{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:57:54Z","timestamp":1793163474668,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["YDZJ202401687ZYTS"],"award-info":[{"award-number":["YDZJ202401687ZYTS"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bcp.2026.117926","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T23:00:55Z","timestamp":1774220455000},"page":"117926","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Propyl gallate mitigates diabetic liver injury via suppressing SLC7A11\/GPX4-mediated hepatic ferroptosis and modulating gut-liver axis"],"prefix":"10.1016","volume":"249","author":[{"given":"Zhaopeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangze","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.bcp.2026.117926_b0005","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000037666","article-title":"A review on associated factors and management measures for sarcopenia in type 2 diabetes mellitus","volume":"103","author":"Zhang","year":"2024","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"10.1016\/j.bcp.2026.117926_b0010","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/msj.20113","article-title":"Emerging concepts in the pathophysiology of type 2 diabetes mellitus","volume":"76","author":"Surampudi","year":"2009","journal-title":"Mt Sinai J. Med."},{"key":"10.1016\/j.bcp.2026.117926_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.624184","article-title":"Dysregulation of leukocyte trafficking in type 2 diabetes: mechanisms and potential therapeutic avenues","volume":"9","author":"Pezhman","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.117926_b0020","article-title":"The prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus","author":"Leen","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bcp.2026.117926_b0025","article-title":"Non-alcoholic fatty liver disease: the emerging burden in cardiometabolic and renal diseases","author":"Eugene","year":"2017","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.bcp.2026.117926_b0030","article-title":"Non-alcoholic fatty liver disease progression to non-alcoholic steatohepatitis-related primary liver cancer","author":"Utibe-Abasi","year":"2021","journal-title":"Liver Cancer"},{"key":"10.1016\/j.bcp.2026.117926_b0035","doi-asserted-by":"crossref","unstructured":"S. Nicholas, E.C. David, Z.W. Louis, L. Daryl Jimian, J.Z. Joseph, L. Marie, K. Zong Jie, C. Claire Alexandra Zhen, L. Ying Ern, T. Bee Choo, K. Guowei, S. Jimmy Bok Yan, M.K. Lee, B.D. John, S. Asim, Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174\u2009772 participants, Lancet (London, England) (2021). doi:10.1016\/s0140-6736(21)00591-2.","DOI":"10.1016\/S0140-6736(21)00591-2"},{"key":"10.1016\/j.bcp.2026.117926_b0040","doi-asserted-by":"crossref","unstructured":"K. Ravi, C. Lakshya, V. Vipin Kumar, N. Priyanshu, B. Diego, P. Siddharth, A. Subash, C. Rashmi, A. Mc Anto, Gut microbiota interactions with anti-diabetic medications and pathogenesis of type 2 diabetes mellitus, World journal of methodology (2022). doi:10.5662\/wjm.v12.i4.246.","DOI":"10.5662\/wjm.v12.i4.246"},{"key":"10.1016\/j.bcp.2026.117926_b0045","doi-asserted-by":"crossref","unstructured":"S. Antonio, L. Framarin, L. Nicola, M. Berrutti, F. Castellino, P. Renato, M. Franco De, P. Elena, M. Giovanni, Altered Gut Microbiota in Type 2 Diabetes: Just a Coincidence?, Current diabetes reports (2018). doi:10.1007\/s11892-018-1057-6.","DOI":"10.1007\/s11892-018-1057-6"},{"key":"10.1016\/j.bcp.2026.117926_b0050","article-title":"Targeting the gut microbiota and its metabolites for type 2 diabetes mellitus","author":"Jiaqiang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bcp.2026.117926_b0055","doi-asserted-by":"crossref","unstructured":"A.-U. Carmen Cecilia, S.C. Sonia, J.T. Mar\u00eda, G.G. Javier, Non-alcoholic steatohepatitis: what can we learn from animal models?, Current medicinal chemistry (2012). doi:10.2174\/092986712799462586.","DOI":"10.2174\/092986712799462586"},{"key":"10.1016\/j.bcp.2026.117926_b0060","article-title":"Association of circulating markers of microbial translocation and hepatic inflammation with liver injury in patients with type 2 diabetes","author":"Leila","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bcp.2026.117926_b0065","doi-asserted-by":"crossref","unstructured":"K.S. Helmut, M. Bernardo, G.N. Manuela, Pathogenesis of Alcoholic Fatty Liver a Narrative Review, Life (Basel, Switzerland) (2023). doi:10.3390\/life13081662.","DOI":"10.3390\/life13081662"},{"key":"10.1016\/j.bcp.2026.117926_b0070","article-title":"The role of gut bacteria and fungi in alcohol-associated liver disease","author":"Liuying","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.bcp.2026.117926_b0075","article-title":"Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications","author":"Jing","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.bcp.2026.117926_b0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.apsb.2024.10.010","article-title":"Akkermansia muciniphila-derived acetate activates the hepatic AMPK\/SIRT1\/PGC-1\u03b1 axis to alleviate ferroptosis in metabolic-associated fatty liver