{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:50:20Z","timestamp":1792122620112,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","award":["WDRY2023-K089"],"award-info":[{"award-number":["WDRY2023-K089"]}],"id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972300"],"award-info":[{"award-number":["81972300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012546","name":"Chongqing Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024CQBSHTB2018"],"award-info":[{"award-number":["2024CQBSHTB2018"]}],"id":[{"id":"10.13039\/100012546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M753879"],"award-info":[{"award-number":["2024M753879"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bcp.2025.117659","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:43:39Z","timestamp":1766130219000},"page":"117659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Senolytic elimination of therapy-induced senescent cells by ABT-263 improves chemotherapeutic efficacy in esophageal squamous cell carcinoma"],"prefix":"10.1016","volume":"245","author":[{"given":"Dan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2403-6056","authenticated-orcid":false,"given":"Jian-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bcp.2025.117659_b0005","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.bcp.2025.117659_b0010","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/j.apsb.2021.03.008","article-title":"Advances and challenges in the treatment of esophageal cancer","volume":"11","author":"He","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.bcp.2025.117659_b0015","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a Path Forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2025.117659_b0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Coppe","year":"2010","journal-title":"Annu. Rev. Pathol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117659_b0025","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41568-022-00450-9","article-title":"Exploiting senescence for the treatment of cancer","volume":"22","author":"Wang","year":"2022","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"10.1016\/j.bcp.2025.117659_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12040822","article-title":"Therapy-Induced Senescence: an \u201cOld\u201d Friend Becomes the Enemy","volume":"12","author":"Saleh","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.bcp.2025.117659_b0035","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1158\/2159-8290.CD-22-0523","article-title":"Cellular senescence is immunogenic and promotes antitumor immunity","volume":"13","author":"Marin","year":"2023","journal-title":"Cancer Discov."},{"issue":"10","key":"10.1016\/j.bcp.2025.117659_b0040","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.trecan.2020.05.004","article-title":"Senescent cells in cancer therapy: friends or foes?","volume":"6","author":"Wang","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.bcp.2025.117659_b0045","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.canlet.2021.07.002","article-title":"Senescent cells in cancer therapy: why and how to remove them","volume":"520","author":"Zhang","year":"2021","journal-title":"Cancer Lett."},{"issue":"7686","key":"10.1016\/j.bcp.2025.117659_b0050","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature25167","article-title":"Senescence-associated reprogramming promotes cancer stemness","volume":"553","author":"Milanovic","year":"2018","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bcp.2025.117659_b0055","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1158\/2159-8290.CD-20-1375","article-title":"Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence","volume":"11","author":"Duy","year":"2021","journal-title":"Cancer Discov."},{"issue":"3","key":"10.1016\/j.bcp.2025.117659_b0060","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41419-018-0303-9","article-title":"Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1\/2-RSK1 pathway","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2025.117659_b0065","doi-asserted-by":"crossref","unstructured":"I. Guccini, A. Revandkar, M. D'Ambrosio, M. Colucci, E. Pasquini, S. Mosole, M. Troiani, D. Brina, R. Sheibani-Tezerji, A.R. Elia, A. Rinaldi, N. Pernigoni, J.H. Ruschoff, S. Dettwiler, A.M. De Marzo, E.S. Antonarakis, C. Borrelli, A.E. Moor, R. Garcia-Escudero, A. Alajati, G. Attanasio, M. Losa, H. Moch, P. Wild, G. Egger, A. Alimonti, Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis, Cancer Cell 39(1) (2021) 68-82 e9.","DOI":"10.1016\/j.ccell.2020.10.012"},{"issue":"4","key":"10.1016\/j.bcp.2025.117659_b0070","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/0008-5472.CAN-19-2830","article-title":"NAMPT inhibition suppresses cancer stem-like cells associated with therapy-induced senescence in ovarian cancer","volume":"80","author":"Nacarelli","year":"2020","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.bcp.2025.117659_b0075","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/s43018-022-00466-y","article-title":"Breast cancer cells survive chemotherapy by activating targetable immune-modulatory programs characterized by PD-L1 or CD80","volume":"3","author":"Shahbandi","year":"2022","journal-title":"Nat Cancer"},{"key":"10.1016\/j.bcp.2025.117659_b0080","doi-asserted-by":"crossref","DOI":"10.1038\/s43018-023-00712-x","article-title":"The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2","author":"Chaib","year":"2024","journal-title":"Nat. Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2025.117659_b0085","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2197836","article-title":"Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway","volume":"15","author":"Zhang","year":"2023","journal-title":"Gut. Microbes"},{"issue":"10","key":"10.1016\/j.bcp.2025.117659_b0090","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13948","article-title":"Strategies for senolytic drug discovery","volume":"22","author":"Power","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2025.117659_b0095","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ebiom.2019.01.056","article-title":"Senolytics and senostatics as adjuvant tumour therapy","volume":"41","author":"Short","year":"2019","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.bcp.2025.117659_b0100","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.celrep.2017.09.085","article-title":"High-throughput functional genetic and compound screens identify targets for senescence induction in cancer","volume":"21","author":"Wang","year":"2017","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.bcp.2025.117659_b0105","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tcb.2018.04.006","article-title":"Two-step senescence-focused cancer therapies","volume":"28","author":"Sieben","year":"2018","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.bcp.2025.117659_b0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1158\/2159-8290.CD-16-0241","article-title":"Cellular senescence promotes adverse effects of chemotherapy and cancer relapse","volume":"7","author":"Demaria","year":"2017","journal-title":"Cancer Discov."