{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T19:43:01Z","timestamp":1782416581039,"version":"3.54.5"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2021-122271OB-I00- MICIU\/AEI \/10.13039\/501100011033"],"award-info":[{"award-number":["PID2021-122271OB-I00- MICIU\/AEI \/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bcp.2026.117943","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:04:45Z","timestamp":1775059485000},"page":"117943","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["Identification of hub genes and lncRNAs driving the transition from early response to methotrexate resistance in HT29 colon cancer cells"],"prefix":"10.1016","volume":"250","author":[{"given":"Ana","family":"Delgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"L\u00f3pez-Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Cullell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Mencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7855-392X","authenticated-orcid":false,"given":"Carlos J.","family":"Ciudad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"No\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.117943_b0005","series-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay","year":"2022"},{"key":"10.1016\/j.bcp.2026.117943_b0010","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1001\/jama.2021.0106","article-title":"Diagnosis and Treatment of Metastatic Colorectal Cancer","volume":"325","author":"Biller","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.bcp.2026.117943_b0015","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.3390\/cancers16081530","article-title":"Colorectal Cancer: Epidemiology, Risk Factors, and Prevention","volume":"16","author":"Roshandel","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bcp.2026.117943_b0020","first-page":"661","article-title":"Diagnostic and therapeutic biomarkers in colorectal cancer: a review","volume":"12","author":"de Assis","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.bcp.2026.117943_b0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10585-015-9715-4","article-title":"Growth pattern of colorectal liver metastasis as a marker of recurrence risk","volume":"32","author":"Eefsen","year":"2015","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.bcp.2026.117943_b0030","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bcp.2026.117943_b0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117943_b0040","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: the Next Generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.117943_b0045","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41575-024-00934-z","article-title":"Mechanisms of metastatic colorectal cancer","volume":"21","author":"Ca\u00f1ellas-Socias","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcp.2026.117943_b0050","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.rdc.2022.03.005","article-title":"Treatment guidelines in Rheumatoid Arthritis","volume":"48","author":"Singh","year":"2022","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"10.1016\/j.bcp.2026.117943_b0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbacli.2015.01.006","article-title":"Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate","volume":"3","author":"Hess","year":"2015","journal-title":"BBA Clin."},{"key":"10.1016\/j.bcp.2026.117943_b0060","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bcp.2007.08.034","article-title":"Transcriptional regulation of aldo-keto reductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: Role in the cell cycle and apoptosis","volume":"75","author":"Selga","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117943_b0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1755-8794-1-35","article-title":"Role of Caveolin 1, E-Cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells","volume":"1","author":"Selga","year":"2008","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.bcp.2026.117943_b0070","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.bcp.2011.08.009","article-title":"Underexpression of miR-224 in methotrexate resistant human colon cancer cells","volume":"82","author":"Mencia","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117943_b0075","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/1471-2407-10-250","article-title":"Overexpression of S100A4 in human cancer cell lines resistant to methotrexate","volume":"10","author":"Menc\u00eda","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bcp.2026.117943_b0080","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/gm83","article-title":"Networking of differentially expressed genes in human cancer cells resistant to methotrexate","volume":"1","author":"Selga","year":"2009","journal-title":"Genome Med."},{"key":"10.1016\/j.bcp.2026.117943_b0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12943-025-02236-7","article-title":"lncRNAs: the unexpected link between protein synthesis and cancer adaptation","volume":"24","author":"Gugnoni","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.117943_b0090","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-biochem-062917-012708","article-title":"Long Noncoding RNAs: Molecular Modalities to Organismal Functions","volume":"89","author":"Rinn","year":"2020","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.bcp.2026.117943_b0095","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","article-title":"Functional Classification and Experimental Dissection of Long Noncoding RNAs","volume":"172","author":"Kopp","year":"2018","journal-title":"Cell"},{"issue":"2012","key":"10.1016\/j.bcp.2026.117943_b0100","first-page":"1435","article-title":"Epigenetic Regulation by Long Noncoding RNAs","volume":"338","author":"Lee","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.117943_b0105","doi-asserted-by":"crossref","unstructured":"R.E. Reggiardo, S.V. Maroli, D.H. Kim, LncRNA Biomarkers of Inflammation and Cancer, in: 2022: pp. 121\u2013145. doi: 10.1007\/978-3-030-92034-0_7.","DOI":"10.1007\/978-3-030-92034-0_7"},{"key":"10.1016\/j.bcp.2026.117943_b0110","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.stem.2014.05.014","article-title":"Long Noncoding RNAs in Cell-Fate programming and Reprogramming","volume":"14","author":"Flynn","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcp.2026.117943_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/7243968","article-title":"Long Noncoding RNAs as Biomarkers in Cancer","volume":"2017","author":"Bolha","year":"2017","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bcp.2026.117943_b0120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1476-4598-10-38","article-title":"The functional role of long non-coding RNA in human