disease","volume":"15","author":"Zhuge","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bcp.2026.117926_b0085","doi-asserted-by":"crossref","unstructured":"S. Yutong, G. Xue, W. Ziwei, Z. Jing, Y. Yanqun, M. Ziyu, Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease, Metabolism: clinical and experimental (2024). doi:10.1016\/j.metabol.2024.155953.","DOI":"10.1016\/j.metabol.2024.155953"},{"key":"10.1016\/j.bcp.2026.117926_b0090","article-title":"Ferroptosis: a new target for hepatic ischemia-reperfusion injury?","author":"Shanshan","year":"2024","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bcp.2026.117926_b0095","article-title":"Hinokitiol ameliorates MASH in mice by therapeutic targeting of hepatic Nrf2 and inhibiting hepatocyte ferroptosis","author":"Xunzhe","year":"2025","journal-title":"Phytomedicine Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.bcp.2026.117926_b0100","article-title":"Role of ferroptosis in non-alcoholic fatty liver disease and its implications for therapeutic strategies","author":"Han","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.bcp.2026.117926_b0105","doi-asserted-by":"crossref","unstructured":"W. Zhili, Z. Yanru, L. Wen\u2010Chao, B. Balamuralikrishnan, X. Xiao, Y. Junhu, X.J. Lei, Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications, Antioxidants (Basel, Switzerland) (2024). doi:10.3390\/antiox13030352.","DOI":"10.3390\/antiox13030352"},{"key":"10.1016\/j.bcp.2026.117926_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103672","article-title":"Hsp90C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels","volume":"85","author":"Li","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.117926_b0115","article-title":"Propyl gallate\/cyclodextrin supramolecular complexes with enhanced solubility and radical scavenging capacity","author":"Li","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.bcp.2026.117926_b0120","article-title":"Formation of the mutagenic\/carcinogenic imidazoquinoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants","author":"Tetsuta","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2026.117926_b0125","article-title":"Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes","author":"Gouri","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.bcp.2026.117926_b0130","article-title":"Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione","author":"Brian","year":"2002","journal-title":"BBA"},{"key":"10.1016\/j.bcp.2026.117926_b0135","article-title":"Lycium barbarum L. leaves ameliorate type 2 diabetes in rats by modulating metabolic profiles and gut microbiota composition","author":"Xueqin","year":"2019","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.bcp.2026.117926_b0140","article-title":"Hepatoprotective effect of protocatechuic acid against type 2 diabetes-induced liver injury","author":"Kaixia","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bcp.2026.117926_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.135219","article-title":"Pharmacokinetic and toxicological overview of propyl gallate food additive","volume":"423","author":"Javaheri-Ghezeldizaj","year":"2023","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.bcp.2026.117926_b0150","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s10787-023-01254-5","article-title":"Effect of ethyl gallate and propyl gallate on dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL\/6J mice: preventive and protective","volume":"31","author":"Chougule","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bcp.2026.117926_b0155","article-title":"Structural insights into the HBV receptor and bile acid transporter NTCP","author":"Jae-Hyun","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117926_b0160","article-title":"Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway","author":"Zu-Guo","year":"2020","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.bcp.2026.117926_b0165","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1007\/s11033-025-11098-7","article-title":"Modulation of inflammatory and cuproptotic crosstalk by Ethyl and propyl gallate: a multi-targeted strategy against experimental colitis","volume":"52","author":"Chougule","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bcp.2026.117926_b0170","article-title":"Impact of gut microbiota and microbiota-related metabolites on hyperlipidemia","author":"Xiaokang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2026.117926_b0175","doi-asserted-by":"crossref","unstructured":"A. Abdolamir, N.M. Reyhaneh, A. Azadeh, S. Giada, P. Kostas, Oxidative Stress in Liver Pathophysiology and Disease, Antioxidants (Basel, Switzerland) (2023). doi:10.3390\/antiox12091653.","DOI":"10.3390\/antiox12091653"},{"key":"10.1016\/j.bcp.2026.117926_b0180","article-title":"Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling","author":"Mi Hye","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.117926_b0185","article-title":"Common pathogenetic pathways of non-alcoholic fatty liver disease and type 2 diabetes mellitus","author":"Charalampos","year":"2023","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.bcp.2026.117926_b0190","article-title":"Role of 2\u2011series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non\u2011alcoholic fatty liver disease (Review)","author":"Weixuan","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2026.117926_b0195","article-title":"Non-alcoholic