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b0085","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S1470-2045(07)70318-2","article-title":"Photodynamic-therapy-activated immune response against distant untreated tumours in recurrent angiosarcoma","volume":"8","author":"Thong","year":"2007","journal-title":"Lancet Oncol."},{"issue":"12 Pt 1","key":"10.1016\/j.bcp.2025.117620_b0090","first-page":"6071","article-title":"Interaction of photodynamic therapy and hyperthermia: tumor response and cell survival studies after treatment of mice in vivo","volume":"45","author":"Henderson","year":"1985","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0095","doi-asserted-by":"crossref","first-page":"12655","DOI":"10.1038\/s41598-019-49064-6","article-title":"Effects of photodynamic therapy with redaporfin on tumor oxygenation and blood flow in a lung cancer mouse model","volume":"9","author":"Karwicka","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2025.117620_b0100","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jss.2020.12.067","article-title":"Porfimer sodium versus PS785 for photodynamic therapy (PDT) of lung cancer xenografts in mice","volume":"263","author":"Nwogu","year":"2021","journal-title":"J. Surg. Res."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0105","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3390\/biomedicines10040857","article-title":"Photodynamic therapy in combination with doxorubicin is superior to monotherapy for the treatment of lung cancer","volume":"10","author":"Cacaccio","year":"2022","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0110","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-2005-861294","article-title":"Prospective study of the effectiveness of percutaneous transhepatic photodynamic therapy for advanced bile duct cancer and the role of intraductal ultrasonography in response assessment","volume":"37","author":"Shim","year":"2005","journal-title":"Endoscopy"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0115","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2340\/00015555-1198","article-title":"Evaluation of recurrence after photodynamic therapy with topical methylaminolaevulinate for 157 basal cell carcinomas in 90 patients","volume":"92","author":"Lindberg-Larsen","year":"2012","journal-title":"Acta Derm. Venereol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b0120","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.3390\/cancers12102793","article-title":"Progress in clinical trials of photodynamic therapy for solid tumors and the role of nanomedicine","volume":"12","author":"Alsaab","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0125","doi-asserted-by":"crossref","DOI":"10.1117\/1.3494561","article-title":"How tissue optics affect dosimetry of photodynamic therapy","volume":"15","author":"Jacques","year":"2010","journal-title":"J. Biomed. Opt."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0130","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1364\/BOE.393524","article-title":"Reactive oxygen species explicit dosimetry to predict local tumor growth for Photofrin-mediated photodynamic therapy","volume":"11","author":"Sheng","year":"2020","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.bcp.2025.117620_b0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jphotochemrev.2015.05.002","article-title":"Enhancing photodynamic therapy of refractory solid cancers: combining second-generation photosensitizers with multi-targeted liposomal delivery","volume":"23","author":"Weijer","year":"2015","journal-title":"J Photochem Photobiol C: Photochem Rev"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0140","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10555-015-9588-7","article-title":"Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies","volume":"34","author":"Broekgaarden","year":"2015","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bcp.2025.117620_b0145","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/978-1-0716-2099-1_20","article-title":"Strategies for improving photodynamic therapy through pharmacological modulation of the immediate early stress response","volume":"2451","author":"de Klerk","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100729","article-title":"Participation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain","volume":"66","author":"Korbelik","year":"2025","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0155","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.18632\/oncotarget.6490","article-title":"Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy","volume":"7","author":"Weijer","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0160","first-page":"239","article-title":"Neovascularization in pancreatic ductal adenocarcinoma: Microvessel count analysis, comparison with non-cancerous regions and other types of carcinomas","volume":"9","author":"Ueda","year":"2002","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0165","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1593\/neo.81618","article-title":"Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma","volume":"11","author":"Erkan","year":"2009","journal-title":"Neoplasia"},{"key":"10.1016\/j.bcp.2025.117620_b0170","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jconrel.2020.09.046","article-title":"Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles","volume":"328","author":"Biancacci","year":"2020","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b0175","article-title":"Repurposing tamoxifen for tumor microenvironment priming and enhanced tumor-targeted drug delivery","volume":"6","author":"Biancacci","year":"2023","journal-title":"Adv Ther (Weinh)"},{"key":"10.1016\/j.bcp.2025.117620_b0180","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jconrel.2023.11.044","article-title":"CCL2 chemokine inhibition primes the tumor vasculature for improved nanomedicine delivery and efficacy","volume":"365","author":"Mockel","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bcp.2025.117620_b0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2016.02.021","article-title":"Sonoporation enhances liposome accumulation and penetration in tumors with low EPR","volume":"231","author":"Theek","year":"2016","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234568","article-title":"Alignment of stroma fibers, microvessel density and immune cell populations determine overall survival in pancreatic cancer-an analysis of stromal morphology","volume":"15","author":"Bolm","year":"2020","journal-title":"PLoS One"},{"issue":"5933","key":"10.1016\/j.bcp.2025.117620_b0195","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.1171362","article-title":"Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer","volume":"324","author":"Olive","year":"2009","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0200","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007","article-title":"Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma","volume":"21","author":"Provenzano","year":"2012","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0205","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/gutjnl-2020-322493","article-title":"Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma","volume":"71","author":"Aoki","year":"2022","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0210","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/gutjnl-2012-302529","article-title":"Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer","volume":"62","author":"Jacobetz","year":"2013","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b0215","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00535-008-2255-9","article-title":"Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma","volume":"43","author":"Thelen","year":"2008","journal-title":"J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0220","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1073\/pnas.95.8.4607","article-title":"Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment","volume":"95","author":"Hobbs","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0225","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0002-9440(10)65006-7","article-title":"Openings between defective endothelial cells explain tumor vessel leakiness","volume":"156","author":"Hashizume","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"16","key":"10.1016\/j.bcp.2025.117620_b0230","first-page":"4129","article-title":"Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor","volume":"59","author":"Monsky","year":"1999","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0235","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1186\/s12885-015-1994-2","article-title":"Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells","volume":"15","author":"Weijer","year":"2015","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0240","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1007\/s12274-016-1059-0","article-title":"Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes","volume":"9","author":"Broekgaarden","year":"2016","journal-title":"Nano Res."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0245","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/14737140.2017.1347505","article-title":"Phthalocyanine induced phototherapy coupled with Doxorubicin; a promising novel treatment for breast cancer","volume":"17","author":"Aniogo","year":"2017","journal-title":"Expert Rev. Anticancer Ther."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0250","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/18715206MTA1uNjQp3","article-title":"A review of chemotherapy and photodynamic therapy for lung cancer treatment","volume":"21","author":"El-Hussein","year":"2021","journal-title":"Anticancer Agents Med Chem."},{"key":"10.1016\/j.bcp.2025.117620_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2022.214656","article-title":"Combination of light and Ru(II) polypyridyl complexes: recent advances in the development of new anticancer drugs","volume":"469","author":"Conti","year":"2022","journal-title":"Coord. Chem. Rev."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0260","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1166\/jbn.2017.2327","article-title":"Photodynamic therapy with liposomal zinc phthalocyanine and tirapazamine increases tumor cell death via DNA damage","volume":"13","author":"Broekgaarden","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.bcp.2025.117620_b0265","article-title":"Combination of phototherapy with immune checkpoint blockade: theory and practice in cancer","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2025.117620_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.104038","article-title":"Photodynamic therapy may salvage chemotherapy failure in gastric cancer: a case report and a literature review","volume":"46","author":"Zhu","year":"2024","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.bcp.2025.117620_b0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1556493","article-title":"Case Report: a novel chemotherapy-free regimen combined with photodynamic therapy, target therapy, and immunotherapy in a geriatric male with huge recurrent scalp and facial angiosarcoma: a report of an extremely rare case and literature review","volume":"16","author":"Maswikiti","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0280","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1186\/s12951-024-02921-7","article-title":"Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT\/ferroptosis\/starvation therapy by reversing the tumor hypoxic microenvironment","volume":"22","author":"Chen","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.bcp.2025.117620_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120985","article-title":"A versatile gas-generator promoting drug release and oxygen replenishment for amplifying photodynamic-chemotherapy synergetic anti-tumor effects","volume":"276","author":"Wang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcp.2025.117620_b0290","article-title":"Surufatinib combined with photodynamic therapy induces ferroptosis to inhibit cholangiocarcinoma in vitro and in tumor models","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0295","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00535-023-02054-y","article-title":"Induction of ferroptosis by photodynamic therapy and enhancement of antitumor effect with ferroptosis inducers","volume":"59","author":"Kojima","year":"2024","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bcp.2025.117620_b0300","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-0716-2099-1_19","article-title":"Inhibition of the HIF-1 survival pathway as a strategy to augment photodynamic therapy efficacy","volume":"2451","author":"de Keijzer","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"45","key":"10.1016\/j.bcp.2025.117620_b0305","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1038\/onc.2011.628","article-title":"Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers","volume":"31","author":"Yamadori","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2025.117620_b0310","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.freeradbiomed.2016.09.010","article-title":"An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy","volume":"99","author":"Zhu","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.117620_b0315","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fonc.2017.00085","article-title":"The KEAP1-NRF2 system in cancer","volume":"7","author":"Taguchi","year":"2017","journal-title":"Front. Oncol."},{"issue":"Pt B","key":"10.1016\/j.bcp.2025.117620_b0320","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2015.05.034","article-title":"Structural basis of Keap1 interactions with Nrf2","volume":"88","author":"Canning","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"16","key":"10.1016\/j.bcp.2025.117620_b0325","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","article-title":"Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2025.117620_b0330","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.freeradbiomed.2013.11.010","article-title":"p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling","volume":"67","author":"Rubio","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0335","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/03602530600971974","article-title":"Mechanistic studies of the Nrf2-Keap1 signaling pathway","volume":"38","author":"Zhang","year":"2006","journal-title":"Drug Metab. Rev."},{"issue":"24","key":"10.1016\/j.bcp.2025.117620_b0340","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1128\/MCB.24.24.10941-10953.2004","article-title":"Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex","volume":"24","author":"Zhang","year":"2004","journal-title":"Mol. Cell Biol."},{"issue":"38","key":"10.1016\/j.bcp.2025.117620_b0345","doi-asserted-by":"crossref","first-page":"15259","DOI":"10.1073\/pnas.1305687110","article-title":"Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex","volume":"110","author":"Baird","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0350","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1021\/tx700302s","article-title":"Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3","volume":"21","author":"Rachakonda","year":"2008","journal-title":"Chem. Res. Toxicol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0355","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/MCB.01704-07","article-title":"Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity","volume":"28","author":"Yamamoto","year":"2008","journal-title":"Mol. Cell Biol."},{"issue":"16","key":"10.1016\/j.bcp.2025.117620_b0360","doi-asserted-by":"crossref","first-page":"14019","DOI":"10.1074\/jbc.M110.190710","article-title":"Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism","volume":"286","author":"Kansanen","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0365","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.celrep.2019.06.047","article-title":"Molecular mechanism of cellular oxidative stress sensing by keap1","volume":"28","author":"Suzuki","year":"2019","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0370","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bcp.2012.11.016","article-title":"The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation","volume":"85","author":"Bryan","year":"2013","journal-title":"Biochem. Pharmacol."},{"issue":"29","key":"10.1016\/j.bcp.2025.117620_b0375","doi-asserted-by":"crossref","first-page":"10070","DOI":"10.1073\/pnas.0502402102","article-title":"Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2","volume":"102","author":"Eggler","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2025.117620_b0380","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.abb.2016.08.005","article-title":"Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants","volume":"617","author":"Dinkova-Kostova","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0385","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/MCB.26.1.221-229.2006","article-title":"Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1","volume":"26","author":"Kobayashi","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"45","key":"10.1016\/j.bcp.2025.117620_b0390","doi-asserted-by":"crossref","first-page":"42769","DOI":"10.1074\/jbc.M206911200","article-title":"Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription","volume":"277","author":"Huang","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0395","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"24","key":"10.1016\/j.bcp.2025.117620_b0400","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/sj.onc.1202237","article-title":"Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes","volume":"17","author":"Venugopal","year":"1998","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0405","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0410","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/mc.20465","article-title":"Molecular mechanisms of Nrf2-mediated antioxidant response","volume":"48","author":"Li","year":"2009","journal-title":"Mol. Carcinog."