carcinomas","volume":"10","author":"Gibb","year":"2011","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.117943_b0125","first-page":"127","article-title":"Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer","volume":"4","author":"Nie","year":"2012","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bcp.2026.117943_b0130","article-title":"Long Non-Coding RNA: a potential strategy for the Diagnosis and Treatment of Colorectal Cancer","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2026.117943_b0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12935-022-02627-6","article-title":"Emerging roles for lncRNA-NEAT1 in colorectal cancer","volume":"22","author":"Azizidoost","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bcp.2026.117943_b0140","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bcp.2013.09.013","article-title":"Polypurine reverse Hoogsteen hairpins as a gene therapy tool against survivin in human prostate cancer PC3 cells in vitro and in vivo","volume":"86","author":"Rodr\u00edguez","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117943_b0145","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1021\/mp400431f","article-title":"Stability and Immunogenicity Properties of the Gene-Silencing Polypurine reverse Hoogsteen Hairpins","volume":"11","author":"Villalobos","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bcp.2026.117943_b0150","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.3390\/ijms24087073","article-title":"In Vitro and In Vivo Effects of the Combination of Polypurine reverse Hoogsteen Hairpins against HER-2 and Trastuzumab in Breast Cancer Cells","volume":"24","author":"L\u00f3pez-Aguilar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117943_b0155","unstructured":"GeneSpring GX, (n.d.)."},{"key":"10.1016\/j.bcp.2026.117943_b0160","unstructured":"Broad Institute, Morpheus, (n.d.). https:\/\/software.broadinstitute.org\/morpheus\/."},{"issue":"2021","key":"10.1016\/j.bcp.2026.117943_b0165","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117943_b0170","unstructured":"J.C. Oliveros, Venny 2.1.0, (n.d.). https:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/ (accessed December 30, 2025)."},{"key":"10.1016\/j.bcp.2026.117943_b0175","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database Hallmark Gene Set Collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.bcp.2026.117943_b0180","doi-asserted-by":"crossref","unstructured":"A. Subramanian, P. Tamayo, V.K. Mootha, S. Mukherjee, B.L. Ebert, M.A. Gillette, A. Paulovich, S.L. Pomeroy, T.R. Golub, E.S. Lander, J.P. Mesirov, Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles, Proceedings of the National Academy of Sciences 102 (2005) 15545\u201315550. doi: 10.1073\/pnas.0506580102.","DOI":"10.1073\/pnas.0506580102"},{"key":"10.1016\/j.bcp.2026.117943_b0185","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein\u2013RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117943_b0190","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a Software Environment for Integrated Models of Biomolecular Interaction Networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.bcp.2026.117943_b0195","doi-asserted-by":"crossref","DOI":"10.2174\/0929867324666170301114127","article-title":"Polypurine reverse Hoogsteen Hairpins as a Gene Silencing Tool for Cancer","volume":"24","author":"Ciudad","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bcp.2026.117943_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114371","article-title":"Nucleic acids therapeutics using PolyPurine reverse Hoogsteen hairpins","volume":"189","author":"No\u00e9","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117943_b0205","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical Basis, Experimental Design, and Computerized simulation of Synergism and Antagonism in Drug Combination Studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bcp.2026.117943_b0210","unstructured":"T.-C. Chou, N. Martin, CompuSyn for Drug Combinations and for General Dose-Effect Analysis: User\u2019s Guide, (2010)."},{"key":"10.1016\/j.bcp.2026.117943_b0215","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1111\/cas.14532","article-title":"5\u2010Fluorouracil resistance mechanisms in colorectal cancer: from classical pathways to promising processes","volume":"111","author":"Blondy","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bcp.2026.117943_b0220","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cell.2010.02.027","article-title":"A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations","volume":"141","author":"Sharma","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.117943_b0225","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117943_b0230","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The Emerging Hallmarks of Cancer Metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2026.117943_b0235","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41568-018-0005-8","article-title":"Revisiting the role of ABC transporters in multidrug-resistant cancer","volume":"18","author":"Robey","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"2011","key":"10.1016\/j.bcp.2026.117943_b0240","first-page":"680","article-title":"Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information","volume":"332","author":"Good","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.117943_b0245","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/cr.2016.149","article-title":"Innate immune signaling and regulation in cancer immunotherapy","volume":"27","author":"Corrales","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.bcp.2026.117943_b0250","doi-asserted-by":"crossref","first-page":"37135","DOI":"10.18632\/oncotarget.5789","article-title":"Caveolin-1, a stress-related oncotarget, in drug resistance","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117943_b0255","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-pathol-011811-120856","article-title":"Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms","volume":"7","author":"Sotgia","year":"2012","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bcp.2026.117943_b0260","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1002\/ijc.31369","article-title":"Caveolin\u20101, cancer and therapy resistance","volume":"143","author":"Ketteler","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.117943_b0265","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3892\/ol.2016.5390","article-title":"Downregulation of caveolin-1 increases the sensitivity of drug-resistant colorectal cancer HCT116 cells to 5-fluorouracil","volume":"13","author":"Li","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bcp.2026.117943_b0270","doi-asserted-by":"crossref","first-page":"111943","DOI":"10.18632\/oncotarget.22955","article-title":"Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells","volume":"8","author":"D\u00edaz-Valdivia","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.117943_b0275","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.117943_b0280","doi-asserted-by":"crossref","first-page":"13993","DOI":"10.3390\/ijms150813993","article-title":"Current