{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:57:05Z","timestamp":1793689025732,"version":"4.5.1"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bcp.2026.117854","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T07:39:19Z","timestamp":1772177959000},"page":"117854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["The cGAS\u2013STING signaling pathway: A central regulator and novel therapeutic target in skeletal muscle pathophysiology"],"prefix":"10.1016","volume":"248","author":[{"given":"Haiyan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongxin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanzhan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-1561","authenticated-orcid":false,"given":"Hualin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bcp.2026.117854_b0005","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117854_b0010","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.molcel.2022.12.023","article-title":"p53 engages the cGAS\/STING cytosolic DNA sensing pathway for tumor suppression","volume":"83","author":"Ghosh","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2026.117854_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1020670","article-title":"Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice","volume":"13","author":"Gong","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.bcp.2026.117854_b0020","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.tcb.2022.11.001","article-title":"Cellular functions of cGAS-STING signaling","volume":"33","author":"Chen","year":"2023","journal-title":"Trends Cell Biol."},{"issue":"12","key":"10.1016\/j.bcp.2026.117854_b0025","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s43018-022-00468-w","article-title":"The cGAS-STING pathway and cancer","volume":"3","author":"Samson","year":"2022","journal-title":"Nat Cancer"},{"issue":"7","key":"10.1016\/j.bcp.2026.117854_b0030","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14824","article-title":"CD300LF(+) microglia impede the neuroinflammation following traumatic brain injury by inhibiting STING pathway","volume":"30","author":"Lu","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.056","article-title":"TBK1 and IKKepsilon Act Redundantly to Mediate STING-Induced NF-kappaB responses in Myeloid Cells","volume":"31","author":"Balka","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2026.117854_b0040","article-title":"Grishin NV et al: Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347(6227):aaa2630","author":"Liu","year":"2015","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bcp.2026.117854_b0045","first-page":"214","article-title":"Acupuncture Pretreatment Reduces Skeletal Muscle Inflammatory Response in EIMD Rats by Activating cGAS-STING-NF-kappaB Signaling Pathway","volume":"30","author":"Li","year":"2024","journal-title":"Altern. Ther. Health Med."},{"issue":"6","key":"10.1016\/j.bcp.2026.117854_b0050","first-page":"H664","article-title":"Menstrual cycle and sex effects on sympathetic responses to acute chemoreflex stress","volume":"308","author":"Usselman","year":"2015","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0055","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41467-023-44239-2","article-title":"Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0060","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/s42003-025-09050-3","article-title":"Mutant p53 variants differentially impact replication initiation and activate cGAS-STING to affect immune checkpoint inhibition","volume":"8","author":"Liu","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bcp.2026.117854_b0065","article-title":"Reproductive safety of STING agonists MSA-2 and manganese-MSA-2","volume":"13(5):tfae172","author":"Cai","year":"2024","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.bcp.2026.117854_b0070","doi-asserted-by":"crossref","first-page":"11181","DOI":"10.2147\/IJN.S483815","article-title":"Photo-Thermally Controllable Tumor Metabolic Modulation to Assist T Cell Activation for Boosting Immunotherapy","volume":"19","author":"Ma","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"7983","key":"10.1016\/j.bcp.2026.117854_b0075","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-023-06621-4","article-title":"Apoptotic stress causes mtDNA release during senescence and drives the SASP","volume":"622","author":"Victorelli","year":"2023","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bcp.2026.117854_b0080","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molcel.2017.06.014","article-title":"Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase is a Subunit of the Human TIM22 Protein import complex","volume":"67","author":"Kang","year":"2017","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0085","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00204-025-04206-w","article-title":"cGAS-STING and autophagy: crosstalk, molecular mechanisms, and targeted therapy","volume":"100","author":"Wang","year":"2026","journal-title":"Arch. Toxicol."},{"issue":"9","key":"10.1016\/j.bcp.2026.117854_b0090","article-title":"Liver-Secreted Extracellular Vesicles Promote Cirrhosis-Associated Skeletal Muscle Injury through mtDNA-cGAS\/STING Axis","volume":"12","author":"Fan","year":"2025","journal-title":"Adv Sci (weinh)"},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0095","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41467-024-45044-1","article-title":"Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS\/STING inflammation during aging","volume":"15","author":"Jimenez-Loygorri","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.117854_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117627","article-title":"RIPK3 deficiency ameliorates diabetic sarcopenia through proteostasis regulation by suppressing inflammatory signaling and cellular stress pathways","volume":"244","author":"Yi","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117854_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117589","article-title":"Dual role of macrophages in skeletal muscle atrophy: Mechanisms and therapeutic