{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:02:22Z","timestamp":1780678942684,"version":"3.54.1"},"reference-count":144,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bcp.2026.117933","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:40:30Z","timestamp":1774582830000},"page":"117933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Long non-coding RNAs: New perspectives for the diagnosis, prognosis, and treatment of pancreatic cancer"],"prefix":"10.1016","volume":"250","author":[{"given":"Francisca Santos","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9802-5657","authenticated-orcid":false,"given":"C\u00e1tia","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandrina Ferreira","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.117933_b0005","unstructured":"Eurostat, Causes of death statistics, Luxembourg, 2025."},{"issue":"2025","key":"10.1016\/j.bcp.2026.117933_b0010","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.annonc.2025.01.014","article-title":"European cancer mortality predictions for the year, with focus on breast cancer","volume":"36","author":"Santucci","year":"2025","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0015","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2026.117933_b0020","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1002\/cam4.2254","article-title":"Association of time interval between cancer diagnosis and initiation of palliative chemotherapy with overall survival in patients with unresectable pancreatic cancer","volume":"8","author":"Lee","year":"2019","journal-title":"Cancer Med."},{"key":"10.1016\/j.bcp.2026.117933_b0025","doi-asserted-by":"crossref","first-page":"17085","DOI":"10.3390\/ijms140817085","article-title":"Non-Coding RNAs and Cancer","volume":"14","author":"Calore","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0030","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0035","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/diseases9010008","article-title":"The biological roles of lncRNAs and future prospects in clinical application","volume":"9","author":"Li","year":"2021","journal-title":"Diseases"},{"key":"10.1016\/j.bcp.2026.117933_b0040","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3390\/onco1020014","article-title":"Decoding the oncogenic signals from the long non-coding RNAs","volume":"1","author":"Nadhan","year":"2021","journal-title":"Onco"},{"key":"10.1016\/j.bcp.2026.117933_b0045","doi-asserted-by":"crossref","unstructured":"International Human Genome Sequencing Consortium, Finishing the euchromatic sequence of the human genome, Nature 431 (2004) 931\u2013945. https:\/\/doi.org\/10.1038\/nature03001.","DOI":"10.1038\/nature03001"},{"key":"10.1016\/j.bcp.2026.117933_b0050","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","article-title":"Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches","volume":"96","author":"Beermann","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bcp.2026.117933_b0055","doi-asserted-by":"crossref","first-page":"18790","DOI":"10.3390\/ijms140918790","article-title":"Long non-coding RNAs and complex human diseases","volume":"14","author":"Li","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0060","doi-asserted-by":"crossref","unstructured":"J. Jarroux, A. Morillon, M. Pinskaya, History, Discovery, and Classification of lncRNAs, in: Adv. Exp. Med. Biol., 2017: pp. 1\u201346. https:\/\/doi.org\/10.1007\/978-981-10-5203-3_1.","DOI":"10.1007\/978-981-10-5203-3_1"},{"key":"10.1016\/j.bcp.2026.117933_b0065","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0070","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.bbagrm.2014.08.012","article-title":"LncRNA: a link between RNA and cancer","volume":"1839","author":"Yang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2026.117933_b0075","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.3390\/ijms20225573","article-title":"Mechanisms and functions of long non-coding RNAs at multiple regulatory levels","volume":"20","author":"Zhang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0080","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2018.00144","article-title":"Micropeptides encoded in transcripts previously identified as long noncoding RNAs: a new chapter in transcriptomics and proteomics","volume":"9","author":"Yeasmin","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.bcp.2026.117933_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300314","article-title":"The tumorigenic effect of lncRNA AFAP1\u2010AS1 is mediated by translated peptide ATMLP under the Control of m 6 a methylation","volume":"10","author":"Pei","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0090","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.117933_b0095","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202009045","article-title":"LNCcation: lncRNA localization and function","volume":"220","author":"Bridges","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0100","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.tibs.2016.07.003","article-title":"Linking long noncoding RNA localization and function","volume":"41","author":"Chen","year":"2016","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.bcp.2026.117933_b0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ncrna.2016.11.002","article-title":"Long non-coding RNAs: mechanism of action and functional utility","volume":"1","author":"Bhat","year":"2016","journal-title":"Noncoding RNA Res."