{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:57:41Z","timestamp":1791082661207,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K11163"],"award-info":[{"award-number":["JP24K11163"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K06842"],"award-info":[{"award-number":["JP23K06842"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K08790"],"award-info":[{"award-number":["JP22K08790"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bcp.2026.117946","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:38:35Z","timestamp":1775230715000},"page":"117946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P1","title":["\u03b2-Hydroxybutyrate modulates intestinal barrier function and visceral sensitivity via a brain AMPK\u2013orexin pathway recruiting histamine H1 receptors, basal forebrain cholinergic neurons, adenosine A2B receptors, and vagal output in rats"],"prefix":"10.1016","volume":"250","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-0906","authenticated-orcid":false,"given":"Masatomo","family":"Ishioh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Nozu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ohgidani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Furube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Miyagishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Funayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Takakusaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikatsu","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bcp.2026.117946_b0005","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/gutjnl-2020-320633","article-title":"Understanding neuroimmune interactions in disorders of gut-brain interaction: from functional to immune-mediated disorders","volume":"72","author":"Vanuytsel","year":"2023","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.bcp.2026.117946_b0010","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrgastro.2011.83","article-title":"New insights into visceral hypersensitivity\u2013clinical implications in IBS","volume":"8","author":"Zhou","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.bcp.2026.117946_b0015","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1097\/j.pain.0000000000001271","article-title":"Chronic stress-associated visceral hyperalgesia correlates with severity of intestinal barrier dysfunction","volume":"159","author":"Creekmore","year":"2018","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.bcp.2026.117946_b0020","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.bcp.2026.117946_b0025","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.coph.2018.08.011","article-title":"Mucosal permeability and mast cells as targets for functional gastrointestinal disorders","volume":"43","author":"Keita","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117946_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134592","article-title":"Brain orexin improves intestinal barrier function via the vagal cholinergic pathway","volume":"714","author":"Okumura","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bcp.2026.117946_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113708","article-title":"Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats","volume":"341","author":"Ishioh","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bcp.2026.117946_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115331","article-title":"Activation of basal forebrain cholinergic neurons improves colonic hyperpermeability through the vagus nerve and adenosine A2B receptors in rats","volume":"206","author":"Ishioh","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117946_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116201","article-title":"Brain histamine improves colonic hyperpermeability through the basal forebrain cholinergic neurons, adenosine A2B receptors and vagus nerve in rats","volume":"224","author":"Ishioh","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117946_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2025.138208","article-title":"Brain AMPK signaling improves intestinal barrier function through brain orexin and the vagal pathway in rats","volume":"854","author":"Funayama","year":"2025","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.bcp.2026.117946_b0055","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2013.09.002","article-title":"Ketone bodies as signaling metabolites","volume":"25","author":"Newman","year":"2014","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.bcp.2026.117946_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2022.100176","article-title":"The SGLT2 inhibitor dapagliflozin promotes systemic FFA mobilization, enhances hepatic \u03b2-oxidation, and induces ketosis","volume":"63","author":"Wallenius","year":"2022","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bcp.2026.117946_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111649","article-title":"Phlorizin attenuates visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome","volume":"139","author":"Nozu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.117946_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112099","article-title":"Tranilast alleviates visceral hypersensitivity and colonic hyperpermeability by suppressing NLRP3 inflammasome activation in irritable bowel syndrome rat models","volume":"133","author":"Nozu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117946_b0075","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.1038\/s41598-017-08055-1","article-title":"Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses","volume":"7","author":"Yamanashi","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2026.117946_b0080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/00365529409090435","article-title":"Evans blue permeation of intestinal mucosa in the rat","volume":"29","author":"Lange","year":"1994","journal-title":"Scand. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.bcp.2026.117946_b0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1538\/expanim.48.137","article-title":"Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium","volume":"48","author":"Kitajima","year":"1999","journal-title":"Exp. Anim."},{"issue":"12","key":"10.1016\/j.bcp.2026.117946_b0090","doi-asserted-by":"crossref","first-page":"e1308","DOI":"10.1371\/journal.pone.0001308","article-title":"Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity","volume":"2","author":"Ukena","year":"2007","journal-title":"PLoS One"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.117946_b0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11010-011-1126-5","article-title":"Antinociceptive effect of VSL#3 on visceral hypersensitivity in a rat model of irritable bowel syndrome: a possible action through nitric oxide pathway and enhance barrier function","volume":"362","author":"Dai","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bcp.2026.117946_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148371","article-title":"Centrally administered GLP-1 analogue improves intestinal barrier function through the brain orexin and the vagal pathway in rats","volume":"1809","author":"Funayama","year":"2023","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.bcp.2026.117946_b0105","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14949","article-title":"Splenectomy prevents brain orexin, ghrelin, or oxytocin but not GLP-1-induced improvement of intestinal barrier function in rats","volume":"37","author":"Funayama","year":"2025","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.bcp.2026.117946_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108116","article-title":"Ghrelin acts in the brain to block colonic hyperpermeability in response to lipopolysaccharide through the vagus nerve","volume":"173","author":"Ishioh","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bcp.2026.117946_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177844","article-title":"Carnosine improves colonic hyperpermeability through the brain histamine H1 receptor, basal forebrain cholinergic neurons, adenosine A2B receptors and vagus nerve in rats","volume":"1002","author":"Ishioh","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2026.117946_b0120","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.14925","article-title":"The neurotensin receptor 1 agonist PD149163 alleviates visceral hypersensitivity and colonic hyperpermeability in rat irritable bowel syndrome model","volume":"36","author":"Nozu","year":"2024","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.bcp.2026.117946_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2025.171394","article-title":"Irisin prevents visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome","volume":"188","author":"Nozu","year":"2025","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.bcp.2026.117946_b0130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jphs.2021.04.001","article-title":"EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome","volume":"146","author":"Nozu","year":"2021","journal-title":"J. Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2026.117946_b0135","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jphs.2021.04.005","article-title":"Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats","volume":"146","author":"Okumura","year":"2021","journal-title":"J. Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2026.117946_b0140","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1053\/gast.2000.19576","article-title":"A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development","volume":"119","author":"Al-Chaer","year":"2000","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.bcp.2026.117946_b0145","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/JOE-18-0441","article-title":"Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-1","volume":"239","author":"Nozu","year":"2018","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.bcp.2026.117946_b0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jphs.2023.07.002","article-title":"Imeglimin prevents visceral hypersensitivity and colonic hyperpermeability in irritable bowel syndrome rat model","volume":"153","author":"Nozu","year":"2023","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2026.117946_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2022.102248","article-title":"Peripheral apelin mediates visceral hypersensitivity and impaired gut barrier in a rat irritable bowel syndrome model","volume":"94","author":"Nozu","year":"2022","journal-title":"Neuropeptides"},{"issue":"8","key":"10.1016\/j.bcp.2026.117946_b0160","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00210-020-01842-0","article-title":"5-HT2A receptors but not cannabinoid receptors in the central nervous system mediate levodopa-induced visceral antinociception in conscious rats","volume":"393","author":"Okumura","year":"2020","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bcp.2026.117946_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.112881","article-title":"Adenosine A(1) receptor agonist induces visceral antinociception via 5-HT(1A), 5-HT(2A), dopamine D(1) or cannabinoid CB(1) receptors, and the opioid system in the central nervous system","volume":"220","author":"Okumura","year":"2020","journal-title":"Physiol. Behav."