strategies","volume":"244","author":"Shang","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117854_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115664","article-title":"Oxidative stress: Roles in skeletal muscle atrophy","volume":"214","author":"Zhang","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"Pt 2","key":"10.1016\/j.bcp.2026.117854_b0115","article-title":"Myokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance","volume":"242","author":"Yi","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117854_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116799","article-title":"Endoplasmic reticulum stress and unfolded protein response: Roles in skeletal muscle atrophy","volume":"234","author":"Ji","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117854_b0125","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s10787-024-01454-7","article-title":"Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3","volume":"32","author":"Ji","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bcp.2026.117854_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1344276","article-title":"Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein degradation systems","volume":"15","author":"Deng","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117854_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115186","article-title":"Celecoxib alleviates denervation-induced muscle atrophy by suppressing inflammation and oxidative stress and improving microcirculation","volume":"203","author":"Zhang","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117854_b0140","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1002\/jcsm.13336","article-title":"Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors gamma degradation and inhibiting fatty acid oxidation","volume":"14","author":"Yan","year":"2023","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bcp.2026.117854_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.139232","article-title":"Polystyrene nanoplastics promote muscle cell senescence through microtubule hyper-stabilization-mediated mitophagy dysfunction and cGAS-sting activation","volume":"496","author":"Cui","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113626","article-title":"CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise","volume":"43","author":"Ma","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2026.117854_b0155","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.freeradbiomed.2025.08.043","article-title":"Exercise training ameliorates high-fat diet-induced skeletal muscle atrophy and ferroptosis via downregulation of STING","volume":"240","author":"Xu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0160","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13649","article-title":"The Stimulator of Interferon Genes Deficiency Attenuates Diabetic Myopathy through Inhibiting NLRP3-Mediated Pyroptosis","volume":"16","author":"Yang","year":"2025","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"6121","key":"10.1016\/j.bcp.2026.117854_b0165","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bcp.2026.117854_b0170","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.cell.2013.07.023","article-title":"Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA","volume":"154","author":"Gao","year":"2013","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.056","article-title":"TBK1 and IKK\u03b5 Act Redundantly to Mediate STING-Induced NF-\u03baB responses in Myeloid Cells","volume":"31","author":"Balka","year":"2020","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0180","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13567-022-01050-z","article-title":"ASFV pD345L protein negatively regulates NF-\u03baB signalling by inhibiting IKK kinase activity","volume":"53","author":"Chen","year":"2022","journal-title":"Vet. Res."},{"issue":"6","key":"10.1016\/j.bcp.2026.117854_b0185","first-page":"214","article-title":"Acupuncture Pretreatment Reduces Skeletal Muscle Inflammatory Response in EIMD Rats by Activating cGAS-STING-NF-\u03baB Signaling Pathway","volume":"30","author":"Li","year":"2024","journal-title":"Altern. Ther. Health Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0190","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1038\/s41467-024-50996-5","article-title":"Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation","volume":"15","author":"Sun","year":"2024","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bcp.2026.117854_b0195","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41419-024-06863-8","article-title":"mtDNA release promotes cGAS-STING activation and accelerated aging of postmitotic muscle cells","volume":"15","author":"Li","year":"2024","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.bcp.2026.117854_b0200","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70657","article-title":"AMPK\/SIRT1\/PGC-1\u03b1 Signaling Pathway: Molecular Mechanisms and Targeted strategies from Energy Homeostasis Regulation to Disease Therapy","volume":"31","author":"Chen","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bcp.2026.117854_b0205","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbaf050","article-title":"Advancements in skeletal muscle tissue engineering: strategies for repair and regeneration of skeletal muscle beyond self-repair","volume":"12","author":"Qi","year":"2025","journal-title":"Regener. Biomater."