{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:53:37Z","timestamp":1787824417632,"version":"build-2784847793"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2022\\u201303342"],"award-info":[{"award-number":["RGPIN-2022\\u201303342"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Government of Singapore Ministry of Education","doi-asserted-by":"publisher","award":["R-148\\u2013000-285\\u2013114"],"award-info":[{"award-number":["R-148\\u2013000-285\\u2013114"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118104","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T15:39:00Z","timestamp":1779550740000},"page":"118104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Role of pregnane X receptor in the upregulation of human aldehyde oxidase gene expression"],"prefix":"10.1016","volume":"251","author":[{"given":"Shiyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Saradhi","family":"Mettu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0742-5223","authenticated-orcid":false,"given":"Aik Jiang","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80900-9","article-title":"An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway","volume":"92","author":"Kliewer","year":"1998","journal-title":"Cell"},{"issue":"21","key":"10.1016\/j.bcp.2026.118104_b0010","doi-asserted-by":"crossref","first-page":"12208","DOI":"10.1073\/pnas.95.21.12208","article-title":"Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction","volume":"95","author":"Bertilsson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"20","key":"10.1016\/j.bcp.2026.118104_b0015","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1101\/gad.12.20.3195","article-title":"SXR, a novel steroid and xenobiotic-sensing nuclear receptor","volume":"12","author":"Blumberg","year":"1998","journal-title":"Genes Dev."},{"issue":"5","key":"10.1016\/j.bcp.2026.118104_b0020","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1172\/JCI3703","article-title":"The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions","volume":"102","author":"Lehmann","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.bcp.2026.118104_b0025","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaf119","article-title":"Physiological functions and pathological roles of PXR","volume":"9","author":"Ikeda","year":"2025","journal-title":"J. Endocr. Soc."},{"issue":"2","key":"10.1016\/j.bcp.2026.118104_b0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/138920008783571774","article-title":"Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues","volume":"9","author":"Pavek","year":"2008","journal-title":"Curr. Drug Metab."},{"issue":"3","key":"10.1016\/j.bcp.2026.118104_b0035","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1517\/17425255.2013.754010","article-title":"Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond","volume":"9","author":"Chai","year":"2013","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"47","key":"10.1016\/j.bcp.2026.118104_b0040","doi-asserted-by":"crossref","first-page":"49307","DOI":"10.1074\/jbc.M407281200","article-title":"Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver","volume":"279","author":"Squires","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2026.118104_b0045","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.bbagrm.2016.02.006","article-title":"Mechanisms of xenobiotic receptor activation: Direct vs. indirect","volume":"1859","author":"Mackowiak","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"5525","key":"10.1016\/j.bcp.2026.118104_b0050","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1126\/science.1060762","article-title":"The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity","volume":"292","author":"Watkins","year":"2001","journal-title":"Science"},{"issue":"36","key":"10.1016\/j.bcp.2026.118104_b0055","doi-asserted-by":"crossref","first-page":"33309","DOI":"10.1074\/jbc.C100375200","article-title":"Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR","volume":"276","author":"Dussault","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2026.118104_b0060","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/87912","article-title":"The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux","volume":"7","author":"Synold","year":"2001","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.118104_b0065","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1124\/jpet.110.172338","article-title":"Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides","volume":"335","author":"Lau","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2026.118104_b0070","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1677\/joe.0.166r011","article-title":"St John's wort, a herbal antidepressant, activates the steroid X receptor","volume":"166","author":"Wentworth","year":"2000","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/mend.14.1.0409","article-title":"The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution","volume":"14","author":"Jones","year":"2000","journal-title":"Mol. Endocrinol."},{"issue":"9","key":"10.1016\/j.bcp.2026.118104_b0080","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.febslet.2007.03.047","article-title":"T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR","volume":"581","author":"Mitro","year":"2007","journal-title":"FEBS Lett."},{"issue":"20","key":"10.1016\/j.bcp.2026.118104_b0085","doi-asserted-by":"crossref","first-page":"15122","DOI":"10.1074\/jbc.M001215200","article-title":"Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands","volume":"275","author":"Moore","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2026.118104_b0090","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1530\/eje.0.1450513","article-title":"Bisphenol-a, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription","volume":"145","author":"Takeshita","year":"2001","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0095","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41467-017-00780-5","article-title":"SPA70 is a potent antagonist of human pregnane X receptor","volume":"8","author":"Lin","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0100","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1124\/mol.106.029264","article-title":"The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor","volume":"71","author":"Zhou","year":"2007","journal-title":"Mol. Pharmacol."