{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:40:39Z","timestamp":1793788839677,"version":"4.6.1"},"reference-count":168,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008781","name":"Pomeranian Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bcp.2026.117742","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:40:09Z","timestamp":1768981209000},"page":"117742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The role of nitric oxide in skin inflammation and the pathogenesis of psoriasis"],"prefix":"10.1016","volume":"246","author":[{"given":"Marzena","family":"Staniszewska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajetan","family":"Kie\u0142bowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estera","family":"Bakinowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Plewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"S\u0142uczanowska-G\u0142\u0105bowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00403-024-02846-z","article-title":"Global burden and future trends in psoriasis epidemiology: insights from the global burden of disease study 2019 and predictions to 2030","volume":"316","author":"Wang","year":"2024","journal-title":"Arch. Dermatol. Res."},{"issue":"10","key":"10.1016\/j.bcp.2026.117742_b0010","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1038\/jid.2009.112","article-title":"The risk of stroke in patients with psoriasis","volume":"129","author":"Gelfand","year":"2009","journal-title":"J. Invest. Dermatol."},{"issue":"9583","key":"10.1016\/j.bcp.2026.117742_b0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"Griffiths","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0020","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0025","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1086\/503821","article-title":"Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene","volume":"78","author":"Nair","year":"2006","journal-title":"Am. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0030","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jaad.2009.07.029","article-title":"Incidence of psoriasis in children: a population-based study","volume":"62","author":"Tollefson","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0035","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jaad.2017.05.019","article-title":"Psoriasis and suicidality: a systematic review and meta-analysis","volume":"77","author":"Singh","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-025-00630-5","article-title":"Psoriasis","volume":"11","author":"Armstrong","year":"2025","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0045","doi-asserted-by":"crossref","first-page":"e802","DOI":"10.1002\/iid3.802","article-title":"Serum LL-37 and inflammatory cytokines levels in psoriasis","volume":"11","author":"Lao","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"issue":"7","key":"10.1016\/j.bcp.2026.117742_b0050","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.immuni.2024.04.022","article-title":"Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation","volume":"57","author":"Subudhi","year":"2024","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0055","doi-asserted-by":"crossref","first-page":"C1757","DOI":"10.1152\/ajpcell.00147.2022","article-title":"Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides","volume":"323","author":"Slominski","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bcp.2026.117742_b0060","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/5821996","article-title":"Evaluation of Kynu, Defb2, Camp, and Penk expression levels as psoriasis marker in the imiquimod-induced psoriasis model","volume":"2024","author":"Emami","year":"2024","journal-title":"Mediators Inflamm."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0065","doi-asserted-by":"crossref","DOI":"10.1111\/apha.70019","article-title":"Proinflammatory cytokines and neuropeptides in psoriasis, depression, and anxiety","volume":"241","author":"Keenan","year":"2025","journal-title":"Acta Physiol. (Oxf.)"},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0070","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/exd.12376","article-title":"Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity","volume":"23","author":"Slominski","year":"2014","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bcp.2026.117742_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111238","article-title":"The significance of CYP11A1 expression in skin physiology and pathology","volume":"530","author":"Slominski","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bcp.2026.117742_b0080","doi-asserted-by":"crossref","DOI":"10.1111\/jdv.70263","article-title":"French guidelines on systemic treatments for moderate-to-severe psoriasis in adults: Update 2025","author":"Masson Regnault","year":"2025","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"9","key":"10.1016\/j.bcp.2026.117742_b0085","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1080\/14712598.2025.2542508","article-title":"Treatment sequences in moderate-to-severe psoriasis: a hospital-based retrospective analysis","volume":"25","author":"Boccia","year":"2025","journal-title":"Expert Opin. Biol. Ther."},{"issue":"10","key":"10.1016\/j.bcp.2026.117742_b0090","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1001\/jamadermatol.2025.2714","article-title":"Biopharmaceutical switching in psoriasis treatment: a systematic review and meta-analysis","volume":"161","author":"Zhang","year":"2025","journal-title":"JAMA Dermatol."