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0415","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1073\/pnas.0307301101","article-title":"Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers","volume":"101","author":"Wakabayashi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0420","doi-asserted-by":"crossref","first-page":"133","DOI":"10.14348\/molcells.2023.0028","article-title":"Molecular Basis of the KEAP1-NRF2 Signaling Pathway","volume":"46","author":"Suzuki","year":"2023","journal-title":"Mol. Cells"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0425","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2010.01.013","article-title":"Nrf2 the rescue: effects of the antioxidative\/electrophilic response on the liver","volume":"244","author":"Klaassen","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0430","first-page":"153","article-title":"Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy","volume":"7","author":"Hagiya","year":"2008","journal-title":"J. Exp. Ther. Oncol."},{"issue":"3\u20134","key":"10.1016\/j.bcp.2025.117620_b0435","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1081\/DMR-200033465","article-title":"Quinone reductases multitasking in the metabolic world","volume":"36","author":"Ross","year":"2004","journal-title":"Drug Metab. Rev."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0440","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem. Sci"},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0445","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1091\/mbc.e08-07-0762","article-title":"Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications","volume":"20","author":"Sakamoto","year":"2009","journal-title":"Mol. Biol. Cell"},{"issue":"22","key":"10.1016\/j.bcp.2025.117620_b0450","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M611336200","article-title":"GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2","volume":"282","author":"Jain","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2025.117620_b0455","first-page":"1497","article-title":"Cytoprotection \u201cgone astray\u201d: Nrf2 and its role in cancer","volume":"7","author":"Geismann","year":"2014","journal-title":"Onco Targets Ther"},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b0460","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1089\/ars.2010.3221","article-title":"Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway","volume":"13","author":"Hayes","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0465","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.taap.2009.08.028","article-title":"Targeting NRF2 signaling for cancer chemoprevention","volume":"244","author":"Kwak","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0470","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s11095-010-0096-8","article-title":"Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis","volume":"27","author":"Kundu","year":"2010","journal-title":"Pharm. Res."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0475","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.canep.2010.06.012","article-title":"Nrf2-ARE signaling pathway and natural products for cancer chemoprevention","volume":"34","author":"Zhao","year":"2010","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.bcp.2025.117620_b0480","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7857186","article-title":"Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician's expectation be matched by the reality?","volume":"2016","author":"Houghton","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0485","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/cas.13537","article-title":"NRF2 addiction in cancer cells","volume":"109","author":"Kitamura","year":"2018","journal-title":"Cancer Sci."},{"issue":"7354","key":"10.1016\/j.bcp.2025.117620_b0490","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature10189","article-title":"Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis","volume":"475","author":"DeNicola","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2025.117620_b0495","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fphys.2013.00246","article-title":"Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels","volume":"4","author":"Kong","year":"2013","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0500","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4161\/epi.23319","article-title":"Aberrant Keap1 methylation in breast cancer and association with clinicopathological features","volume":"8","author":"Barbano","year":"2013","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0505","first-page":"85","article-title":"Nrf2 expression in endometrial serous carcinomas and its precancers","volume":"4","author":"Chen","year":"2010","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0510","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/cam4.2101","article-title":"Nrf2 in cancers: a double-edged sword","volume":"8","author":"Wu","year":"2019","journal-title":"Cancer Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0515","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1158\/0008-5472.CAN-13-1655","article-title":"Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination","volume":"74","author":"Hast","year":"2014","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0520","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1158\/0008-5472.CAN-10-2939","article-title":"Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo","volume":"71","author":"Suzuki","year":"2011","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0525","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1158\/0008-5472.CAN-12-3227","article-title":"CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma","volume":"73","author":"Ooi","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2025.117620_b0530","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.lungcan.2019.05.002","article-title":"Impact of KEAP1\/NFE2L2\/CUL3 mutations on duration of response to EGFR tyrosine kinase inhibitors in EGFR mutated non-small cell lung cancer","volume":"134","author":"Hellyer","year":"2019","journal-title":"Lung Cancer"},{"key":"10.1016\/j.bcp.2025.117620_b0535","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/159459","article-title":"Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1\/CUL3\/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer","volume":"2014","author":"Martinez","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"15","key":"10.1016\/j.bcp.2025.117620_b0540","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.7150\/ijbs.67379","article-title":"Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4\/Pten mutant mice","volume":"17","author":"Zhao","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2025.117620_b0545","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.freeradbiomed.2013.06.041","article-title":"Oncogenic functions of the transcription factor Nrf2","volume":"65","author":"Ganan-Gomez","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0550","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2443.2010.01473.x","article-title":"Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution","volume":"16","author":"Taguchi","year":"2011","journal-title":"Genes Cells"},{"issue":"36","key":"10.1016\/j.bcp.2025.117620_b0555","doi-asserted-by":"crossref","first-page":"13568","DOI":"10.1073\/pnas.0806268105","article-title":"Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy","volume":"105","author":"Shibata","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0560","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.21037\/jtd.2016.06.08","article-title":"Mutations and expression of the NFE2L2\/KEAP1\/CUL3 pathway in chinese patients with lung squamous cell carcinoma","volume":"8","author":"Zhang","year":"2016","journal-title":"J. Thorac. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0565","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/lsm.21154","article-title":"The enhanced anti-cancer effect of hexenyl ester of 5-aminolaevulinic acid photodynamic therapy in adriamycin-resistant compared to non-resistant breast cancer cells","volume":"44","author":"Yoon","year":"2012","journal-title":"Lasers Surg. Med."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0570","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrc3278","article-title":"NRF2 and cancer: the good, the bad and the importance of context","volume":"12","author":"Sporn","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0575","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.freeradbiomed.2012.05.038","article-title":"An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses","volume":"53","author":"Lee","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"23","key":"10.1016\/j.bcp.2025.117620_b0580","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242316890","article-title":"Cellular mechanisms of singlet oxygen in photodynamic therapy","volume":"24","author":"Przygoda","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.bcp.2025.117620_b0585","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1073\/pnas.0611328104","article-title":"The role of singlet oxygen and oxygen concentration in photodynamic inactivation of bacteria","volume":"104","author":"Maisch","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b0590","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s43630-024-00620-8","article-title":"Generation of singlet oxygen inside living cells: correlation between phosphorescence decay lifetime, localization and outcome of photodynamic action","volume":"23","author":"Szewczyk","year":"2024","journal-title":"Photochem. Photobiol. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0595","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1161\/RES.0000000000000110","article-title":"Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the american heart association","volume":"119","author":"Griendling","year":"2016","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0600","article-title":"Superoxide radicals in the execution of cell death","volume":"11","author":"Fujii","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bcp.2025.117620_b0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102527","article-title":"How abundant are superoxide and hydrogen peroxide in the vasculature lumen, how far can they reach?","volume":"58","author":"Sousa","year":"2022","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0610","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nchembio.85","article-title":"Reconciling the chemistry and biology of reactive oxygen species","volume":"4","author":"Winterbourn","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0615","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1083\/jcb.201708007","article-title":"Superoxide dismutases: dual roles in controlling ROS damage and regulating ROS signaling","volume":"217","author":"Wang","year":"2018","journal-title":"J. Cell Biol."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0620","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1089\/ars.2013.5486","article-title":"Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver","volume":"21","author":"Reiniers","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0625","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.freeradbiomed.2012.01.013","article-title":"Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia\/reperfusion injury","volume":"52","author":"van Golen","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.117620_b0630","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9829176","article-title":"Evolution of the knowledge of free radicals and other oxidants","volume":"2020","author":"Di Meo","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2025.117620_b0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102250","article-title":"In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity","volume":"50","author":"Ledo","year":"2022","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0640","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.redox.2013.01.011","article-title":"An assay for the rate of removal of extracellular hydrogen peroxide by cells","volume":"1","author":"Wagner","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2025.117620_b0645","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/stresses2030019","article-title":"Chemistry of hydrogen peroxide formation and elimination in mammalian cells, and its role in various pathologies","volume":"2","author":"Andr\u00e9s","year":"2022","journal-title":"Stresses"},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0650","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1073\/pnas.95.7.3566","article-title":"Diffusion of peroxynitrite across erythrocyte membranes","volume":"95","author":"Denicola","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2025.117620_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbc.2024.100033","article-title":"Diffusion of peroxynitrite, its precursors, and derived reactive species, and the effect of cell membranes","volume":"9","author":"M\u00f6ller","year":"2024","journal-title":"Redox Biochemistry and Chemistry"},{"issue":"23","key":"10.1016\/j.bcp.2025.117620_b0660","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0665","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1465-9921-12-92","article-title":"Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system","volume":"12","author":"Gao","year":"2011","journal-title":"Respir. Res."},{"issue":"24","key":"10.1016\/j.bcp.2025.117620_b0670","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1038\/sj.onc.1209378","article-title":"Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity","volume":"25","author":"Nowis","year":"2006","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b0675","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.phymed.2013.04.018","article-title":"Synergistic enhancement of antitumor effect of beta-Lapachone by photodynamic induction of quinone oxidoreductase (NQO1)","volume":"20","author":"Lamberti","year":"2013","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0680","article-title":"Formyl-peptide receptor 2 signaling modulates SLC7A11\/xCT expression and activity in tumor cells","volume":"13","author":"Pecchillo Cimmino","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0685","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2006.01.013","article-title":"Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer","volume":"21","author":"Padmanabhan","year":"2006","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0690","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1053\/j.gastro.2008.06.082","article-title":"Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer","volume":"135","author":"Shibata","year":"2008","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0695","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1158\/1535-7163.MCT-09-0589","article-title":"Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth","volume":"9","author":"Zhang","year":"2010","journal-title":"Mol. Cancer Ther."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0700","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135257","article-title":"Cancer cell growth is differentially affected by constitutive activation of NRF2 by KEAP1 deletion and pharmacological activation of NRF2 by the synthetic triterpenoid, RTA 405","volume":"10","author":"Probst","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0705","doi-asserted-by":"crossref","first-page":"12846","DOI":"10.1038\/s41598-018-31281-0","article-title":"A catalogue of somatic NRF2 gain-of-function mutations in cancer","volume":"8","author":"Kerins","year":"2018","journal-title":"Sci. Rep."