},{"key":"10.1016\/j.bcp.2026.117933_b0110","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.chembiol.2019.08.002","article-title":"Neutralization of the positive charges on histone tails by RNA promotes an open chromatin structure,","volume":"26","author":"Dueva","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0115","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000568","article-title":"Noncoding RNA gas5 is a growth arrest\u2013 and starvation-associated repressor of the glucocorticoid receptor","volume":"3","author":"Kino","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bcp.2026.117933_b0120","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41467-017-02113-y","article-title":"Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function","volume":"9","author":"Miao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.117933_b0125","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.molcel.2013.08.017","article-title":"Circular intronic long noncoding RNAs","volume":"51","author":"Zhang","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2026.117933_b0130","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ijc.32483","article-title":"A novel lncRNA\u2010LINC01116 regulates tumorigenesis of glioma by targeting VEGFA","volume":"146","author":"Ye","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.117933_b0135","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1159\/000490931","article-title":"LncRNA PCGEM1 induces ovarian carcinoma tumorigenesis and progression through RhoA pathway","volume":"47","author":"Chen","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.117933_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111023","article-title":"LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma","volume":"133","author":"Sheng","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.117933_b0145","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13046-019-1139-6","article-title":"Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma","volume":"38","author":"Zhang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.117933_b0150","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ccell.2016.03.004","article-title":"Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA","volume":"29","author":"Qu","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.117933_b0155","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.canlet.2021.03.018","article-title":"Long non-coding RNAs in the doxorubicin resistance of cancer cells","volume":"508","author":"Ashrafizaveh","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2026.117933_b0160","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"Gupta","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117933_b0165","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/onc.2012.193","article-title":"HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer","volume":"32","author":"Kim","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.117933_b0170","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.3390\/ijms15034060","article-title":"Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA Binding motif protein 38 in hepatocellular carcinoma cells","volume":"15","author":"Ding","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0175","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1158\/0008-5472.CAN-11-1021","article-title":"Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers","volume":"71","author":"Kogo","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.117933_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109774","article-title":"H19 lncRNA: roles in tumorigenesis","volume":"123","author":"Ghafouri-Fard","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.117933_b0185","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13045-019-0747-0","article-title":"The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy","volume":"12","author":"Wang","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0190","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.18632\/oncotarget.7270","article-title":"Regulation of laryngeal squamous cell cancer progression by the lncRNA H19\/miR-148a-3p\/DNMT1 axis","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117933_b0195","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1038\/sj.onc.1206928","article-title":"MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer","volume":"22","author":"Ji","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.117933_b0200","article-title":"Diagnostic, prognostic, and therapeutic significance of long non-coding RNA MALAT1 in cancer","volume":"1875","author":"Goyal","year":"2021","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Rev. Cancer"},{"issue":"2010","key":"10.1016\/j.bcp.2026.117933_b0205","first-page":"689","article-title":"Long noncoding RNA as modular scaffold of histone modification complexes","volume":"329","author":"Tsai","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.117933_b0210","first-page":"5975","article-title":"DD3: a new prostate-specific gene, highly overexpressed in prostate cancer","volume":"59","author":"Bussemakers","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.117933_b0215","first-page":"2695","article-title":"DD3(PCA3), a very sensitive and specific marker to detect prostate tumors","volume":"62","author":"de Kok","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.117933_b0220","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/JU.0000000000003491","article-title":"Early detection of prostate cancer: AUA\/SUO guideline Part I: prostate cancer screening","volume":"210","author":"Wei","year":"2023","journal-title":"J. Urol."