{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:17:53Z","timestamp":1778059073442,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015226","name":"Shengjing Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bcp.2026.117701","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:38:19Z","timestamp":1767976699000},"page":"117701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["TTC3-mediated ubiquitination of APPL1 is suppression involved in the anti-asthmatic effects of the substance P receptor antagonist WIN62577"],"prefix":"10.1016","volume":"246","author":[{"given":"Miao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.117701_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112189","article-title":"Precision medicine for severe asthma - Biological targeted therapy","volume":"134","author":"Sun","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2026.117701_b0010","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jaip.2024.01.023","article-title":"Phenotyping of severe asthma in the era of broad-acting anti-asthma biologics","volume":"12","author":"Bourdin","year":"2024","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"1","key":"10.1016\/j.bcp.2026.117701_b0015","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12931-024-02812-3","article-title":"Barriers to clinical remission in severe asthma","volume":"25","author":"Farinha","year":"2024","journal-title":"Respir. Res."},{"issue":"2","key":"10.1016\/j.bcp.2026.117701_b0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jcp.20061","article-title":"The role of substance P in inflammatory disease","volume":"201","author":"O'Connor","year":"2004","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117701_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25063213","article-title":"The role of peptides in asthma-obesity phenotype","volume":"25","author":"Russjan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2026.117701_b0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1631\/jzus.B2300455","article-title":"Advances in the research and application of neurokinin-1 receptor antagonists","volume":"25","author":"Hong","year":"2024","journal-title":"J. Zhejiang Univ. Sci. B"},{"issue":"20","key":"10.1016\/j.bcp.2026.117701_b0035","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1080\/15384101.2022.2092166","article-title":"Substance P promotes the progression of bronchial asthma through activating the PI3K\/AKT\/NF-kappaB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells","volume":"21","author":"Li","year":"2022","journal-title":"Cell Cycle"},{"issue":"1","key":"10.1016\/j.bcp.2026.117701_b0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1476-9255-8-18","article-title":"The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro","volume":"8","author":"Li","year":"2011","journal-title":"J. Inflamm. (Lond.)"},{"issue":"2","key":"10.1016\/j.bcp.2026.117701_b0045","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41419-019-1308-8","article-title":"TTC3 contributes to TGF-beta(1)-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation","volume":"10","author":"Kim","year":"2019","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.117701_b0050","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12931-024-02706-4","article-title":"Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma","volume":"25","author":"Yu","year":"2024","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.117701_b0055","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1042\/BST20160191","article-title":"APPL1 is a multifunctional endosomal signaling adaptor protein","volume":"45","author":"Diggins","year":"2017","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"10.1016\/j.bcp.2026.117701_b0060","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/13880209.2023.2173252","article-title":"Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor","volume":"61","author":"Zhang","year":"2023","journal-title":"Pharm. Biol."},{"issue":"4","key":"10.1016\/j.bcp.2026.117701_b0065","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/all.15121","article-title":"Glutamine deficiency shifts the asthmatic state toward neutrophilic airway inflammation","volume":"77","author":"Kim","year":"2022","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.bcp.2026.117701_b0070","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/all.15882","article-title":"DEL-1, as an anti-neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma","volume":"79","author":"Jia","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.bcp.2026.117701_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154941","article-title":"TMT-based quantitative proteomics revealed protective efficacy of Icariside II against airway inflammation and remodeling via inhibiting LAMP2, CTSD and CTSS Expression in OVA-Induced Chronic Asthma Mice","volume":"118","author":"Zhou","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.117701_b0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1167605","article-title":"Semaphorin 7a aggravates TGF-beta1-induced airway EMT through the FAK\/ERK1\/2 signaling pathway in asthma","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117701_b0085","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12931-018-0861-5","article-title":"Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells","volume":"19","author":"Smith","year":"2018","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.117701_b0090","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00408-024-00701-6","article-title":"Neutralization of CX3CL1 attenuates TGF-beta-induced fibroblast differentiation through NF-kappaB activation and mitochondrial dysfunction in airway fibrosis","volume":"202","author":"Cheng","year":"2024","journal-title":"Lung"},{"issue":"3","key":"10.1016\/j.bcp.2026.117701_b0095","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.alit.2024.04.002","article-title":"Emerging cell and molecular targets for treating mucus hypersecretion in asthma","volume":"73","author":"Jaramillo","year":"2024","journal-title":"Allergol. Int."