},{"issue":"23","key":"10.1016\/j.bcp.2025.117659_b0115","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1158\/0008-5472.CAN-21-0752","article-title":"Elimination of radiation-induced senescence in the brain tumor microenvironment attenuates glioblastoma recurrence","volume":"81","author":"Fletcher-Sananikone","year":"2021","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117659_b0120","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41467-023-36124-9","article-title":"Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma","volume":"14","author":"Salam","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2025.117659_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107943","article-title":"The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy","volume":"230","author":"Basu","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2025.117659_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114765","article-title":"Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy","volume":"193","author":"Carpenter","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2025.117659_b0135","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1038\/s41418-020-0564-6","article-title":"BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer","volume":"27","author":"Shahbandi","year":"2020","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.bcp.2025.117659_b0140","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1002\/1878-0261.12761","article-title":"Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X(L) -BAX interaction","volume":"14","author":"Saleh","year":"2020","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.bcp.2025.117659_b0145","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/s41467-022-29824-1","article-title":"Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer","volume":"13","author":"Troiani","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2025.117659_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109441","article-title":"The Cancer SENESCopedia: a delineation of cancer cell senescence","volume":"36","author":"Jochems","year":"2021","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.bcp.2025.117659_b0155","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/nprot.2009.191","article-title":"Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo","volume":"4","author":"Debacq-Chainiaux","year":"2009","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.bcp.2025.117659_b0160","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"issue":"9","key":"10.1016\/j.bcp.2025.117659_b0165","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1158\/0008-5472.CAN-07-5836","article-title":"ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor","volume":"68","author":"Tse","year":"2008","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2025.117659_b0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/cdd.2017.186","article-title":"BCL-2 family proteins: changing partners in the dance towards death","volume":"25","author":"Kale","year":"2018","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.bcp.2025.117659_b0175","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrm2312","article-title":"Apoptosis: controlled demolition at the cellular level","volume":"9","author":"Taylor","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.bcp.2025.117659_b0180","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41418-024-01439-7","article-title":"Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state","volume":"32","author":"Jochems","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2025.117659_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.822816","article-title":"Why senescent cells are resistant to apoptosis: an insight for senolytic development","volume":"10","author":"Hu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"279","key":"10.1016\/j.bcp.2025.117659_b0190","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa4642","article-title":"Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy","volume":"7","author":"Leverson","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.bcp.2025.117659_b0195","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1074\/jbc.M112.422204","article-title":"Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation","volume":"288","author":"Vela","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2025.117659_b0200","doi-asserted-by":"crossref","first-page":"15208","DOI":"10.1038\/ncomms15208","article-title":"Senescent tumor cells lead the collective invasion in thyroid cancer","volume":"8","author":"Kim","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2025.117659_b0205","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles' heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bcp.2025.117659_b0210","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nm.4010","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","volume":"22","author":"Chang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2025.117659_b0215","doi-asserted-by":"crossref","unstructured":"C. Aguayo-Mazzucato, J. Andle, T.B. Lee, Jr., A. Midha, L. Talemal, V. Chipashvili, J. Hollister-Lock, J. van Deursen, G. Weir, S. Bonner-Weir, Acceleration of beta Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes, Cell Metab 30(1) (2019) 129-142 e4.","DOI":"10.1016\/j.cmet.2019.05.006"},{"issue":"594","key":"10.1016\/j.bcp.2025.117659_b0220","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb0203","article-title":"Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair","volume":"13","author":"Mylonas","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.bcp.2025.117659_b0225","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12945","article-title":"Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction","volume":"18","author":"Walaszczyk","year":"2019","journal-title":"Aging Cell"},{"issue":"14","key":"10.1016\/j.bcp.2025.117659_b0230","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13143585","article-title":"Targeting c-IAP1, c-IAP2, and Bcl-2 eliminates senescent glioblastoma cells following temozolomide treatment","volume":"13","author":"Schwarzenbach","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.bcp.2025.117659_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13030386","article-title":"Senolytic targeting of Bcl-2 anti-apoptotic family increases cell death in irradiated sarcoma cells","volume":"13","author":"Lafontaine","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"12","key":"10.1016\/j.bcp.2025.117659_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111826","article-title":"BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis","volume":"41","author":"Bharti","year":"2022","journal-title":"Cell Rep."},{"issue":"24","key":"10.1016\/j.bcp.2025.117659_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413233","article-title":"Effects and related mechanisms of the senolytic agent ABT-263 on the survival of irradiated A549 and Ca9-22 cancer cells","volume":"22","author":"Sato","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2025.117659_b0250","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd.2016.253","article-title":"From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors","volume":"16","author":"Ashkenazi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.bcp.2025.117659_b0255","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1182\/blood-2011-04-347849","article-title":"Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets","volume":"118","author":"Schoenwaelder","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2025.117659_b0260","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3389\/fcell.2020.00354","article-title":"The senolytic drug navitoclax (ABT-263) causes trabecular bone loss and impaired osteoprogenitor function in aged mice","volume":"8","author":"Sharma","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.bcp.2025.117659_b0265","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev. Cell"},{"issue":"7942","key":"10.1016\/j.bcp.2025.117659_b0270","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41586-022-05535-x","article-title":"Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration","volume":"613","author":"Moiseeva","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2025.117659_b0275","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13142","article-title":"Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity","volume":"19","author":"Gonzalez-Gualda","year":"2020","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.bcp.2025.117659_b0280","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.3324\/haematol.2022.281915","article-title":"Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells","volume":"108","author":"Jia","year":"2023","journal-title":"Haematologica"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225009244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295225009244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:14:14Z","timestamp":1781698454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295225009244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":56,"alternative-id":["S0006295225009244"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117659","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Senolytic elimination of therapy-induced senescent cells by ABT-263 improves chemotherapeutic efficacy in esophageal squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2025.117659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117659"}}