},{"issue":"24","key":"10.1016\/j.bcp.2026.117742_b0095","doi-asserted-by":"crossref","first-page":"11285","DOI":"10.1073\/pnas.88.24.11285","article-title":"Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger","volume":"88","author":"O'Dell","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt 3","key":"10.1016\/j.bcp.2026.117742_b0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J"},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0105","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bph.14533","article-title":"Nitric oxide synthase enzymology in the 20 years after the Nobel Prize","volume":"176","author":"Stuehr","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2026.117742_b0110","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1074\/jbc.M109.038240","article-title":"Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation","volume":"285","author":"Giroud","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"27","key":"10.1016\/j.bcp.2026.117742_b0115","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The L-arginine-nitric oxide pathway","volume":"329","author":"Moncada","year":"1993","journal-title":"N. Engl. J. Med."},{"issue":"10 Suppl","key":"10.1016\/j.bcp.2026.117742_b0120","doi-asserted-by":"crossref","first-page":"2820S","DOI":"10.1093\/jn\/134.10.2820S","article-title":"Arginine metabolic enzymes, nitric oxide and infection","volume":"134","author":"Mori","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.bcp.2026.117742_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107781","article-title":"Inducible nitric oxide synthase (iNOS): more than an inducible enzyme? Rethinking the classification of NOS isoforms","volume":"216","author":"Farahani","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"20","key":"10.1016\/j.bcp.2026.117742_b0130","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1182\/blood-2012-07-442277","article-title":"Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease","volume":"120","author":"Cortese-Krott","year":"2012","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1055\/s-0038-1655925","article-title":"Identification of the NO synthase isoforms expressed in human neutrophil granulocytes, megakaryocytes and platelets","volume":"77","author":"Wallerath","year":"1997","journal-title":"Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0140","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1152\/physrev.00042.2007","article-title":"eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues","volume":"89","author":"Balligand","year":"2009","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0145","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrcardio.2017.224","article-title":"Nitric oxide signalling in cardiovascular health and disease","volume":"15","author":"Farah","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"6 Pt 2","key":"10.1016\/j.bcp.2026.117742_b0150","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1161\/01.HYP.23.6.1121","article-title":"Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions","volume":"23","author":"Forstermann","year":"1994","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0155","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13075-023-03042-6","article-title":"Re-thinking osteoarthritis pathogenesis: what can we learn (and what do we need to unlearn) from mouse models about the mechanisms involved in disease development","volume":"25","author":"Poulsen","year":"2023","journal-title":"Arthritis Res. Ther."},{"issue":"8","key":"10.1016\/j.bcp.2026.117742_b0160","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/cvr\/cvx058","article-title":"Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischaemic insult: role of PYK2","volume":"113","author":"Bibli","year":"2017","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2362.1991.tb01383.x","article-title":"Endogenous nitric oxide: physiology, pathology and clinical relevance","volume":"21","author":"Moncada","year":"1991","journal-title":"Eur. J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0170","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","article-title":"Role of nitric oxide in inflammatory diseases","volume":"15","author":"Sharma","year":"2007","journal-title":"Inflammopharmacology"},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0175","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1189\/jlb.0310149","article-title":"The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation","volume":"88","author":"Kobayashi","year":"2010","journal-title":"J. Leukoc. Biol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0180","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF03401781","article-title":"Inducible nitric oxide synthase and inflammatory diseases","volume":"6","author":"Zamora","year":"2000","journal-title":"Mol. Med."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0185","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.niox.2010.04.007","article-title":"Regulation of the expression of inducible nitric oxide synthase","volume":"23","author":"Pautz","year":"2010","journal-title":"Nitric Oxide"},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0190","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/med.21599","article-title":"Inducible nitric oxide synthase: Regulation, structure, and inhibition","volume":"40","author":"Cinelli","year":"2020","journal-title":"Med. Res. Rev."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0195","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1203\/01.PDR.0000113464.93042.A4","article-title":"Enhanced iNOS expression in leukocytes and circulating endothelial cells is associated with the progression of coronary artery lesions in acute Kawasaki disease","volume":"55","author":"Yu","year":"2004","journal-title":"Pediatr. Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0200","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jacc.2005.11.016","article-title":"Nitric oxide metabolites and cardiovascular disease markers, mediators, or both?","volume":"47","author":"Lundberg","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0205","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.bjp.0707224","article-title":"Recent developments in nitric oxide donor drugs","volume":"151","author":"Miller","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2026.117742_b0210","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1089\/ars.2012.5066","article-title":"Specificity in S-nitrosylation: a short-range mechanism for NO signaling?","volume":"19","author":"Martinez-Ruiz","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0215","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1161\/01.RES.58.4.531","article-title":"Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries","volume":"58","author":"Forstermann","year":"1986","journal-title":"Circ. Res."