},{"key":"10.1016\/j.bcp.2026.117933_b0225","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.eururo.2012.11.014","article-title":"Prospective multicentre evaluation of PCA3 and TMPRSS2-ERG gene fusions as diagnostic and prognostic urinary biomarkers for prostate cancer","volume":"65","author":"Leyten","year":"2014","journal-title":"Eur. Urol."},{"key":"10.1016\/j.bcp.2026.117933_b0230","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.eururo.2008.06.071","article-title":"Clinical utility of the PCA3 urine assay in european men scheduled for repeat biopsy","volume":"54","author":"Haese","year":"2008","journal-title":"Eur. Urol."},{"key":"10.1016\/j.bcp.2026.117933_b0235","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/mc.22739","article-title":"Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma","volume":"57","author":"Shen","year":"2018","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bcp.2026.117933_b0240","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/JME-12-0008","article-title":"MEG3 noncoding RNA: a tumor suppressor","volume":"48","author":"Zhou","year":"2012","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bcp.2026.117933_b0245","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.3892\/ol.2020.11809","article-title":"Long non\u2013coding RNA GAS5 in human cancer (Review)","volume":"20","author":"Yang","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bcp.2026.117933_b0250","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/cgt.2017.29","article-title":"PTENP1 acts as a ceRNA to regulate PTEN by sponging miR-19b and explores the biological role of PTENP1 in breast cancer","volume":"24","author":"Li","year":"2017","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.bcp.2026.117933_b0255","doi-asserted-by":"crossref","first-page":"24731","DOI":"10.1074\/jbc.M702029200","article-title":"Activation of p53 by MEG3 Non-coding RNA","volume":"282","author":"Zhou","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.117933_b0260","first-page":"3850","article-title":"lncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway","volume":"21","author":"Wei","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0265","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13046-015-0197-7","article-title":"Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression","volume":"34","author":"Peng","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.117933_b0270","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41419-020-2735-2","article-title":"Low GAS5 expression may predict poor survival and cisplatin resistance in cervical cancer","volume":"11","author":"Fang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.117933_b0275","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/07357907.2021.1928167","article-title":"Circulating long non-coding RNA GAS5: a non-invasive molecular marker for prognosis, response to treatment and survival in non-small cell lung cancer","volume":"39","author":"Al Mourgi","year":"2021","journal-title":"Cancer Invest."},{"key":"10.1016\/j.bcp.2026.117933_b0280","series-title":"Molecular Basis of Disease 1832","first-page":"1613","article-title":"Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines, Biochimica et Biophysica Acta (BBA)","author":"Pickard","year":"2013"},{"key":"10.1016\/j.bcp.2026.117933_b0285","doi-asserted-by":"crossref","first-page":"16187","DOI":"10.1007\/s13277-016-5429-8","article-title":"LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT\/mTOR signaling pathway","volume":"37","author":"Xue","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0290","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1158\/1535-7163.MCT-14-0245","article-title":"Pseudogene PTENP1 functions as a competing endogenous RNA to suppress clear-cell renal cell Carcinoma progression","volume":"13","author":"Yu","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bcp.2026.117933_b0295","first-page":"393","article-title":"LncRNA PTENP1 inhibits cervical cancer progression by suppressing miR-106b, Artif. Cells Nanomed","volume":"48","author":"Fan","year":"2020","journal-title":"Biotechnol"},{"key":"10.1016\/j.bcp.2026.117933_b0300","article-title":"Long non-coding RNAs in cancer: implications for diagnosis, prognosis, and therapy","volume":"7","author":"Qian","year":"2020","journal-title":"Front. Med. (lausanne)."},{"key":"10.1016\/j.bcp.2026.117933_b0305","doi-asserted-by":"crossref","first-page":"v56","DOI":"10.1093\/annonc\/mdv295","article-title":"Cancer of the pancreas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"26","author":"Ducreux","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0310","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.5260","article-title":"Why is pancreatic cancer so deadly? the pathologist\u2019s view","volume":"248","author":"Hruban","year":"2019","journal-title":"J. Pathol."