{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:54:24Z","timestamp":1787860464506,"version":"build-2784847793"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bcp.2026.117868","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:53:59Z","timestamp":1772841239000},"page":"117868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Baimaside, a flavonoid glycoside from Apocynum venetum, ameliorates sepsis by allosterically inhibiting NF-\u03baB p50-mediated IL-6 transcription"],"prefix":"10.1016","volume":"248","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingnan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2182-7840","authenticated-orcid":false,"given":"Yanlong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10141","key":"10.1016\/j.bcp.2026.117868_b0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2026.117868_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104363","article-title":"Immunopathophysiology of human sepsis","volume":"86","author":"Wiersinga","year":"2022","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.bcp.2026.117868_b0015","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/imr.12499","article-title":"The immune system's role in sepsis progression, resolution, and long-term outcome","volume":"274","author":"Delano","year":"2016","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.bcp.2026.117868_b0020","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41590-019-0368-3","article-title":"Innate immunity to intracellular lps","volume":"20","author":"Rathinam","year":"2019","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117868_b0025","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bcp.2026.117868_b0030","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","article-title":"Toll-like receptors and the control of immunity","volume":"180","author":"Fitzgerald","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bcp.2026.117868_b0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"Lps\/tlr4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.bcp.2026.117868_b0040","article-title":"Tlr4 signaling pathway modulators as potential therapeutics in inflammation and sepsis","volume":"5","author":"Kuzmich","year":"2017","journal-title":"Vaccines (basel)"},{"issue":"1","key":"10.1016\/j.bcp.2026.117868_b0045","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s10753-018-0890-8","article-title":"Review: the role and mechanisms of macrophage autophagy in sepsis","volume":"42","author":"Qiu","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.bcp.2026.117868_b0050","article-title":"Macrophage polarization: an important role in inflammatory diseases","volume":"15","author":"Luo","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.117868_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107791","article-title":"The roles of macrophage polarization in the host immune response to sepsis","volume":"96","author":"Chen","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.bcp.2026.117868_b0060","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/s12276-021-00649-0","article-title":"Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms","volume":"53","author":"Kang","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.bcp.2026.117868_b0065","first-page":"e0387","article-title":"Accuracy for mortality prediction with additive biomarkers including interleukin-6 in critically ill patients: a multicenter prospective observational study","volume":"3","author":"Yamamoto","year":"2021","journal-title":"Crit Care Explor"},{"issue":"5","key":"10.1016\/j.bcp.2026.117868_b0070","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1128\/IAI.73.5.2751-2757.2005","article-title":"Role of interleukin-6 in mortality from and physiologic response to sepsis","volume":"73","author":"Remick","year":"2005","journal-title":"Infect. Immun."},{"issue":"7","key":"10.1016\/j.bcp.2026.117868_b0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.medcli.2016.06.001","article-title":"prognostic value of interleukin 6 for death of patients with sepsis","volume":"147","author":"Pall\u00e1s Beneyto","year":"2016","journal-title":"Med. Clin. (Barc.)"},{"issue":"10","key":"10.1016\/j.bcp.2026.117868_b0080","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41577-023-00856-y","article-title":"Targeting il-6 trans-signalling: past, present and future prospects","volume":"23","author":"Rose-John","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.bcp.2026.117868_b0085","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1097\/00003246-199512000-00002","article-title":"Anti-interleukin-6 antibody treatment improves survival during gut-derived sepsis in a time-dependent manner by enhancing host defense","volume":"23","author":"Gennari","year":"1995","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.117868_b0090","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4049\/jimmunol.170.1.503","article-title":"Protective effects of il-6 blockade in sepsis are linked to reduced c5a receptor expression","volume":"170","author":"Riedemann","year":"2003","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117868_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004174","article-title":"Therapeutic potential of il6r blockade for the treatment of sepsis and sepsis-related death: a mendelian randomisation study","volume":"20","author":"Hamilton","year":"2023","journal-title":"PLoS Med."