{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:03:48Z","timestamp":1791133428587,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016305","name":"First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013050","name":"Guangdong Provincial Applied Science and Technology Research and Development Program","doi-asserted-by":"publisher","award":["242301420008"],"award-info":[{"award-number":["242301420008"]}],"id":[{"id":"10.13039\/501100013050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bcp.2026.117918","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:44:12Z","timestamp":1773967452000},"page":"117918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["CSDE1-mediated histone lactylation modification of the HOXD9 promoter promotes gastric cancer progression"],"prefix":"10.1016","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1172-3653","authenticated-orcid":false,"given":"Hongyu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songcheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leli","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.117918_b0005","first-page":"128","article-title":"Comparative study of cancer profiles between 2020 and 2022 using global cancer statistics (GLOBOCAN)","volume":"4","author":"Cao","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"key":"10.1016\/j.bcp.2026.117918_b0010","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10120-024-01484-8","article-title":"Adjuvant treatment for locally advanced gastric cancer: an Asian perspective","volume":"27","author":"Kim","year":"2024","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.bcp.2026.117918_b0015","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117918_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101059","article-title":"Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer","volume":"73","author":"Li","year":"2024","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bcp.2026.117918_b0025","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1038\/s41467-023-42025-8","article-title":"Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.117918_b0030","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1158\/0008-5472.CAN-23-3513","article-title":"H3K18 lactylation potentiates immune escape of non-small cell lung cancer","volume":"84","author":"Zhang","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.117918_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216680","article-title":"Regulation of newly identified lysine lactylation in cancer","volume":"587","author":"Gao","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2026.117918_b0040","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/cac2.12549","article-title":"The regulatory roles and clinical significance of glycolysis in tumor","volume":"44","author":"Qiao","year":"2024","journal-title":"Cancer Commun. (lond)"},{"key":"10.1016\/j.bcp.2026.117918_b0045","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.semcancer.2022.09.007","article-title":"Tumor glycolysis, an essential sweet tooth of tumor cells","volume":"86","author":"Paul","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bcp.2026.117918_b0050","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41388-024-03243-6","article-title":"Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer","volume":"44","author":"Tsukihara","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.117918_b0055","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.tem.2024.01.011","article-title":"Lysine lactylation in the regulation of tumor biology","volume":"35","author":"Yang","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bcp.2026.117918_b0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12964-019-0496-2","article-title":"The role of CSDE1 in translational reprogramming and human diseases","volume":"18","author":"Guo","year":"2020","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bcp.2026.117918_b0065","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/carcin\/bgt052","article-title":"Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a","volume":"34","author":"Yin","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2026.117918_b0070","doi-asserted-by":"crossref","unstructured":"K. S. Moore, N. Yagci, F. van Alphen, N. A. Paolini, R. Horos, N. M. Held, R. H. Houtkooper, E. van den Akker, A. B. Meijer, P. A. C. t Hoen, M. von Lindern, Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line, Sci Rep 8 (2018) 2628, https:\/\/doi.org\/10.1038\/s41598-018-20518-7.","DOI":"10.1038\/s41598-018-20518-7"},{"key":"10.1016\/j.bcp.2026.117918_b0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.molcel.2006.06.012","article-title":"Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis","volume":"23","author":"Bushell","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2026.117918_b0080","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/stem.712","article-title":"The RNA-binding protein Unr prevents mouse embryonic stem cells differentiation toward the primitive endoderm lineage","volume":"29","author":"Elatmani","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.bcp.2026.117918_b0085","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/sj.emboj.7601468","article-title":"A role for hnRNP C1\/C2 and Unr in internal initiation of translation during mitosis","volume":"26","author":"Schepens","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.117918_b0090","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ccell.2016.10.004","article-title":"UNR\/CSDE1 drives a post-transcriptional program to promote melanoma invasion and metastasis","volume":"30","author":"Wurth","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.117918_b0095","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41419-023-05862-5","article-title":"The HOXD9-mediated PAXIP1-AS1 regulates gastric cancer progression through PABPC1\/PAK1 modulation","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.117918_b0100","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1476-4598-10-60","article-title":"Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells","volume":"10","author":"Tabuse","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.117918_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113583","article-title":"HOXD9 contributes to the Warburg effect and tumor metastasis in non-small cell lung cancer via transcriptional activation of PFKFB3","volume":"427","author":"Wan","year":"2023","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bcp.2026.117918_b0110","doi-asserted-by":"crossref","first-page":"341","DOI":"10.31083\/j.fbl2910341","article-title":"HOXD9 enhances the release of HMGB1 and boosts glycolysis in glioblastoma under hypoxic conditions, leading to tumor growth by activating the transcription of PFKFB3","volume":"29","author":"Xu","year":"2024","journal-title":"Front Biosci. (landmark Ed)"},{"key":"10.1016\/j.bcp.2026.117918_b0115","doi-asserted-by":"crossref","first-page":"e1614","DOI":"10.1002\/ctm2.1614","article-title":"Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: oncometabolite fuels oncogenic transcription","volume":"14","author":"Zhang","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bcp.2026.117918_b0120","doi-asserted-by":"crossref","unstructured":"Z. Zong, F. Xie, S. Wang, X. Wu, Z. Zhang, B. Yang, F. Zhou, Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis, Cell 187 (2024) 2375-2392 e2333, https:\/\/doi.org\/10.1016\/j.cell.2024.04.002.","DOI":"10.1016\/j.cell.2024.04.002"},{"key":"10.1016\/j.bcp.2026.117918_b0125","article-title":"AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy","author":"Hong","year":"2025","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2026.117918_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110211","article-title":"Coordinated post-transcriptional control of oncogene-induced senescence by UNR\/CSDE1","volume":"38","author":"Avolio","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2026.117918_b0135","doi-asserted-by":"crossref","DOI":"10.1242\/dev.201890","article-title":"The RNA-binding protein CSDE1 promotes hematopoietic stem and progenitor cell generation via translational control of Wnt signaling","volume":"150","author":"Li","year":"2023","journal-title":"Development"},{"key":"10.1016\/j.bcp.2026.117918_b0140","doi-asserted-by":"crossref","DOI":"10.1093\/narcan\/zcae014","article-title":"CSDE1: a versatile regulator of gene expression in cancer","author":"Ciocia","year":"2024","journal-title":"NAR Cancer 6"},{"key":"10.1016\/j.bcp.2026.117918_b0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The emerging hallmarks of cancer metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2026.117918_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2022.02.033","article-title":"Lactylation-driven METTL3-mediated RNA m(6)A modification promotes immunosuppression of tumor-infiltrating myeloid cells","volume":"82","author":"Xiong","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2026.117918_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2024.07.011","article-title":"Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2026.117918_b0160","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41467-024-55165-2","article-title":"Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions","volume":"16","author":"Shao","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.117918_b0165","article-title":"Endothelial cell-derived lactate triggers bone mesenchymal stem cell histone lactylation to attenuate osteoporosis","volume":"10","author":"Wu","year":"2023","journal-title":"Adv. Sci. (weinh)"},{"key":"10.1016\/j.bcp.2026.117918_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1412672","article-title":"New insights into the roles of lactylation in cancer","volume":"15","author":"Zhu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117918_b0175","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s13046-019-1399-1","article-title":"HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3","volume":"38","author":"Zhu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:13:09Z","timestamp":1778710389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":35,"alternative-id":["S0006295226002510"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117918","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CSDE1-mediated histone lactylation modification of the HOXD9 promoter promotes gastric cancer progression","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117918"}}