},{"issue":"29","key":"10.1016\/j.bcp.2025.117620_b0710","doi-asserted-by":"crossref","first-page":"20508","DOI":"10.18632\/oncotarget.24974","article-title":"Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells","volume":"9","author":"Lisek","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2025.117620_b0715","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28083","article-title":"Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer","volume":"6","author":"Sayin","year":"2017","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b0720","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107158","article-title":"The sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencing","volume":"9","author":"Choi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2025.117620_b0725","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.biopha.2018.09.159","article-title":"NQO1 induction mediated by photodynamic therapy synergizes with beta-Lapachone-halogenated derivative against melanoma","volume":"108","author":"Lamberti","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2025.117620_b0730","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.abb.2006.02.009","article-title":"Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin","volume":"449","author":"Dabrowski","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0735","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2025.117620_b0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.124268","article-title":"Homologous-targeting biomimetic nanoparticles for photothermal therapy and Nrf2-siRNA amplified photodynamic therapy against oral tongue squamous cell carcinoma","volume":"388","author":"Shi","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.bcp.2025.117620_b0745","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102056","article-title":"Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway","volume":"45","author":"Shui","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2025.117620_b0750","doi-asserted-by":"crossref","first-page":"44497","DOI":"10.1038\/srep44497","article-title":"Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms","volume":"7","author":"Kralova","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0755","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12987-017-0055-4","article-title":"Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress","volume":"14","author":"Ibbotson","year":"2017","journal-title":"Fluids Barriers CNS"},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0760","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41419-022-05044-9","article-title":"High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1\/MRP1 upregulation","volume":"13","author":"de Souza","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2025.117620_b0765","article-title":"Autophagy regulation and photodynamic therapy: insights to improve outcomes of cancer treatment","volume":"10","author":"Martins","year":"2020","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0770","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.molcel.2010.09.012","article-title":"Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop","volume":"40","author":"Steffen","year":"2010","journal-title":"Mol. Cell"},{"issue":"14","key":"10.1016\/j.bcp.2025.117620_b0775","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.cub.2014.06.004","article-title":"Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97","volume":"24","author":"Sha","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bcp.2025.117620_b0780","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b0785","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0790","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","article-title":"NF-kappaB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"22","key":"10.1016\/j.bcp.2025.117620_b0795","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25225474","article-title":"An overview of Nrf2 signaling pathway and its role in inflammation","volume":"25","author":"Saha","year":"2020","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b0800","doi-asserted-by":"crossref","first-page":"6933","DOI":"10.4049\/jimmunol.180.10.6933","article-title":"Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2- production in a two-hit model of alcohol intoxication and burn injury","volume":"180","author":"Li","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2025.117620_b0805","article-title":"Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"14","key":"10.1016\/j.bcp.2025.117620_b0810","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"A NRF2 regulated and the immunosuppressive microenvironment reversed nanoplatform for cholangiocarcinoma photodynamic-gas therapy","volume":"11","author":"Wang","year":"2024","journal-title":"Adv Sci (weinh)"},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0815","doi-asserted-by":"crossref","first-page":"F464","DOI":"10.1152\/ajprenal.00501.2020","article-title":"Nrf2 mediates hypoxia-inducible HIF1alpha activation in kidney tubular epithelial cells","volume":"320","author":"Potteti","year":"2021","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bcp.2025.117620_b0820","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101210","article-title":"Impairment of HIF-1alpha-mediated metabolic adaption by NRF2-silencing in breast cancer cells","volume":"24","author":"Lee","year":"2019","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0825","doi-asserted-by":"crossref","first-page":"364","DOI":"10.18632\/aging.202137","article-title":"Enhancer-bound Nrf2 licenses HIF-1alpha transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells","volume":"13","author":"Jin","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bcp.2025.117620_b0830","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.freeradbiomed.2022.11.039","article-title":"Overactivated NRF2 induces pseudohypoxia in hepatocellular carcinoma by stabilizing HIF-1alpha","volume":"194","author":"Zheng","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0835","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1158\/0008-5472.CAN-10-3007","article-title":"NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1alpha","volume":"71","author":"Kim","year":"2011","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b0840","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1167\/iovs.09-3648","article-title":"Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K\/AKT signaling through inhibition of the lipid phosphatase PTEN","volume":"50","author":"Pitha-Rowe","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"40","key":"10.1016\/j.bcp.2025.117620_b0845","doi-asserted-by":"crossref","first-page":"65389","DOI":"10.18632\/oncotarget.11700","article-title":"Activation of AKT pathway by Nrf2\/PDGFA feedback loop contributes to HCC progression","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b0850","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3390\/toxins14110733","article-title":"Role of PI3K\/Akt-mediated Nrf2\/HO-1 signaling pathway in resveratrol alleviation of zearalenone-induced oxidative stress and apoptosis in TM4 cells","volume":"14","author":"Xu","year":"2022","journal-title":"Toxins (basel)"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b0855","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096035","article-title":"Nrf2 negatively regulates melanogenesis by modulating PI3K\/Akt signaling","volume":"9","author":"Shin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2025.117620_b0860","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2019.111672","article-title":"The ROS-KRAS-Nrf2 axis in the control of the redox homeostasis and the intersection with survival-apoptosis pathways: implications for photodynamic therapy","volume":"202","author":"Ferino","year":"2020","journal-title":"J. Photochem. Photobiol. B"},{"issue":"17","key":"10.1016\/j.bcp.2025.117620_b0865","doi-asserted-by":"crossref","first-page":"17301","DOI":"10.1074\/jbc.M500363200","article-title":"EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity","volume":"280","author":"Koolpe","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b0870","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1158\/0008-5472.CAN-18-3257","article-title":"Inhibition of EphB4-Ephrin-B2 signaling reprograms the tumor immune microenvironment in head and neck cancers","volume":"79","author":"Bhatia","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2025.117620_b0875","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jconrel.2017.05.015","article-title":"Overcoming photodynamic resistance and tumor targeting dual-therapy mediated by indocyanine green conjugated gold nanospheres","volume":"258","author":"Li","year":"2017","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b0880","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1562\/0031-8655(2000)072<0186:POAAIP>2.0.CO;2","article-title":"Phototransformations of 5-aminolevulinic acid-induced protoporphyrin IX in vitro: a spectroscopic study","volume":"72","author":"Bagdonas","year":"2000","journal-title":"Photochem. Photobiol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0885","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1039\/b703361c","article-title":"Increase in protoporphyrin IX after 5-aminolevulinic acid based photodynamic therapy is due to local re-synthesis","volume":"6","author":"de Bruijn","year":"2007","journal-title":"Photochem. Photobiol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b0890","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pdpdt.2011.12.004","article-title":"Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro","volume":"9","author":"Hagiya","year":"2012","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"13","key":"10.1016\/j.bcp.2025.117620_b0895","first-page":"1824","article-title":"Enhancement of the effect of methyl pyropheophorbide-a-mediated photodynamic therapy was achieved by increasing ROS through inhibition of Nrf2-HO-1 or Nrf2-ABCG2 signaling","volume":"17","author":"Tian","year":"2017","journal-title":"Anticancer Agents Med Chem."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0900","doi-asserted-by":"crossref","first-page":"17639","DOI":"10.1038\/s41598-019-54065-6","article-title":"The balance between NRF2\/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells","volume":"9","author":"Silva","year":"2019","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.bcp.2025.117620_b0905","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1158\/1078-0432.CCR-11-0736","article-title":"Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism","volume":"17","author":"Fath","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0910","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.gendis.2022.02.009","article-title":"Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC)","volume":"9","author":"Hong","year":"2022","journal-title":"Genes Dis"},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b0915","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1083\/jcb.201804161","article-title":"Glutathione metabolism in cancer progression and treatment resistance","volume":"217","author":"Bansal","year":"2018","journal-title":"J. Cell Biol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0920","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1080\/15384101.2016.1158374","article-title":"GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment","volume":"15","author":"Zhao","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2025.117620_b0925","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.102078","article-title":"Dihydroartemisinin administration improves the effectiveness of 5-aminolevulinic acid-mediated photodynamic therapy for the treatment of high-risk human papillomavirus infection","volume":"33","author":"Li","year":"2021","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"27","key":"10.1016\/j.bcp.2025.117620_b0930","doi-asserted-by":"crossref","first-page":"24393","DOI":"10.18632\/oncotarget.5162","article-title":"Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death","volume":"6","author":"Kwon","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2025.117620_b0935","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2017.12.025","article-title":"Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis","volume":"416","author":"Chang","year":"2018","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0940","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00044.2017","article-title":"Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells","volume":"314","author":"Adedoyin","year":"2018","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b0945","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.7150\/ijbs.59404","article-title":"Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells","volume":"17","author":"Wei","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2025.117620_b0950","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111152","article-title":"HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation","volume":"399","author":"Lv","year":"2024","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0955","article-title":"Crosstalk between heme oxygenase-1 and iron metabolism in macrophages: implications for the modulation of inflammation and immunity","volume":"11","author":"de Oliveira","year":"2022","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.bcp.2025.117620_b0960","doi-asserted-by":"crossref","first-page":"10111","DOI":"10.1038\/ncomms10111","article-title":"Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0965","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1073\/pnas.1600459113","article-title":"Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7","volume":"113","author":"Ismail","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"33","key":"10.1016\/j.bcp.2025.117620_b0970","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1002\/anie.200604697","article-title":"Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs","volume":"46","author":"Stocks","year":"2007","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b0975","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/s13046-019-1413-7","article-title":"Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK\/ATF4\/HSPA5 pathway in glioma cells","volume":"38","author":"Chen","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b0980","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20193314","article-title":"Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition","volume":"40","author":"Yi","year":"2020","journal-title":"Biosci. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b0985","doi-asserted-by":"crossref","DOI":"10.3892\/or.2021.8191","article-title":"Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response\u2013induced upregulation of CHAC1 expression","volume":"46","author":"Wang","year":"2021","journal-title":"Oncol. Rep."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b0990","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18335","article-title":"Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway","volume":"28","author":"Ji","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2025.117620_b0995","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fncel.2017.00310","article-title":"Dihydroartemisinin exerts anti-tumor activity by inducing mitochondrion and endoplasmic reticulum apoptosis and autophagic cell death in human glioblastoma cells","volume":"11","author":"Qu","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bcp.2025.117620_b1000","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/ijpvm.IJPVM_258_17","article-title":"Dihydroartemisinin induces apoptosis in human bladder cancer cell lines through reactive oxygen species, mitochondrial membrane potential, and cytochrome c pathway","volume":"8","author":"Poupel","year":"2017","journal-title":"Int. J. Prev. Med."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1005","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s10495-006-0016-x","article-title":"Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy","volume":"12","author":"Kocanova","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.bcp.2025.117620_b1010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102572","article-title":"Halofuginone enhances the anti-tumor effect of ALA-PDT by suppressing NRF2 signaling in cSCC","volume":"37","author":"Lv","year":"2022","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1015","doi-asserted-by":"crossref","first-page":"6404","DOI":"10.1021\/acsami.1c22861","article-title":"Enhanced ROS-boosted phototherapy against pancreatic cancer via Nrf2-mediated stress-defense pathway suppression and ferroptosis induction","volume":"14","author":"Tao","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1020","doi-asserted-by":"crossref","first-page":"396","DOI":"10.14348\/molcells.2015.2183","article-title":"3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway","volume":"38","author":"Hou","year":"2015","journal-title":"Mol. Cells"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1025","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00280-010-1313-1","article-title":"Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone)","volume":"67","author":"Cai","year":"2011","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b1030","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1158\/1940-6207.CAPR-09-0081","article-title":"Flavones as colorectal cancer chemopreventive agents\u2013phenol-o-methylation enhances efficacy","volume":"2","author":"Cai","year":"2009","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"14","key":"10.1016\/j.bcp.2025.117620_b1035","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1080\/14786419.2022.2039138","article-title":"New flavone, and cytotoxicity activity of Rauia resinosa ethanolic extract and constituents","volume":"37","author":"Sousa","year":"2023","journal-title":"Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1040","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0031-9422(00)00248-X","article-title":"Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities","volume":"55","author":"Tomazela","year":"2000","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1045","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/bmc.1120","article-title":"Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection","volume":"23","author":"Cai","year":"2009","journal-title":"Biomed. Chromatogr."