{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:09:27Z","timestamp":1778713767939,"version":"3.51.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bcp.2026.117878","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:25:30Z","timestamp":1773073530000},"page":"117878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mechanism of action of REDD1 in depression and its targeted intervention"],"prefix":"10.1016","volume":"249","author":[{"given":"Wei","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ting","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 4","key":"10.1016\/j.bcp.2026.117878_b0005","article-title":"Novel molecular insights into the role of CRH type 1 receptor in the pathophysiology of depression","volume":"242","author":"Rakeshkumar","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117878_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2020.101943","article-title":"The gut microbiota in anxiety and depression - a systematic review","volume":"83","author":"Simpson","year":"2021","journal-title":"Clin. Psychol. Rev."},{"issue":"10161","key":"10.1016\/j.bcp.2026.117878_b0015","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2026.117878_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123175","article-title":"p75NTR mediated chronic restraint stress-induced depression-like behaviors in mice via hippocampal mTOR pathway","volume":"358","author":"Peng","year":"2024","journal-title":"Life Sci."},{"issue":"14","key":"10.1016\/j.bcp.2026.117878_b0025","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1056\/NEJMoa2304145","article-title":"Esketamine nasal spray versus quetiapine for treatment-resistant depression","volume":"389","author":"Reif","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"17","key":"10.1016\/j.bcp.2026.117878_b0030","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1111\/bph.15596","article-title":"Perspectives for therapy of treatment-resistant depression","volume":"179","author":"Papp","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"Suppl 6","key":"10.1016\/j.bcp.2026.117878_b0035","first-page":"7","article-title":"Depression: the case for a monoamine deficiency","volume":"61","author":"Delgado","year":"2000","journal-title":"J. Clin. Psychiatry"},{"issue":"14","key":"10.1016\/j.bcp.2026.117878_b0040","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.2174\/138161209788168001","article-title":"Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today","volume":"15","author":"L\u00f3pez-Mu\u00f1oz","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bcp.2026.117878_b0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbi.2024.04.002","article-title":"Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model","volume":"119","author":"Xu","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bcp.2026.117878_b0050","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12974-023-02964-x","article-title":"Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis","volume":"20","author":"Wu","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"10","key":"10.1016\/j.bcp.2026.117878_b0055","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1038\/npp.2016.271","article-title":"Cacna1c in the prefrontal cortex regulates depression-related behaviors via REDD1","volume":"42","author":"Kabir","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"10.1016\/j.bcp.2026.117878_b0060","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nm.3513","article-title":"REDD1 is essential for stress-induced synaptic loss and depressive behavior","volume":"20","author":"Ota","year":"2014","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.117878_b0065","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bcp.2026.117878_b0070","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/bcp.12845","article-title":"New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs","volume":"82","author":"Ign\u00e1cio","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117878_b0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12868-017-0357-0","article-title":"Effects of escitalopram and paroxetine on mTORC1 signaling in the rat hippocampus under chronic restraint stress","volume":"18","author":"Seo","year":"2017","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bcp.2026.117878_b0080","first-page":"1642","article-title":"Fluoxetine regulates hippocampal synaptic plasticity in CUMS depression rats","author":"Shen","year":"2016","journal-title":"Chin. J. Pathophysiol."},{"issue":"5994","key":"10.1016\/j.bcp.2026.117878_b0085","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.bcp.2026.117878_b0090","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1128\/MCB.22.7.2283-2293.2002","article-title":"Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis","volume":"22","author":"Shoshani","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117878_b0095","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S1097-2765(02)00706-2","article-title":"REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species","volume":"10","author":"Ellisen","year":"2002","journal-title":"Mol. Cell"},{"issue":"29","key":"10.1016\/j.bcp.2026.117878_b0100","doi-asserted-by":"crossref","first-page":"27053","DOI":"10.1074\/jbc.M303723200","article-title":"Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals","volume":"278","author":"Wang","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"46","key":"10.1016\/j.bcp.2026.117878_b0105","doi-asserted-by":"crossref","first-page":"31378","DOI":"10.1074\/jbc.M803384200","article-title":"Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4","volume":"283","author":"Knowles","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.bcp.2026.117878_b0110","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1158\/0008-5472.CAN-10-1769","article-title":"Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1","volume":"71","author":"Ben