},{"issue":"6","key":"10.1016\/j.bcp.2026.117868_b0100","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","article-title":"The two nf-kappab activation pathways and their role in innate and adaptive immunity","volume":"25","author":"Bonizzi","year":"2004","journal-title":"Trends Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117868_b0105","first-page":"343","article-title":"Nf-kappab and its regulation on the immune system","volume":"1","author":"Liang","year":"2004","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bcp.2026.117868_b0110","doi-asserted-by":"crossref","DOI":"10.1038\/sigtrans.2017.23","article-title":"Nf-\u03bab signaling in inflammation","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther 2"},{"issue":"1","key":"10.1016\/j.bcp.2026.117868_b0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1478-811X-11-23","article-title":"Atypical i\u03bab proteins - nuclear modulators of nf-\u03bab signaling","volume":"11","author":"Schuster","year":"2013","journal-title":"Cell Commun. Signal"},{"issue":"2","key":"10.1016\/j.bcp.2026.117868_b0120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1515\/bmc-2012-0039","article-title":"Role of nuclear i\u03babs in inflammation regulation","volume":"4","author":"Chiba","year":"2013","journal-title":"Biomol. Concepts"},{"issue":"6996","key":"10.1016\/j.bcp.2026.117868_b0125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature02738","article-title":"Regulation of toll\/il-1-receptor-mediated gene expression by the inducible nuclear protein ikappabzeta","volume":"430","author":"Yamamoto","year":"2004","journal-title":"Nature"},{"issue":"40","key":"10.1016\/j.bcp.2026.117868_b0130","doi-asserted-by":"crossref","first-page":"66310","DOI":"10.18632\/oncotarget.11624","article-title":"I\u03bab\u03b6: an emerging player in cancer","volume":"7","author":"Willems","year":"2016","journal-title":"Oncotarget"},{"issue":"29","key":"10.1016\/j.bcp.2026.117868_b0135","doi-asserted-by":"crossref","first-page":"27657","DOI":"10.1074\/jbc.M103426200","article-title":"A novel ikappab protein, ikappab-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappab in the nuclei","volume":"276","author":"Yamazaki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.117868_b0140","doi-asserted-by":"crossref","unstructured":"Cartwright T., Perkins N.D., C L.W., Nfkb1: A suppressor of inflammation, ageing and cancer, Febs j 283(10) (2016) 1812-22.","DOI":"10.1111\/febs.13627"},{"issue":"1","key":"10.1016\/j.bcp.2026.117868_b0145","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jmb.2008.03.060","article-title":"The nuclear i kappab protein i kappab zeta specifically binds nf-kappab p50 homodimers and forms a ternary complex on kappab DNA","volume":"379","author":"Trinh","year":"2008","journal-title":"J. Mol. Biol."},{"issue":"11\u201312","key":"10.1016\/j.bcp.2026.117868_b0150","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1101\/gad.351630.124","article-title":"Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an nf-\u03bab p50-i\u03bab\u03b6 pathway","volume":"38","author":"Daly","year":"2024","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.bcp.2026.117868_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/biom13091310","article-title":"X-ray crystallographic study of preferred spacing by the nf-\u03bab p50 homodimer on \u03bab DNA","volume":"13","author":"Zhu","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2026.117868_b0160","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jchromb.2017.01.041","article-title":"Purification of quercetin-3-o-sophoroside and isoquercitrin from poacynum hendersonii leaves using macroporous resins followed by sephadex lh-20 column chromatography","volume":"1048","author":"Li","year":"2017","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bcp.2026.117868_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.125880","article-title":"A comparison of the absorption and metabolism of the major quercetin in brassica, quercetin-3-o-sophoroside, to that of quercetin aglycone, in rats","volume":"311","author":"Wang","year":"2020","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.bcp.2026.117868_b0170","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.clnu.2018.03.006","article-title":"Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects","volume":"38","author":"L\u00f3pez-Chill\u00f3n","year":"2019","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bcp.2026.117868_b0175","first-page":"295","article-title":"Simultaneous qualitative and quantitative analysis of phenolic acids and flavonoids for the quality control of apocynum venetum l","volume":"85","author":"An","year":"2013","journal-title":"Leaves by Hplc-Dad-Esi-It-Tof-Ms and Hplc-Dad, J Pharm Biomed Anal"},{"key":"10.1016\/j.bcp.2026.117868_b0180","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.14966","article-title":"Apocynum venetum, a medicinal, economical and ecological plant: a review update","volume":"11","author":"Xiang","year":"2023","journal-title":"PeerJ"},{"issue":"11","key":"10.1016\/j.bcp.2026.117868_b0185","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/pros.23536","article-title":"Quercetin protects against chronic prostatitis in rat model through nf-\u03bab and mapk signaling pathways","volume":"78","author":"Meng","year":"2018","journal-title":"Prostate"},{"issue":"1","key":"10.1016\/j.bcp.2026.117868_b0190","first-page":"248","article-title":"Quercetin inhibits nthi-triggered cxcr4 activation through suppressing ikk\u03b1\/nf-\u03bab and mapk signaling pathways in otitis media","volume":"42","author":"Ma","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2026.117868_b0195","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of nf-kappab transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.bcp.2026.117868_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102349","article-title":"An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of nf\u03bab p50\/rela","volume":"298","author":"Baughman","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.117868_b0205","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1188253","article-title":"The central inflammatory regulator i\u03bab\u03b6: Induction, regulation and physiological functions","volume":"14","author":"Feng","year":"2023","journal-title":"Front. Immunol."},{"issue":"11\u201312","key":"10.1016\/j.bcp.2026.117868_b0210","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1101\/gad.351892.124","article-title":"Structural and biochemical analyses of the nuclear i\u03bab\u03b6 protein in complex with the nf-\u03bab p50 homodimer","volume":"38","author":"Zhu","year":"2024","journal-title":"Genes Dev."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:20:58Z","timestamp":1777450858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"alternative-id":["S0006295226002005"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117868","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baimaside, a flavonoid glycoside from Apocynum venetum, ameliorates sepsis by allosterically inhibiting NF-\u03baB p50-mediated IL-6 transcription","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117868"}}