{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:02:25Z","timestamp":1780678945273,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["FAMP202110K"],"award-info":[{"award-number":["FAMP202110K"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["21NSFCP27"],"award-info":[{"award-number":["21NSFCP27"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260458"],"award-info":[{"award-number":["82260458"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Province Science and Technology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bcp.2026.117945","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:15:28Z","timestamp":1775387728000},"page":"117945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Fangchinoline derivative LYY-34 suppresses TNBC by inhibiting BLM DNA helicase from unfolding of c-MYC promoter G-quadruplex DNA"],"prefix":"10.1016","volume":"250","author":[{"given":"Xiaohua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Shan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Da","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-2587","authenticated-orcid":false,"given":"Jielin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.117945_b0005","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bcp.2026.117945_b0010","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bcp.2026.117945_b0015","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1056\/NEJMoa1904819","article-title":"Clinical and genomic risk to guide the use of adjuvant therapy for breast cancer","volume":"380","author":"Sparano","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.117945_b0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s43556-022-00071-6","article-title":"Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy","volume":"3","author":"Yang","year":"2022","journal-title":"Mol Biomed."},{"key":"10.1016\/j.bcp.2026.117945_b0025","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1093\/nar\/gkae642","article-title":"TRF2-RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM-DNA2-dependent 5'-end resection","volume":"52","author":"Liang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117945_b0030","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1093\/nar\/gkv361","article-title":"BLM unfolds G-quadruplexes in different structural environments through different mechanisms","volume":"43","author":"Wu","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117945_b0035","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1038\/s41467-023-41705-9","article-title":"A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.117945_b0040","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ijbiomac.2021.03.060","article-title":"Bloom helicase explicitly unwinds 3'-tailed G4DNA structure in prostate cancer cells","volume":"180","author":"Zhu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bcp.2026.117945_b0045","article-title":"Human RecQ helicases in DNA double-strand break repair","volume":"9","author":"Lu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.117945_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.634789","article-title":"Functions of BLM helicase in cells: is it acting like a double-edged sword?","volume":"12","author":"Kaur","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.bcp.2026.117945_b0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.chembiol.2012.10.016","article-title":"A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells","volume":"20","author":"Nguyen","year":"2013","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bcp.2026.117945_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002894","article-title":"Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles","volume":"8","author":"Thompson","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bcp.2026.117945_b0065","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1158\/1535-7163.MCT-14-0939","article-title":"Transcriptomic and protein expression analysis reveals clinicopathological significance of bloom syndrome helicase (BLM) in breast cancer","volume":"14","author":"Arora","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bcp.2026.117945_b0070","first-page":"869","article-title":"Effects of silencing BLM DNA helicase expression on proliferation and apoptosis of MDA-MB-468 triple-negative breast cancer cells","volume":"47","author":"Huang","year":"2022","journal-title":"J. Guizhou Med. Univ."},{"key":"10.1016\/j.bcp.2026.117945_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103756","article-title":"Therapeutic targeting of \u201cundruggable\u201d MYC","volume":"75","author":"Llombart","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bcp.2026.117945_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/cells9041038","article-title":"Structural and biophysical insights into the function of the intrinsically disordered Myc oncoprotein","volume":"9","author":"Beaulieu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.117945_b0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41571-021-00549-2","article-title":"The MYC oncogene - the grand orchestrator of cancer growth and immune evasion","volume":"19","author":"Dhanasekaran","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bcp.2026.117945_b0090","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1093\/nar\/gkv862","article-title":"G-quadruplexes and their regulatory roles in biology","volume":"43","author":"Rhodes","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117945_b0095","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1111\/j.1742-4658.2010.07759.x","article-title":"Making sense of G-quadruplex and i-motif functions in oncogene promoters","volume":"277","author":"Brooks","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.bcp.2026.117945_b0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2478\/jomb-2018-0012","article-title":"Importance of copy number alterations of FGFR1 and C-MYC genes in triple negative breast cancer","volume":"38","author":"Nedeljkovic","year":"2019","journal-title":"J. Med. Biochem."