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0210","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12967-023-04369-z","article-title":"Mitochondrial dysfunction: roles in skeletal muscle atrophy","volume":"21","author":"Chen","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bcp.2026.117854_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.947387","article-title":"Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function","volume":"13","author":"Yan","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117854_b0220","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/SHK.0000000000002613","article-title":"cGAS-STING-NFkappaB pathway plays a role in burn injury-induced muscle wasting","volume":"64","author":"Xie","year":"2025","journal-title":"Shock"},{"issue":"17","key":"10.1016\/j.bcp.2026.117854_b0225","article-title":"CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding a Novel TMEFF1-339aa Protein","volume":"10","author":"Chen","year":"2023","journal-title":"Adv Sci (weinh)"},{"issue":"2","key":"10.1016\/j.bcp.2026.117854_b0230","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tem.2025.05.004","article-title":"Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise","volume":"37","author":"Ma","year":"2026","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.bcp.2026.117854_b0235","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.immuni.2024.02.019","article-title":"New frontiers in the cGAS-STING intracellular DNA-sensing pathway","volume":"57","author":"Dvorkin","year":"2024","journal-title":"Immunity"},{"issue":"17","key":"10.1016\/j.bcp.2026.117854_b0240","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.devcel.2024.05.012","article-title":"Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation","volume":"59","author":"Garcia","year":"2024","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0245","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13104-022-06113-0","article-title":"Effects of end-stage osteoarthritis on markers of skeletal muscle Long INterspersed Element-1 activity","volume":"15","author":"Osburn","year":"2022","journal-title":"BMC. Res. Notes"},{"issue":"7","key":"10.1016\/j.bcp.2026.117854_b0250","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s43587-025-00907-0","article-title":"Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy","volume":"5","author":"Xiang","year":"2025","journal-title":"Nat. Aging"},{"issue":"8","key":"10.1016\/j.bcp.2026.117854_b0255","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13152","article-title":"Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome","volume":"19","author":"Mu","year":"2020","journal-title":"Aging Cell"},{"issue":"11\u201312","key":"10.1016\/j.bcp.2026.117854_b0260","doi-asserted-by":"crossref","first-page":"e2430","DOI":"10.1093\/milmed\/usae184","article-title":"Doxycycline-Mediated Inhibition of Snake Venom Phospholipase and Metalloproteinase","volume":"189","author":"Arens","year":"2024","journal-title":"Mil. Med."},{"key":"10.1016\/j.bcp.2026.117854_b0265","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/bs.irn.2025.04.007","article-title":"Viral agents in neuromuscular pathology","volume":"180","author":"Singh","year":"2025","journal-title":"Int. Rev. Neurobiol."},{"issue":"10","key":"10.1016\/j.bcp.2026.117854_b0270","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1038\/s41401-023-01185-5","article-title":"The role of the cGAS-STING signaling pathway in viral infections, inflammatory and autoimmune diseases","volume":"45","author":"Wang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.bcp.2026.117854_b0275","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41556-023-01343-1","article-title":"Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal","volume":"26","author":"Newman","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"7899","key":"10.1016\/j.bcp.2026.117854_b0280","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41586-022-04421-w","article-title":"The cGAS-STING pathway drives type I IFN immunopathology in COVID-19","volume":"603","author":"Domizio","year":"2022","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2026.117854_b0285","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1093\/rheumatology\/keae425","article-title":"Circulating cell-free DNA promotes inflammation in dermatomyositis patients with anti-NXP2 antibodies via the cGAS\/STING pathway","volume":"64","author":"Wang","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bcp.2026.117854_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103232","article-title":"Elevated type I IFN signalling directly affects CD8(+) T-cell distribution and autoantigen recognition of the skeletal muscles in active JDM patients","volume":"146","author":"Huang","year":"2024","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0295","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13046-025-03555-9","article-title":"Bridging innate and adaptive tumor immunity: cGAS-STING pathway activation to potentiate immune checkpoint blockade","volume":"44","author":"Li","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.bcp.2026.117854_b0300","doi-asserted-by":"crossref","first-page":"958","DOI":"10.2337\/db22-0654","article-title":"Regulation of Monocyte Activation by PPAR\u03b1 through Interaction with the cGAS-STING Pathway","volume":"72","author":"Dong","year":"2023","journal-title":"Diabetes"},{"issue":"48","key":"10.1016\/j.bcp.2026.117854_b0305","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2208934119","article-title":"Modulation of cGAS-STING signaling by PPAR\u03b1 in a mouse model of ischemia-induced retinopathy","volume":"119","author":"Ma","year":"2022","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.bcp.2026.117854_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115251","article-title":"Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling","volume":"44","author":"Chen","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2026.117854_b0315","article-title":"Tao Hong Si Wu decoction attenuates myocardial injury in diabetic mice by regulating the cGAS\/STING\/NLRP3 axis","volume":"15(12):413","author":"Shen","year":"2025","journal-title":"3 Biotech"},{"key":"10.1016\/j.bcp.2026.117854_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154922","article-title":"Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING\/NLRP3 signalling pathway","volume":"117","author":"Fang","year":"2023","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.bcp.2026.117854_b0325","doi-asserted-by":"crossref","first-page":"26084","DOI":"10.31083\/FBL26084","article-title":"cGAS\/STING\/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy","volume":"30","author":"Li","year":"2025","journal-title":"Front Biosci (landmark