},{"key":"10.1016\/j.bcp.2026.117933_b0315","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/474905","article-title":"Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN","volume":"2014","author":"Distler","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bcp.2026.117933_b0320","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/PAT.0b013e32835f2205","article-title":"Classification, morphology and molecular pathology of premalignant lesions of the pancreas","volume":"45","author":"Cooper","year":"2013","journal-title":"Pathology"},{"key":"10.1016\/j.bcp.2026.117933_b0325","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bpg.2013.04.001","article-title":"Precancerous lesions of the pancreas","volume":"27","author":"Zamboni","year":"2013","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.bcp.2026.117933_b0330","doi-asserted-by":"crossref","first-page":"33535","DOI":"10.1038\/srep33535","article-title":"Analysis of long non-coding RNA expression profiles in pancreatic ductal adenocarcinoma","volume":"6","author":"Fu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.117933_b0335","doi-asserted-by":"crossref","first-page":"10484","DOI":"10.1038\/s41598-017-09754-5","article-title":"Linc-ing circulating long non-coding RNAs to the diagnosis and malignant prediction of intraductal papillary mucinous neoplasms of the pancreas","volume":"7","author":"Permuth","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.117933_b0340","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1158\/1078-0432.CCR-21-3581","article-title":"Molecular characterization of KRAS Wild-type tumors in patients with pancreatic adenocarcinoma","volume":"28","author":"Philip","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.117933_b0345","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/cas.16456","article-title":"Molecular subtyping and genomic profiling expand precision medicine in KRAS wild\u2010type pancreatic cancer","volume":"116","author":"Su","year":"2025","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0350","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.7150\/jca.14922","article-title":"Cancer of the pancreas: molecular pathways and current advancement in treatment","volume":"7","author":"Polireddy","year":"2016","journal-title":"J. Cancer"},{"key":"10.1016\/j.bcp.2026.117933_b0355","first-page":"96","article-title":"The MAPK (ERK) pathway: investigational combinations for the treatment of BRAF-mutated metastatic Melanoma","volume":"38","author":"McCain","year":"2013","journal-title":"P T"},{"key":"10.1016\/j.bcp.2026.117933_b0360","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.18632\/oncotarget.6830","article-title":"Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923\/KRAS pathway","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117933_b0365","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1038\/s41598-017-05274-4","article-title":"The lncRNA MALAT1 acts as a competing endogenous RNA to regulate KRAS expression by sponging miR-217 in pancreatic ductal adenocarcinoma","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.117933_b0370","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41422-022-00726-7","article-title":"A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers","volume":"33","author":"Cheng","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.bcp.2026.117933_b0375","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7150\/ijbs.23230","article-title":"The role of TGF-\u03b2\/SMAD4 signaling in cancer","volume":"14","author":"Zhao","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0380","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1111\/cas.14509","article-title":"Long non\u2010coding RNAs and TGF\u2010\u03b2 signaling in cancer","volume":"111","author":"Papoutsoglou","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0385","first-page":"981","article-title":"Long non\u2010coding RNA SNHG16 decreased SMAD4 to induce gemcitabine resistance in pancreatic cancer via EZH2\u2010mediated epigenetic modification, Kaohsiung","volume":"38","author":"Yu","year":"2022","journal-title":"J. Med. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0390","first-page":"1093","article-title":"Long non\u2013coding RNA PVT1 promotes epithelial\u2013mesenchymal transition via the TGF\u2013\u03b2\/Smad pathway in pancreatic cancer cells","volume":"40","author":"Zhang","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bcp.2026.117933_b0395","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ccell.2016.03.010","article-title":"Long noncoding RNAs in cancer pathways","volume":"29","author":"Schmitt","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.117933_b0400","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbrc.2016.01.169","article-title":"Fenofibrate inhibited pancreatic cancer cells proliferation via activation of p53 mediated by upregulation of LncRNA MEG3","volume":"471","author":"Hu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.117933_b0405","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.630262","article-title":"Pancreatic cancer progression is regulated by IPO7\/p53\/LncRNA MALAT1\/MiR-129-5p positive feedback loop","volume":"9","author":"Xu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0410","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.7150\/thno.30988","article-title":"Hypoxia-induced feedback of HIF-1\u03b1 