{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:50:17Z","timestamp":1793731817364,"version":"4.6.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS26H110002"],"award-info":[{"award-number":["LMS26H110002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bcp.2026.117729","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:25:28Z","timestamp":1768955128000},"page":"117729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia"],"prefix":"10.1016","volume":"246","author":[{"given":"Yujie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingru","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxue","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-5418","authenticated-orcid":false,"given":"Cuiping","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.117729_b0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-024-02013-w","article-title":"Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications","volume":"9","author":"Li","year":"2024","journal-title":"Sig. Trans. Target. Ther."},{"key":"10.1016\/j.bcp.2026.117729_b0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.imbio.2018.11.010","article-title":"Reactive oxygen species (ROS) in macrophage activation and function in diabetes","volume":"224","author":"Rendra","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.bcp.2026.117729_b0015","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1093\/jxb\/erae193","article-title":"Redox signaling and oxidative stress in systemic acquired resistance","volume":"75","author":"Liu","year":"2024","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.bcp.2026.117729_b0020","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.redox.2018.11.013","article-title":"Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency","volume":"20","author":"Kim","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.117729_b0025","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/jocd.12930","article-title":"An overview of herbal alternatives in androgenetic alopecia","volume":"18","author":"Dhariwala","year":"2019","journal-title":"J. Cosm. Dermatol."},{"key":"10.1016\/j.bcp.2026.117729_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells14110779","article-title":"Revolutionary approaches to hair regrowth: follicle neogenesis, Wnt\/\u00df-catenin signaling, and emerging therapies","volume":"14","author":"Mehta","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.117729_b0035","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00403-018-1826-8","article-title":"Androgen modulation of Wnt\/\u03b2-catenin signaling in androgenetic alopecia","volume":"310","author":"Premanand","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.bcp.2026.117729_b0040","doi-asserted-by":"crossref","DOI":"10.1111\/j.1755-148X.2010.00808.x","article-title":"A neuroendocrinological perspective on human hair follicle pigmentation","volume":"24","author":"Paus","year":"2011","journal-title":"Pigm. Cell Melanoma Res."},{"key":"10.1016\/j.bcp.2026.117729_b0045","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000516301","article-title":"Hair follicle melanogenesis reflected in hair pigmentation as a developmental factor in alopecia areata","volume":"7","author":"Juhasz","year":"2021","journal-title":"Skin Appendage Disord."},{"key":"10.1016\/j.bcp.2026.117729_b0050","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/jid.2015.28","article-title":"Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia","volume":"135","author":"Upton","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bcp.2026.117729_b0055","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202302207R","article-title":"Epidermal ET-1 signal induces activation of resting hair follicles by upregulating the PI3K\/AKT pathway in the dermis","volume":"38","author":"Gao","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2026.117729_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111862","article-title":"The regulatory mechanisms of mitophagy and oxidative stress in androgenetic alopecia","volume":"132","author":"Bi","year":"2025","journal-title":"Cell. Signall."},{"key":"10.1016\/j.bcp.2026.117729_b0065","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Sig. Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2026.117729_b0070","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1210\/en.2014-1266","article-title":"Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep","volume":"155","author":"Padmanabhan","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2026.117729_b0075","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41392-023-01709-9","article-title":"Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Trans. Target. Ther."},{"key":"10.1016\/j.bcp.2026.117729_b0080","doi-asserted-by":"crossref","first-page":"39259","DOI":"10.31083\/FBL39259","article-title":"Norcholic acid promotes m1 macrophage polarization in acute pancreatitis by activating the Wnt\/\u03b2-catenin pathway","volume":"30","author":"Liu","year":"2025","journal-title":"Front. Biosci. (landmark Ed)."},{"key":"10.1016\/j.bcp.2026.117729_b0085","article-title":"Estrogenic control of mitochondrial function","volume":"31","author":"Klinge","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.117729_b0090","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s10571-025-01592-8","article-title":"The role of estrogen in mitochondrial disease","volume":"45","author":"Huang","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bcp.2026.117729_b0095","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.1007\/s12035-024-04469-x","article-title":"Role of mitochondrial dysfunctions in neurodegenerative disorders: advances in mitochondrial biology","volume":"62","author":"Kathiresan","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bcp.2026.117729_b0100","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/CS20160485","article-title":"Mitochondria: a central target for sex differences in pathologies","volume":"131","author":"Ventura-Clapier","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.bcp.2026.117729_b0105","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/AGINGADV.AGINGADV-D-24-00012","article-title":"Estrogen receptors in mitochondrial metabolism: age-related changes and implications for pregnancy complications","volume":"1","author":"Hinton","year":"2024","journal-title":"Aging Adv."