},{"issue":"36","key":"10.1016\/j.bcp.2026.118104_b0105","doi-asserted-by":"crossref","first-page":"32453","DOI":"10.1074\/jbc.M111245200","article-title":"Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics","volume":"277","author":"Takeshita","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0110","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/00498254.2019.1626029","article-title":"Aldehyde oxidase; new approaches to old problems","volume":"50","author":"Beedham","year":"2020","journal-title":"Xenobiotica"},{"issue":"16","key":"10.1016\/j.bcp.2026.118104_b0115","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1074\/jbc.REV119.007741","article-title":"Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes","volume":"295","author":"Terao","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2026.118104_b0120","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/03602532.2022.2144879","article-title":"Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development","volume":"54","author":"Gajula","year":"2022","journal-title":"Drug Metab. Rev."},{"issue":"8","key":"10.1016\/j.bcp.2026.118104_b0125","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/jcph.504","article-title":"The pharmacokinetics and safety of idelalisib in subjects with moderate or severe hepatic impairment","volume":"55","author":"Jin","year":"2015","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118104_b0130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.abb.2018.10.017","article-title":"Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs","volume":"659","author":"Ogiso","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.bcp.2026.118104_b0135","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1007\/s00204-022-03304-3","article-title":"Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions","volume":"96","author":"Rendic","year":"2022","journal-title":"Arch. Toxicol."},{"issue":"12","key":"10.1016\/j.bcp.2026.118104_b0140","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1177\/0091270006293753","article-title":"Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6","volume":"46","author":"Walsky","year":"2006","journal-title":"J. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118104_b0145","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1124\/dmd.123.001257","article-title":"Mechanistic investigation of the time-dependent aldehyde oxidase inhibitor hydralazine","volume":"51","author":"Barnes","year":"2023","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.molpha.2025.100097","article-title":"Mechanism-based inactivation of human aldehyde oxidase by erlotinib: Mechanistic insights from structural analogs and molecular docking","volume":"108","author":"Kweh","year":"2026","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118104_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108020","article-title":"Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity","volume":"233","author":"Pang","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2026.118104_b0160","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.phrs.2017.03.007","article-title":"Differential activation of pregnane X receptor by carnosic acid, carnosol, ursolic acid, and rosmarinic acid","volume":"120","author":"Seow","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1124\/dmd.118.082099","article-title":"Evaluation of carbazeran 4-oxidation and O6-benzylguanine 8-oxidation as catalytic markers of human aldehyde oxidase: Impact of cytosolic contamination of liver microsomes","volume":"47","author":"Xie","year":"2019","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2026.118104_b0170","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.70058","article-title":"Heat-assisted in-solution protein denaturation and digestion and UHPLC\u2013MS\/MS quantification of human cytosolic aldehyde oxidase","volume":"40","author":"Chen","year":"2026","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"11","key":"10.1016\/j.bcp.2026.118104_b0175","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.bcp.2013.04.002","article-title":"Agonism of human pregnane X receptor by rilpivirine and etravirine: comparison with first generation non-nucleoside reverse transcriptase inhibitors","volume":"85","author":"Sharma","year":"2013","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.bcp.2026.118104_b0180","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1124\/dmd.115.066639","article-title":"Age-specific regulation of drug-processing genes in mouse liver by ligands of xenobiotic-sensing transcription factors","volume":"44","author":"Li","year":"2016","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bcp.2026.118104_b0185","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1124\/jpet.120.265249","article-title":"In vitro inhibition of human aldehyde oxidase activity by clinically relevant concentrations of gefitinib and erlotinib: Comparison with select metabolites, molecular docking analysis, and impact on hepatic metabolism of zaleplon and methotrexate","volume":"374","author":"Tan","year":"2020","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2026.118104_b0190","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bcp.2015.07.036","article-title":"Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A","volume":"97","author":"Foo","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118104_b0195","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1124\/dmd.107.018689","volume":"36","author":"Gupta","year":"2008","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0200","first-page":"1","volume":"10","year":"2013","journal-title":"Nat. Methods"},{"issue":"37","key":"10.1016\/j.bcp.2026.118104_b0205","doi-asserted-by":"crossref","first-page":"38379","DOI":"10.1074\/jbc.M404949200","article-title":"The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR)","volume":"279","author":"Burk","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2026.118104_b0210","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1124\/dmd.32.3.340","article-title":"Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression","volume":"32","author":"Gardner-Stephen","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bcp.2026.118104_b0215","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jcp.1040760202","article-title":"Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species","volume":"76","author":"Perry","year":"1970","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0220","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cell.2014.03.012","article-title":"Nuclear Receptors, RXR, and the big