},{"key":"10.1016\/j.bcp.2026.117945_b0105","article-title":"Non-fused imidazole-biphenyl analogs repress triple-negative breast cancer growth by mainly stabilizing the c-MYC G-quadruplex via a multi-site binding mode","volume":"88\u201389","author":"Wang","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bcp.2026.117945_b0110","doi-asserted-by":"crossref","first-page":"6720","DOI":"10.1021\/acs.jmedchem.0c02202","article-title":"New dibenzoquinoxalines inhibit triple-negative breast cancer growth by dual targeting of topoisomerase 1 and the c-MYC G-quadruplex","volume":"64","author":"Hu","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2026.117945_b0115","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1093\/nar\/gkz835","article-title":"New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription","volume":"47","author":"Hu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117945_b0120","doi-asserted-by":"crossref","first-page":"14513","DOI":"10.1021\/acsomega.0c01176","article-title":"Recognition and unfolding of c-MYC and telomeric G-quadruplex DNAs by the RecQ C-terminal domain of human bloom syndrome helicase","volume":"5","author":"Lee","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.bcp.2026.117945_b0125","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.aca.2013.01.001","article-title":"Simultaneous determination of fangchinoline and tetrandrine in Stephania tetrandra S. Moore by using 1-alkyl-3-methylimidazolium-based ionic liquids as the RP-HPLC mobile phase additives","volume":"767","author":"Tang","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bcp.2026.117945_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112995","article-title":"History of uses, phytochemistry, pharmacological activities, quality control and toxicity of the root of Stephania tetrandra S. Moore: a review","volume":"260","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.117945_b0135","first-page":"634","article-title":"Research progress on pharmacological action and clinical application of Stephania Tetrandrae Radix","volume":"42","author":"Wang","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.bcp.2026.117945_b0140","doi-asserted-by":"crossref","first-page":"769","DOI":"10.7314\/APJCP.2014.15.2.769","article-title":"Fangchinoline inhibits cell proliferation via Akt\/GSK-3beta\/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells","volume":"15","author":"Wang","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.bcp.2026.117945_b0145","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3892\/ol.2016.5457","article-title":"Anti-metastatic activity of fangchinoline in human gastric cancer AGS cells","volume":"13","author":"Chen","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bcp.2026.117945_b0150","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1159\/000481698","article-title":"Fangchinoline induces apoptosis, autophagy and energetic impairment in bladder cancer","volume":"43","author":"Fan","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.117945_b0155","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3892\/ijmm.2017.3013","article-title":"Fangchinoline suppresses the proliferation, invasion and tumorigenesis of human osteosarcoma cells through the inhibition of PI3K and downstream signaling pathways","volume":"40","author":"Li","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bcp.2026.117945_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156484","article-title":"Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K\/AKT pathway dysregulation","volume":"140","author":"Xie","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.117945_b0165","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s13277-015-3990-1","article-title":"Fangchinoline suppresses the growth and invasion of human glioblastoma cells by inhibiting the kinase activity of Akt and Akt-mediated signaling cascades","volume":"37","author":"Guo","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bcp.2026.117945_b0170","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1186\/s12885-019-6146-7","article-title":"Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase","volume":"19","author":"Zhang","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bcp.2026.117945_b0175","article-title":"The effects of bisbenzylisoquinoline alkaloid tetrandrine derivative HL-22 on the biological propertiles of the BLM helicase","volume":"43","author":"Zhang","year":"2018","journal-title":"J. Guizhou Med. Univ."},{"key":"10.1016\/j.bcp.2026.117945_b0180","first-page":"934","article-title":"Effects of bisbenzylisoquinoline alkaloid tetrandrine derivative HL-27 on biological properties of BLM helicase","volume":"34","author":"Zhang","year":"2018","journal-title":"Chin. Pharmacol. Bull."