},{"key":"10.1016\/j.bcp.2026.117729_b0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12929-022-00800-7","article-title":"Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts","volume":"29","author":"Jung","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bcp.2026.117729_b0115","article-title":"Antioxidant actions of melatonin: a systematic review of animal studies","volume":"13","author":"Monteiro","year":"2024","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.bcp.2026.117729_b0120","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.bbamcr.2009.06.001","article-title":"Regulation of mitochondrial respiratory chain biogenesis by estrogens\/estrogen receptors and physiological, pathological and pharmacological implications","volume":"1793","author":"Chen","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2026.117729_b0125","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/nyas.12872","article-title":"Estrogen receptor-\u03b2 in mitochondria: implications for mitochondrial bioenergetics and tumorigenesis","volume":"1350","author":"Liao","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bcp.2026.117729_b0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jsbmb.2013.02.016","article-title":"Comparative analysis of genes encoding key steroid core oxidation enzymes in fast-growing Mycobacterium spp. strains","volume":"138","author":"Bragin","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bcp.2026.117729_b0135","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/jcp.20476","article-title":"Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume: physiological role in neurones","volume":"206","author":"Safiulina","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bcp.2026.117729_b0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/cac2.12510","article-title":"Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites","volume":"44","author":"Kim","year":"2024","journal-title":"Cancer Commun.. (lond)"},{"key":"10.1016\/j.bcp.2026.117729_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113476","article-title":"Quantitative proteomics analysis reveals that cyclooxygenase-2 modulates mitochondrial respiratory Chain complex IV in cardiomyocytes","volume":"23","author":"Alvarez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117729_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156733","article-title":"COX-2 optimizes cardiac mitochondrial biogenesis and exerts a cardioprotective effect during sepsis","volume":"182","author":"Yin","year":"2024","journal-title":"Cytokine"},{"key":"10.1016\/j.bcp.2026.117729_b0155","doi-asserted-by":"crossref","DOI":"10.1039\/D5MD00196J","article-title":"Recent advances in targeting COX-2 for cancer therapy: a review","author":"Kassab","year":"2025","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.bcp.2026.117729_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116259","article-title":"Targeting cyclooxygenase-2 for chemoprevention of inflammation-associated intestinal carcinogenesis: an update","volume":"228","author":"Chun","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117729_b0165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.0959-9673.2005.00412.x","article-title":"Ultrastructural evaluation of the radioprotective effects of melatonin against X-ray-induced skin damage in Albino rats","volume":"86","author":"Hussein","year":"2005","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.bcp.2026.117729_b0170","article-title":"Mitochondria-targeting therapeutic strategies for chronic kidney disease","volume":"231","author":"Sun","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117729_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: a comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications","volume":"13","author":"Mustafa","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.117729_b0180","first-page":"4000","article-title":"Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-\u03b2 and mitochondrial signaling pathway","volume":"22","author":"Zhu","year":"2018","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"10.1016\/j.bcp.2026.117729_b0185","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.tcb.2014.08.005","article-title":"Mitochondria: from cell death executioners to regulators of cell differentiation","volume":"24","author":"Kasahara","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bcp.2026.117729_b0190","article-title":"Quercitrin stimulates hair growth with enhanced expression of growth factors via activation of MAPK\/CREB signaling pathway","volume":"25","author":"Kim","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2026.117729_b0195","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yfrne.2018.01.001","article-title":"An energetic view of stress: focus on mitochondria","volume":"49","author":"Picard","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bcp.2026.117729_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105301","article-title":"Glucocorticoid impairs mitochondrial quality control in neurons","volume":"152","author":"Choi","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bcp.2026.117729_b0205","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1016\/j.jid.2018.04.033","article-title":"Vitamin D receptor is required for proliferation, migration, and differentiation of epidermal stem cells and progeny during cutaneous wound repair","volume":"138","author":"Oda","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bcp.2026.117729_b0210","first-page":"0433","article-title":"Mitophagy promotes hair regeneration by activating glutathione metabolism","volume":"7","author":"Wang","year":"2024","journal-title":"Research (wash D c)."},{"key":"10.1016\/j.bcp.2026.117729_b0215","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jid.2017.10.021","article-title":"Topical inhibition of the electron transport chain can stimulate the hair cycle","volume":"138","author":"Miranda","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bcp.2026.117729_b0220","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/jid.2014.475","article-title":"Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions","volume":"135","author":"Kloepper","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bcp.2026.117729_b0225","doi-asserted-by":"crossref","first-page":"44648","DOI":"10.31083\/FBL44648","article-title":"Modulation of mitochondrial dynamics in primary hippocampal cultures of 5xFAD mice by Mdivi-1, MFP, and exogenous zinc","volume":"30","author":"Chaplygina","year":"2025","journal-title":"Front. Biosci. (landmark Ed)."},{"key":"10.1016\/j.bcp.2026.117729_b0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012131","article-title":"Mitochondrial DNA changes in genes of respiratory complexes III, IV and V could be related to brain tumours in humans","volume":"23","author":"Kozakiewicz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117729_b0235","article-title":"Mitochondria-targeted antioxidant therapeutics for traumatic brain injury","volume":"13","author":"Modi","year":"2024","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.bcp.2026.117729_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043739","article-title":"Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: perspectives and limitations","volume":"24","author":"Fields","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117729_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116811","article-title":"MitoQ alleviates H2O2-induced mitochondrial dysfunction in keratinocytes through the Nrf2\/PINK1 pathway","volume":"234","author":"Zhao","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117729_b0250","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.2147\/DDDT.S214907","article-title":"Minoxidil and its use in hair disorders: a review","volume":"13","author":"Suchonwanit","year":"2019","journal-title":"Drug Des. Devel. Ther."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226000602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226000602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:41:20Z","timestamp":1778056880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226000602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"alternative-id":["S0006295226000602"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117729","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117729"}}