{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:56:17Z","timestamp":1790477777786,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2023NSCQ-MSX0291"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0291"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bcp.2026.117806","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:51:45Z","timestamp":1770882705000},"page":"117806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["METTL3-m6A-MALAT1 axis exacerbates the autophagy impairment and lipid accumulation in NAFLD by regulating miR-690"],"prefix":"10.1016","volume":"247","author":[{"given":"Guowei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzhi","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.117806_b0005","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2026.117806_b0010","article-title":"Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD)","volume":"13","author":"Rong","year":"2022","journal-title":"Front Endocrinol (lausanne)"},{"key":"10.1016\/j.bcp.2026.117806_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2024.111648","article-title":"Epidemiology of NAFLD - Focus on diabetes","volume":"210","author":"Younossi","year":"2024","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bcp.2026.117806_b0020","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41575-021-00448-y","article-title":"The complex link between NAFLD and type 2 diabetes mellitus - mechanisms and treatments","volume":"18","author":"Targher","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcp.2026.117806_b0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S2213-8587(22)00003-1","article-title":"A global view of the interplay between non-alcoholic fatty liver disease and diabetes","volume":"10","author":"Stefan","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.bcp.2026.117806_b0030","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.aohep.2020.09.006","article-title":"Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease","volume":"19","author":"Arab","year":"2020","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.bcp.2026.117806_b0035","doi-asserted-by":"crossref","unstructured":"D.J. Klionsky, G. Petroni, R.K. Amaravadi, E.H. Baehrecke, A. Ballabio, P. Boya, J.M. Bravo-San Pedro, K. Cadwell, F. Cecconi, A.M.K. Choi, M.E. Choi, C.T. Chu, P. Codogno, M.I. Colombo, A.M. Cuervo, V. Deretic, I. Dikic, Z. Elazar, E.L. Eskelinen, G.M. Fimia, D.A. Gewirtz, D.R. Green, M. Hansen, M. J\u00e4\u00e4ttel\u00e4, T. Johansen, G. Juh\u00e1sz, V. Karantza, C. Kraft, G. Kroemer, N.T. Ktistakis, S. Kumar, C. Lopez-Otin, K.F. Macleod, F. Madeo, J. Martinez, A. Mel\u00e9ndez, N. Mizushima, C. M\u00fcnz, J.M. Penninger, R.M. Perera, M. Piacentini, F. Reggiori, D.C. Rubinsztein, K.M. Ryan, J. Sadoshima, L. Santambrogio, L. Scorrano, H.U. Simon, A.K. Simon, A. Simonsen, A. Stolz, N. Tavernarakis, S.A. Tooze, T. Yoshimori, J. Yuan, Z. Yue, Q. Zhong, L. Galluzzi, F. Pietrocola, Autophagy in major human diseases, Embo j 40 (2021) e108863. 10.15252\/embj.2021108863.","DOI":"10.15252\/embj.2021108863"},{"key":"10.1016\/j.bcp.2026.117806_b0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.117806_b0045","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.15252\/embj.201796697","article-title":"Molecular definitions of autophagy and related processes","volume":"36","author":"Galluzzi","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.117806_b0050","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/hepr.12282","article-title":"Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease","volume":"44","author":"Fukuo","year":"2014","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.bcp.2026.117806_b0055","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/hepr.13071","article-title":"Formation of p62-positive inclusion body is associated with macrophage polarization in non-alcoholic fatty liver disease","volume":"48","author":"Fukushima","year":"2018","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.bcp.2026.117806_b0060","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/15548627.2023.2254191","article-title":"Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease","volume":"20","author":"Ren","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2026.117806_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117072","article-title":"miR-690 ameliorates hepatic steatosis by targeting NF-KappaB P65 and regulating 15-LOX to induce autophagy in db\/db mice","volume":"240","author":"Guo","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117806_b0070","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1111\/febs.16027","article-title":"Regulatory noncoding RNAs: functions and applications in health and disease","volume":"288","author":"Arraiano","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.bcp.2026.117806_b0075","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bcp.2026.117806_b0080","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41420-025-02667-7","article-title":"Long non-coding RNAs and autophagy: dual drivers of Hepatocellular carcinoma progression","volume":"11","author":"Goyal","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.bcp.2026.117806_b0085","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3892\/or.2017.5416","article-title":"Long non-coding RNAs act as regulators of cell autophagy in diseases (Review)","volume":"37","author":"Xu","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bcp.2026.117806_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2021.100584","article-title":"Silencing lncRNA NEAT1 reduces nonalcoholic fatty liver fat deposition by regulating the miR-139-5p\/c-Jun\/SREBP-1c