{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:07:06Z","timestamp":1783922826783,"version":"3.55.0"},"reference-count":213,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["KK333302"],"award-info":[{"award-number":["KK333302"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Finnish Cultural Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"Paivikki and Sakari Sohlberg Fundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013511","name":"Eye Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopion Yliopistollinen Sairaala","doi-asserted-by":"publisher","award":["KK5503770"],"award-info":[{"award-number":["KK5503770"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118114","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:28:28Z","timestamp":1780122508000},"page":"118114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["The role of Wnt signalling in the pathogenesis and therapy of age-related macular degeneration (AMD)"],"prefix":"10.1016","volume":"251","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3414-4032","authenticated-orcid":false,"given":"Juha M.T.","family":"Hyttinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antero","family":"Salminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Kauppinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Kaarniranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118114_b0005","doi-asserted-by":"crossref","unstructured":"J.B. Jonas, C.M.G. Cheung, S. Panda-Jonas, Updates on the epidemiology of age-related macular degeneration, Asia Pac. J. Ophthalmol. (Phila) 6 (2017) 493\u2013497,doi: 10.22608\/APO.2017251.","DOI":"10.22608\/APO.2017251"},{"key":"10.1016\/j.bcp.2026.118114_b0010","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.bcp.2026.118114_b0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jama.2023.26074","article-title":"Age-related macular degeneration: a review","volume":"331","author":"Fleckenstein","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.bcp.2026.118114_b0020","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.mam.2012.04.005","article-title":"Understanding age-related macular degeneration (AMD): relationships between the photoreceptor\/retinal pigment epithelium\/Bruch's membrane\/choriocapillaris complex","volume":"33","author":"Bhutto","year":"2012","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bcp.2026.118114_b0025","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1016\/j.ophtha.2019.09.024","article-title":"Age-related macular degeneration Preferred Practice Pattern\u00ae","volume":"127","author":"Flaxel","year":"2020","journal-title":"Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0030","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.3390\/cells11213453","article-title":"A linkage between angiogenesis and inflammation in neovascular age-related macular degeneration","volume":"11","author":"Heloter\u00e4","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118114_b0035","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1167\/iovs.09-3639","article-title":"Relationship between RPE and choriocapillaris in age-related macular degeneration","volume":"50","author":"McLeod","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0040","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1080\/14712598.2021.1830969","article-title":"Ranibizumab for myopic choroidal neovascularization","volume":"20","author":"Ng","year":"2020","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.bcp.2026.118114_b0045","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s12967-015-0683-x","article-title":"Wnt signaling in age-related macular degeneration: human macular tissue and mouse model","volume":"13","author":"Tuo","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biochi.2023.03.001","article-title":"Wnt\/\u03b2-catenin signaling pathway-a versatile player in apoptosis and autophagy","volume":"211","author":"Ma","year":"2023","journal-title":"Biochimie"},{"key":"10.1016\/j.bcp.2026.118114_b0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0060","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41392-025-02142-w","article-title":"Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances","volume":"10","author":"Xue","year":"2025","journal-title":"Sig. Transduct. Target Ther."},{"key":"10.1016\/j.bcp.2026.118114_b0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10456-008-9095-3","article-title":"Wnt\/Frizzled signaling in angiogenesis","volume":"11","author":"Zerlin","year":"2008","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bcp.2026.118114_b0070","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(87)90038-9","article-title":"The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless","volume":"50","author":"Rijsewijk","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0075","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0092-8674(91)90633-A","article-title":"A new nomenclature for int-1 and related genes: The Wnt family","volume":"64","author":"Nusse","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0080","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.bcp.2026.118114_b0090","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.cels.2023.06.004","article-title":"The time-resolved genomic impact of Wnt\/\u03b2-catenin signaling","volume":"14","author":"Pagella","year":"2023","journal-title":"Cell Syst."