},{"issue":"16","key":"10.1016\/j.bcp.2025.117620_b1050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168949","article-title":"Synthesis of new AIEE-active chalcones for imaging of mitochondria in living cells and zebrafish in vivo","volume":"22","author":"Luo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1055","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cbi.2013.03.012","article-title":"2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells","volume":"203","author":"Kim","year":"2013","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1060","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s10059-013-0123-9","article-title":"4-methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2\/ARE-mediated defense mechanism in A549 lung cancer cells","volume":"36","author":"Lim","year":"2013","journal-title":"Mol. Cells"},{"issue":"Pt A","key":"10.1016\/j.bcp.2025.117620_b1065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.fct.2017.05.032","article-title":"Regulatory effects of 4-methoxychalcone on adipocyte differentiation through PPARgamma activation and reverse effect on TNF-alpha in 3T3-L1 cells","volume":"106","author":"Han","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bcp.2025.117620_b1070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1874104501105010061","article-title":"Kinetic analysis of some chalcones and synthetic chalcone analogues on the fenton-reaction initiated deoxyribose degradation assay","volume":"5","author":"Perjesi","year":"2011","journal-title":"Open Med. Chem. J."},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b1075","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1021\/acschembio.5b00448","article-title":"A small molecule inhibits deregulated NRF2 transcriptional activity in cancer","volume":"10","author":"Bollong","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bcp.2025.117620_b1080","unstructured":"N.M. Stacks, Apigenin and naringenin: natural sources, pharmacology and role in cancer prevention. Biochemistry Research Trends. 2015: Nova Science Publishers, Incorporated."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1085","first-page":"195","article-title":"Interspecies difference of luteolin and apigenin after oral administration of Chrysanthemum morifolium extract and prediction of human pharmacokinetics","volume":"68","author":"Li","year":"2013","journal-title":"Pharmazie"},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1090","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10895-007-0222-0","article-title":"Acidichromism and ionochromism of luteolin and apigenin, the main components of the naturally occurring yellow weld: a spectrophotometric and fluorimetric study","volume":"17","author":"Favaro","year":"2007","journal-title":"J. Fluoresc."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b1095","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/carcin\/bgn201","article-title":"Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study","volume":"29","author":"Kaur","year":"2008","journal-title":"Carcinogenesis"},{"issue":"24","key":"10.1016\/j.bcp.2025.117620_b1100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413455","article-title":"Apigenin induces autophagy and cell death by targeting EZH2 under hypoxia conditions in gastric cancer cells","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"31","key":"10.1016\/j.bcp.2025.117620_b1105","doi-asserted-by":"crossref","first-page":"31216","DOI":"10.18632\/oncotarget.5157","article-title":"Apigenin blocks IKKalpha activation and suppresses prostate cancer progression","volume":"6","author":"Shukla","year":"2015","journal-title":"Oncotarget"},{"issue":"52","key":"10.1016\/j.bcp.2025.117620_b1110","doi-asserted-by":"crossref","first-page":"15118","DOI":"10.1021\/jp9052538","article-title":"Absorption and emission of the apigenin and luteolin flavonoids: a TDDFT investigation","volume":"113","author":"Amat","year":"2009","journal-title":"J. Phys. Chem. A"},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b1115","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/carcin\/bgt108","article-title":"Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402\/ADM cells to doxorubicin via inhibiting PI3K\/Akt\/Nrf2 pathway","volume":"34","author":"Gao","year":"2013","journal-title":"Carcinogenesis"},{"issue":"47","key":"10.1016\/j.bcp.2025.117620_b1120","doi-asserted-by":"crossref","first-page":"82085","DOI":"10.18632\/oncotarget.18294","article-title":"Apigenin sensitizes BEL-7402\/ADM cells to doxorubicin through inhibiting miR-101\/Nrf2 pathway","volume":"8","author":"Gao","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s13046-018-0929-6","article-title":"Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects","volume":"37","author":"Xu","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b1130","article-title":"Regulation of Nrf2\/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?","volume":"9","author":"T","year":"2020","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1135","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.canlet.2016.06.023","article-title":"Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells","volume":"380","author":"Coombs","year":"2016","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1140","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3892\/ol.2017.5619","article-title":"The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells","volume":"13","author":"Mostafavi-Pour","year":"2017","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1145","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.exphem.2004.01.007","article-title":"Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line","volume":"32","author":"Tarumoto","year":"2004","journal-title":"Exp. Hematol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1150","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.freeradbiomed.2005.10.034","article-title":"Ascorbic acid suppresses cell death in rat DS-sarcoma cancer cells induced by 5-aminolevulinic acid-based photodynamic therapy","volume":"40","author":"Frank","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.117620_b1155","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3389\/fonc.2020.01483","article-title":"Mechanisms and applications of the anti-cancer effect of pharmacological ascorbic acid in cervical cancer cells","volume":"10","author":"Wu","year":"2020","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b1160","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1080\/01635581.2020.1819346","article-title":"Chemoprevention of prostate cancer cells by vitamin c plus quercetin: role of Nrf2 in inducing oxidative stress","volume":"73","author":"Abbasi","year":"2021","journal-title":"Nutr. Cancer"},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b1165","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.freeradbiomed.2005.12.027","article-title":"Ascorbate enhances the toxicity of the photodynamic action of Verteporfin in HL-60 cells","volume":"40","author":"Kramarenko","year":"2006","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1170","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/lsm.21157","article-title":"Enhancement of photodynamic antitumor effect with pro-oxidant ascorbate","volume":"44","author":"Wei","year":"2012","journal-title":"Lasers Surg. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1175","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/biof.129","article-title":"The outcome of 5-ALA-mediated photodynamic treatment in melanoma cells is influenced by vitamin C and heme oxygenase-1","volume":"37","author":"Grimm","year":"2011","journal-title":"Biofactors"},{"issue":"17","key":"10.1016\/j.bcp.2025.117620_b1180","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202110832","article-title":"Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics","volume":"61","author":"Koo","year":"2022","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-11-1","article-title":"Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2","volume":"11","author":"Wagner","year":"2011","journal-title":"BMC Complement. Altern. Med."},{"issue":"18","key":"10.1016\/j.bcp.2025.117620_b1190","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1021\/jm5007534","article-title":"Novel nitric oxide-releasing derivatives of brusatol as anti-inflammatory agents: design, synthesis, biological evaluation, and nitric oxide release studies","volume":"57","author":"Tang","year":"2014","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1195","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s42003-020-0996-z","article-title":"Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kgamma isoform","volume":"3","author":"Pei","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bcp.2025.117620_b1200","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jchromb.2017.04.012","article-title":"Determination of brusatol in plasma and tissues by LC-MS method and its application to a pharmacokinetic and distribution study in mice","volume":"1053","author":"Guo","year":"2017","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bcp.2025.117620_b1205","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jpba.2016.02.046","article-title":"Determination of a potential antitumor quassinoid in rat plasma by UPLC-MS\/MS and its application in a pharmacokinetic study","volume":"124","author":"Zhang","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bcp.2025.117620_b1210","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.freeradbiomed.2014.11.003","article-title":"Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2","volume":"78","author":"Olayanju","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1215","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/mc.22609","article-title":"Brusatol overcomes chemoresistance through inhibition of protein translation","volume":"56","author":"Harder","year":"2017","journal-title":"Mol. Carcinog."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1220","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.1014275108","article-title":"Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism","volume":"108","author":"Ren","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2025.117620_b1225","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106059","article-title":"Brusatol has therapeutic efficacy in non-small cell lung cancer by targeting Skp1 to inhibit cancer growth and metastasis","volume":"176","author":"Xing","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1230","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1074\/mcp.M115.055509","article-title":"Application of mass spectrometry profiling to establish brusatol as an inhibitor of global protein synthesis","volume":"15","author":"Vartanian","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b1235","doi-asserted-by":"crossref","DOI":"10.3390\/biom9100550","article-title":"Brusatol, a Nrf2 inhibitor targets STAT3 signaling cascade in head and neck squamous cell carcinoma","volume":"9","author":"Lee","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2025.117620_b1240","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jare.2020.07.004","article-title":"Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma","volume":"26","author":"Lee","year":"2020","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bcp.2025.117620_b1245","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119907","article-title":"Brusatol inhibits laryngeal cancer cell proliferation and metastasis via abrogating JAK2\/STAT3 signaling mediated epithelial-mesenchymal transition","volume":"284","author":"Zhou","year":"2021","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1250","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/CAD.0000000000001022","article-title":"Brusatol reverses lipopolysaccharide-induced epithelial-mesenchymal transformation and induces apoptosis through PI3K\/Akt\/NF-\u043aB pathway in human gastric cancer SGC-7901 cells","volume":"32","author":"Chen","year":"2021","journal-title":"Anticancer Drugs"},{"issue":"Suppl 4","key":"10.1016\/j.bcp.2025.117620_b1255","first-page":"S436","article-title":"Inhibitory and cytotoxic activities of chrysin on human breast adenocarcinoma cells by induction of apoptosis","volume":"12","author":"Samarghandian","year":"2016","journal-title":"Pharmacogn. Mag."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1260","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/01480545.2019.1687510","article-title":"Toxicological evaluation of a flavonoid, chrysin: morphological, behavioral, biochemical and histopathological assessments in rats","volume":"44","author":"Yao","year":"2021","journal-title":"Drug Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1265","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2125.2001.01317.x","article-title":"Disposition and metabolism of the flavonoid chrysin in normal volunteers","volume":"51","author":"Walle","year":"2001","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1270","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.3390\/ijms11052188","article-title":"Apoptotic effects of chrysin in human cancer cell lines","volume":"11","author":"Khoo","year":"2010","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1275","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cbi.2013.08.008","article-title":"Chrysin enhances sensitivity of BEL-7402\/ADM cells to doxorubicin by suppressing PI3K\/Akt\/Nrf2 and ERK\/Nrf2 pathway","volume":"206","author":"Gao","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bcp.2025.117620_b1280","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2147\/DDDT.S160020","article-title":"Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK\/Nrf2 signaling pathway","volume":"12","author":"Wang","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1285","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00204-012-0913-4","article-title":"Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes","volume":"87","author":"Huang","year":"2013","journal-title":"Arch. Toxicol."},{"issue":"7\u20138","key":"10.1016\/j.bcp.2025.117620_b1290","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/1747519820907248","article-title":"Novel photosensitizing properties of porphyrin\u2013chrysin derivatives with antitumor activity in vitro","volume":"44","author":"Liu","year":"2020","journal-title":"J. Chem. Res."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b1295","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1007\/s11010-021-04105-5","article-title":"Chrysin attenuates high-fat-diet-induced myocardial oxidative stress via upregulating eNOS and Nrf2 target genes in rats","volume":"476","author":"Yuvaraj","year":"2021","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1300","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4155\/fmc-2019-0285","article-title":"Small molecular Nrf2 inhibitors as chemosensitizers for cancer therapy","volume":"12","author":"Lin","year":"2020","journal-title":"Future Med. Chem."},{"issue":"37","key":"10.1016\/j.bcp.2025.117620_b1305","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1038\/onc.2017.153","article-title":"A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer","volume":"36","author":"Choi","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2025.117620_b1310","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107509","article-title":"Spleen tyrosine kinase regulates crosstalk of hypoxia-inducible factor-1alpha and nuclear factor (erythroid-derived2)-like 2 for B cell survival","volume":"95","author":"Jang","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1315","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/bjd.13284","article-title":"Topical corticosteroid reduces inflammation without compromising the efficacy of photodynamic therapy for actinic keratoses: a randomized clinical trial","volume":"171","author":"Wiegell","year":"2014","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1320","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/ijc.27343","article-title":"Cryptotanshinone down-regulates androgen receptor signaling by modulating lysine-specific demethylase 1 function","volume":"131","author":"Wu","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1325","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/emm.2005.18","article-title":"Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro","volume":"37","author":"Hur","year":"2005","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1330","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0731-7085(99)00098-9","article-title":"Reversed-phase liquid chromatographic determination of cryptotanshinone and its active metabolite in pig plasma and urine","volume":"21","author":"Xue","year":"1999","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1335","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/00498250701827685","article-title":"Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza)","volume":"38","author":"Pan","year":"2008","journal-title":"Xenobiotica"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1340","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1386-1425(03)00286-5","article-title":"Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I","volume":"60","author":"Li","year":"2004","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.bcp.2025.117620_b1345","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3389\/fphar.2020.01264","article-title":"Uncovering the mechanisms of cryptotanshinone as a therapeutic agent against hepatocellular carcinoma","volume":"11","author":"Luo","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117620_b1350","doi-asserted-by":"crossref","DOI":"10.3389\/fddsv.2022.815017","article-title":"A mini-review of the anticancer properties of cryptotanshinone: a quinoid diterpene extracted from the root of salvia miotiorrhiza bunge","volume":"2","author":"Naziri","year":"2022","journal-title":"Front. Drug Discovery"},{"key":"10.1016\/j.bcp.2025.117620_b1355","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111332","article-title":"A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen","volume":"137","author":"Li","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1360","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1159\/000430398","article-title":"Cryptotanshinone reverses cisplatin resistance of human lung carcinoma A549 cells through down-regulating Nrf2 pathway","volume":"37","author":"Xia","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2025.117620_b1365","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13020-020-00303-3","article-title":"Cryptotanshinone from Salvia miltiorrhiza Bunge (Danshen) inhibited inflammatory responses via TLR4\/MyD88 signaling pathway","volume":"15","author":"Li","year":"2020","journal-title":"Chin. Med."