Status of Long Non-Coding RNAs in Human Cancer with specific Focus on Colorectal Cancer","volume":"15","author":"Smolle","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117943_b0285","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1038\/s41598-018-25530-5","article-title":"Colon Cancer-Upregulated Long Non-Coding RNA lincDUSP Regulates Cell Cycle Genes and Potentiates Resistance to Apoptosis","volume":"8","author":"Forrest","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.117943_b0290","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1158\/0008-5472.CAN-16-2634","article-title":"Long Noncoding RNA and Cancer: a New Paradigm","volume":"77","author":"Bhan","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.117943_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100866","article-title":"Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: from prediction to druggability","volume":"65","author":"Eptaminitaki","year":"2022","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bcp.2026.117943_b0300","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bbrc.2017.03.042","article-title":"TUG1 mediates methotrexate resistance in colorectal cancer via miR-186\/CPEB2 axis","volume":"491","author":"Li","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.117943_b0305","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1111\/jcmm.14071","article-title":"Lnc RNA KCNQ 1 OT 1 enhanced the methotrexate resistance of colorectal cancer cells by regulating miR-760\/ PPP 1R1B via the cAMP signalling pathway","volume":"23","author":"Xian","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2026.117943_b0310","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.yexcr.2016.12.003","article-title":"H19 mediates methotrexate resistance in colorectal cancer through activating Wnt\/\u03b2-catenin pathway","volume":"350","author":"Wu","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bcp.2026.117943_b0315","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ebiom.2018.12.049","article-title":"MALAT1 sponges miR-106b-5p to promote the invasion and metastasis of colorectal cancer via SLAIN2 enhanced microtubules mobility","volume":"41","author":"Zhuang","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bcp.2026.117943_b0320","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s41419-020-03164-8","article-title":"LncRNA NEAT1 remodels chromatin to promote the 5-Fu resistance by maintaining colorectal cancer stemness","volume":"11","author":"Zhu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.117943_b0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0333072","article-title":"Differential regulation of long noncoding RNAs by endogenous and exogenous reactive oxygen species-generating prooxidants in NIH3T3 cells","volume":"20","author":"Kurokawa","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.117943_b0330","first-page":"72","article-title":"Oxidative stress and its Modulation by Ladostigil Alter the Expression of Abundant Long Non-Coding RNAs in SH-SY5Y Cells","volume":"8","author":"Zohar","year":"2022","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.bcp.2026.117943_b0335","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12943-015-0458-2","article-title":"The H19 Long non-coding RNA in cancer initiation, progression and metastasis \u2013 a proposed unifying theory","volume":"14","author":"Raveh","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.117943_b0340","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cellsig.2019.01.013","article-title":"Inhibition of MALAT1 reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer","volume":"57","author":"Tang","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bcp.2026.117943_b0345","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200533","article-title":"Inhibition of lncRNA-NEAT1 sensitizes 5-Fu resistant cervical cancer cells through de-repressing the microRNA-34a\/LDHA axis","volume":"41","author":"Shao","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bcp.2026.117943_b0350","doi-asserted-by":"crossref","first-page":"15131","DOI":"10.1002\/jcb.28775","article-title":"Long noncoding RNA H19 promotes chemotherapy resistance in choriocarcinoma cells","volume":"120","author":"Yu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2026.117943_b0355","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/WNR.0000000000002157","article-title":"Long noncoding RNA MALAT1 promotes angiogenesis through the caveolin-1\/VEGF pathway after cerebral ischemic injury","volume":"36","author":"Lin","year":"2025","journal-title":"Neuroreport"},{"key":"10.1016\/j.bcp.2026.117943_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110761","article-title":"Cognitive\u2013exercise dual-task intervention ameliorates cognitive decline in natural aging rats via inhibiting the promotion of LncRNA NEAT1\/miR-124\u20133p on caveolin-1-PI3K\/Akt\/GSK3\u03b2 Pathway","volume":"202","author":"Li","year":"2023","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bcp.2026.117943_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120958","article-title":"Tumor progress intercept by intervening in Caveolin-1 related intercellular communication via ROS-sensitive c-Myc targeting therapy","volume":"275","author":"Zhou","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bcp.2026.117943_b0370","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bcp.2018.06.020","article-title":"Functional pharmacogenomics and toxicity of PolyPurine reverse Hoogsteen hairpins directed against survivin in human cells","volume":"155","author":"F\u00e9lix","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117943_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116976","article-title":"Inhibition of PCSK9 with polypurine reverse hoogsteen hairpins: a novel gene therapy approach","volume":"238","author":"L\u00f3pez-Aguilar","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117943_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107884","article-title":"Polypurine reverse hoogsteen hairpins as a therapeutic tool for SARS-CoV-2 infection","volume":"300","author":"Ciudad","year":"2024","journal-title":"J. Biol. Chem."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:14:28Z","timestamp":1780676068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":76,"alternative-id":["S0006295226002765"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117943","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of hub genes and lncRNAs driving the transition from early response to methotrexate resistance in HT29 colon cancer cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117943","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117943"}}