},{"key":"10.1016\/j.bcp.2026.118114_b0095","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1242\/jcs.072132","article-title":"WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification","volume":"123","author":"Coombs","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0100","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.4049\/jimmunol.181.7.4441","article-title":"Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts","volume":"181","author":"Sen","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bcp.2026.118114_b0105","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1007\/s00018-016-2260-8","article-title":"Adherens junction and E-cadherin complex regulation by epithelial polarity","volume":"73","author":"Coopman","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0110","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.it.2018.08.006","article-title":"Canonical and non-canonical Wnt signaling in immune cells","volume":"39","author":"Chae","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bcp.2026.118114_b0115","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.biopha.2017.06.061","article-title":"The many postures of noncanonical Wnt signaling in development and diseases","volume":"93","author":"Xiao","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118114_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106250","article-title":"Molecular pathogenesis of subretinal fibrosis in neovascular AMD focusing on epithelial-mesenchymal transformation of retinal pigment epithelium","volume":"185","author":"Liu","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bcp.2026.118114_b0125","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/gb-2004-5-7-234","article-title":"The Frizzled family: receptors for multiple signal transduction pathways","volume":"5","author":"Huang","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219721","article-title":"FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cord","volume":"15","author":"Alrefaei","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118114_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106367","article-title":"The CRD of Frizzled 7 exhibits chondroprotective effects in osteoarthritis via inhibition of the canonical Wnt3a\/\u03b2-catenin signaling pathway","volume":"82","author":"Ding","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2026.118114_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113354","article-title":"Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids","volume":"42","author":"Alsaadi","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2026.118114_b0145","doi-asserted-by":"crossref","unstructured":"N. Tsutsumi, S. Mukherjee, D. Waghray, C.Y. Janda, K.M. Jude, Y. Miao, et al., Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling, eLlife 9 (2020) e58464. https:\/\/doi.org\/10.7554\/eLife.58464.","DOI":"10.7554\/eLife.58464"},{"key":"10.1016\/j.bcp.2026.118114_b0150","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1242\/dev.129.17.4089","article-title":"Pygopus encodes a nuclear protein essential for wingless\/Wnt signaling","volume":"129","author":"Belenkaya","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.bcp.2026.118114_b0155","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cell.2006.01.053","article-title":"Parafibromin\/Hyrax activates Wnt\/Wg target gene transcription by direct association with beta-catenin\/Armadillo","volume":"125","author":"Mosimann","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0160","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1073\/pnas.1013751108","article-title":"The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels","volume":"108","author":"Griffin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2026.118114_b0165","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1073\/pnas.1009353108","article-title":"Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2026.118114_b0170","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molcel.2017.06.009","article-title":"Wnt-dependent inactivation of the Groucho\/TLE co-repressor by the HECT E3 ubiquitin ligase Hyd\/UBR5","volume":"67","author":"Flack","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0175","doi-asserted-by":"crossref","first-page":"746","DOI":"10.12688\/f1000research.11034.1","article-title":"Wnt target genes and where to find them","volume":"6","author":"Ramakrishnan","year":"2017","journal-title":"F1000Res."},{"key":"10.1016\/j.bcp.2026.118114_b0180","unstructured":"Www-reference: https:\/\/wnt.stanford.edu\/target_genes (consulted in M 2026)."},{"key":"10.1016\/j.bcp.2026.118114_b0185","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-394592-1.00008-9","article-title":"Wnt regulation of planar cell polarity (PCP)","volume":"101","author":"Gao","year":"2012","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1599355","article-title":"Frizzled receptors: gatekeepers of Wnt signaling in development and disease","volume":"13","author":"Martinez-Marin","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0195","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13460","article-title":"WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem\/progenitor cells via activating the calcium\/calcineurin A\/NFATC2 pathway","volume":"56","author":"Wan","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bcp.2026.118114_b0200","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.pbio.0040115","article-title":"Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context","volume":"4","author":"Mikels","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0205","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1083\/jcb.200303158","article-title":"Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation","volume":"162","author":"Topol","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0210","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1038\/oncsis.2017.69","article-title":"Non-canonical