{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:43:41Z","timestamp":1791924221776,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["202423"],"award-info":[{"award-number":["202423"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2026JGB096"],"award-info":[{"award-number":["2026JGB096"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["2026ZZTS0056"],"award-info":[{"award-number":["2026ZZTS0056"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011496","name":"Changsha Science and Technology Bureau","doi-asserted-by":"publisher","award":["kq2208356"],"award-info":[{"award-number":["kq2208356"]}],"id":[{"id":"10.13039\/501100011496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010451","name":"Hunan Province Health Bureau","doi-asserted-by":"publisher","award":["W20243009"],"award-info":[{"award-number":["W20243009"]}],"id":[{"id":"10.13039\/501100010451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010451","name":"Hunan Province Health Bureau","doi-asserted-by":"publisher","award":["W20243026"],"award-info":[{"award-number":["W20243026"]}],"id":[{"id":"10.13039\/501100010451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270750"],"award-info":[{"award-number":["82270750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019092","name":"Science Fund for Distinguished Young Scholars of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ20085"],"award-info":[{"award-number":["2025JJ20085"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ6603"],"award-info":[{"award-number":["2024JJ6603"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118094","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:08:39Z","timestamp":1779376119000},"page":"118094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["Lyn attenuates cisplatin-induced acute kidney injury by inhibition of RIPK1-mediated apoptosis and necroptosis"],"prefix":"10.1016","volume":"251","author":[{"given":"Nannan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jishi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-7948","authenticated-orcid":false,"given":"Juan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bcp.2026.118094_b0005","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrd1691","article-title":"Cellular processing of platinum anticancer drugs [J]","volume":"4","author":"Wang","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.bcp.2026.118094_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094618","article-title":"Nephrotoxicity as a complication of chemotherapy and immunotherapy in the treatment of colorectal cancer, melanoma and non-small cell lung cancer [j]","volume":"22","author":"Jagie\u0142a","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40620-017-0392-z","article-title":"Cisplatin nephrotoxicity: a review of the literature [J]","volume":"31","author":"Manohar","year":"2018","journal-title":"J. Nephrol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41581-022-00631-7","article-title":"Cisplatin nephrotoxicity: new insights and therapeutic implications [J]","volume":"19","author":"Tang","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118094_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.semnephrol.2023.151341","article-title":"Cisplatin nephrotoxicity: novel insights into mechanisms and preventative strategies [J]","volume":"42","author":"Motwani","year":"2022","journal-title":"Semin. Nephrol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118094_b0030","doi-asserted-by":"crossref","first-page":"F1073","DOI":"10.1152\/ajprenal.00354.2020","article-title":"AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury [J]","volume":"319","author":"Jin","year":"2020","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0035","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5301\/jn.5000177","article-title":"Erythropoietin protects against cisplatin-induced nephrotoxicity by attenuating endoplasmic reticulum stress-induced apoptosis [J]","volume":"26","author":"Kong","year":"2013","journal-title":"J. Nephrol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0040","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202302019R","article-title":"Ezetimibe ameliorates cisplatin-induced nephrotoxicity: a novel therapeutic approach via modulating AMPK\/Nrf2\/TXNIP signaling [J]","volume":"38","author":"Fathy","year":"2024","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.bcp.2026.118094_b0045","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1016\/j.ymthe.2023.06.016","article-title":"Genetic and pharmacological inhibition of GRPR protects against acute kidney injury via attenuating renal inflammation and necroptosis [J]","volume":"31","author":"Li","year":"2023","journal-title":"Mol. Ther."