Sahra","year":"2011","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2026.117878_b0115","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/annrheumdis-2018-213181","article-title":"REDD1\/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)","volume":"78","author":"Frangou","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.bcp.2026.117878_b0120","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cmet.2016.10.016","article-title":"Macrophage metabolism shapes angiogenesis in tumors","volume":"24","author":"Mantovani","year":"2016","journal-title":"Cell Metab."},{"issue":"11\u201312","key":"10.1016\/j.bcp.2026.117878_b0125","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1101\/gad.335166.119","article-title":"REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors","volume":"34","author":"Qiao","year":"2020","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.bcp.2026.117878_b0130","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41419-019-1373-z","article-title":"Regulatory roles of miR-22\/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury","volume":"10","author":"Liu","year":"2019","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.bcp.2026.117878_b0135","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1038\/s12276-023-01056-3","article-title":"The stress-responsive protein REDD1 and its pathophysiological functions","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.bcp.2026.117878_b0140","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41419-021-03899-y","article-title":"RTP801\/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer\u2019s disease","volume":"12","author":"P\u00e9rez-Sisqu\u00e9s","year":"2021","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.bcp.2026.117878_b0145","doi-asserted-by":"crossref","first-page":"C807","DOI":"10.1152\/ajpcell.00340.2020","article-title":"Is REDD1 a metabolic double agent? Lessons from physiology and pathology","volume":"319","author":"Britto","year":"2020","journal-title":"Am J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117878_b0150","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/emm.2003.53","article-title":"Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity","volume":"35","author":"Kim","year":"2003","journal-title":"Exp. Mol. Med."},{"issue":"8","key":"10.1016\/j.bcp.2026.117878_b0155","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1096\/fj.201701436R","article-title":"REDD-1 aggravates endotoxin-induced inflammation via atypical NF-\u03baB activation","volume":"32","author":"Lee","year":"2018","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.bcp.2026.117878_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/nu15122719","article-title":"Rice germ attenuates chronic unpredictable mild stress-induced muscle atrophy","volume":"15","author":"Batsukh","year":"2023","journal-title":"Nutrients"},{"issue":"Pt 1","key":"10.1016\/j.bcp.2026.117878_b0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/BJ20050553","article-title":"Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT\/enhancer-binding protein","volume":"392","author":"Lin","year":"2005","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.bcp.2026.117878_b0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1101\/gad.1617608","article-title":"Hypoxia regulates TSC1\/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling","volume":"22","author":"DeYoung","year":"2008","journal-title":"Genes Dev."},{"issue":"10","key":"10.1016\/j.bcp.2026.117878_b0175","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1073\/pnas.0907705107","article-title":"Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis","volume":"107","author":"Horak","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2026.117878_b0180","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.brainresbull.2013.08.002","article-title":"RTP801 immunoreactivity in retinal ganglion cells and its down-regulation in cultured cells protect them from light and cobalt chloride","volume":"98","author":"del Olmo-Aguado","year":"2013","journal-title":"Brain Res. Bull."},{"issue":"23","key":"10.1016\/j.bcp.2026.117878_b0185","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1101\/gad.322704","article-title":"The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila","volume":"18","author":"Reiling","year":"2004","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.bcp.2026.117878_b0190","doi-asserted-by":"crossref","first-page":"780","DOI":"10.4161\/cc.8.5.7887","article-title":"REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells","volume":"8","author":"Chang","year":"2009","journal-title":"Cell Cycle"},{"issue":"3","key":"10.1016\/j.bcp.2026.117878_b0195","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.3892\/mmr.2016.4835","article-title":"Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging","volume":"13","author":"Choi","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2026.117878_b0200","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41401-024-01374-w","article-title":"Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson\u2019s