and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein","volume":"9","author":"Liu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2026.117933_b0415","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrc2602","article-title":"Cell cycle, CDKs and cancer: a changing paradigm","volume":"9","author":"Malumbres","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bcp.2026.117933_b0420","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.3390\/ijms20112615","article-title":"LncRNAs regulatory networks in cellular senescence","volume":"20","author":"Puvvula","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0425","doi-asserted-by":"crossref","unstructured":"P. Kumar P, U. Emechebe, R. Smith, S. Franklin, B. Moore, M. Yandell, S.L. Lessnick, A.M. Moon, Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex, Elife 3 (2014). https:\/\/doi.org\/10.7554\/eLife.02805.","DOI":"10.7554\/eLife.02805"},{"key":"10.1016\/j.bcp.2026.117933_b0430","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1007\/s00432-017-2478-3","article-title":"A novel interplay between HOTAIR and DNA methylation in osteosarcoma cells indicates a new therapeutic strategy","volume":"143","author":"Li","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0435","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1038\/emboj.2013.221","article-title":"A novel non\u2010coding RNA lncRNA\u2010JADE connects DNA damage signalling to histone H4 acetylation","volume":"32","author":"Wan","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.117933_b0440","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ijbiomac.2017.03.123","article-title":"The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: an in vivo and in vitro study","volume":"102","author":"Chen","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bcp.2026.117933_b0445","article-title":"Long non-coding RNA DLEU2L targets miR-210-3p to suppress gemcitabine resistance in pancreatic cancer cells via BRCA2 regulation","volume":"8","author":"Xu","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bcp.2026.117933_b0450","doi-asserted-by":"crossref","first-page":"8725","DOI":"10.2147\/OTT.S219900","article-title":"LncRNA CASC15 functions as an unfavorable predictor of ovarian cancer prognosis and inhibits tumor progression through regulation of miR-221\/ARID1A axis","volume":"12","author":"Shi","year":"2019","journal-title":"Onco. Targets. Ther."},{"key":"10.1016\/j.bcp.2026.117933_b0455","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.21037\/jgo-22-1014","article-title":"LncRNA NORAD mediates KMT2D expression by targeting miR-204-5p and affects the growth of gastric cancer","volume":"13","author":"Chen","year":"2022","journal-title":"J. Gastrointest. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0460","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1101\/gr.140061.112","article-title":"BRAF V600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration","volume":"22","author":"Flockhart","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.bcp.2026.117933_b0465","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1164368","article-title":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses","volume":"321","author":"Jones","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.117933_b0470","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/s41419-019-2123-y","article-title":"Long noncoding RNA LINC01111 suppresses pancreatic cancer aggressiveness by regulating DUSP1 expression via microRNA-3924","volume":"10","author":"Pan","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.117933_b0475","doi-asserted-by":"crossref","first-page":"18016","DOI":"10.1074\/jbc.RA118.004006","article-title":"MEG8 long noncoding RNA contributes to epigenetic progression of the epithelial-mesenchymal transition of lung and pancreatic cancer cells","volume":"293","author":"Terashima","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.117933_b0480","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.3390\/ijms23126559","article-title":"Long non-coding RNA MIR31HG promotes the transforming growth factor \u03b2-induced epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma cells","volume":"23","author":"Ko","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0485","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.719855","article-title":"LncRNA SNHG7 regulates mesenchymal stem cell through the Notch1\/Jagged1\/Hes-1 signaling pathway and influences folfirinox resistance in pancreatic cancer","volume":"11","author":"Cheng","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0490","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3892\/ijo.2022.5406","article-title":"Long non\u2013coding RNA 01614 hyperactivates WNT\/\u03b2\u2013catenin signaling to promote pancreatic cancer progression by suppressing GSK\u20133\u03b2","volume":"61","author":"Chen","year":"2022","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0495","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1038\/s41388-021-01762-0","article-title":"Tumor-derived exosomal long noncoding RNA LINC01133, regulated by Periostin, contributes to pancreatic ductal adenocarcinoma epithelial-mesenchymal transition through the Wnt\/\u03b2-catenin pathway by silencing AXIN2","volume":"40","author":"Liu","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.117933_b0500","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","article-title":"Pancreatic cancer: advances and