},{"issue":"16","key":"10.1016\/j.bcp.2025.117620_b1370","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25163602","article-title":"Neuroprotective effects of cryptotanshinone in a direct reprogramming model of parkinson's disease","volume":"25","author":"Lee","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2025.117620_b1375","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173647","article-title":"Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase","volume":"890","author":"Cao","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117620_b1380","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104740","article-title":"Non-classical cardenolides from Calotropis gigantea exhibit anticancer effect as HIF-1 inhibitors","volume":"109","author":"Zheng","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003088-197702010-00001","article-title":"Clinical pharmacokinetics of digoxin","volume":"2","author":"Iisalo","year":"1977","journal-title":"Clin. Pharmacokinet."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1390","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0378-4347(00)83601-4","article-title":"Analysis of digoxin at therapeutic concentrations using high-performance liquid chromatography with post-column derivatization","volume":"381","author":"Kwong","year":"1986","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.bcp.2025.117620_b1395","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101131","article-title":"Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway","volume":"22","author":"Zhou","year":"2019","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b1400","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20211056","article-title":"Digoxin exerts anticancer activity on human nonsmall cell lung cancer cells by blocking PI3K\/Akt pathway","volume":"41","author":"Wang","year":"2021","journal-title":"Biosci. Rep."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b1405","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26071905","article-title":"Na(+)\/K(+)-ATPase revisited: on its mechanism of action, role in cancer, and activity modulation","volume":"26","author":"Bejcek","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2025.117620_b1410","unstructured":"M.N.V. David, M. Shetty, Digoxin, [Updated 2024 Nov 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK556025\/."},{"issue":"2\u20133","key":"10.1016\/j.bcp.2025.117620_b1415","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1054\/tube.2002.0330","article-title":"Population pharmacokinetics of ethionamide in patients with tuberculosis","volume":"82","author":"Zhu","year":"2002","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1016\/j.bcp.2025.117620_b1420","unstructured":"Brown, M.J., et al., Clinical Pharmacology - E-Book. 2018: Elsevier Health Sciences."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1425","first-page":"4","article-title":"Validated UV-spectrophotometric method for the ethionamide estimation in bulk, tablet and nanoparticles","volume":"9","author":"Sujit Kumar Debnath","year":"2017","journal-title":"Int J Drug Dev & Res"},{"key":"10.1016\/j.bcp.2025.117620_b1430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2015.12.008","article-title":"Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells","volume":"292","author":"Peng","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117620_b1435","article-title":"Febrifugine dihydrochloride as a new oral chemotherapeutic agent against visceral leishmaniasis infection","volume":"236\u2013237","author":"Pandey","year":"2022","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bcp.2025.117620_b1440","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2016.12.041","article-title":"Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation","volume":"103","author":"Tsuchida","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1445","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1128\/AAC.49.3.1169-1176.2005","article-title":"Antimalarial activities and therapeutic properties of febrifugine analogs","volume":"49","author":"Jiang","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2025.117620_b1450","doi-asserted-by":"crossref","unstructured":"Singh Ningthoujam, S., et al., Chapter 3 - Febrifugine and Its Analogs: Studies for Their Antimalarial and Other Therapeutic Properties, in Studies in Natural Products Chemistry, R. Atta ur, Editor. 2015, Elsevier. p. 93-112.","DOI":"10.1016\/B978-0-444-63460-3.00003-1"},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1455","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/0007-1935(89)90116-4","article-title":"Pharmacokinetics of halofuginone in cattle","volume":"145","author":"Kinabo","year":"1989","journal-title":"Br. Vet. J."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1460","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/jb\/mvab025","article-title":"Targeting Nrf2-antioxidant signalling reverses acquired cabazitaxel resistance in prostate cancer cells","volume":"170","author":"Endo","year":"2021","journal-title":"J. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1465","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/molecules20010573","article-title":"Halofuginone - the multifaceted molecule","volume":"20","author":"Pines","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2025.117620_b1470","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116794","article-title":"Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis","volume":"235","author":"Zaghloul","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117620_b1475","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102224","article-title":"Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: involvement of NRF2 regulation","volume":"49","author":"Yuan","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2025.117620_b1480","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopha.2018.01.100","article-title":"Halofuginone attenuates intervertebral discs degeneration by suppressing collagen I production and inactivating TGFbeta and NF-kappaB pathway","volume":"101","author":"Luo","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1485","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3892\/ijo.2013.2157","article-title":"Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9","volume":"44","author":"Jin","year":"2014","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1490","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nchembio.790","article-title":"Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase","volume":"8","author":"Keller","year":"2012","journal-title":"Nat. Chem. Biol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b1495","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.ejca.2005.12.027","article-title":"Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours","volume":"42","author":"de Jonge","year":"2006","journal-title":"Eur. J. Cancer"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1500","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/pros.10059","article-title":"Growth inhibition of prostate cancer xenografts by halofuginone","volume":"51","author":"Gavish","year":"2002","journal-title":"Prostate"},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b1505","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.5012\/bkcs.2014.35.12.3623","article-title":"Synthesis and biological evaluation of novel IM3829 (4-(2-Cyclohexylethoxy)aniline) derivatives as potent radiosensitizers","volume":"35","author":"Ahn","year":"2014","journal-title":"Bull. Kor. Chem. Soc."},{"key":"10.1016\/j.bcp.2025.117620_b1510","doi-asserted-by":"crossref","unstructured":"G.B. Migliori, Infectious Diseases || Antituberculosis Agents, fourth ed., vol. 2, Elsevier, 2017, pp. 1264-1276.e2. https:\/\/doi.org\/10.1016\/B978-0-7020-6285-8.00148-9.","DOI":"10.1016\/B978-0-7020-6285-8.00148-9"},{"key":"10.1016\/j.bcp.2025.117620_b1515","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.redox.2015.06.020","article-title":"Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis","volume":"6","author":"Verma","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2025.117620_b1520","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.lfs.2018.02.037","article-title":"Isoniazid induces apoptosis: Role of oxidative stress and inhibition of nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)","volume":"199","author":"Verma","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2025.117620_b1525","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jconrel.2018.04.038","article-title":"Mitochondria-targeted prostate cancer therapy using a near-infrared fluorescence dye-monoamine oxidase a inhibitor conjugate","volume":"279","author":"Lv","year":"2018","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1530","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1039\/C6SC03028A","article-title":"Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity","volume":"8","author":"Smith","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bcp.2025.117620_b1535","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152749","article-title":"Oral isoniazid causes oxidative stress, oocyte deterioration and infertility in mice","volume":"455","author":"Qiao","year":"2021","journal-title":"Toxicology"},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b1540","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091151","article-title":"Rapid tumor targeting of renal-clearable ZW800-1 conjugate for efficient photothermal cancer therapy","volume":"9","author":"Park","year":"2021","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1545","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/cam4.1949","article-title":"The discovery and characterization of K-563, a novel inhibitor of the Keap1\/Nrf2 pathway produced by Streptomyces sp","volume":"8","author":"Hori","year":"2019","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1550","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12885-021-08158-z","article-title":"Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt\/mTOR signaling","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1555","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.freeradbiomed.2007.10.050","article-title":"Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity","volume":"44","author":"Triantafyllou","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.117620_b1560","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fitote.2016.10.008","article-title":"Pharmacokinetics of dietary kaempferol and its metabolite 4-hydroxyphenylacetic acid in rats","volume":"115","author":"Zabela","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bcp.2025.117620_b1565","doi-asserted-by":"crossref","unstructured":"Mukai, R., et al., Determination of Subcellular Localization of Flavonol in Cultured Cells by Laser Scanning, in Laser Scanning, Theory and Applications, C.-C. Wang, Editor. 2011.","DOI":"10.5772\/15717"},{"key":"10.1016\/j.bcp.2025.117620_b1570","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108700","article-title":"Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells","volume":"697","author":"Fouzder","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1575","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1039\/C9FO02951F","article-title":"Kaempferol modulates TCDD- and t-BHQ-induced drug-metabolizing enzymes and luteolin enhances this effect","volume":"11","author":"Kitakaze","year":"2020","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1580","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.tiv.2011.01.008","article-title":"Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2","volume":"25","author":"Niestroy","year":"2011","journal-title":"Toxicol. In Vitro"},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b1585","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.freeradbiomed.2011.03.008","article-title":"Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2\/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs","volume":"50","author":"Tang","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1590","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.7314\/APJCP.2014.15.6.2911","article-title":"Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway","volume":"15","author":"Chian","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b1595","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1292\/jvms.16-0196","article-title":"Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats","volume":"78","author":"Kanai","year":"2016","journal-title":"J. Vet. Med. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1600","first-page":"3842","article-title":"Luteolin inhibits cell cycle progression and induces apoptosis of breast cancer cells through downregulation of human telomerase reverse transcriptase","volume":"17","author":"Huang","year":"2019","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1605","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1021\/jf072612+","article-title":"Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin","volume":"56","author":"Zhou","year":"2008","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1610","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2014.04.039","article-title":"Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo","volume":"447","author":"Chian","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0238-y","article-title":"Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells","volume":"51","author":"Kang","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"13","key":"10.1016\/j.bcp.2025.117620_b1620","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.7314\/APJCP.2014.15.13.5311","article-title":"Luteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling","volume":"15","author":"Sabzichi","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b1625","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/bdd.1956","article-title":"Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin","volume":"36","author":"Paredes-Gonzalez","year":"2015","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.bcp.2025.117620_b1630","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.abb.2014.05.023","article-title":"Luteolin modulates expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways in hepatic cells","volume":"557","author":"Zhang","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2025.117620_b1635","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.fct.2013.05.058","article-title":"Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury","volume":"59","author":"Zhang","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1640","doi-asserted-by":"crossref","DOI":"10.1177\/1010428318815413","article-title":"Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes","volume":"41","author":"Urpilainen","year":"2019","journal-title":"Tumour Biol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b1645","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.7150\/ijbs.18830","article-title":"Metformin sensitizes non-small cell lung cancer cells to an epigallocatechin-3-gallate (EGCG) treatment by suppressing the Nrf2\/HO-1 signaling pathway","volume":"13","author":"Yu","year":"2017","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1650","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.taap.2013.05.010","article-title":"Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways","volume":"271","author":"Do","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1655","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13058-015-0540-0","article-title":"Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study","volume":"17","author":"Dowling","year":"2015","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.bcp.2025.117620_b1660","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.freeradbiomed.2014.06.010","article-title":"Metformin induces microRNA-34a to downregulate the Sirt1\/Pgc-1alpha\/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents","volume":"74","author":"Do","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.117620_b1665","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119421","article-title":"Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer","volume":"222","author":"Broekgaarden","year":"2019","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1670","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3892\/ol.2017.6237","article-title":"Metformin enhances the cytotoxicity of 5-aminolevulinic acid-mediated photodynamic therapy in vitro","volume":"14","author":"Osaki","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bcp.2025.117620_b1675","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jphotobiol.2014.04.027","article-title":"Metformin associated with photodynamic therapy\u2013a novel oncological direction","volume":"138","author":"Nenu","year":"2014","journal-title":"J. Photochem. Photobiol. B"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1680","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2165\/11534750-000000000-00000","article-title":"Clinical pharmacokinetics of metformin","volume":"50","author":"Graham","year":"2011","journal-title":"Clin. Pharmacokinet."