},{"issue":"46","key":"10.1016\/j.bcp.2026.117742_b0220","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1021\/acs.biochem.1c00276","article-title":"Revisiting nitric oxide signaling: where was it, and where is it going?","volume":"60","author":"Marletta","year":"2021","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0225","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2008.03.020","article-title":"The chemical biology of nitric oxide: implications in cellular signaling","volume":"45","author":"Thomas","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.bcp.2026.117742_b0230","article-title":"S-nitrosylation: an emerging paradigm of redox signaling","volume":"8","author":"Fernando","year":"2019","journal-title":"Antioxidants (basel)"},{"issue":"7","key":"10.1016\/j.bcp.2026.117742_b0235","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1074\/jbc.R111.285742","article-title":"Regulation by S-nitrosylation of protein post-translational modification","volume":"287","author":"Hess","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.117742_b0240","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.niox.2014.07.002","article-title":"Nitrosothiol signaling and protein nitrosation in cell death","volume":"42","author":"Iyer","year":"2014","journal-title":"Nitric Oxide"},{"issue":"9","key":"10.1016\/j.bcp.2026.117742_b0245","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.bbapap.2013.04.017","article-title":"Oxygen binding to partially nitrosylated hemoglobin","volume":"1834","author":"Fago","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0250","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bbabio.2011.09.002","article-title":"Cytochrome c oxidase and nitric oxide in action: molecular mechanisms and pathophysiological implications","volume":"1817","author":"Sarti","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0255","article-title":"Research progress on gas signal molecular therapy for Parkinson's disease","volume":"18","author":"Wang","year":"2023","journal-title":"Open Life Sci."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0260","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1089\/ars.2012.4703","article-title":"Emerging role of protein-protein transnitrosylation in cell signaling pathways","volume":"18","author":"Nakamura","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0265","doi-asserted-by":"crossref","first-page":"A17","DOI":"10.1016\/S0167-5699(05)80006-4","article-title":"Nonspecific defence mechanism: the role of nitric oxide","volume":"12","author":"Liew","year":"1991","journal-title":"Immunol. Today"},{"issue":"29","key":"10.1016\/j.bcp.2026.117742_b0270","doi-asserted-by":"crossref","first-page":"26480","DOI":"10.1074\/jbc.M302238200","article-title":"Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression","volume":"278","author":"Connelly","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"6765","key":"10.1016\/j.bcp.2026.117742_b0275","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/47520","article-title":"Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0280","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jss.2007.12.756","article-title":"Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: the role of nitric oxide","volume":"149","author":"Chen","year":"2008","journal-title":"J. Surg. Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0285","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0290","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/01.RES.0000035038.41739.CB","article-title":"Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood","volume":"91","author":"Rassaf","year":"2002","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0295","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/(SICI)1520-7560(199907\/08)15:4<283::AID-DMRR42>3.0.CO;2-U","article-title":"Nitric oxide and its role in lipid peroxidation","volume":"15","author":"Violi","year":"1999","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0300","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/152308601300185179","article-title":"Mechanisms of the antioxidant effects of nitric oxide","volume":"3","author":"Wink","year":"2001","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0305","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2567.2004.01906.x","article-title":"Danger signals derived from stressed and necrotic epithelial cells activate human eosinophils","volume":"112","author":"Stenfeldt","year":"2004","journal-title":"Immunology"},{"issue":"18","key":"10.1016\/j.bcp.2026.117742_b0310","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1161\/01.CIR.0000014928.45119.73","article-title":"Nitric oxide and angiogenesis","volume":"105","author":"Cooke","year":"2002","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0315","doi-asserted-by":"crossref","first-page":"C236","DOI":"10.1152\/ajpcell.1998.274.1.C236","article-title":"Podokinesis in endothelial cell migration: role of nitric oxide","volume":"274","author":"Noiri","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0320","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.molmed.2004.02.001","article-title":"Role of eNOS in neovascularization: NO for endothelial progenitor cells","volume":"10","author":"Duda","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bcp.2026.117742_b0325","unstructured":"D. ML, M. ZS. Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders. L. M, B. B, J. M, editors. Cambridge: Academic Press; 2023."