fatty liver disease, metabolic syndrome, and type 2 diabetes mellitus: where do we stand today?","author":"Bojan","year":"2022","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.bcp.2026.117926_b0200","article-title":"The beneficial impact of curcumin on cardiac lipotoxicity","author":"Sajad","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117926_b0205","doi-asserted-by":"crossref","unstructured":"S. Changting, G. Yang, M. Jing, H. Eun-Kyung, Z. Benyin, Y. Yongjing, Z. Xiaofeng, Z. Dejun, Metabolomic Profiling Reveals Protective Effects and Mechanisms of Sea Buckthorn Sterol against Carbon Tetrachloride-Induced Acute Liver Injury in Rats, Molecules (Basel, Switzerland) (2022). doi:10.3390\/molecules27072224.","DOI":"10.3390\/molecules27072224"},{"key":"10.1016\/j.bcp.2026.117926_b0210","article-title":"Lipid peroxidation-induced ferroptosis as a therapeutic target for mitigating neuronal injury and inflammation in sepsis-associated encephalopathy: insights into the hippocampal PEBP-1\/15-LOX\/GPX4 pathway","author":"Haosen","year":"2024","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bcp.2026.117926_b0215","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.foodchem.2016.08.065","article-title":"Inhibitory effects of propyl gallate on membrane lipids metabolism and its relation to increasing storability of harvested longan fruit","volume":"217","author":"Lin","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.bcp.2026.117926_b0220","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejphar.2017.03.005","article-title":"n-Propyl gallate suppresses lipopolysaccharide-induced inducible nitric oxide synthase activation through protein kinase C\u03b4-mediated up-regulation of heme oxygenase-1 in RAW264.7 macrophages","volume":"801","author":"Jeon","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117926_b0225","article-title":"Morin, a dietary bioflavonol suppresses monosodium urate crystal-induced inflammation in an animal model of acute gouty arthritis with reference to NLRP3 inflammasome, hypo-xanthine phospho-ribosyl transferase, and inflammatory mediators","author":"Chitra","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117926_b0230","doi-asserted-by":"crossref","unstructured":"P. Sang Mi, M. Byung-Gu, J. Ji Yun, J. Kyung Hwan, L. Chul Won, A.K. Kwang\u2010Youn, K. Young Woo, C. Youn-Woong, C. Il Je, K. Sae\u2010Kwang, K. Sang Chan, Combination of Pelargonium sidoides and Coptis chinensis root inhibits nuclear factor kappa B-mediated inflammatory response in vitro and in vivo, BMC complementary and alternative medicine (2018). doi:10.1186\/s12906-018-2088-x.","DOI":"10.1186\/s12906-018-2088-x"},{"key":"10.1016\/j.bcp.2026.117926_b0235","article-title":"Anti-inflammatory action of high molecular weight Mytilus edulis hydrolysates fraction in LPS-induced RAW264.7 macrophage via NF-\u03baB and MAPK pathways","author":"Young-Sang","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.bcp.2026.117926_b0240","article-title":"Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a D-galactose-induced aging mouse model by modulating the gut microbiota","author":"Kangliang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.bcp.2026.117926_b0245","article-title":"Structural characterization of polysaccharides from Medicago sativa L. roots and lipid-lowering activity in oleic acid-induced HepG2 cells","author":"Xuegui","year":"2023","journal-title":"Process Biochem."},{"key":"10.1016\/j.bcp.2026.117926_b0250","article-title":"Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2\/xCT\/GPX4 signaling pathway","author":"Yanyan","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.bcp.2026.117926_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103657","article-title":"Ferroptosis in acute liver failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions","volume":"84","author":"He","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.117926_b0260","doi-asserted-by":"crossref","unstructured":"L. Miao, Y. Shuhua, H. Jianxin, L. Peng, Z. Yi, D. Shuang Lin, C. Xinliang, G. Jiayi, W. Jun, H. Jianbin, The Protective Effect of Grape-Seed Proanthocyanidin Extract on Oxidative Damage Induced by Zearalenone in Kunming Mice Liver, International journal of molecular sciences (2016). doi:10.3390\/ijms17060808.","DOI":"10.3390\/ijms17060808"},{"key":"10.1016\/j.bcp.2026.117926_b0265","article-title":"Inhibition of ferroptosis attenuate lipopolysaccharide-induced early pregnancy loss by protecting against decidual damage of stromal cells","author":"Yanmei","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Pt A","key":"10.1016\/j.bcp.2026.117926_b0270","article-title":"Hu Gan Tang ameliorates metabolic-associated fatty liver disease by inhibiting ferroptosis through the Nrf2\/GPX4 pathway","volume":"353","author":"Cui","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.117926_b0275","article-title":"Electroacupuncture inhibits neural ferroptosis in rat model of traumatic brain injury via activating system Xc - \/GSH\/GPX4 axis","author":"Na","year":"2024","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.bcp.2026.117926_b0280","article-title":"Metabolomic signatures for liver tissue and cecum contents in high-fat diet-induced obese mice based on UHPLC-Q-TOF\/MS","author":"Hongying","year":"2021","journal-title":"Nutr. Metabol."