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b1685","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/acschembio.6b00651","article-title":"Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors","volume":"11","author":"Singh","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bcp.2025.117620_b1690","article-title":"Antidiabetic agent DPP-4i facilitates murine breast cancer metastasis by oncogenic ROS-NRF2-HO-1 axis via a positive NRF2-HO-1 feedback loop","volume":"11","author":"Li","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2025.117620_b1695","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.123979","article-title":"CoWO4-x-based nanoplatform for multimode imaging and enhanced photothermal\/photodynamic therapy","volume":"385","author":"Liu","year":"2020","journal-title":"Chem. Eng. J."},{"issue":"5\u20136","key":"10.1016\/j.bcp.2025.117620_b1700","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000518248","article-title":"Death-associated protein kinase 1 regulates oxidative stress in cardiac ischemia reperfusion injury","volume":"210","author":"Li","year":"2021","journal-title":"Cells Tissues Organs"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1705","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.18632\/oncotarget.13825","article-title":"Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b1710","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s002040000157","article-title":"Kinetic parameters and intraindividual fluctuations of ochratoxin a plasma levels in humans","volume":"74","author":"Studer-Rohr","year":"2000","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1715","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/carcin\/bgs368","article-title":"Ochratoxin A-induced cell proliferation and tumor promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1","volume":"34","author":"Kumar","year":"2013","journal-title":"Carcinogenesis"},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b1720","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1515\/znb-2008-1111","article-title":"Photophysics of ochratoxin a in aqueous solution","volume":"63","author":"Steinbr\u00fcck","year":"2008","journal-title":"Zeitschrift F\u00fcr Naturforschung B"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1725","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3390\/toxins6010371","article-title":"A review of the evidence that ochratoxin a is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity","volume":"6","author":"Limonciel","year":"2014","journal-title":"Toxins (Basel)"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1730","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1439-0396.2008.00838.x","article-title":"Ochratoxin a impairs Nrf2-dependent gene expression in porcine kidney tubulus cells","volume":"93","author":"Boesch-Saadatmandi","year":"2009","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1735","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/toxsci\/kfl169","article-title":"Reduction in antioxidant defenses may contribute to ochratoxin a toxicity and carcinogenicity","volume":"96","author":"Cavin","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1740","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00204-011-0780-4","article-title":"Transcriptomic alterations induced by Ochratoxin a in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model","volume":"86","author":"Jennings","year":"2012","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1745","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/toxsci\/kfp090","article-title":"Ochratoxin A-mediated DNA and protein damage: roles of nitrosative and oxidative stresses","volume":"110","author":"Cavin","year":"2009","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1750","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3892\/ijo.2013.2229","article-title":"Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine","volume":"44","author":"Duong","year":"2014","journal-title":"Int. J. Oncol."},{"issue":"17","key":"10.1016\/j.bcp.2025.117620_b1755","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1016\/j.bmc.2007.05.070","article-title":"Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors","volume":"15","author":"Hayakawa","year":"2007","journal-title":"Bioorg. Med. Chem."},{"issue":"49","key":"10.1016\/j.bcp.2025.117620_b1760","doi-asserted-by":"crossref","first-page":"19589","DOI":"10.1073\/pnas.0709483104","article-title":"Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha","volume":"104","author":"Wang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1765","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00262-013-1396-8","article-title":"Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer","volume":"62","author":"Iclozan","year":"2013","journal-title":"Cancer Immunol. Immunother."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1770","doi-asserted-by":"crossref","first-page":"e205","DOI":"10.1038\/bcj.2014.25","article-title":"Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARalpha promoter region","volume":"4","author":"Sakamoto","year":"2014","journal-title":"Blood Cancer J."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b1775","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1200\/JCO.1992.10.11.1666","article-title":"Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer","volume":"10","author":"Smith","year":"1992","journal-title":"J. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b1780","first-page":"2138","article-title":"Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia","volume":"52","author":"Muindi","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2025.117620_b1785","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.inoche.2015.05.007","article-title":"Fluorescence of retinoic acid in the presence of metal salts","volume":"57","author":"Vogler","year":"2015","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.bcp.2025.117620_b1790","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev.nutr.24.012003.132407","article-title":"Retinoic acid receptors and cancers","volume":"24","author":"Soprano","year":"2004","journal-title":"Annu. Rev. Nutr."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1795","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/excr.1997.3495","article-title":"All-trans-retinoic acid blocks cell cycle progression of human ovarian adenocarcinoma cells at late G1","volume":"232","author":"Wu","year":"1997","journal-title":"Exp. Cell Res."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1800","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/bjc.2014.380","article-title":"Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells","volume":"111","author":"Valenzuela","year":"2014","journal-title":"Br. J. Cancer"},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b1805","doi-asserted-by":"crossref","first-page":"27005","DOI":"10.3390\/ijms161126008","article-title":"Immunoregulatory cell depletion improves the efficacy of photodynamic therapy-generated cancer vaccines","volume":"16","author":"Korbelik","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2025.117620_b1810","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113678","article-title":"All-trans retinoic acid enhances the anti-tumour effects of fimaporfin-based photodynamic therapy","volume":"155","author":"Wong","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b1815","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.freeradbiomed.2008.09.010","article-title":"NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity","volume":"45","author":"Tan","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2025.117620_b1820","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.105038","article-title":"Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells","volume":"70","author":"Fouzder","year":"2021","journal-title":"Toxicol. In Vitro"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1825","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s11101-014-9375-z","article-title":"Trigonelline and related nicotinic acid metabolites: occurrence, biosynthesis, taxonomic considerations, and their roles in planta and in human health","volume":"14","author":"Ashihara","year":"2014","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.bcp.2025.117620_b1830","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8592348","article-title":"Potential applications of NRF2 inhibitors in cancer therapy","volume":"2019","author":"Panieri","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1835","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jnutbio.2010.03.011","article-title":"Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression","volume":"22","author":"Boettler","year":"2011","journal-title":"J. Nutr. Biochem."},{"issue":"40","key":"10.1016\/j.bcp.2025.117620_b1840","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1038\/onc.2012.493","article-title":"Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity","volume":"32","author":"Arlt","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2025.117620_b1845","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.redox.2016.12.010","article-title":"Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis","volume":"11","author":"Roh","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2025.117620_b1850","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/1471-2407-14-271","article-title":"Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1","volume":"14","author":"Ding","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bcp.2025.117620_b1855","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115224","article-title":"Antibiotic pretreatment promotes orally-administered triptolide absorption and aggravates hepatotoxicity and intestinal injury in mice","volume":"292","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b1860","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1248\/bpb.30.702","article-title":"Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats","volume":"30","author":"Shao","year":"2007","journal-title":"Biol. Pharm. Bull."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b1865","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.2217\/pgs.13.122","article-title":"Triptolide, a chinese herbal extract, enhances drug sensitivity of resistant myeloid leukemia cell lines through downregulation of HIF-1alpha and Nrf2","volume":"14","author":"Chen","year":"2013","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.bcp.2025.117620_b1870","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.680167","article-title":"Triptolide downregulates the expression of NRF2 target genes by increasing cytoplasmic localization of NRF2 in A549 cells","volume":"12","author":"Nam","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b1875","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160783","article-title":"Minnelide\/triptolide impairs mitochondrial function by regulating SIRT3 in P53-dependent manner in non-small cell lung cancer","volume":"11","author":"Kumar","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1880","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/jso.24653","article-title":"Heat shock protein 70 in pancreatic diseases: friend or foe","volume":"116","author":"Giri","year":"2017","journal-title":"J. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1885","first-page":"830","article-title":"Triptolide inhibits vascular endothelial growth factor-mediated angiogenesis in human breast cancer cells","volume":"16","author":"Liu","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1890","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/10717544.2018.1425777","article-title":"Dual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide","volume":"25","author":"Lin","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bcp.2025.117620_b1895","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13020-019-0270-9","article-title":"Naturally occurring anti-cancer compounds: shining from chinese herbal medicine","volume":"14","author":"Luo","year":"2019","journal-title":"Chin. Med."},{"key":"10.1016\/j.bcp.2025.117620_b1900","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154945","article-title":"Mitigation of triptolide-induced testicular Sertoli cell damage by melatonin via regulating the crosstalk between SIRT1 and NRF2","volume":"118","author":"Qin","year":"2023","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b1905","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.apsb.2021.02.001","article-title":"Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy","volume":"11","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b1910","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ptr.2645","article-title":"Toxicological studies of wogonin in experimental animals","volume":"23","author":"Qi","year":"2009","journal-title":"Phytother. Res."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1915","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/np900068t","article-title":"Scuteflorins a and B, dihydropyranocoumarins from Scutellaria lateriflora","volume":"72","author":"Li","year":"2009","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1920","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.3390\/molecules19055538","article-title":"Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats","volume":"19","author":"Talbi","year":"2014","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1925","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bcp.2014.09.008","article-title":"Wogonin reverses multi-drug resistance of human myelogenous leukemia K562\/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2\/ARE signaling pathway","volume":"92","author":"Xu","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2025.117620_b1930","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.12659\/MSM.913829","article-title":"Wogonin increases cisplatin sensitivity in ovarian cancer cells through inhibition of the phosphatidylinositol 3-kinase (PI3K)\/Akt pathway","volume":"25","author":"Xing","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b1935","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/mc.21921","article-title":"Drug resistance associates with activation of Nrf2 in MCF-7\/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response","volume":"52","author":"Zhong","year":"2013","journal-title":"Mol. Carcinog."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b1940","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3109\/10715762.2014.897342","article-title":"Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells","volume":"48","author":"Qian","year":"2014","journal-title":"Free Radic. Res."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b1945","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s10495-016-1284-8","article-title":"Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer","volume":"21","author":"Kim","year":"2016","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1950","doi-asserted-by":"crossref","first-page":"e1283","DOI":"10.1038\/cddis.2014.221","article-title":"NF-kappaB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis","volume":"5","author":"Yao","year":"2014","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b1955","article-title":"Prostaglandin E2 and cancer: insight into tumor progression and immunity","volume":"9","author":"Finetti","year":"2020","journal-title":"Biology (basel)"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1960","first-page":"10","article-title":"Critical protein GAPDH and its regulatory mechanisms in cancer cells","volume":"12","author":"Zhang","year":"2015","journal-title":"Cancer Biol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1965","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2013.01.052","article-title":"Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-\u03b2-cyclodextrin","volume":"445","author":"Mekjaruskul","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bcp.2025.117620_b1970","doi-asserted-by":"crossref","first-page":"01008","DOI":"10.1051\/matecconf\/201819201008","article-title":"Pluronic lecithin organogel with d-limonene as a transdermal delivery system for Kaempferia parviflora extract","volume":"192","author":"Rangsimawong","year":"2018","journal-title":"MATEC Web Conf."