challenges","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.117933_b0505","doi-asserted-by":"crossref","DOI":"10.1093\/narcan\/zcad055","article-title":"Single-cell transcriptomics reveals long noncoding RNAs associated with tumor biology and the microenvironment in pancreatic cancer","volume":"5","author":"Dang","year":"2023","journal-title":"NAR Cancer"},{"key":"10.1016\/j.bcp.2026.117933_b0510","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nm.2344","article-title":"Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy","volume":"17","author":"Collisson","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2026.117933_b0515","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.3398","article-title":"Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma","volume":"47","author":"Moffitt","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bcp.2026.117933_b0520","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117933_b0525","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature14169","article-title":"Whole genomes redefine the mutational landscape of pancreatic cancer","volume":"518","author":"Waddell","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117933_b0530","doi-asserted-by":"crossref","unstructured":"B.J. Raphael, R.H. Hruban, A.J. Aguirre, R.A. Moffitt, J.J. Yeh, C. Stewart, A.G. Robertson, A.D. Cherniack, M. Gupta, G. Getz, S.B. Gabriel, M. Meyerson, C. Cibulskis, S.S. Fei, T. Hinoue, H. Shen, P.W. Laird, S. Ling, Y. Lu, G.B. Mills, R. Akbani, P. Loher, E.R. Londin, I. Rigoutsos, A.G. Telonis, E.A. Gibb, A. Goldenberg, A.M. Mezlini, K.A. Hoadley, E. Collisson, E. Lander, B.A. Murray, J. Hess, M. Rosenberg, L. Bergelson, H. Zhang, J. Cho, G. Tiao, J. Kim, D. Livitz, I. Leshchiner, B. Reardon, E. Van Allen, A. Kamburov, R. Beroukhim, G. Saksena, S.E. Schumacher, M.S. Noble, D.I. Heiman, N. Gehlenborg, J. Kim, M.S. Lawrence, V. Adsay, G. Petersen, D. Klimstra, N. Bardeesy, M.D.M. Leiserson, R. Bowlby, K. Kasaian, I. Birol, K.L. Mungall, S. Sadeghi, J.N. Weinstein, P.T. Spellman, Y. Liu, L.T. Amundadottir, J. Tepper, A.D. Singhi, R. Dhir, D. Paul, T. Smyrk, L. Zhang, P. Kim, J. Bowen, J. Frick, J.M. Gastier-Foster, M. Gerken, K. Lau, K.M. Leraas, T.M. Lichtenberg, N.C. Ramirez, J. Renkel, M. Sherman, L. Wise, P. Yena, E. Zmuda, J. Shih, A. Ally, M. Balasundaram, R. Carlsen, A. Chu, E. Chuah, A. Clarke, N. Dhalla, R.A. Holt, S.J.M. Jones, D. Lee, Y. Ma, M.A. Marra, M. Mayo, R.A. Moore, A.J. Mungall, J.E. Schein, P. Sipahimalani, A. Tam, N. Thiessen, K. Tse, T. Wong, D. Brooks, J.T. Auman, S. Balu, T. Bodenheimer, D.N. Hayes, A.P. Hoyle, S.R. Jefferys, C.D. Jones, S. Meng, P.A. Mieczkowski, L.E. Mose, C.M. Perou, A.H. Perou, J. Roach, Y. Shi, J. V. Simons, T. Skelly, M.G. Soloway, D. Tan, U. Veluvolu, J.S. Parker, M.D. Wilkerson, A. Korkut, Y. Senbabaoglu, P. Burch, R. McWilliams, K. Chaffee, A. Oberg, W. Zhang, M.-C. Gingras, D.A. Wheeler, L. Xi, M. Albert, J. Bartlett, H. Sekhon, Y. Stephen, Z. Howard, M. Judy, A. Breggia, R.T. Shroff, S. Chudamani, J. Liu, L. Lolla, R. Naresh, T. Pihl, Q. Sun, Y. Wan, Y. Wu, S. Jennifer, K. Roggin, K.-F. Becker, M. Behera, J. Bennett, L. Boice, E. Burks, C.G. Carlotti Junior, J. Chabot, D. Pretti da Cunha Tirapelli, J. Sebasti\u00e3o dos Santos, M. Dubina, J. Eschbacher, M. Huang, L. Huelsenbeck-Dill, R. Jenkins, A. Karpov, R. Kemp, V. Lyadov, S. Maithel, G. Manikhas, E. Montgomery, H. Noushmehr, A. Osunkoya, T. Owonikoko, O. Paklina, O. Potapova, S. Ramalingam, W.K. Rathmell, K. Rieger-Christ, C. Saller, G. Setdikova, A. Shabunin, G. Sica, T. Su, T. Sullivan, P. Swanson, K. Tarvin, M. Tavobilov, L.B. Thorne, S. Urbanski, O. Voronina, T. Wang, D. Crain, E. Curley, J. Gardner, D. Mallery, S. Morris, J. Paulauskis, R. Penny, C. Shelton, T. Shelton, K.-P. Janssen, O. Bathe, N. Bahary, J. Slotta-Huspenina, A. Johns, H. Hibshoosh, R.F. Hwang, A. Sepulveda, A. Radenbaugh, S.B. Baylin, M. Berrios, M.S. Bootwalla, A. Holbrook, P.H. Lai, D.T. Maglinte, S. Mahurkar, T.J. Triche, D.J. Van Den Berg, D.J. Weisenberger, L. Chin, R. Kucherlapati, M. Kucherlapati, A. Pantazi, P. Park, G. Saksena, D. Voet, P. Lin, S. Frazer, T. Defreitas, S. Meier, L. Chin, S.Y. Kwon, Y.H. Kim, S.-J. Park, S.-S. Han, S.H. Kim, H. Kim, E. Furth, M. Tempero, C. Sander, A. Biankin, D. Chang, P. Bailey, A. Gill, J. Kench, S. Grimmond, A. Johns, A.P. Cancer Genome Initiative (APGI, R. Postier, R. Zuna, H. Sicotte, J.A. Demchok, M.L. Ferguson, C.M. Hutter, K.R. Mills Shaw, M. Sheth, H.J. Sofia, R. Tarnuzzer, Z. Wang, L. Yang, J. (Julia) Zhang, I. Felau, J.C. Zenklusen, Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma, Cancer Cell 32 (2017) 185-203.e13. https:\/\/doi.org\/10.1016\/j.ccell.2017.07.007.","DOI":"10.1016\/j.ccell.2017.07.007"},{"key":"10.1016\/j.bcp.2026.117933_b0535","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cca.2019.08.013","article-title":"Biochemical diagnostics of pancreatic cancer - present and future","volume":"498","author":"Jelski","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bcp.2026.117933_b0540","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.dld.2018.08.009","article-title":"Prognostic stratification of resected pancreatic ductal adenocarcinoma: past, present, and future","volume":"50","author":"Barhli","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.bcp.2026.117933_b0545","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1158\/2767-9764.CRC-22-0190","article-title":"Diagnostic