},{"issue":"8","key":"10.1016\/j.bcp.2026.117742_b0330","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/sj.cdd.4401261","article-title":"Nitric oxide: NO apoptosis or turning it ON?","volume":"10","author":"Brune","year":"2003","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.bcp.2026.117742_b0335","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/sj.cdd.4401095","article-title":"Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis","volume":"9","author":"Barsacchi","year":"2002","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.bcp.2026.117742_b0340","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41574-025-01107-x","article-title":"Neuro-immuno-endocrinology of the skin: how environment regulates body homeostasis","volume":"21","author":"Slominski","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0345","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41435-020-0096-6","article-title":"Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders","volume":"21","author":"Slominski","year":"2020","journal-title":"Genes Immun."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0350","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s11033-024-09782-1","article-title":"Psoriatic skin transcript phenotype: androgen\/estrogen and cortisone\/cortisol imbalance with increasing DNA damage response","volume":"51","author":"Basar Kilic","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bcp.2026.117742_b0355","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1575917","article-title":"From sensation to regulation: the diverse functions of peripheral sensory nervous system","volume":"16","author":"Mei","year":"2025","journal-title":"Front. Immunol."},{"issue":"11\u201312","key":"10.1016\/j.bcp.2026.117742_b0360","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1078\/0171-9335-00425","article-title":"Nitric oxide regulates synthesis of gene products involved in keratinocyte differentiation and ceramide metabolism","volume":"83","author":"Gallala","year":"2004","journal-title":"Eur. J. Cell Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0365","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1523-1747.1998.00268.x","article-title":"Biphasic effect of exogenous nitric oxide on proliferation and differentiation in skin derived keratinocytes but not fibroblasts","volume":"111","author":"Krischel","year":"1998","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0370","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1751-1097.2009.00682.x","article-title":"Ultraviolet B light-induced nitric oxide\/peroxynitrite imbalance in keratinocytes\u2013implications for apoptosis and necrosis","volume":"86","author":"Wu","year":"2010","journal-title":"Photochem. Photobiol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121551","article-title":"Nitric oxide enhances keratinocyte cell migration by regulating Rho GTPase via cGMP-PKG signalling","volume":"10","author":"Zhan","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.bcp.2026.117742_b0380","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/BF02505267","article-title":"Immunohistochemical localization of NO synthases in normal human skin and psoriatic skin","volume":"288","author":"Sakai","year":"1996","journal-title":"Arch. Dermatol. Res."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0385","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1346-8138.1997.tb02748.x","article-title":"Immunohistochemical localization of nitric oxide synthase in normal human skin: expression of endothelial-type and inducible-type nitric oxide synthase in keratinocytes","volume":"24","author":"Shimizu","year":"1997","journal-title":"J. Dermatol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0390","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s004030050316","article-title":"Expression of nitric oxide synthase III (eNOS) mRNA by human skin cells: melanocytes but not keratinocytes express eNOS mRNA","volume":"290","author":"Jackson","year":"1998","journal-title":"Arch. Dermatol. Res."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0395","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1172\/JCI119206","article-title":"Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis","volume":"99","author":"Romero-Graillet","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0400","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2133.1996.tb06963.x","article-title":"Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes","volume":"134","author":"Sirsjo","year":"1996","journal-title":"Br. J. Dermatol."},{"issue":"8915","key":"10.1016\/j.bcp.2026.117742_b0405","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0140-6736(94)91328-5","article-title":"Epidermal keratinocyte expression of inducible nitric oxide synthase in skin lesions of psoriasis vulgaris","volume":"344","author":"Kolb-Bachofen","year":"1994","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0410","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2340\/0001555577436440","article-title":"Inducible nitric oxide synthase demonstrated in allergic and irritant contact dermatitis","volume":"77","author":"Ormerod","year":"1997","journal-title":"Acta Derm. Venereol."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.117742_b0415","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s004030050268","article-title":"Detection of nitric oxide and nitric oxide synthases in psoriasis","volume":"290","author":"Ormerod","year":"1998","journal-title":"Arch. Dermatol. Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0420","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/1523-1747.ep12343428","article-title":"Human dermal fibroblasts produce nitric oxide and express both constitutive and inducible nitric oxide synthase isoforms","volume":"106","author":"Wang","year":"1996","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0425","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/1523-1747.ep12345471","article-title":"Neuropeptides induce release of nitric oxide from human dermal microvascular endothelial cells","volume":"106","author":"Bull","year":"1996","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0430","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s004030100211","article-title":"Lipopolysaccharide and cytokines induce nitric oxide synthase and produce nitric oxide in cultured normal human melanocytes","volume":"293","author":"Rocha","year":"2001","journal-title":"Arch. Dermatol. Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0435","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jdermsci.2012.09.014","article-title":"Suppression of melanogenesis by a newly synthesized compound, MHY966 via the nitric oxide\/protein kinase G signaling pathway in murine skin","volume":"68","author":"Choi","year":"2012","journal-title":"J. Dermatol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0440","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/ijc.10808","article-title":"Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP-1 gene induction in human melanoma cell lines","volume":"103","author":"Ishii","year":"2003","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0445","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1006\/niox.2000.0307","article-title":"Enhancement of fibroblast collagen synthesis by nitric oxide","volume":"4","author":"Witte","year":"2000","journal-title":"Nitric Oxide"},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0450","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1006\/bbrc.1998.8681","article-title":"Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds","volume":"246","author":"Thornton","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"14","key":"10.1016\/j.bcp.2026.117742_b0455","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1096\/fasebj.13.14.2002","article-title":"Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair","volume":"13","author":"Frank","year":"1999","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0460","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.niox.2004.04.005","article-title":"Nitric oxide function in the skin","volume":"10","author":"Cals-Grierson","year":"2004","journal-title":"Nitric Oxide"},{"issue":"Pt 3","key":"10.1016\/j.bcp.2026.117742_b0465","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/bj3460719","article-title":"Identification of copper\/zinc superoxide dismutase as a nitric oxide-regulated gene in human (HaCaT) keratinocytes: implications for keratinocyte proliferation","volume":"346","author":"Frank","year":"2000","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0470","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(95)12062-9","article-title":"Substance P and nitric oxide mediate would healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation","volume":"200","author":"Benrath","year":"1995","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0475","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1046\/j.1523-1747.1999.00784.x","article-title":"The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization","volume":"113","author":"Stallmeyer","year":"1999","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.bcp.2026.117742_b0480","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/sj.jid.5700742","article-title":"Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption","volume":"127","author":"Ikeyama","year":"2007","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0485","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.0022-202X.2004.22731.x","article-title":"The neuronal nitric oxide synthase is upregulated in mouse skin repair and in response to epidermal growth factor in human HaCaT keratinocytes","volume":"123","author":"Boissel","year":"2004","journal-title":"J. Invest. Dermatol."},{"issue":"10","key":"10.1016\/j.bcp.2026.117742_b0490","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/exd.14176","article-title":"Inducible nitric oxide synthase is required for epidermal permeability barrier homeostasis in mice","volume":"29","author":"Dang","year":"2020","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0495","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1046\/j.1523-1747.2000.00116.x","article-title":"Nitric oxide inhibits cornified envelope formation in human keratinocytes by inactivating transglutaminases and activating protein 1","volume":"115","author":"Rossi","year":"2000","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0500","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.niox.2006.10.007","article-title":"Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes","volume":"16","author":"Rabkin","year":"2007","journal-title":"Nitric Oxide"},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0505","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1600-0714.2006.00439.x","article-title":"Dual effect of nitric oxide in immortalized and malignant human oral keratinocytes: induction of apoptosis and differentiation","volume":"35","author":"Lee","year":"2006","journal-title":"J. Oral Pathol. Med."},{"issue":"Pt 3","key":"10.1016\/j.bcp.2026.117742_b0510","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1042\/bj3310713","article-title":"Control of growth and differentiation of normal human epithelial cells through the manipulation of reactive nitrogen species","volume":"331","author":"Vallette","year":"1998","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0515","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/abbi.1995.1231","article-title":"NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation","volume":"318","author":"Arnelle","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0520","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/bph.14484","article-title":"Nitrite and nitrate chemical biology and signalling","volume":"176","author":"DeMartino","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0525","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.niox.2009.10.006","article-title":"Non-enzymatic NO production in human skin: effect of UVA on cutaneous NO stores","volume":"22","author":"Suschek","year":"2010","journal-title":"Nitric Oxide"},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0530","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1210\/en.2017-03230","article-title":"How UV light touches the brain and endocrine system through skin, and why","volume":"159","author":"Slominski","year":"2018","journal-title":"Endocrinology"},{"issue":"14","key":"10.1016\/j.bcp.2026.117742_b0535","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2308374121","article-title":"Photo-neuro-immuno-endocrinology: how the ultraviolet radiation regulates the body, brain, and immune system","volume":"121","author":"Slominski","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0540","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.freeradbiomed.2004.11.018","article-title":"Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms","volume":"38","author":"Paunel","year":"2005","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0545","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/jid.2008.296","article-title":"Enzyme-independent NO stores in human skin: quantification and influence of UV radiation","volume":"129","author":"Mowbray","year":"2009","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.bcp.2026.117742_b0550","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/jid.2014.27","article-title":"UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase","volume":"134","author":"Liu","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bcp.2026.117742_b0555","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.freeradbiomed.2013.09.022","article-title":"Mechanism and biological relevance of blue-light (420-453 nm)-induced nonenzymatic nitric oxide generation from photolabile nitric oxide derivates in human skin in vitro and in vivo","volume":"65","author":"Oplander","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0560","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/carcin\/bgh021","article-title":"Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB","volume":"25","author":"Chun","year":"2004","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0565","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/sj.jid.5701096","article-title":"Topically applied nitric oxide induces T-lymphocyte infiltration in human skin, but minimal inflammation","volume":"128","author":"Mowbray","year":"2008","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0570","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1046\/j.1523-1747.1999.00692.x","article-title":"The inflammatory and cytotoxic effects of a nitric oxide releasing cream on normal skin","volume":"113","author":"Ormerod","year":"1999","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0575","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0014-2999(92)90526-A","article-title":"Modulation of acute inflammation by endogenous nitric oxide","volume":"211","author":"Ialenti","year":"1992","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0580","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1476-5381.1995.tb13230.x","article-title":"Modulation by nitric oxide of prostaglandin biosynthesis in the rat","volume":"114","author":"Sautebin","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0585","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0014-2999(95)00581-5","article-title":"Endogenous nitric oxide increases prostaglandin biosynthesis in carrageenin rat paw oedema","volume":"286","author":"Sautebin","year":"1995","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0590","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1006\/bbrc.1995.2378","article-title":"Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level","volume":"214","author":"Andrew","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0595","doi-asserted-by":"crossref","first-page":"L764","DOI":"10.1152\/ajplung.00165.2004","article-title":"Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells","volume":"287","author":"Sparkman","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"8","key":"10.1016\/j.bcp.2026.117742_b0600","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.4049\/jimmunol.152.8.4102","article-title":"Nitric oxide regulates endotoxin-induced TNF-alpha production by human neutrophils","volume":"152","author":"Van Dervort","year":"1994","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0605","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1159\/000345351","article-title":"Nitric oxide activates IL-6 production and expression in human renal epithelial cells","volume":"36","author":"Demirel","year":"2012","journal-title":"Am. J. Nephrol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0610","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/00365520310000681","article-title":"Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis","volume":"38","author":"Kankuri","year":"2003","journal-title":"Scand. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0615","first-page":"62","article-title":"Nitric oxide-dependent regulation of pro-inflammatory cytokines in group B streptococcal inflammation of rat lung","volume":"33","author":"Raykova","year":"2003","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2026.117742_b0620","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1084\/jem.20140654","article-title":"NOS1-derived nitric oxide promotes NF-kappaB transcriptional activity through inhibition of suppressor of cytokine signaling-1","volume":"212","author":"Baig","year":"2015","journal-title":"J. Exp. Med."},{"issue":"Suppl 3","key":"10.1016\/j.bcp.2026.117742_b0625","article-title":"Role of nitric oxide in the regulation of T cell functions","volume":"65","author":"Niedbala","year":"2006","journal-title":"Ann. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.bcp.2026.117742_b0630","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1038\/jid.2015.277","article-title":"Nitric se","volume":"135","author":"Qin","year":"2015","journal-title":"J. Invest. Dermatol."