},{"key":"10.1016\/j.bcp.2026.117945_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115908","article-title":"Bisbenzylisoquinoline alkaloid fangchinoline derivative HY-2 inhibits breast cancer cells by suppressing BLM DNA helicase","volume":"169","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.117945_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118566","article-title":"Membrane-coated BLM gene silencing plasmids and doxorubicin nanoparticles targeted for synergistic inhibition of triple-negative breast cancer","volume":"192","author":"Ai","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.117945_b0195","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s12282-024-01597-z","article-title":"Mesenchymal-like immune-altered is the fourth robust triple-negative breast cancer molecular subtype","volume":"31","author":"Jezequel","year":"2024","journal-title":"Breast Cancer-Tokyo."},{"key":"10.1016\/j.bcp.2026.117945_b0200","doi-asserted-by":"crossref","first-page":"11528","DOI":"10.1093\/nar\/gku856","article-title":"RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP","volume":"42","author":"Budhathoki","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117945_b0205","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1021\/bi9000535","article-title":"Escherichia coli DnaB helicase-DnaC protein complex: allosteric effects of the nucleotides on the nucleic acid binding and the kinetic mechanism of NTP hydrolysis","volume":"48","author":"Roychowdhury","year":"2009","journal-title":"3 Biochemistry"},{"key":"10.1016\/j.bcp.2026.117945_b0210","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1093\/nar\/29.13.2843","article-title":"The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases","volume":"29","author":"Mohaghegh","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117945_b0215","doi-asserted-by":"crossref","first-page":"17766","DOI":"10.1074\/jbc.M709749200","article-title":"The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities","volume":"283","author":"Popuri","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.117945_b0220","doi-asserted-by":"crossref","first-page":"10521","DOI":"10.1021\/ja1038165","article-title":"G-quadruplex hinders translocation of BLM helicase on DNA: a real-time fluorescence spectroscopic unwinding study and comparison with duplex substrates","volume":"132","author":"Liu","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bcp.2026.117945_b0225","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ymgme.2021.03.003","article-title":"Bloom syndrome and the underlying causes of genetic instability","volume":"133","author":"Ababou","year":"2021","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bcp.2026.117945_b0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030189","article-title":"The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures","volume":"7","author":"Kamath-Loeb","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.117945_b0235","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jmb.2006.01.077","article-title":"A conserved G4 DNA binding domain in RecQ family helicases","volume":"358","author":"Huber","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bcp.2026.117945_b0240","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1093\/nar\/gkf530","article-title":"G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition","volume":"30","author":"Huber","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117945_b0245","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1093\/nar\/gki609","article-title":"Prevalence of quadruplexes in the human genome","volume":"33","author":"Huppert","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.117945_b0250","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2019.37.15_suppl.e12550","article-title":"MYC as a therapeutic target for the treatment of triple-negative breast cancer","volume":"37","author":"Foley","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bcp.2026.117945_b0255","article-title":"Development of acridone derivatives: targeting c-MYC transcription in triple-negative breast cancer with inhibitory potential","volume":"13","author":"Liang","year":"2023","journal-title":"Antioxidants (basel)"},{"key":"10.1016\/j.bcp.2026.117945_b0260","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115947","article-title":"On the road to fight cancer: the potential of G-quadruplex ligands as novel therapeutic agents","volume":"22","author":"Alessandrini","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.117945_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102154","article-title":"MYC as a target for cancer treatment","volume":"94","author":"Duffy","year":"2021","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.bcp.2026.117945_b0270","article-title":"Primaquine inhibits the endosomal trafficking and nuclear localization of EGFR and induces the apoptosis of breast cancer cells by nuclear EGFR\/Stat3-mediated c-Myc downregulation","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:23:45Z","timestamp":1780676625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":54,"alternative-id":["S0006295226002789"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117945","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fangchinoline derivative LYY-34 suppresses TNBC by inhibiting BLM DNA helicase from unfolding of c-MYC promoter G-quadruplex DNA","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117945"}}