disease in mice by eliminating RTP801 and \u03b1-synuclein autophagic degradation obstacle","volume":"46","author":"Wang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"issue":"11","key":"10.1016\/j.bcp.2026.117878_b0205","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1021\/bi902135e","article-title":"Structural analysis and functional implications of the negative mTORC1 regulator REDD1","volume":"49","author":"Vega-Rubin-de-Celis","year":"2010","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.bcp.2026.117878_b0210","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/embor.2009.93","article-title":"REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase","volume":"10","author":"Katiyar","year":"2009","journal-title":"EMBO Rep."},{"issue":"10","key":"10.1016\/j.bcp.2026.117878_b0215","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300847RR","article-title":"Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1\/CDKN2A\/REDD1\/FoXO1\/FasL signaling pathway in D-galactose-induced aging mice","volume":"37","author":"Liu","year":"2023","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.bcp.2026.117878_b0220","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1523\/JNEUROSCI.4011-10.2011","article-title":"RTP801\/REDD1 regulates the timing of cortical neurogenesis and neuron migration","volume":"31","author":"Malagelada","year":"2011","journal-title":"J. Neurosci."},{"issue":"335","key":"10.1016\/j.bcp.2026.117878_b0225","doi-asserted-by":"crossref","first-page":"ra68","DOI":"10.1126\/scisignal.2005103","article-title":"REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling","volume":"7","author":"Dennis","year":"2014","journal-title":"Sci. Signal."},{"issue":"24","key":"10.1016\/j.bcp.2026.117878_b0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249482","article-title":"REDD1 is involved in amyloid \u03b2-induced synaptic dysfunction and memory impairment","volume":"21","author":"Yi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bcp.2026.117878_b0235","doi-asserted-by":"crossref","first-page":"14771","DOI":"10.1002\/jcb.28737","article-title":"Suppression of REDD1 attenuates oxygen glucose deprivation\/reoxygenation-evoked ischemic injury in neuron by suppressing mTOR-mediated excessive autophagy","volume":"120","author":"Sun","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"9","key":"10.1016\/j.bcp.2026.117878_b0240","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1093\/cercor\/bhx201","article-title":"miR-181a participates in contextual fear memory formation via activating mTOR signaling pathway","volume":"28","author":"Xu","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bcp.2026.117878_b0245","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuint.2019.03.019","article-title":"Increased REDD1 facilitates neuronal damage after subarachnoid hemorrhage","volume":"128","author":"Su","year":"2019","journal-title":"Neurochem. Int."},{"issue":"7","key":"10.1016\/j.bcp.2026.117878_b0250","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41419-020-02775-5","article-title":"Synaptic RTP801 contributes to motor-learning dysfunction in Huntington\u2019s disease","volume":"11","author":"Mart\u00edn-Flores","year":"2020","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.bcp.2026.117878_b0255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25073845","article-title":"Huntington\u2019s disease: complex pathogenesis and therapeutic strategies","volume":"25","author":"Tong","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2026.117878_b0260","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s13311-012-0112-2","article-title":"Huntington\u2019s disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease","volume":"9","author":"Ehrlich","year":"2012","journal-title":"Neurotherapeutics"},{"issue":"11","key":"10.1016\/j.bcp.2026.117878_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110521","article-title":"Striatum expresses region-specific plasticity consistent with distinct memory abilities","volume":"38","author":"Perez","year":"2022","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.bcp.2026.117878_b0270","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.drudis.2020.05.001","article-title":"Role of oxidative stress in depression","volume":"25","author":"Bhatt","year":"2020","journal-title":"Drug Discov. Today"},{"issue":"9","key":"10.1016\/j.bcp.2026.117878_b0275","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41582-025-01116-4","article-title":"Neuroimmune, metabolic and oxidative stress pathways in major depressive disorder","volume":"21","author":"Maes","year":"2025","journal-title":"Nat. Rev. Neurol."