{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:08:02Z","timestamp":1783922882556,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470762"],"award-info":[{"award-number":["82470762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170750"],"award-info":[{"award-number":["82170750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118082","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:55:32Z","timestamp":1779144932000},"page":"118082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Chemerin represses macrophage-myofibroblast transition and attenuates renal fibrosis"],"prefix":"10.1016","volume":"251","author":[{"given":"Jianhang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5792-8262","authenticated-orcid":false,"given":"Xinzhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118082_b0005","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0140-6736(21)00519-5","article-title":"Chronic kidney disease","volume":"398","author":"Kalantar-Zadeh","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2026.118082_b0010","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic Kidney Disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2026.118082_b0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Ruiz-Ortega","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bcp.2026.118082_b0020","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ki.5000054","article-title":"Renal fibrosis: new insights into the pathogenesis and therapeutics","volume":"69","author":"Liu","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.bcp.2026.118082_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010408","article-title":"Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences","volume":"22","author":"Panizo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118082_b0030","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41581-019-0135-6","article-title":"Epigenetics and epigenomics in diabetic kidney disease and metabolic memory","volume":"15","author":"Kato","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bcp.2026.118082_b0035","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrneph.2014.246","article-title":"Diverse origins of the myofibroblast-implications for kidney fibrosis","volume":"11","author":"Falke","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bcp.2026.118082_b0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-020-2941-1","article-title":"Decoding myofibroblast origins in human kidney fibrosis","volume":"589","author":"Kuppe","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118082_b0045","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.kint.2018.10.017","article-title":"Myofibroblasts acquire retinoic acid-producing ability during fibroblast-to-myofibroblast transition following kidney injury","volume":"95","author":"Nakamura","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.bcp.2026.118082_b0050","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2353\/ajpath.2009.090096","article-title":"Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice","volume":"175","author":"Li","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bcp.2026.118082_b0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2026.118082_b0060","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1515\/hsz-2021-0409","article-title":"Chemerin - exploring a versatile adipokine","volume":"403","author":"Fischer","year":"2022","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118082_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1120774","article-title":"Chemerin levels in chronic kidney disease: a systematic review and meta-analysis","volume":"14","author":"Behnoush","year":"2023","journal-title":"Front Endocrinol (lausanne)"},{"key":"10.1016\/j.bcp.2026.118082_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156772","article-title":"Chemerin, TNF - alpha and the degree of albuminuria in patients with diabetic kidney disease","volume":"184","author":"El-Tahir","year":"2024","journal-title":"Cytokine"},{"key":"10.1016\/j.bcp.2026.118082_b0075","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000530763","article-title":"CMKLR1 Antagonist Alpha-NETA Protects against Diabetic Nephropathy in mice","volume":"48","author":"Peng","year":"2023","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.bcp.2026.118082_b0080","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1111\/jcmm.14237","article-title":"Chemerin\/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy","volume":"23","author":"Shang","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2026.118082_b0085","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2337\/dc09-1351","article-title":"Serum levels of the adipokine chemerin in relation to renal function","volume":"33","author":"Pfau","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bcp.2026.118082_b0090","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/s42003-024-07377-x","article-title":"Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK\/NRF2\/SLC7A11 axis","volume":"7","author":"Ma","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bcp.2026.118082_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106133","article-title":"CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson's disease","volume":"177","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2026.118082_b0100","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1681\/ASN.2016050573","article-title":"Macrophage-to-Myofibroblast transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury","volume":"28","author":"Wang","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.bcp.2026.118082_b0105","doi-asserted-by":"crossref","first-page":"e2495","DOI":"10.1038\/cddis.2016.402","article-title":"Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis","volume":"7","author":"Meng","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.118082_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1461919","article-title":"Advances in macrophage-myofibroblast transformation in fibrotic diseases","volume":"15","author":"Ban","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118082_b0115","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2026.118082_b0120","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-981-13-8871-2_12","article-title":"Myofibroblast in Kidney Fibrosis: Origin, Activation, and Regulation","volume":"1165","author":"Yuan","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bcp.2026.118082_b0125","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41580-024-00716-0","article-title":"Fibroblast and myofibroblast activation in normal tissue repair and fibrosis","volume":"25","author":"Younesi","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118082_b0130","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm.3218","article-title":"Origin and function of myofibroblasts in kidney fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2026.118082_b0135","article-title":"METTL3 Potentiates M2 Macrophage-Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF-beta1\/Smad3 Pathway","volume":"12","author":"Yao","year":"2025","journal-title":"Adv Sci (weinh)"},{"key":"10.1016\/j.bcp.2026.118082_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156324","article-title":"Inhibition of PKM2 by shikonin impedes TGF-beta1 expression by repressing histone lactylation to alleviate renal fibrosis","volume":"136","author":"Xiang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118082_b0145","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/pr.116.013177","article-title":"International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin(1)) and GPR1 (Chemerin(2)) Nomenclature, Pharmacology, and Function","volume":"70","author":"Kennedy","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bcp.2026.118082_b0150","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1084\/jem.20080300","article-title":"Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis","volume":"205","author":"Zabel","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bcp.2026.118082_b0155","doi-asserted-by":"crossref","first-page":"10953","DOI":"10.2147\/JIR.S530754","article-title":"Role of Interleukin-6 in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Focus on the JAK\/STAT Pathway and Macrophage Polarization","volume":"18","author":"Yu","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bcp.2026.118082_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The Role of M1\/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118082_b0165","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","article-title":"Akt Signaling Pathway in Macrophage Activation and M1\/M2 Polarization","volume":"198","author":"Vergadi","year":"2017","journal-title":"J. Immunol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600417X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600417X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:29:15Z","timestamp":1783920555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522600417X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"alternative-id":["S000629522600417X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118082","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemerin represses macrophage-myofibroblast transition and attenuates renal fibrosis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118082"}}