},{"issue":"17","key":"10.1016\/j.bcp.2026.117946_b0170","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.3748\/wjg.v12.i17.2781","article-title":"Establishment of model of visceral pain due to colorectal distension and its behavioral assessment in rats","volume":"12","author":"Yang","year":"2006","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.bcp.2026.117946_b0175","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/0016-5085(94)90833-8","article-title":"Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats","volume":"107","author":"Okumura","year":"1994","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.bcp.2026.117946_b0180","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1006\/bbrc.1998.9994","article-title":"Stimulation of gastric acid secretion by centrally administered orexin-a in conscious rats","volume":"254","author":"Takahashi","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2026.117946_b0185","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000533275","article-title":"Brain Neuropeptides, Neuroinflammation, and Irritable Bowel Syndrome","volume":"105","author":"Ishioh","year":"2024","journal-title":"Digestion"},{"issue":"3","key":"10.1016\/j.bcp.2026.117946_b0190","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s13105-023-00962-4","article-title":"Ghrelin prevents lethality in a rat endotoxemic model through central effects on the vagal pathway and adenosine A2B signaling : Brain ghrelin and anti-septic action","volume":"79","author":"Igarashi","year":"2023","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.117946_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.113914","article-title":"Oxytocin acts centrally in the brain to improve leaky gut through the vagus nerve and a cannabinoid signaling in rats","volume":"254","author":"Okumura","year":"2022","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bcp.2026.117946_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114262","article-title":"Centrally administered orexin prevents lipopolysaccharide and colchicine induced lethality via the vagal cholinergic pathway in a sepsis model in rats","volume":"182","author":"Igarashi","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"6785","key":"10.1016\/j.bcp.2026.117946_b0205","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117946_b0210","doi-asserted-by":"crossref","unstructured":"R. Krikorian, M.D. Shidler, K. Dangelo, S.C. Couch, S.C. Benoit, D.J. Clegg, Dietary ketosis enhances memory in mild cognitive impairment, Neurobiol Aging 33(2) (2012) 425.e19-27.doi:10.1016\/j.neurobiolaging.2010.10.006.","DOI":"10.1016\/j.neurobiolaging.2010.10.006"},{"issue":"3","key":"10.1016\/j.bcp.2026.117946_b0215","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/alz.12206","article-title":"A ketogenic drink improves cognition in mild cognitive impairment: results of a 6-month RCT","volume":"17","author":"Fortier","year":"2021","journal-title":"Alzheimers Dement."},{"issue":"23","key":"10.1016\/j.bcp.2026.117946_b0220","doi-asserted-by":"crossref","first-page":"9273","DOI":"10.1523\/JNEUROSCI.21-23-09273.2001","article-title":"Orexin\/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus","volume":"21","author":"Eriksson","year":"2001","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bcp.2026.117946_b0225","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0306-4522(01)00512-7","article-title":"Orexins\/hypocretins excite basal forebrain cholinergic neurones","volume":"108","author":"Eggermann","year":"2001","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.bcp.2026.117946_b0230","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI57813","article-title":"A ketogenic diet suppresses seizures in mice through adenosine A1 receptors","volume":"121","author":"Masino","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"8023","key":"10.1016\/j.bcp.2026.117946_b0235","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41586-024-07611-w","article-title":"Adenosine signalling to astrocytes coordinates brain metabolism and function","volume":"632","author":"Theparambil","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.117946_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102343","article-title":"D-beta-hydroxybutyrate up-regulates Claudin-1 and alleviates the intestinal hyperpermeability in lipopolysaccharide-treated mice","volume":"87","author":"Wang","year":"2024","journal-title":"Tissue Cell"},{"issue":"3","key":"10.1016\/j.bcp.2026.117946_b0245","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1207\/s15327558ijbm1303_4","article-title":"Effects of fasting therapy on irritable bowel syndrome","volume":"13","author":"Kanazawa","year":"2006","journal-title":"Int. J. Behav. Med."},{"key":"10.1016\/j.bcp.2026.117946_b0250","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-nutr-071816-064916","article-title":"\u03b2-Hydroxybutyrate: a Signaling Metabolite","volume":"37","author":"Newman","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bcp.2026.117946_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.nutr.26.061505.111258","article-title":"Fuel metabolism in starvation","volume":"26","author":"Cahill","year":"2006","journal-title":"Annu. Rev. Nutr."},{"issue":"7","key":"10.1016\/j.bcp.2026.117946_b0260","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.3174\/ajnr.A5648","article-title":"\u03b2-Hydroxybutyrate Detection with Proton MR Spectroscopy in Children with Drug-Resistant Epilepsy on the Ketogenic Diet","volume":"39","author":"Wright","year":"2018","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"10","key":"10.1016\/j.bcp.2026.117946_b0265","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1172\/JCI105650","article-title":"Brain metabolism during fasting","volume":"46","author":"Owen","year":"1967","journal-title":"J. Clin. Invest."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226002790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:11:01Z","timestamp":1780675861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226002790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":53,"alternative-id":["S0006295226002790"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117946","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2-Hydroxybutyrate modulates intestinal barrier function and visceral sensitivity via a brain AMPK\u2013orexin pathway recruiting histamine H1 receptors, basal forebrain cholinergic neurons, adenosine A2B receptors, and vagal output in rats","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.117946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117946"}}