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1975","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1186\/s12935-021-02282-3","article-title":"Chemoprotective and chemosensitizing effects of apigenin on cancer therapy","volume":"21","author":"Nozhat","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b1980","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2174\/1872213X13666190816160240","article-title":"Probing into therapeutic anti-cancer potential of apigenin: recent trends and future directions","volume":"13","author":"Sharma","year":"2019","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b1985","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061305","article-title":"The therapeutic potential of apigenin","volume":"20","author":"Salehi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b1990","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1002\/ptr.6647","article-title":"Apigenin as an anticancer agent","volume":"34","author":"Imran","year":"2020","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b1995","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12935-021-01888-x","article-title":"Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment","volume":"21","author":"Javed","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b2000","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004793","article-title":"Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1\/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers","volume":"10","author":"Kaneko","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bcp.2025.117620_b2005","article-title":"Chemotherapeutic effects of Apigenin in breast cancer: Preclinical evidence and molecular mechanisms; enhanced bioavailability by nanoparticles","volume":"34","author":"Adel","year":"2022","journal-title":"Biotechnol. Rep,"},{"issue":"13","key":"10.1016\/j.bcp.2025.117620_b2010","doi-asserted-by":"crossref","first-page":"9092","DOI":"10.1074\/jbc.M112.436790","article-title":"Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8","volume":"288","author":"Corpe","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2015","doi-asserted-by":"crossref","first-page":"11372","DOI":"10.1038\/s41598-018-29386-7","article-title":"Hormetic dose response to (L)-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression","volume":"8","author":"Cho","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2025.117620_b2020","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fphar.2020.00211","article-title":"Therapeutic use of vitamin c in cancer: physiological considerations","volume":"11","author":"Roa","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2025","first-page":"443","article-title":"Ascorbic acid: chemistry, biology and the treatment of cancer","volume":"1826","author":"Du","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"30","key":"10.1016\/j.bcp.2025.117620_b2030","doi-asserted-by":"crossref","first-page":"18982","DOI":"10.1074\/jbc.272.30.18982","article-title":"Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid","volume":"272","author":"Rumsey","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"36","key":"10.1016\/j.bcp.2025.117620_b2035","doi-asserted-by":"crossref","first-page":"28246","DOI":"10.1074\/jbc.M000988200","article-title":"Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes","volume":"275","author":"Rumsey","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b2040","doi-asserted-by":"crossref","DOI":"10.3390\/nu12051501","article-title":"Two faces of vitamin c-antioxidative and pro-oxidative agent","volume":"12","author":"Ka\u017amierczak-Bara\u0144ska","year":"2020","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2045","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1021\/acs.analchem.7b00043","article-title":"Preparation and practical applications of 2',7'-dichlorodihydrofluorescein in redox assays","volume":"89","author":"Reiniers","year":"2017","journal-title":"Anal. Chem."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2025.117620_b2050","first-page":"177","article-title":"Oxidative DNA damage in cancer patients: a cause or a consequence of the disease development?","volume":"531","author":"Olinski","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bcp.2025.117620_b2055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.semcancer.2021.04.001","article-title":"Role of iron in cancer","volume":"76","author":"Salnikow","year":"2021","journal-title":"Semin. Cancer Biol."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2025.117620_b2060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10585-018-9876-z","article-title":"Pharmacologic ascorbate (P-AscH-) suppresses hypoxia-inducible Factor-1\u03b1 (HIF-1\u03b1) in pancreatic adenocarcinoma","volume":"35","author":"Wilkes","year":"2018","journal-title":"Clin. Exp. Metastasis"},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2065","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ccr.2007.08.004","article-title":"HIF-dependent antitumorigenic effect of antioxidants in vivo","volume":"12","author":"Gao","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2025.117620_b2070","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3389\/fphys.2018.00809","article-title":"Potential mechanisms of action for vitamin c in cancer: reviewing the evidence","volume":"9","author":"Vissers","year":"2018","journal-title":"Front. Physiol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b2075","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41568-019-0135-7","article-title":"Targeting cancer vulnerabilities with high-dose vitamin C","volume":"19","author":"Ngo","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17070997","article-title":"Brusatol enhances the radiosensitivity of A549 cells by promoting ROS production and enhancing DNA damage","volume":"17","author":"Sun","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2085","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110289","article-title":"Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon cytochrome P450 3A5-targeted inhibition","volume":"27","author":"Cutrona","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.bcp.2025.117620_b2090","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.actbio.2018.09.017","article-title":"Platelet-mimicking nanoparticles co-loaded with W(18)O(49) and metformin alleviate tumor hypoxia for enhanced photodynamic therapy and photothermal therapy","volume":"80","author":"Zuo","year":"2018","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b2095","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1007\/s12274-016-1274-8","article-title":"Liposomes co-loaded with metformin and chlorin e6 modulate tumor hypoxia during enhanced photodynamic therapy","volume":"10","author":"Song","year":"2016","journal-title":"Nano Res."},{"key":"10.1016\/j.bcp.2025.117620_b2100","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.freeradbiomed.2021.04.006","article-title":"Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair","volume":"169","author":"Qin","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"13","key":"10.1016\/j.bcp.2025.117620_b2105","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1080\/10408398.2012.724480","article-title":"Ochratoxin a and human health risk: a review of the evidence","volume":"55","author":"Bui-Klimke","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2110","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1053\/j.gastro.2010.04.046","article-title":"Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways","volume":"139","author":"Mujumdar","year":"2010","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b2115","first-page":"3413","article-title":"Triptolide induces autophagy and apoptosis through ERK activation in human breast cancer MCF-7 cells","volume":"15","author":"Gao","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2120","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3892\/etm.2014.1729","article-title":"Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt\/beta-catenin signaling pathway","volume":"8","author":"Shao","year":"2014","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b2125","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.7314\/APJCP.2012.13.4.1611","article-title":"Triptolide inhibits proliferation and induces apoptosis of human melanoma A375 cells","volume":"13","author":"Tao","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2130","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3892\/ijo.2017.3850","article-title":"Triptolide inhibits viability and induces apoptosis in liver cancer cells through activation of the tumor suppressor gene p53","volume":"50","author":"Sun","year":"2017","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2135","first-page":"3929","article-title":"Triptolide induces protective autophagy and apoptosis in human cervical cancer cells by downregulating Akt\/mTOR activation","volume":"16","author":"Qin","year":"2018","journal-title":"Oncol. Lett."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2140","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3892\/or.2016.4957","article-title":"Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway","volume":"36","author":"Zhao","year":"2016","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3892\/mmr.2013.1783","article-title":"Triptolide induces apoptosis in endometrial cancer via a p53\u2013independent mitochondrial pathway","volume":"9","author":"Wang","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2150","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/php.14020","article-title":"Trials and errors in the realm of photodynamic therapy: Viability and ROS detection","volume":"101","author":"Kessel","year":"2025","journal-title":"Photochem. Photobiol."},{"issue":"17","key":"10.1016\/j.bcp.2025.117620_b2155","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174148","article-title":"Robustness of clonogenic assays as a biomarker for cancer cell radiosensitivity","volume":"20","author":"Matsui","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b2160","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bcp.2025.117620_b2165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13578-019-0309-8","article-title":"Brusatol, an NRF2 inhibitor for future cancer therapeutic","volume":"9","author":"Cai","year":"2019","journal-title":"Cell Biosci."},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b2170","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.bbamcr.2014.05.003","article-title":"Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer","volume":"1843","author":"Namani","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b2175","article-title":"Regulation of cell proliferation and Nrf2-mediated antioxidant defense: conservation of keap1 cysteines and Nrf2 binding site in the context of the evolution of KLHL family","volume":"13","author":"Shilovsky","year":"2023","journal-title":"Life (Basel)"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2180","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s42003-021-02100-6","article-title":"Molecular basis for the disruption of Keap1-Nrf2 interaction via Hinge & Latch mechanism","volume":"4","author":"Horie","year":"2021","journal-title":"Commun. Biol."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2185","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17030447","article-title":"KEAP1-NRF2 interaction in cancer: competitive interactors and their role in carcinogenesis","volume":"17","author":"Oskomic","year":"2025","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2190","doi-asserted-by":"crossref","first-page":"12437","DOI":"10.1038\/s41598-019-48763-4","article-title":"PIDD interaction with KEAP1 as a new mutation-independent mechanism to promote NRF2 stabilization and chemoresistance in NSCLC","volume":"9","author":"Ji","year":"2019","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2195","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1073\/pnas.0308347100","article-title":"Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes","volume":"101","author":"Kang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b2200","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.7150\/ijbs.94883","article-title":"The m-TORC1 inhibitor Sirolimus increases the effectiveness of Photodynamic therapy in the treatment of cutaneous Squamous Cell Carcinoma, impairing NRF2 antioxidant signaling","volume":"20","author":"Nicolas-Morala","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2205","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1038\/s41598-019-41313-y","article-title":"Characterisation of resistance mechanisms developed by basal cell carcinoma cells in response to repeated cycles of Photodynamic Therapy","volume":"9","author":"Lucena","year":"2019","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2210","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening","volume":"47","author":"Halgren","year":"2004","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2215","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy","volume":"47","author":"Friesner","year":"2004","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b2220","first-page":"250","article-title":"Photodynamic therapy of cancer: an update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2225","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1040-8428(84)80016-5","article-title":"Photodynamic therapy (PDT) of malignant tumors","volume":"2","author":"Dougherty","year":"1984","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"10","key":"10.1016\/j.bcp.2025.117620_b2230","first-page":"1133","article-title":"Treatment of superficial bladder cancer","volume":"122","author":"Morales","year":"1980","journal-title":"Can. Med. Assoc. J."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2235","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0090-4295(85)90125-6","article-title":"Whole bladder photodynamic therapy for transitional cell carcinoma of bladder","volume":"26","author":"Nseyo","year":"1985","journal-title":"Urology"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2240","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0016-5085(95)90058-6","article-title":"Long-term survival after photodynamic therapy for esophageal cancer","volume":"108","author":"Sibille","year":"1995","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2245","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0738-081X(01)00170-5","article-title":"Laser and photodynamic therapy in the management of cutaneous malignancies","volume":"19","author":"Zeitouni","year":"2001","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.bcp.2025.117620_b2250","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pdpdt.2018.09.009","article-title":"Photodynamic therapy for Bowen's Disease (squamous cell carcinoma in situ) current review and update","volume":"24","author":"O'Connell","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b2255","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0025-6196(12)62606-8","article-title":"Laser photodynamic therapy for bladder cancer","volume":"61","author":"Benson","year":"1986","journal-title":"Mayo Clin. Proc."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2260","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/archotol.129.7.709","article-title":"Meta-tetra(hydroxyphenyl)chlorin photodynamic therapy in early-stage squamous cell carcinoma of the head and neck","volume":"129","author":"Copper","year":"2003","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b2265","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1054\/ijom.2001.0160","article-title":"Treatment of squamous cell carcinoma of the lip using Foscan-mediated photodynamic therapy","volume":"30","author":"Kubler","year":"2001","journal-title":"Int. J. Oral Maxillofac. Surg."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b2270","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10103-008-0630-7","article-title":"Optimal conditions for successful ablation of high-grade dysplasia in Barrett's oesophagus using aminolaevulinic acid photodynamic therapy","volume":"24","author":"Mackenzie","year":"2009","journal-title":"Lasers Med. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b2275","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1046\/j.1365-2133.1996.d01-1076.x","article-title":"Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease","volume":"135","author":"Morton","year":"1996","journal-title":"Br. J. Dermatol."