Ed)"},{"issue":"12","key":"10.1016\/j.bcp.2026.117854_b0330","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1007\/s00204-025-04150-9","article-title":"Interplay of cGAS-STING and ferroptosis: crosstalk, molecular mechanisms, and therapeutic prospects","volume":"99","author":"Wang","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bcp.2026.117854_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116203","article-title":"Crosstalk between cGAS-STING and pyroptosis: from molecular mechanisms to therapeutic strategies","volume":"172","author":"Wang","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2026.117854_b0340","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2022.10.014","article-title":"Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS\/STING signaling dependent on LKB1\/AMPK\/ULK1-mediated autophagy","volume":"51","author":"Lu","year":"2023","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0345","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00018-023-05096-w","article-title":"MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury","volume":"81","author":"Jiang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2026.117854_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115407","article-title":"Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies","volume":"208","author":"Wang","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0355","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/antiox12010044","article-title":"Potential Therapeutic strategies for Skeletal Muscle Atrophy","volume":"12","author":"Huang","year":"2022","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.bcp.2026.117854_b0360","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.917113","article-title":"Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies","volume":"13","author":"Shen","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bcp.2026.117854_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114954","article-title":"Biogenesis and function of extracellular vesicles in pathophysiological processes of skeletal muscle atrophy","volume":"198","author":"Wang","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2026.117854_b0370","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.3390\/antiox11091686","article-title":"Inflammation: Roles in Skeletal Muscle Atrophy","volume":"11","author":"Ji","year":"2022","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.bcp.2026.117854_b0375","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1729941","article-title":"Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions","volume":"16","author":"Gong","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117854_b0380","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1732718","article-title":"Macrophage polarization: molecular mechanisms, disease implications, and targeted therapeutic strategies","volume":"16","author":"Ji","year":"2025","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.bcp.2026.117854_b0385","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300347","article-title":"Nutritional strategies for Muscle Atrophy: current evidence and underlying Mechanisms","volume":"68","author":"Shen","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"issue":"9","key":"10.1016\/j.bcp.2026.117854_b0390","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1007\/s00415-022-11146-3","article-title":"Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases","volume":"269","author":"Zhao","year":"2022","journal-title":"J. Neurol."},{"key":"10.1016\/j.bcp.2026.117854_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114144","article-title":"cGAS-STING mediates neutrophil extracellular traps-induced EMT in myositis-associated interstitial lung disease: STING as a potential therapeutic target","volume":"149","author":"Feng","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0400","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10565-025-10051-5","article-title":"cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction","volume":"41","author":"Yu","year":"2025","journal-title":"Cell Biol. Toxicol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117854_b0405","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1152\/japplphysiol.00038.2025","article-title":"Effect of aging, endurance training, and denervation on innate immune signaling in skeletal muscle","volume":"138","author":"Khemraj","year":"2025","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bcp.2026.117854_b0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123831","article-title":"Cationic nanoparticle targets cGAS-STING axis to drive functional orofacial muscle regeneration","volume":"328","author":"Sui","year":"2026","journal-title":"Biomaterials"},{"issue":"20","key":"10.1016\/j.bcp.2026.117854_b0415","doi-asserted-by":"crossref","first-page":"11317","DOI":"10.3390\/ijms252011317","article-title":"SAT1\/ALOX15 Signaling Pathway is involved in Ferroptosis after Skeletal Muscle Contusion","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0420","doi-asserted-by":"crossref","first-page":"65","DOI":"10.14797\/mdcvj.1428","article-title":"Pulmonary Vein Thrombus after Mitral Valve Transcatheter Edge-to-Edge Repair","volume":"20","author":"Rana","year":"2024","journal-title":"Methodist Debakey Cardiovasc. J."},{"issue":"10","key":"10.1016\/j.bcp.2026.117854_b0425","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.3390\/ijms25105277","article-title":"Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2026.117854_b0430","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/ggi.14850","article-title":"Bidirectional effect of uric acid on C2C12 myotubes and its partial mechanism","volume":"24","author":"Li","year":"2024","journal-title":"Geriatr. Gerontol. Int."