},{"issue":"5","key":"10.1016\/j.bcp.2026.117926_b0285","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/ibd.20824","article-title":"Differential susceptibility of P-glycoprotein deficient mice to colitis induction by environmental insults","volume":"15","author":"Staley","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.117926_b0290","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/big.2015.0029","article-title":"Type 2 diabetes mellitus trajectories and associated risks","volume":"4","author":"Oh","year":"2016","journal-title":"Big Data"},{"issue":"3","key":"10.1016\/j.bcp.2026.117926_b0295","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2022-003282","article-title":"Fecal microbiota transplantation ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota in db\/db mice","volume":"11","author":"Chen","year":"2023","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.bcp.2026.117926_b0300","article-title":"Alterations of the Gut Microbiome and Metabolome in patients with Proliferative Diabetic Retinopathy","author":"Panpan","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bcp.2026.117926_b0305","article-title":"Cordyceps cicadae polysaccharides ameliorated renal interstitial fibrosis in diabetic nephropathy rats by repressing inflammation and modulating gut microbiota dysbiosis","author":"Junling","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bcp.2026.117926_b0310","article-title":"Integrated 16S rRNA sequencing, metagenomics, and metabolomics to characterize gut microbial composition, function, and fecal metabolic phenotype in non-obese type 2 diabetic goto-kakizaki rats","author":"Weijun","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bcp.2026.117926_b0315","article-title":"Moringa oleifera leaves protein enhances intestinal permeability by activating TLR4 upstream signaling and disrupting tight junctions","author":"Xiaoxue","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117926_b0320","article-title":"Evidence for tight junction protein disruption in intestinal mucosa of malignant obstructive jaundice patients","author":"Na","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bcp.2026.117926_b0325","doi-asserted-by":"crossref","unstructured":"Y. Alper, T. Sevil Arabac\u0131, S. Duran, B. Fatma, K. Merve Meric, D.O. Nilsu, \u00c7. Yusuf Burak, K. \u00d6zlem, A. Burak, A. Esra, Y. Meral, \u00c7. \u015eule, Y. Berrak \u00c7, The effects of antibiotics and melatonin on hepato-intestinal inflammation and gut microbial dysbiosis induced by a short-term high-fat diet consumption in rats, The British journal of nutrition (2019). doi:10.1017\/s0007114519001466.","DOI":"10.1017\/S0007114519001466"},{"key":"10.1016\/j.bcp.2026.117926_b0330","article-title":"A flavonoid-rich extract of bergamot juice improves high-fat diet-induced intestinal permeability and associated hepatic damage in mice","author":"Giovanni Enrico","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.bcp.2026.117926_b0335","doi-asserted-by":"crossref","unstructured":"P. Parth, S. Rachana, F.F. Jane, P.R. Muredach, Human experimental endotoxemia in modeling the pathophysiology, genomics, and therapeutics of innate immunity in complex cardiometabolic diseases, Arteriosclerosis, thrombosis, and vascular biology (2014). doi:10.1161\/atvbaha.114.304455.","DOI":"10.1161\/ATVBAHA.114.304455"},{"key":"10.1016\/j.bcp.2026.117926_b0340","article-title":"HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease","author":"Varun","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.117926_b0345","article-title":"Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers","author":"Luying","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.bcp.2026.117926_b0350","article-title":"High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice","author":"Weiling","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bcp.2026.117926_b0355","article-title":"Pharmaceutical activation or genetic absence of ClC-2 alters tight junctions during experimental colitis","author":"Younggeon","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.bcp.2026.117926_b0360","article-title":"Formononetin administration ameliorates dextran sulfate sodium-induced acute colitis by inhibiting NLRP3 inflammasome signaling pathway","author":"Dacheng","year":"2018","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bcp.2026.117926_b0365","article-title":"Xylan acetate ester ameliorates ulcerative colitis through intestinal barrier repair and inflammation inhibition via regulation of macrophage M1 polarization","author":"Huiling","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:12:47Z","timestamp":1778710367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":73,"alternative-id":["S0006295226002595"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117926","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propyl gallate mitigates diabetic liver injury via suppressing SLC7A11\/GPX4-mediated hepatic ferroptosis and modulating gut-liver axis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117926","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117926"}}