},{"issue":"22","key":"10.1016\/j.bcp.2026.117742_b0635","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.1100667108","article-title":"Regulation of type 17 helper T-cell function by nitric oxide during inflammation","volume":"108","author":"Niedbala","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0640","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1006\/cyto.1995.0056","article-title":"The modulation of IL-6 and TNF-alpha release by nitric oxide following stimulation of J774 cells with LPS and IFN-gamma","volume":"7","author":"Deakin","year":"1995","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0645","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S1081-1206(10)62600-2","article-title":"Differential regulation of human blood monocyte and alveolar macrophage inflammatory cytokine production by nitric oxide","volume":"82","author":"Dinakar","year":"1999","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0650","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1165\/ajrcmb.14.3.8845178","article-title":"Alveolar macrophages autoregulate IL-1 and IL-6 production by endogenous nitric oxide","volume":"14","author":"Persoons","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0655","first-page":"271","article-title":"Inhibitory effects of nitric oxide and interleukin-10 on production of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages","volume":"20","author":"Qiu","year":"1999","journal-title":"Zhongguo Yao Li Xue Bao"},{"issue":"8","key":"10.1016\/j.bcp.2026.117742_b0660","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.4049\/jimmunol.163.8.4182","article-title":"Nitric oxide suppresses human T lymphocyte proliferation through IFN-gamma-dependent and IFN-gamma-independent induction of apoptosis","volume":"163","author":"Allione","year":"1999","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0665","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.jaci.2017.05.023","article-title":"Nitric oxide induces human CLA(+)CD25(+)Foxp3(+) regulatory T cells with skin-homing potential","volume":"140","author":"Yu","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0670","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/sj.bjp.0705854","article-title":"Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis","volume":"143","author":"Hyun","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0675","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/0378-6323.16232","article-title":"A study of serum nitric oxide levels in psoriasis","volume":"71","author":"Gokhale","year":"2005","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0680","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1084\/jem.184.5.2007","article-title":"A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes","volume":"184","author":"Bruch-Gerharz","year":"1996","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.bcp.2026.117742_b0685","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/eji.1830230851","article-title":"Induction of macrophage nitric oxide production by interferon-gamma and tumor necrosis factor-alpha is enhanced by interleukin-10","volume":"23","author":"Corradin","year":"1993","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0690","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2133.2010.09766.x","article-title":"Arginase is overactive in psoriatic skin","volume":"163","author":"Abeyakirthi","year":"2010","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0695","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)63811-4","article-title":"Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation","volume":"162","author":"Bruch-Gerharz","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.bcp.2026.117742_b0700","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1001\/archderm.1997.03890480132027","article-title":"The relationship between nitric oxide production and activity of the disease in patients with psoriasis","volume":"133","author":"Orem","year":"1997","journal-title":"Arch. Dermatol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0705","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.4049\/jimmunol.174.6.3695","article-title":"IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes","volume":"174","author":"Boniface","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0710","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2014.03.003","article-title":"An innovative three-dimensional model of normal human skin to study the proinflammatory psoriatic effects of tumor necrosis factor-alpha and interleukin-17","volume":"68","author":"Donetti","year":"2014","journal-title":"Cytokine"},{"issue":"7","key":"10.1016\/j.bcp.2026.117742_b0715","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.jid.2019.01.014","article-title":"IL-17 and IL-22 promote keratinocyte stemness in the germinative compartment in psoriasis","volume":"139","author":"Ekman","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0720","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41419-024-06842-z","article-title":"NOS2-derived low levels of NO drive psoriasis pathogenesis","volume":"15","author":"Kohler","year":"2024","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.bcp.2026.117742_b0725","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/exd.14001","article-title":"Evidence on the direct correlation between miR-31 and IL-22 axis in IMQ-induced psoriasis","volume":"28","author":"Abdallah","year":"2019","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0730","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202215674","article-title":"Metabolic rewiring in keratinocytes by miR-31-5p identifies therapeutic intervention for psoriasis","volume":"15","author":"Wang","year":"2023","journal-title":"EMBO Mol. Med."},{"issue":"Pt 3","key":"10.1016\/j.bcp.2026.117742_b0735","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.semcancer.2021.09.014","article-title":"The interaction of Helicobacter pylori with cancer immunomodulatory stromal cells: New insight into gastric cancer pathogenesis","volume":"86","author":"Navashenaq","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bcp.2026.117742_b0740","article-title":"Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.117742_b0745","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2021.104207","article-title":"Proteomic analysis of psoriatic skin lesions in a chinese population","volume":"240","author":"Wang","year":"2021","journal-title":"J. Proteomics"},{"key":"10.1016\/j.bcp.2026.117742_b0750","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3389\/fimmu.2020.01432","article-title":"Quantitative proteomic profile of psoriatic epidermis identifies OAS2 as a novel biomarker for disease activity","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0755","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0165-2478(02)00259-6","article-title":"A complementary note on the Morhenn's hypothesis on the pathomechanism of psoriasis","volume":"85","author":"Namazi","year":"2003","journal-title":"Immunol. Lett."