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0435","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/jcsm.13112","article-title":"The impact of senescence on muscle wasting in chronic kidney disease","volume":"14","author":"Huang","year":"2023","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bcp.2026.117854_b0440","volume":"12","author":"Zhang","year":"2021","journal-title":"Inflammasomes and Fibrosis. Front Immunol"},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0445","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1212\/WNL.0000000000009727","article-title":"Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: Study of 121 cases","volume":"95","author":"Allenbach","year":"2020","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0450","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13075-017-1383-0","article-title":"RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis","volume":"19","author":"Su\u00e1rez-Calvet","year":"2017","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.bcp.2026.117854_b0455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0319216","article-title":"Implications of tissue specific STING protein flux and abundance on inflammation and the development of targeted therapeutics","volume":"20","author":"Angel","year":"2025","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0460","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12931-025-03170-4","article-title":"YAP\/TAZ-mediated nuclear membrane rupture in promoting senescence of skeletal muscle associated with COPD","volume":"26","author":"Gong","year":"2025","journal-title":"Respir. Res."},{"issue":"W1","key":"10.1016\/j.bcp.2026.117854_b0465","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117854_b0470","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.toxicon.2018.07.029","article-title":"Light emitting diode (LED) therapy reduces local pathological changes induced by Bothrops asper snake venom","volume":"152","author":"Campos","year":"2018","journal-title":"Toxicon"},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0475","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10103-024-04116-w","article-title":"Effect of combined red and infrared wavelengths on inflammation, hemorrhage, and muscle damage caused by Bothrops leucurus snake venom","volume":"39","author":"da Silva","year":"2024","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.bcp.2026.117854_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112215","article-title":"Preclinical evaluation of single domain antibody efficacy in mitigating local tissue damage induced by Bothrops snake envenomation","volume":"134","author":"Prado","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.bcp.2026.117854_b0485","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/v15091801","article-title":"Innate Immune Response to Viral Vectors in Gene Therapy","volume":"15","author":"Wang","year":"2023","journal-title":"Viruses"},{"issue":"13\u201314","key":"10.1016\/j.bcp.2026.117854_b0490","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1089\/hum.2024.040","article-title":"Innate Immune Sensing of Adeno-Associated Virus Vectors","volume":"35","author":"Cao","year":"2024","journal-title":"Hum. Gene Ther."},{"issue":"2","key":"10.1016\/j.bcp.2026.117854_b0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtm.2025.101464","article-title":"A myotropic AAV vector combined with skeletal muscle cis-regulatory elements improve glycogen clearance in mouse models of Pompe disease","volume":"33","author":"Sellier","year":"2025","journal-title":"Mol. Ther. Methods Clin. Dev."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtm.2025.101409","article-title":"Immune-driven gene expression loss following intramuscular AAV delivery to non-human primates is only transient","volume":"33","author":"Journou","year":"2025","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.bcp.2026.117854_b0505","article-title":"LED photobiomodulation reduces myonecrosis and hemorrhage caused by PI metalloproteinase isolated from Bothrops jararacussu venom","volume":"267","author":"Ferreira","year":"2025","journal-title":"J. Photochem. Photobiol. B"},{"issue":"7","key":"10.1016\/j.bcp.2026.117854_b0510","doi-asserted-by":"crossref","first-page":"7667","DOI":"10.1007\/s00210-025-03835-3","article-title":"Nanocarrier-mediated modulation of cGAS-STING signaling pathway to disrupt tumor microenvironment","volume":"398","author":"Pindiprolu","year":"2025","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"36","key":"10.1016\/j.bcp.2026.117854_b0515","doi-asserted-by":"crossref","DOI":"10.4028\/b-XDTcg5","article-title":"Emerging cGAS-STING Agonist-based Nanotherapeutics: Mechanistic Insights and applications in Cancer Combination Therapy","volume":"12","author":"Wang","year":"2025","journal-title":"Adv Sci (weinh)"},{"key":"10.1016\/j.bcp.2026.117854_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102602","article-title":"The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders","volume":"104","author":"Kalinkovich","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bcp.2026.117854_b0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107137","article-title":"cGAS-STING targeting offers a novel therapeutic paradigm in cardiovascular diseases","volume":"211","author":"Wang","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.bcp.2026.117854_b0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102691","article-title":"cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases","volume":"105","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2026.117854_b0535","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12974-025-03563-8","article-title":"cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives","volume":"22","author":"Li","year":"2025","journal-title":"J. Neuroinflammation"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226001851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226001851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:36:10Z","timestamp":1777448170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226001851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":107,"alternative-id":["S0006295226001851"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117854","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cGAS\u2013STING signaling pathway: A central regulator and novel therapeutic target in skeletal muscle pathophysiology","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117854"}}