pathway","volume":"27","author":"Jin","year":"2022","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.bcp.2026.117806_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110190","article-title":"LncRNA HOTAIR regulates the lipid accumulation in non-alcoholic fatty liver disease via miR-130b-3p\/ROCK1 axis","volume":"90","author":"Guo","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bcp.2026.117806_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.858558","article-title":"LncRNA MALAT1 Promotes PPAR\u03b1\/CD36-Mediated Hepatic Lipogenesis in Nonalcoholic Fatty Liver Disease by Modulating miR-206\/ARNT Axis","volume":"10","author":"Xiang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bcp.2026.117806_b0105","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41422-018-0040-8","article-title":"Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.bcp.2026.117806_b0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13045-019-0805-7","article-title":"The interplay between m6A RNA methylation and noncoding RNA in cancer","volume":"12","author":"Ma","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bcp.2026.117806_b0115","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s12935-021-02113-5","article-title":"The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1\/miR-26b\/HMGA2 axis","volume":"21","author":"Zhao","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bcp.2026.117806_b0120","doi-asserted-by":"crossref","unstructured":"P. Liu, B. Zhang, Z. Chen, Y. He, Y. Du, Y. Liu, X. Chen, m(6)A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145\/FAK pathway, Aging (Albany NY) 12 (2020) 5280\u20135299. 10.18632\/aging.102950.","DOI":"10.18632\/aging.102950"},{"key":"10.1016\/j.bcp.2026.117806_b0125","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1007\/s12033-023-00953-2","article-title":"METTL3 Mediated MALAT1 m6A Modification Promotes Proliferation and Metastasis in Osteosarcoma Cells","volume":"66","author":"Zhang","year":"2024","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.bcp.2026.117806_b0130","doi-asserted-by":"crossref","DOI":"10.3390\/nu15030687","article-title":"Understanding NAFLD: From Case Identification to Interventions, Outcomes, and Future Perspectives","volume":"15","author":"Clayton-Chubb","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bcp.2026.117806_b0135","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.gastrohep.2023.09.014","article-title":"Long non-coding RNAs as modulators and therapeutic targets in non-alcoholic fatty liver disease (NAFLD)","volume":"47","author":"Tao","year":"2024","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcp.2026.117806_b0140","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2018.03.127","article-title":"Long noncoding RNA lncARSR promotes hepatic lipogenesis via Akt\/SREBP-1c pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis","volume":"499","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.117806_b0145","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2022.08.007","article-title":"Current advancements and future perspectives of long noncoding RNAs in lipid metabolism and signaling","volume":"48","author":"Duan","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bcp.2026.117806_b0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13046-024-03134-4","article-title":"m(6)A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma","volume":"43","author":"Lin","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.117806_b0155","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/s41418-023-01183-4","article-title":"GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p\/MARCH7\/NLRP3 axis-mediated pyroptosis","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2026.117806_b0160","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1089\/dna.2023.0410","article-title":"m6A RNA Methylation and Implications for Hepatic Lipid Metabolism","volume":"43","author":"Ming","year":"2024","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bcp.2026.117806_b0165","article-title":"PXR Activation Relieves Deoxynivalenol-Induced Liver Oxidative Stress Via Malat1 LncRNA m(6)A Demethylation","volume":"11","author":"Feng","year":"2024","journal-title":"Adv Sci (weinh)"},{"key":"10.1016\/j.bcp.2026.117806_b0170","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/15548627.2021.1895658","article-title":"The m\u00e9nage \u00e0 trois of autophagy, lipid droplets and liver disease","volume":"18","author":"Filali-Mouncef","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2026.117806_b0175","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117806_b0180","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fphys.2020.00850","article-title":"Lipophagy Impairment Is Associated With Disease Progression in NAFLD","volume":"11","author":"Carotti","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bcp.2026.117806_b0185","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13075-023-03035-5","article-title":"FTO-mediated m6A demethylation of pri-miR-3591 alleviates osteoarthritis progression","volume":"25","author":"Liu","year":"2023","journal-title":"Arthritis Res. Ther."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226001371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226001371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:07:42Z","timestamp":1779109662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226001371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"alternative-id":["S0006295226001371"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117806","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"METTL3-m6A-MALAT1 axis exacerbates the autophagy impairment and lipid accumulation in NAFLD by regulating miR-690","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117806"}}