},{"issue":"12","key":"10.1016\/j.bcp.2026.117878_b0280","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.2337\/db22-0355","article-title":"Activation of disulfide redox switch in REDD1 promotes oxidative stress under hyperglycemic conditions","volume":"71","author":"Miller","year":"2022","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.bcp.2026.117878_b0285","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1074\/jbc.M706643200","article-title":"Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis","volume":"283","author":"Kimball","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2026.117878_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000301","article-title":"Proteome-wide analysis of chaperone-mediated autophagy targeting motifs","volume":"17","author":"Kirchner","year":"2019","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117878_b0295","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1053\/j.gastro.2020.09.016","article-title":"DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia","volume":"160","author":"Miao","year":"2021","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.bcp.2026.117878_b0300","article-title":"Reversing persistent PTEN activation after traumatic brain injury fuels long-term axonal regeneration via Akt\/mTORC1 signaling cascade","volume":"12","author":"Shi","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"issue":"1","key":"10.1016\/j.bcp.2026.117878_b0305","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1038\/s41467-021-22908-4","article-title":"Tanc2-mediated mTOR inhibition balances mTORC1\/2 signaling in the developing mouse brain and human neurons","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.bcp.2026.117878_b0310","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/1028415X.2023.2254542","article-title":"Antidepressant-like effects of tomatidine and tomatine, steroidal alkaloids from unripe tomatoes, via activation of mTORC1 in the medial prefrontal cortex in lipopolysaccharide-induced depression model mice","volume":"27","author":"Deyama","year":"2024","journal-title":"Nutr. Neurosci."},{"issue":"6","key":"10.1016\/j.bcp.2026.117878_b0315","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/s41386-020-0644-9","article-title":"Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin","volume":"45","author":"Abdallah","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.bcp.2026.117878_b0320","doi-asserted-by":"crossref","first-page":"C583","DOI":"10.1152\/ajpcell.00464.2008","article-title":"REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch","volume":"296","author":"Miyazaki","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"10","key":"10.1016\/j.bcp.2026.117878_b0325","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.freeradbiomed.2009.02.020","article-title":"The regulated in development and DNA damage response 2 (REDD2) gene mediates human monocyte cell death through a reduction in thioredoxin-1 expression","volume":"46","author":"Imen","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.bcp.2026.117878_b0330","doi-asserted-by":"crossref","first-page":"E122","DOI":"10.1152\/ajpendo.00341.2014","article-title":"REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization","volume":"308","author":"Kelleher","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"51","key":"10.1016\/j.bcp.2026.117878_b0335","doi-asserted-by":"crossref","first-page":"39128","DOI":"10.1074\/jbc.M610023200","article-title":"Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.117878_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152270","article-title":"Rapid proteasomal degradation of the stress response protein REDD2 is mediated by the E3 ligase HUWE1","volume":"777","author":"VanCleave","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.bcp.2026.117878_b0345","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/s41386-024-01895-2","article-title":"Ketamine induced synaptic plasticity operates independently of long-term potentiation","volume":"49","author":"Piazza","year":"2024","journal-title":"Neuropsychopharmacology"},{"issue":"22","key":"10.1016\/j.bcp.2026.117878_b0350","doi-asserted-by":"crossref","first-page":"8077","DOI":"10.1021\/acs.analchem.1c01510","article-title":"Digital Loop-mediated isothermal amplification-based absolute methylation quantification revealed hypermethylated DAPK1 in cervical cancer patients","volume":"93","author":"Tan","year":"2021","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.bcp.2026.117878_b0355","first-page":"1795","article-title":"Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.117878_b0360","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/mp.2017.85","article-title":"Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects","volume":"23","author":"Li","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bcp.2026.117878_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147436","article-title":"LncRNA-MIAT promotes neural cell autophagy and apoptosis in ischemic stroke by up-regulating REDD1","volume":"1763","author":"Guo","year":"2021","journal-title":"Brain Res."},{"issue":"9","key":"10.1016\/j.bcp.2026.117878_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113332","article-title":"Single-cell transcriptomics of neuroinflammation and cerebrovascular endothelial cells in the aged rat hippocampus","volume":"28","author":"Liu","year":"2025","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.bcp.2026.117878_b0375","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/cvr\/cvz152","article-title":"TXNIP\/Redd1 signalling and excessive autophagy: a novel mechanism of myocardial ischaemia\/reperfusion injury in mice","volume":"116","author":"Gao","year":"2020","journal-title":"Cardiovasc. Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:18:35Z","timestamp":1778710715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":75,"alternative-id":["S0006295226002108"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117878","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism of action of REDD1 in depression and its targeted intervention","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117878"}}