{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:08:51Z","timestamp":1778713731087,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["23A320037"],"award-info":[{"award-number":["23A320037"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004773","name":"Henan University","doi-asserted-by":"publisher","award":["Y48005"],"award-info":[{"award-number":["Y48005"]}],"id":[{"id":"10.13039\/501100004773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["262300421550"],"award-info":[{"award-number":["262300421550"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bcp.2026.117908","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:37:06Z","timestamp":1773851826000},"page":"117908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting FOSL2 via knockdown: a druggable strategy for protecting against hepatic ischemia\/reperfusion injury through ATF4 suppression"],"prefix":"10.1016","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5161-2183","authenticated-orcid":false,"given":"Zexin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiasai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keqiang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2026.117908_b0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/j.2040-4603.2017.tb00741.x","article-title":"Ischemia\/Reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr. Physiol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117908_b0010","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jhep.2013.06.017","article-title":"Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu","volume":"59","author":"Peralta","year":"2013","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.bcp.2026.117908_b0015","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/j.2040-4603.2013.tb00510.x","article-title":"Kupffer cells in the liver","volume":"3","author":"Dixon","year":"2013","journal-title":"Compr. Physiol."},{"issue":"Suppl. 1","key":"10.1016\/j.bcp.2026.117908_b0020","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1016\/j.ijsu.2016.05.050","article-title":"Hepatic ischemia reperfusion injury: a systematic review of literature and the role of current drugs and biomarkers","volume":"33","author":"Cannistr\u00e0","year":"2016","journal-title":"Int. J. Surg."},{"issue":"14","key":"10.1016\/j.bcp.2026.117908_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/cells11142222","article-title":"Role of Immuno-Inflammatory Signals in Liver Ischemia-Reperfusion Injury","volume":"11","author":"Kaltenmeier","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.117908_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109408","article-title":"Transcription factor Fra-2 and its emerging role in matrix deposition, proliferation and inflammation in chronic lung diseases","volume":"64","author":"Birnhuber","year":"2019","journal-title":"Cell. Signal."},{"issue":"23","key":"10.1016\/j.bcp.2026.117908_b0035","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz6105","article-title":"Reprogramming of tumor-associated macrophages by targeting \u03b2-catenin\/FOSL2\/ARID5A signaling: a potential treatment of lung cancer","volume":"6","author":"Sarode","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.bcp.2026.117908_b0040","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12943-023-01734-w","article-title":"SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2\/IL6 axis","volume":"22","author":"Njouendou","year":"2023","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.bcp.2026.117908_b0045","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/j.gim.2022.09.002","article-title":"FOSL2 truncating variants in the last exon cause a neurodevelopmental disorder with scalp and enamel defects","volume":"24","author":"Cospain","year":"2022","journal-title":"Genet. Med."},{"issue":"8","key":"10.1016\/j.bcp.2026.117908_b0050","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1172\/JCI125366","article-title":"Fra-2-expressing macrophages promote lung fibrosis in mice","volume":"129","author":"Ucero","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bcp.2026.117908_b0055","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s42003-023-04534-6","article-title":"The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions","volume":"6","author":"Stellato","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bcp.2026.117908_b0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.909270","article-title":"Fra-2 is a dominant negative regulator of natural killer cell development","volume":"13","author":"Schnoegl","year":"2022","journal-title":"Front. Immunol."},{"issue":"13","key":"10.1016\/j.bcp.2026.117908_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107826","article-title":"The AP1 Transcription factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development","volume":"31","author":"Renoux","year":"2020","journal-title":"Cell Rep."},{"issue":"11","key":"10.1016\/j.bcp.2026.117908_b0070","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1161\/CIRCRESAHA.122.321725","article-title":"Targeting Wnt-\u00df-catenin-FOSL signaling ameliorates right ventricular remodeling","volume":"132","author":"Nayakanti","year":"2023","journal-title":"Circ. Res."},{"issue":"22","key":"10.1016\/j.bcp.2026.117908_b0075","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00022-18","article-title":"Fra-2 expression in osteoblasts regulates systemic inflammation and lung injury through osteopontin","volume":"38","author":"Luo","year":"2018","journal-title":"Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117908_b0080","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1007\/s13577-022-00760-y","article-title":"FOSL2 deficiency delays nonalcoholic steatohepatitis progression by regulating LY6D-mediated NLRP3 activation","volume":"35","author":"Hu","year":"2022","journal-title":"Hum. Cell"},{"key":"10.1016\/j.bcp.2026.117908_b0085","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.biopha.2018.07.151","article-title":"MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-\u03b2\/Smad3 signaling pathway","volume":"107","author":"Sun","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"40","key":"10.1016\/j.bcp.2026.117908_b0090","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1038\/onc.2017.146","article-title":"ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner","volume":"36","author":"Chen","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.117908_b0095","article-title":"ATF4 Contributes to Abdominal Aortic Aneurysm Formation via Modulating M1 Macrophage Polarization and Inflammation","author":"Yu","year":"2024","journal-title":"Aging Dis."},{"issue":"14","key":"10.1016\/j.bcp.2026.117908_b0100","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.18632\/aging.204875","article-title":"Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK\/eIF2\u03b1 axis","volume":"15","author":"Zhu","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.bcp.2026.117908_b0105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41420-023-01456-4","article-title":"Vitamin D receptor attenuate ischemia-reperfusion kidney injury via inhibiting ATF4","volume":"9","author":"Tang","year":"2023","journal-title":"Cell Death Discov."