Bang","volume":"157","author":"Evans","year":"2014","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.bcp.2026.118104_b0225","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082354","article-title":"Retinoid X receptor antagonists","volume":"19","author":"Watanabe","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.bcp.2026.118104_b0230","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1073\/pnas.0438010100","article-title":"Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor","volume":"100","author":"Xie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0235","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1124\/dmd.32.1.140","article-title":"An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes","volume":"32","author":"Soars","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.bcp.2026.118104_b0240","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/sj.bjp.0707601","article-title":"Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells","volume":"153","author":"Martin","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2026.118104_b0245","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1128\/AAC.01124-13","article-title":"Induction of influx and efflux transporters and cytochrome P450 3A4 in primary human hepatocytes by rifampin, rifabutin, and rifapentine","volume":"57","author":"Williamson","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030895","article-title":"Pregnane X receptor and yin yang 1 contribute to the differential tissue expression and induction of CYP3A5 and CYP3A4","volume":"7","author":"Nem","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bcp.2026.118104_b0255","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1124\/jpet.105.098160","article-title":"Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor","volume":"317","author":"Faucette","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.bcp.2026.118104_b0260","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3565(25)12840-1","article-title":"Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes","volume":"277","author":"Kumar","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2026.118104_b0265","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1023\/A:1011924314899","article-title":"Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers","volume":"15","author":"Alsenz","year":"1998","journal-title":"Pharm. Res."},{"issue":"10","key":"10.1016\/j.bcp.2026.118104_b0270","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1124\/dmd.107.016089","article-title":"Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions","volume":"35","author":"Dixit","year":"2007","journal-title":"Drug Metab. Dispos."},{"issue":"8","key":"10.1016\/j.bcp.2026.118104_b0275","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/01.fpc.0000220561.59972.7a","article-title":"Identification of potential pharmacological and toxicological targets differentiating structural analogs by a combination of transcriptional profiling and promoter analysis in LS-180 and Caco-2 adenocarcinoma cell lines","volume":"16","author":"Hartley","year":"2006","journal-title":"Pharmacogenet. Genomics"},{"issue":"7","key":"10.1016\/j.bcp.2026.118104_b0280","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1124\/dmd.30.7.795","article-title":"CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes","volume":"30","author":"Luo","year":"2002","journal-title":"Drug Metab. Dispos."},{"issue":"6","key":"10.1016\/j.bcp.2026.118104_b0285","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1124\/dmd.109.026526","article-title":"Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells","volume":"37","author":"McGinnity","year":"2009","journal-title":"Drug Metab. Dispos."},{"issue":"9","key":"10.1016\/j.bcp.2026.118104_b0290","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1093\/cid\/cir184","article-title":"Why do we use 600 mg of rifampicin in tuberculosis treatment?","volume":"52","author":"van Ingen","year":"2011","journal-title":"Clin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.bcp.2026.118104_b0295","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1164\/rccm.201407-1264OC","article-title":"A dose-ranging trial to optimize the dose of rifampin in the treatment of tuberculosis","volume":"191","author":"Boeree","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.bcp.2026.118104_b0300","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00641-18","article-title":"Protein binding of first-line antituberculosis drugs","volume":"62","author":"Alghamdi","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bcp.2026.118104_b0305","unstructured":"Food and Drug Administration, M12 Drug Interaction Studies: Guidance for Industry, U.S Department of Health and Human Services, Food and Drug Administration (CBER)2024. Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research."},{"key":"10.1016\/j.bcp.2026.118104_b0310","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bcp.2018.04.017","article-title":"Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions","volume":"154","author":"Takaoka","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118104_b0315","doi-asserted-by":"crossref","first-page":"8668","DOI":"10.1074\/jbc.M308137200","article-title":"Regulation and biochemistry of mouse molybdo-flavoenzymes. the DBA\/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase","volume":"279","author":"Vila","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bcp.2026.118104_b0320","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41401-019-0336-3","article-title":"Nimesulide increases the aldehyde oxidase activity of humans and rats","volume":"41","author":"Zhou","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"17","key":"10.1016\/j.bcp.2026.118104_b0325","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1128\/MCB.01899-08","article-title":"C\/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists","volume":"29","author":"Vernochet","year":"2009","journal-title":"Mol. Cell Biol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:34:50Z","timestamp":1783920890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226004399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":65,"alternative-id":["S0006295226004399"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118104","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of pregnane X receptor in the upregulation of human aldehyde oxidase gene expression","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118104"}}