},{"issue":"33","key":"10.1016\/j.bcp.2026.117701_b0100","doi-asserted-by":"crossref","first-page":"22426","DOI":"10.1074\/jbc.M109.028357","article-title":"Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1\/LKB1-dependent and phospholipase C\/Ca2+\/Ca2+\/calmodulin-dependent protein kinase kinase-dependent pathways","volume":"284","author":"Zhou","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2026.117701_b0105","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.1038\/s41467-023-41145-5","article-title":"MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention","volume":"14","author":"Qiu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.117701_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155149","article-title":"Phytochemicals as treatment for allergic asthma: Therapeutic effects and mechanisms of action","volume":"122","author":"Jasemi","year":"2024","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.bcp.2026.117701_b0115","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1111\/all.15473","article-title":"Biologics and airway remodeling in severe asthma","volume":"77","author":"Varricchi","year":"2022","journal-title":"Allergy"},{"issue":"22","key":"10.1016\/j.bcp.2026.117701_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216042","article-title":"Bronchial asthma, airway remodeling and lung fibrosis as successive steps of one process","volume":"24","author":"Savin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2026.117701_b0125","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00018-024-05114-5","article-title":"KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3\/Akt\/mTOR pathway","volume":"81","author":"Zhang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2026.117701_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.722170","article-title":"Periostin in Allergy and Inflammation","volume":"12","author":"Sonnenberg-Riethmacher","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.117701_b0135","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.matbio.2016.07.011","article-title":"Fibronectin, the extracellular glue","volume":"60\u201361","author":"Zollinger","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bcp.2026.117701_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101600","article-title":"Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy","volume":"36","author":"Kong","year":"2020","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117701_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030380","article-title":"From drosophila to human: biological function of E3 ligase godzilla and its role in disease","volume":"11","author":"Cabana","year":"2022","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.bcp.2026.117701_b0150","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1042\/BJ20130760","article-title":"TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt","volume":"455","author":"Cheng","year":"2013","journal-title":"Biochem. J"},{"issue":"4","key":"10.1016\/j.bcp.2026.117701_b0155","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/jcb.24722","article-title":"Adiponectin mediated APPL1-AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts","volume":"115","author":"Dadson","year":"2014","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2026.117701_b0160","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00018-021-04044-w","article-title":"LKB1 deficiency upregulates RELM-alpha to drive airway goblet cell metaplasia","volume":"79","author":"Li","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.bcp.2026.117701_b0165","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/med.22014","article-title":"Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases","volume":"44","author":"Yang","year":"2024","journal-title":"Med. Res. Rev."},{"issue":"7","key":"10.1016\/j.bcp.2026.117701_b0170","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.7150\/ijbs.94548","article-title":"Neuropeptide substance P attenuates colitis by suppressing inflammation and ferroptosis via the cGAS-STING signaling pathway","volume":"20","author":"Lan","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2026.117701_b0175","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1007\/s13311-021-01077-8","article-title":"Neurokinin Receptor 1 (NK1R) Antagonist Aprepitant Enhances Hematoma Clearance by Regulating Microglial Polarization via PKC\/p38MAPK\/NFkappaB Pathway after Experimental Intracerebral Hemorrhage in mice","volume":"18","author":"Jin","year":"2021","journal-title":"Neurotherapeutics"},{"issue":"2","key":"10.1016\/j.bcp.2026.117701_b0180","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/cea.14575","article-title":"Allergen immunotherapy for the prevention and treatment of asthma","volume":"55","author":"Batard","year":"2025","journal-title":"Clin. Exp. Allergy"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.117701_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2013.12.020","article-title":"Polymeric delivery systems for dexamethasone","volume":"96","author":"Urbanska","year":"2014","journal-title":"Life Sci."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226000328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226000328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:40:57Z","timestamp":1778056857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226000328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":37,"alternative-id":["S0006295226000328"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117701","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TTC3-mediated ubiquitination of APPL1 is suppression involved in the anti-asthmatic effects of the substance P receptor antagonist WIN62577","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117701"}}