},{"issue":"3","key":"10.1016\/j.bcp.2026.117908_b0110","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1007\/s10753-020-01410-x","article-title":"Sufentanil protects the liver from ischemia\/reperfusion-induced inflammation and apoptosis by inhibiting ATF4-Induced TP53BP2 Expression","volume":"44","author":"Zhou","year":"2021","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.bcp.2026.117908_b0115","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41419-020-2424-1","article-title":"MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia\/reperfusion injury through AMPK\u03b1 activation","volume":"11","author":"Zheng","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.117908_b0120","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/191624","article-title":"The protective effects of curcumin on experimental acute liver lesion induced by intestinal ischemia-reperfusion through inhibiting the pathway of NF-\u03baB in a rat model","volume":"2014","author":"Fan","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2026.117908_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155429","article-title":"Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury via MAPK pathway","volume":"141","author":"Li","year":"2021","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.bcp.2026.117908_b0130","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/jmcb\/mjv066","article-title":"IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia\/reperfusion injury in liver","volume":"8","author":"Liu","year":"2016","journal-title":"J. Mol. Cell Biol."},{"issue":"18","key":"10.1016\/j.bcp.2026.117908_b0135","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1111\/febs.16336","article-title":"Nrf2 and oxidative stress in liver ischemia\/reperfusion injury","volume":"289","author":"Bardallo","year":"2022","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.bcp.2026.117908_b0140","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/mt.2008.237","article-title":"Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism","volume":"17","author":"Devey","year":"2009","journal-title":"Mol. Ther."},{"issue":"5\u20136","key":"10.1016\/j.bcp.2026.117908_b0145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2119\/2007-00134.Vardanian","article-title":"Molecular mediators of liver ischemia and reperfusion injury: a brief review","volume":"14","author":"Vardanian","year":"2008","journal-title":"Mol. Med."},{"issue":"4","key":"10.1016\/j.bcp.2026.117908_b0150","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41575-021-00549-8","article-title":"Liver ischaemia-reperfusion injury: a new understanding of the role of innate immunity","volume":"19","author":"Hirao","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117908_b0155","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.bcp.2026.117908_b0160","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bcp.2026.117908_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.803037","article-title":"Macrophage polarization and its role in liver disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.117908_b0170","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.3389\/fimmu.2019.03112","article-title":"Macrophage phenotype and function in liver disorder","volume":"10","author":"Dou","year":"2019","journal-title":"Front. Immunol."},{"issue":"13","key":"10.1016\/j.bcp.2026.117908_b0175","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180451","article-title":"ZBP1-mediated apoptosis and inflammation exacerbate steatotic liver ischemia\/reperfusion injury","volume":"134","author":"Liu","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2026.117908_b0180","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3389\/fimmu.2020.01193","article-title":"Effect of hepatic macrophage polarization and apoptosis on liver ischemia and reperfusion injury during liver transplantation","volume":"11","author":"Ye","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117908_b0185","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/hep.26607","article-title":"M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease","volume":"59","author":"Wan","year":"2014","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.bcp.2026.117908_b0190","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.2353\/ajpath.2006.050645","article-title":"Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia-reperfusion: some answers","volume":"168","author":"Massip-Salcedo","year":"2006","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.bcp.2026.117908_b0195","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jhep.2012.05.012","article-title":"Nilotinib protects the murine liver from ischemia\/reperfusion injury","volume":"57","author":"Ocuin","year":"2012","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117908_b0200","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jhep.2014.06.020","article-title":"Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K\/Akt pathway","volume":"61","author":"Zhang","year":"2014","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117908_b0205","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41419-021-03538-6","article-title":"EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2","volume":"12","author":"Cui","year":"2021","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.bcp.2026.117908_b0210","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1111\/jcmm.16493","article-title":"NR4A1 knockdown confers hepatoprotection against ischaemia-reperfusion injury by suppressing TGF\u03b21 via inhibition of CYR61\/NF-\u03baB in mouse hepatocytes","volume":"25","author":"Cao","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.117908_b0215","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2478\/jtim-2023-0105","article-title":"FOSL2 participates in renal fibrosis via SGK1-mediated epithelial-mesenchymal transition of proximal tubular epithelial cells","volume":"11","author":"Liu","year":"2023","journal-title":"J Transl Int Med."},{"key":"10.1016\/j.bcp.2026.117908_b0220","article-title":"FOSL2 activates TGF-\u03b21-mediated GLUT1\/mTOR signaling to promote diabetic kidney disease","author":"He","year":"2024","journal-title":"J Diabetes Investig."},{"issue":"6","key":"10.1016\/j.bcp.2026.117908_b0225","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/sj.emboj.7600596","article-title":"TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death","volume":"24","author":"Ohoka","year":"2005","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bcp.2026.117908_b0230","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/jcmm.12166","article-title":"ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression","volume":"18","author":"Wang","year":"2014","journal-title":"J. Cell Mol. Med."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:15:50Z","timestamp":1778710550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"alternative-id":["S0006295226002418"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117908","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting FOSL2 via knockdown: a druggable strategy for protecting against hepatic ischemia\/reperfusion injury through ATF4 suppression","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117908","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117908"}}