accuracy of blood-based biomarkers for pancreatic cancer: a systematic review and meta-analysis","volume":"2","author":"Kane","year":"2022","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.bcp.2026.117933_b0550","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41698-022-00283-7","article-title":"Blood-derived lncRNAs as biomarkers for cancer diagnosis: the good, the bad and the beauty","volume":"6","author":"Badowski","year":"2022","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0555","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3390\/cancers11081170","article-title":"Noncoding RNAs in extracellular fluids as cancer biomarkers: the new frontier of liquid biopsies","volume":"11","author":"Pardini","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bcp.2026.117933_b0560","doi-asserted-by":"crossref","first-page":"7120","DOI":"10.18632\/oncotarget.6859","article-title":"Identifying and functionally characterizing tissue-specific and ubiquitously expressed human lncRNAs","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117933_b0565","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/emermed-2017-206735","article-title":"What is an ROC curve?","volume":"34","author":"Hoo","year":"2017","journal-title":"Emerg Med. J."},{"key":"10.1016\/j.bcp.2026.117933_b0570","doi-asserted-by":"crossref","first-page":"25408","DOI":"10.18632\/oncotarget.8323","article-title":"Salivary HOTAIR and PVT1 as novel biomarkers for early pancreatic cancer","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117933_b0575","doi-asserted-by":"crossref","first-page":"71773","DOI":"10.18632\/oncotarget.12365","article-title":"Plasma and tumor levels of Linc-pint are diagnostic and prognostic biomarkers for pancreatic cancer","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117933_b0580","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.3748\/wjg.v25.i46.6728","article-title":"Long non-coding RNA HULC as a diagnostic and prognostic marker of pancreatic cancer","volume":"25","author":"Ou","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bcp.2026.117933_b0585","doi-asserted-by":"crossref","first-page":"56383","DOI":"10.18632\/oncotarget.10891","article-title":"Construction and analysis of dysregulated lncRNA-associated ceRNA network identified novel lncRNA biomarkers for early diagnosis of human pancreatic cancer","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117933_b0590","article-title":"Integrative analysis of 5-hydroxymethylcytosine and transcriptional profiling identified 5hmC-modified lncRNA panel as non-invasive biomarkers for diagnosis and prognosis of pancreatic cancer","volume":"10","author":"Li","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0595","first-page":"3427","article-title":"Novel three\u2013lncRNA signature predicts survival in patients with pancreatic cancer","volume":"40","author":"Wu","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bcp.2026.117933_b0600","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.7150\/jca.27823","article-title":"A Panel of 12-lncRNA signature predicts survival of pancreatic adenocarcinoma","volume":"10","author":"Zhang","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.bcp.2026.117933_b0605","doi-asserted-by":"crossref","first-page":"15619","DOI":"10.1002\/jcp.28209","article-title":"LINC00052 functions as a tumor suppressor through negatively modulating miR\u2010330\u20103p in pancreatic cancer","volume":"234","author":"Xiong","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bcp.2026.117933_b0610","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1038\/s41388-022-02253-6","article-title":"Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair","volume":"41","author":"Zhang","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.117933_b0615","doi-asserted-by":"crossref","first-page":"8860","DOI":"10.18632\/aging.102307","article-title":"Long non-coding SBF2-AS1 acting as a competing endogenous RNA to sponge microRNA-142-3p to participate in gemcitabine resistance in pancreatic cancer via upregulating TWF1","volume":"11","author":"Hua","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.bcp.2026.117933_b0620","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1158\/0008-5472.CAN-21-0281","article-title":"LncRNA HIF1A-AS1 promotes gemcitabine resistance of pancreatic cancer by enhancing glycolysis through modulating the AKT\/YB1\/HIF1\u03b1 pathway","volume":"81","author":"Xu","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.117933_b0625","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12943-020-01237-y","article-title":"LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt\/\u03b2-catenin and autophagy pathway through modulating the miR-619-5p\/Pygo2 and miR-619-5p\/ATG14 axes","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.117933_b0630","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.2147\/OTT.S234924","article-title":"LncRNA HOTTIP participates in cisplatin resistance of tumor cells by regulating miR-137 expression in pancreatic cancer","volume":"13","author":"Yin","year":"2020","journal-title":"Onco. Targets. Ther."