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2280","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0016-5107(03)70021-2","article-title":"Phase II study of photodynamic therapy and metal stent as palliative treatment for nonresectable hilar cholangiocarcinoma","volume":"57","author":"Dumoulin","year":"2003","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bcp.2025.117620_b2285","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pdpdt.2016.10.001","article-title":"Treatment of unresectable extrahepatic cholangiocarcinoma using hematoporphyrin photodynamic therapy: a prospective study","volume":"16","author":"Yang","year":"2016","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2290","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.ejca.2014.01.008","article-title":"Randomised phase II trial of photodynamic therapy plus oral fluoropyrimidine, S-1, versus photodynamic therapy alone for unresectable hilar cholangiocarcinoma","volume":"50","author":"Park","year":"2014","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2295","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pdpdt.2012.12.005","article-title":"Photodynamic therapy for cholangiocarcinoma using low dose mTHPC (Foscan((R)))","volume":"10","author":"Kniebuhler","year":"2013","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b2300","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1111\/j.1572-0241.2005.00318.x","article-title":"Palliation of nonresectable bile duct cancer: improved survival after photodynamic therapy","volume":"100","author":"Zoepf","year":"2005","journal-title":"Am. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2305","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.gie.2018.09.007","article-title":"Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer","volume":"89","author":"DeWitt","year":"2019","journal-title":"Gastrointest. Endosc."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2310","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/bjc.2014.95","article-title":"Phase I\/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer","volume":"110","author":"Huggett","year":"2014","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b2315","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/gut.50.4.549","article-title":"Photodynamic therapy for cancer of the pancreas","volume":"50","author":"Bown","year":"2002","journal-title":"Gut"},{"issue":"14","key":"10.1016\/j.bcp.2025.117620_b2320","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1056\/NEJMoa0908721","article-title":"Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer","volume":"362","author":"Valle","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2325","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/09298673113209990211","article-title":"Development and in vitro proof-of-concept of interstitially targeted zinc- phthalocyanine liposomes for photodynamic therapy","volume":"21","author":"Broekgaarden","year":"2014","journal-title":"Curr. Med. Chem."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b2330","doi-asserted-by":"crossref","first-page":"19960","DOI":"10.3390\/ijms160819960","article-title":"Inhibition of NF-kappaB in tumor cells exacerbates immune cell activation following photodynamic therapy","volume":"16","author":"Broekgaarden","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2025.117620_b2335","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124004","article-title":"Nanobody-mediated targeting of zinc phthalocyanine with polymer micelles as nanocarriers","volume":"655","author":"Mesquita","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"23","key":"10.1016\/j.bcp.2025.117620_b2340","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314974","article-title":"The impact of nanobody density on the targeting efficiency of PEGylated liposomes","volume":"23","author":"Mesquita","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b2345","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1039\/C6NR00014B","article-title":"Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy","volume":"8","author":"Broekgaarden","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.bcp.2025.117620_b2350","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2022.112500","article-title":"Metallated phthalocyanines and their hydrophilic derivatives for multi-targeted oncological photodynamic therapy","volume":"234","author":"Dias","year":"2022","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.bcp.2025.117620_b2355","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2024.112903","article-title":"Comparative analysis of whole cell-derived vesicular delivery systems for photodynamic therapy of extrahepatic cholangiocarcinoma","volume":"254","author":"Li","year":"2024","journal-title":"J. Photochem. Photobiol. B"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2360","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1124\/pr.110.004044","article-title":"The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer","volume":"66","author":"Heger","year":"2014","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2365","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.wem.2016.01.002","article-title":"Fatal honey poisoning caused by Tripterygium wilfordii Hook f in southwest china: a case series","volume":"27","author":"Zhang","year":"2016","journal-title":"Wilderness Environ. Med."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b2370","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/ssu.2980110504","article-title":"Photodynamic therapy for recurrent supratentorial gliomas","volume":"11","author":"Muller","year":"1995","journal-title":"Semin. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b2375","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/lsm.22781","article-title":"Photodynamic therapy via navigational bronchoscopy for peripheral lung cancer in dogs","volume":"50","author":"Musani","year":"2018","journal-title":"Lasers Surg. Med."},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b2380","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.molmed.2019.05.007","article-title":"PRMTs and arginine methylation: cancer's best-kept secret?","volume":"25","author":"Jarrold","year":"2019","journal-title":"Trends Mol. Med."},{"issue":"41","key":"10.1016\/j.bcp.2025.117620_b2385","doi-asserted-by":"crossref","first-page":"67532","DOI":"10.18632\/oncotarget.11376","article-title":"Protein arginine methylation\/demethylation and cancer","volume":"7","author":"Poulard","year":"2016","journal-title":"Oncotarget"},{"issue":"16","key":"10.1016\/j.bcp.2025.117620_b2390","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25168854","article-title":"Role of PRMT1 and PRMT5 in Breast Cancer","volume":"25","author":"Martinez","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2025.117620_b2395","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2024.1455415","article-title":"Therapeutic targeting potential of the protein lysine and arginine methyltransferases to reverse cancer chemoresistance","volume":"11","author":"Micallef","year":"2024","journal-title":"Front. Mol. Biosci."},{"issue":"8","key":"10.1016\/j.bcp.2025.117620_b2400","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/j.bbamcr.2016.05.009","article-title":"Methylation of arginine by PRMT1 regulates Nrf2 transcriptional activity during the antioxidative response","volume":"1863","author":"Liu","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.bcp.2025.117620_b2405","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/med.21257","article-title":"Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents","volume":"32","author":"Magesh","year":"2012","journal-title":"Med. Res. Rev."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b2410","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-006890","article-title":"PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis","volume":"11","author":"Wang","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"7_Supplement","key":"10.1016\/j.bcp.2025.117620_b2415","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1158\/1538-7445.AM2023-6279","article-title":"Abstract 6279: CTS2190, a next-generation epigenetic inhibitor for targeting type I PRMT deregulated human tumors","volume":"83","author":"Shi","year":"2023","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2420","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41416-023-02276-0","article-title":"Phase 1 study of GSK3368715, a type I PRMT inhibitor, in patients with advanced solid tumors","volume":"129","author":"El-Khoueiry","year":"2023","journal-title":"Br. J. Cancer"},{"issue":"11","key":"10.1016\/j.bcp.2025.117620_b2425","article-title":"Structure, activity, and Function of PRMT1","volume":"11","author":"Thiebaut","year":"2021","journal-title":"Life (Basel)"},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2430","doi-asserted-by":"crossref","first-page":"8232","DOI":"10.1038\/s41467-024-52507-y","article-title":"PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in clear cell renal cell carcinoma","volume":"15","author":"Walton","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2025.117620_b2435","article-title":"Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma","volume":"14","author":"Nguyen","year":"2023","journal-title":"Front. Immunol."},{"issue":"21","key":"10.1016\/j.bcp.2025.117620_b2440","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1158\/0008-5472.CAN-11-2572","article-title":"Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer\/testis antigen P1A","volume":"73","author":"Mroz","year":"2013","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b2445","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/intimm\/dxaf003","article-title":"Beneficial effects on T cells by photodynamic therapy with talaporfin enhance cancer immunotherapy","volume":"37","author":"Ezzaldeen","year":"2025","journal-title":"Int. Immunol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b2450","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015194","article-title":"Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response","volume":"5","author":"Mroz","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2025.117620_b2455","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121918","article-title":"Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy","volume":"292","author":"Lou","year":"2023","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.bcp.2025.117620_b2460","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/lsm.20362","article-title":"Photodynamic therapy and anti-tumor immunity","volume":"38","author":"Gollnick","year":"2006","journal-title":"Lasers Surg. Med."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2465","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/10717544.2020.1745327","article-title":"Developing protein arginine methyltransferase 1 (PRMT1) inhibitor TC-E-5003 as an antitumor drug using INEI drug delivery systems","volume":"27","author":"Zhang","year":"2020","journal-title":"Drug Deliv."},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b2470","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093058","article-title":"Protein arginine methyltransferase 1 (PRMT1) selective inhibitor, TC-E 5003, has anti-inflammatory properties in TLR4 signaling","volume":"21","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2025.117620_b2475","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113831","article-title":"PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity","volume":"43","author":"Djajawi","year":"2024","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b2480","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1073\/pnas.051618798","article-title":"Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice","volume":"98","author":"Ramos-Gomez","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2485","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12964-020-00568-z","article-title":"Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1\/NRF2 pathway activation","volume":"18","author":"Gong","year":"2020","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bcp.2025.117620_b2490","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"12","key":"10.1016\/j.bcp.2025.117620_b2495","article-title":"Nrf2 and Oxidative stress: a General Overview of Mechanisms and Implications in Human Disease","volume":"11","author":"Ngo","year":"2022","journal-title":"Antioxidants (basel)"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2500","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/php.13749","article-title":"Recent photosensitizer developments, delivery strategies and combination-based approaches for photodynamic therapy(dagger)","volume":"99","author":"Marino-Ocampo","year":"2023","journal-title":"Photochem. Photobiol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2505","article-title":"Current challenges and opportunities of photodynamic therapy against cancer","volume":"15","author":"Huis In't Veld","year":"2023","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2510","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1011-1344(01)00267-6","article-title":"State of the art in the delivery of photosensitizers for photodynamic therapy","volume":"66","author":"Konan","year":"2002","journal-title":"J. Photochem. Photobiol. B"},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2515","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1572-1000(05)00060-8","article-title":"Mechanisms in photodynamic therapy: Part three-Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction","volume":"2","author":"Castano","year":"2005","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b2520","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/acs.molpharmaceut.2c00455","article-title":"Utility of intravenous curcumin nanodelivery systems for improving in vivo pharmacokinetics and anticancer pharmacodynamics","volume":"19","author":"Bagheri","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bcp.2025.117620_b2525","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.phrs.2018.06.013","article-title":"Canonical and non-canonical mechanisms of Nrf2 activation","volume":"134","author":"Silva-Islas","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bcp.2025.117620_b2530","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s40139-017-0131-0","article-title":"Non-canonical activation of NRF2: New insights and its relevance to disease","volume":"5","author":"Dodson","year":"2017","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.bcp.2025.117620_b2535","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1232241","article-title":"An update on the bridging factors connecting autophagy and Nrf2 antioxidant pathway","volume":"11","author":"Ning","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"7\u20138","key":"10.1016\/j.bcp.2025.117620_b2540","article-title":"ROS-Nrf2 pathway mediates the development of TGF-beta1-induced epithelial-mesenchymal transition through the activation of Notch signaling","volume":"100","author":"Yazaki","year":"2021","journal-title":"Eur. J. Cell Biol."},{"issue":"9","key":"10.1016\/j.bcp.2025.117620_b2545","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1007\/s00262-023-03479-3","article-title":"TGF-beta1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy","volume":"72","author":"Han","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"issue":"6","key":"10.1016\/j.bcp.2025.117620_b2550","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/intbio\/zyz021","article-title":"NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial\/mesenchymal phenotype","volume":"11","author":"Bocci","year":"2019","journal-title":"Integr Biol (Camb)"},{"key":"10.1016\/j.bcp.2025.117620_b2555","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.807324","article-title":"Nrf2 modulates the hybrid epithelial\/mesenchymal phenotype and notch signaling during collective cancer migration","volume":"9","author":"Vilchez Mercedes","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.bcp.2025.117620_b2560","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12967-023-04287-0","article-title":"The promoting effect and mechanism of Nrf2 on cell metastasis in cervical cancer","volume":"21","author":"Zhang","year":"2023","journal-title":"J. Transl. Med."},{"issue":"7","key":"10.1016\/j.bcp.2025.117620_b2565","doi-asserted-by":"crossref","first-page":"562","DOI":"10.4252\/wjsc.v12.i7.562","article-title":"Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species","volume":"12","author":"Zhang","year":"2020","journal-title":"World J Stem Cells"},{"key":"10.1016\/j.bcp.2025.117620_b2570","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102849","article-title":"Effects of Curcumin-mediated photodynamic therapy on autophagy and epithelial-mesenchymal transition of lung cancer cells","volume":"38","author":"Shao","year":"2022","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.bcp.2025.117620_b2575","doi-asserted-by":"crossref","first-page":"38646","DOI":"10.1038\/srep38646","article-title":"Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225008858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225008858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:20:15Z","timestamp":1776759615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225008858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":515,"alternative-id":["S0006295225008858"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117620","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological targeting of nuclear factor (erythroid-derived 2)-like 2 (NRF2): a potential strategy to improve the efficacy of oncological photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117620"}}