},{"issue":"14","key":"10.1016\/j.bcp.2026.118094_b0050","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1042\/CS20190599","article-title":"RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress [J]","volume":"133","author":"Wang","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"issue":"8","key":"10.1016\/j.bcp.2026.118094_b0055","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41573-020-0071-y","article-title":"Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target [J]","volume":"19","author":"Mifflin","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.bcp.2026.118094_b0060","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation [J]","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.bcp.2026.118094_b0065","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/cdd.2014.77","article-title":"Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis [J]","volume":"21","author":"Wu","year":"2014","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.bcp.2026.118094_b0070","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1681\/ASN.2014080741","article-title":"A role for tubular necroptosis in cisplatin-induced AKI [J]","volume":"26","author":"Xu","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"issue":"20","key":"10.1016\/j.bcp.2026.118094_b0075","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1111\/bph.16152","article-title":"Compound-42 alleviates acute kidney injury by targeting RIPK3-mediated necroptosis [J]","volume":"180","author":"He","year":"2023","journal-title":"Br. J. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118094_b0080","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s10495-023-01905-6","article-title":"Necroptosis inhibitors: mechanisms of action and therapeutic potential [J]","volume":"29","author":"Zhou","year":"2024","journal-title":"Apoptosis"},{"issue":"4","key":"10.1016\/j.bcp.2026.118094_b0085","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1021\/acs.jmedchem.2c01621","article-title":"From (tool)bench to bedside: the potential of necroptosis inhibitors [J]","volume":"66","author":"Gardner","year":"2023","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bcp.2026.118094_b0090","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab152","article-title":"The Src-family kinase lyn in immunoreceptor signaling [J]","volume":"162","author":"Brian","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2026.118094_b0095","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ebiom.2016.12.010","article-title":"Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma [J]","volume":"15","author":"Wang","year":"2017","journal-title":"EBioMedicine"},{"issue":"706","key":"10.1016\/j.bcp.2026.118094_b0100","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abe3410","article-title":"Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome [J]","volume":"14","author":"Tang","year":"2021","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bcp.2026.118094_b0105","doi-asserted-by":"crossref","first-page":"16032","DOI":"10.1038\/sigtrans.2016.32","article-title":"Lyn prevents aberrant inflammatory responses to Pseudomonas infection in mammalian systems by repressing a SHIP-1-associated signaling cluster [J]","volume":"1","author":"Li","year":"2016","journal-title":"Signal Transduct. Target. Ther."},{"issue":"11","key":"10.1016\/j.bcp.2026.118094_b0110","doi-asserted-by":"crossref","first-page":"L1376","DOI":"10.1152\/ajplung.00219.2015","article-title":"Deletion of Src family kinase Lyn aggravates endotoxin-induced lung inflammation [J]","volume":"309","author":"Gao","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bcp.2026.118094_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115523","article-title":"Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis [J]","volume":"211","author":"Li","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41583-018-0093-1","article-title":"Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases [J]","volume":"20","author":"Yuan","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.bcp.2026.118094_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.07.041","article-title":"TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging [J]","volume":"174","author":"Xu","year":"2018","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bcp.2026.118094_b0130","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/ncb3608","article-title":"MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death [J]","volume":"19","author":"Dondelinger","year":"2017","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0135","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1038\/s41467-022-34080-4","article-title":"Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation [J]","volume":"13","author":"Tu","year":"2022","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bcp.2026.118094_b0140","doi-asserted-by":"crossref","first-page":"F695","DOI":"10.1152\/ajprenal.00684.2013","article-title":"Regulation of proximal tubular cell differentiation and proliferation in primary culture by matrix stiffness and ECM components [J]","volume":"307","author":"Chen","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000042803.28024.92","article-title":"Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells [J]","volume":"14","author":"Townsend","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"issue":"21","key":"10.1016\/j.bcp.2026.118094_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218246","article-title":"Inhibition of Src family kinases ameliorates LPS-induced acute kidney injury and mitochondrial dysfunction in mice [J]","volume":"21","author":"Pak","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bcp.2026.118094_b0155","doi-asserted-by":"crossref","DOI":"10.1038\/labinvest.3700445","article-title":"Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy [J]","volume":"86","author":"Mima","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bcp.2026.118094_b0160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mce.2015.09.008","article-title":"Inhibition of c-Src\/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db\/db mice [J]","volume":"417","author":"Wu","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118094_b0165","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.kint.2016.06.038","article-title":"Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3 [J]","volume":"90","author":"Seo","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.bcp.2026.118094_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155378","article-title":"Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis [J]","volume":"139","author":"Li","year":"2023","journal-title":"Metabolism"},{"key":"10.1016\/j.bcp.2026.118094_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1103062","article-title":"Autophagy and necroptosis in cisplatin-induced acute kidney injury: recent advances regarding their role and therapeutic potential [J]","volume":"14","author":"Alassaf","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118094_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2023.100227","article-title":"Arginase 2 promotes cisplatin-induced acute kidney injury by the inflammatory response of macrophages [J]","volume":"103","author":"Uchida","year":"2023","journal-title":"Lab. Invest."},{"issue":"15","key":"10.1016\/j.bcp.2026.118094_b0185","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128834","article-title":"Necroptosis: a crucial pathogenic mediator of human disease [J]","volume":"4","author":"Choi","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.bcp.2026.118094_b0190","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3389\/fphar.2018.00384","article-title":"Necrostatin-1 attenuates cisplatin-induced nephrotoxicity through suppression of apoptosis and oxidative stress and retains klotho expression [J]","volume":"9","author":"Ning","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.bcp.2026.118094_b0195","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1172\/JCI45586","article-title":"Inhibition of PKC\u03b4 reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer [J]","volume":"121","author":"Pabla","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.bcp.2026.118094_b0200","doi-asserted-by":"crossref","DOI":"10.3390\/biom12070984","article-title":"Src family kinases: a potential therapeutic target for acute kidney injury [J]","volume":"12","author":"Li","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2026.118094_b0205","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.semcdb.2020.06.013","article-title":"Regulatory mechanisms of RIPK1 in cell death and inflammation [J]","volume":"109","author":"Liu","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118094_b0210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1042\/BCJ20240569","article-title":"Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury [J]","volume":"482","author":"Pefanis","year":"2025","journal-title":"Biochem. J"},{"issue":"Supplement_1","key":"10.1016\/j.bcp.2026.118094_b0215","doi-asserted-by":"crossref","DOI":"10.2337\/db20-24-LB","article-title":"24-LB: RIPK1 activation induces necroptosis, proinflammation, and profibrosis in kidney of STZ\/HFD-induced diabetic mice [J]","volume":"69","author":"Chen","year":"2020","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.bcp.2026.118094_b0220","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1159\/000529995","article-title":"Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor [J]","volume":"9","author":"Yu","year":"2023","journal-title":"Kidney Dis. (Basel)"},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0225","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/s41467-020-15466-8","article-title":"Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [J]","volume":"11","author":"Laurien","year":"2020","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bcp.2026.118094_b0230","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20250279","article-title":"RIPK1 autophosphorylation at S161 mediates cell death and inflammation [J]","volume":"222","author":"Koerner","year":"2025","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118094_b0235","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41467-017-00406-w","article-title":"Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis [J]","volume":"8","author":"Geng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118094_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1067164","article-title":"Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells [J]","volume":"13","author":"Blanchett","year":"2022","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118094_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115796","article-title":"The E3 ubiquitin-protein ligase RNF4 promotes TNF-\u03b1-induced cell death triggered by RIPK1 [J]","volume":"22","author":"Shimada","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118094_b0250","first-page":"0823","article-title":"USP53 drives ethanol-induced myocardial injury by promoting K63 deubiquitination-dependent RIPK1 activation at K377 [J]","volume":"8","author":"Pan","year":"2025","journal-title":"Research (Wash D C)"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:25:42Z","timestamp":1783920342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226004296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":50,"alternative-id":["S0006295226004296"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118094","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lyn attenuates cisplatin-induced acute kidney injury by inhibition of RIPK1-mediated apoptosis and necroptosis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118094"}}