},{"issue":"4","key":"10.1016\/j.bcp.2026.117742_b0760","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/bjd.14546","article-title":"Increased airway inflammation in patients with psoriasis","volume":"175","author":"Damiani","year":"2016","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0765","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00403-012-1230-8","article-title":"Role of cellular oxidative stress and cytochrome c in the pathogenesis of psoriasis","volume":"304","author":"Gabr","year":"2012","journal-title":"Arch. Dermatol. Res."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0770","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2013.03.070","article-title":"Effects of nitric oxide on cell proliferation: novel insights","volume":"62","author":"Napoli","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2026.117742_b0775","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2015.06.002","article-title":"Signaling and stress: the redox landscape in NOS2 biology","volume":"87","author":"Thomas","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.117742_b0780","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/jocd.15975","article-title":"IL-17A is involved in the hyperplasia of blood vessels in local lesions of psoriasis by inhibiting autophagy","volume":"23","author":"Wang","year":"2024","journal-title":"J. Cosmet. Dermatol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117742_b0785","doi-asserted-by":"crossref","first-page":"H343","DOI":"10.1152\/ajpheart.00446.2017","article-title":"Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation","volume":"314","author":"Alba","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bcp.2026.117742_b0790","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112229","article-title":"Anti-psoriatic and anti-inflammatory effects of Kaempferia parviflora in keratinocytes and macrophage cells","volume":"143","author":"Takuathung","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.117742_b0795","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1515\/jbcpp-2023-0254","article-title":"Pioglitazone attenuate level of myeloperoxidases and nitic oxide in psoriatic lesion: a proof-of-concept study in a imiquimod induced psoriasis model in rat","volume":"35","author":"Chatterjee","year":"2024","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2026.117742_b0800","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s13205-018-1337-5","article-title":"Role of nitric oxide-scavenging activity of Karanjin and Pongapin in the treatment of Psoriasis","volume":"8","author":"Ghosh","year":"2018","journal-title":"3 Biotech"},{"issue":"6","key":"10.1016\/j.bcp.2026.117742_b0805","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1007\/s00210-024-03655-x","article-title":"Limonin alleviates imiquimod-induced psoriasis-like skin inflammation in mice model by downregulating inflammatory responses","volume":"398","author":"Li","year":"2025","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0810","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27030591","article-title":"Promising strategies in plant-derived treatments of psoriasis-update of in vitro, in vivo, and clinical trials studies","volume":"27","author":"Nowak-Perlak","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0815","first-page":"3537","article-title":"Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF\u2011\u03b1\u2011induced HaCaT cell proliferation and the underlying mechanism in psoriasis","volume":"18","author":"Leng","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bcp.2026.117742_b0820","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114064","article-title":"Exploring acemannan-loaded nanogel formulation for the treatment of IMQ-induced psoriasis-like inflammation: In vitro characterization and in vivo efficacy assessment","volume":"148","author":"Alqarni","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"Pt 2","key":"10.1016\/j.bcp.2026.117742_b0825","article-title":"Therapeutic potential of Rosa rugosa polysaccharide and its nanofiber membrane in psoriasis via PI3K-AKT\/mTOR pathway inhibition","volume":"320","author":"Chen","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117742_b0830","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1046\/j.1365-2133.2000.03483.x","article-title":"Treatment of psoriasis with topical NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis","volume":"142","author":"Ormerod","year":"2000","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117742_b0835","doi-asserted-by":"crossref","first-page":"16043","DOI":"10.1155\/MI\/2006\/16043","article-title":"Nitric oxide levels in patients with psoriasis treated with methotrexate","volume":"2006","author":"Tekin","year":"2006","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bcp.2026.117742_b0840","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/164_2020_382","article-title":"Nitric oxide synthase inhibitors into the clinic at last","volume":"264","author":"Dao","year":"2021","journal-title":"Handb. Exp. Pharmacol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226000730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226000730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:32:25Z","timestamp":1778056345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226000730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":168,"alternative-id":["S0006295226000730"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117742","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of nitric oxide in skin inflammation and the pathogenesis of psoriasis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117742"}}