},{"key":"10.1016\/j.bcp.2026.117933_b0635","first-page":"38","article-title":"Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling","volume":"8","author":"Zhou","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bcp.2026.117933_b0640","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.2147\/CMAR.S174066","article-title":"Inhibition of long non-coding RNA HOTAIR enhances radiosensitivity via regulating autophagy in pancreatic cancer","volume":"10","author":"Wu","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.bcp.2026.117933_b0645","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1007\/s13277-015-4234-0","article-title":"The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic ductal adenocarcinoma by regulating the expression of Wnt inhibitory factor 1","volume":"37","author":"Jiang","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0650","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41571-018-0035-x","article-title":"Clinical utility of circulating non-coding RNAs - an update","volume":"15","author":"Anfossi","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bcp.2026.117933_b0655","doi-asserted-by":"crossref","unstructured":"T. Shi, G. Gao, Y. Cao, Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics., Dis. Markers 2016 (2016) 9085195. https:\/\/doi.org\/10.1155\/2016\/9085195.","DOI":"10.1155\/2016\/9085195"},{"key":"10.1016\/j.bcp.2026.117933_b0660","doi-asserted-by":"crossref","first-page":"8087","DOI":"10.1039\/C9RA07858D","article-title":"A simple and rapid colorimetric detection of serum lncRNA biomarkers for diagnosis of pancreatic cancer","volume":"10","author":"Lou","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.bcp.2026.117933_b0665","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.7150\/jca.62631","article-title":"Suppressing LncRNA HOXA-AS3 by CRISPR-dCas9 inhibits pancreatic cancer development","volume":"12","author":"Zhang","year":"2021","journal-title":"J. Cancer"},{"key":"10.1016\/j.bcp.2026.117933_b0670","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s43042-020-00074-4","article-title":"Strategies to target long non-coding RNAs in cancer treatment: progress and challenges","volume":"21","author":"Fathi Dizaji","year":"2020","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"10.1016\/j.bcp.2026.117933_b0675","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/nar\/gkv1206","article-title":"Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides","volume":"44","author":"Lennox","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117933_b0680","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tips.2022.01.008","article-title":"The potential of long noncoding RNA therapies","volume":"43","author":"Mercer","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0685","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.apsb.2022.12.005","article-title":"The tumor therapeutic potential of long non-coding RNA delivery and targeting","volume":"13","author":"Han","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bcp.2026.117933_b0690","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.7150\/jca.32052","article-title":"Circulating lncRNA ABHD11-AS1 serves as a biomarker for early pancreatic cancer diagnosis","volume":"10","author":"Liu","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.bcp.2026.117933_b0695","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.7150\/jca.18073","article-title":"Microarray analysis of the expression profile of long non-coding RNAs indicates lncRNA RP11-263F15.1 as a biomarker for diagnosis and prognostic prediction of pancreatic ductal adenocarcinoma","author":"Huang","year":"2017","journal-title":"J. Cancer 8"},{"key":"10.1016\/j.bcp.2026.117933_b0700","doi-asserted-by":"crossref","first-page":"35684","DOI":"10.18632\/oncotarget.5533","article-title":"Expression profile of long non-coding RNAs in pancreatic cancer and their clinical significance as biomarkers","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117933_b0705","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1007\/s13277-014-2850-8","article-title":"Overexpression of long non-coding RNA MALAT1 is correlated with clinical progression and unfavorable prognosis in pancreatic cancer","volume":"36","author":"Pang","year":"2015","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0710","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1007\/s13277-015-4252-y","article-title":"Downregulation of lncRNA-ATB correlates with clinical progression and unfavorable prognosis in pancreatic cancer","volume":"37","author":"Qu","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bcp.2026.117933_b0715","first-page":"2230","article-title":"Association of LncRNA HMlincRNA717 with prognosis in pancreatic cancer","volume":"20","author":"Sun","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2026.117933_b0720","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.biopha.2017.10.157","article-title":"Long non-coding RNA GAS5 antagonizes the chemoresistance of pancreatic cancer cells through down-regulation of miR-181c-5p","volume":"97","author":"Gao","year":"2018","journal-title":"Biomed. Pharmacother."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:24:08Z","timestamp":1780676648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":144,"alternative-id":["S0006295226002662"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117933","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long non-coding RNAs: New perspectives for the diagnosis, prognosis, and treatment of pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117933"}}