WNT\/PCP signalling in cancer: Fzd6 takes centre stage","volume":"6","author":"Corda","year":"2017","journal-title":"Oncogenesis"},{"key":"10.1016\/j.bcp.2026.118114_b0215","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41569-022-00718-5","article-title":"Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications","volume":"19","author":"Akoumianakis","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bcp.2026.118114_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101149","article-title":"Non-canonical Wnt signaling in the eye","volume":"95","author":"Shah","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bcp.2026.118114_b0225","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/jnc.12464","article-title":"CaMKII represses transcriptionally active \u03b2-catenin to mediate acute ethanol neurodegeneration and can phosphorylate \u03b2-catenin","volume":"128","author":"Flentke","year":"2014","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bcp.2026.118114_b0230","doi-asserted-by":"crossref","first-page":"22429","DOI":"10.1074\/jbc.R600015200","article-title":"Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors","volume":"281","author":"Gordon","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118114_b0235","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"key":"10.1016\/j.bcp.2026.118114_b0240","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00018-022-04620-8","article-title":"Wnt\/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure","volume":"79","author":"Shi","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0245","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1177\/1358863X16666693","article-title":"WNT5A-JNK regulation of vascular insulin resistance in human obesity","volume":"21","author":"Farb","year":"2016","journal-title":"Vasc. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0250","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.1200421109","article-title":"Wnt5a-ror-dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis","volume":"109","author":"Ho","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2026.118114_b0255","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.887100","article-title":"Vangl as a master scaffold for Wnt\/planar cell polarity signaling in development and disease","volume":"10","author":"Dreyer","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0260","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41467-024-55396-3","article-title":"Structural basis of human VANGL-PRICKLE interaction","volume":"16","author":"Song","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118114_b0265","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/01913123.2017.1348418","article-title":"Loss of endothelial planar cell polarity and cellular clearance mechanisms in age-related macular degeneration","volume":"41","author":"Campos","year":"2017","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.bcp.2026.118114_b0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007840","article-title":"The planar cell polarity protein VANG-1\/Vangl negatively regulates Wnt\/\u03b2-catenin signaling through a Dvl dependent mechanism","volume":"14","author":"Mentink","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bcp.2026.118114_b0275","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1080\/15548627.2022.2069437","article-title":"Autophagy in age-related macular degeneration","volume":"19","author":"Kaarniranta","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2026.118114_b0280","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.3390\/antiox12071368","article-title":"Antioxidative role of heterophagy, autophagy, and mitophagy in the retina and their association with the age-related macular degeneration (AMD) etiopathogenesis","volume":"12","author":"Nita","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bcp.2026.118114_b0285","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1126\/science.1193497","article-title":"Autophagy and metabolism","volume":"330","author":"Rabinowitz","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.118114_b0290","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102796","article-title":"The role of secretory autophagy and exosomes in the accumulation of drusen during the development of age-related macular degeneration (AMD)","volume":"110","author":"Hyttinen","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bcp.2026.118114_b0300","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.micpath.2018.12.016","article-title":"A role for Wnt\/\u03b2-catenin signalling in suppressing Bacillus Calmette-Guerin-induced macrophage autophagy","volume":"127","author":"Wu","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bcp.2026.118114_b0305","doi-asserted-by":"crossref","first-page":"C836","DOI":"10.1152\/ajpcell.00554.2007","article-title":"A GSK-3\/TSC2\/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression","volume":"295","author":"Buller","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bcp.2026.118114_b0310","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cell.2006.06.055","article-title":"TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth","volume":"126","author":"Inoki","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0315","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12951-020-00663-w","article-title":"The mTOR\/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles","volume":"18","author":"Wang","year":"2020","journal-title":"J. Nanobiotechnol."},{"issue":"9B","key":"10.1016\/j.bcp.2026.118114_b0320","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1111\/j.1582-4934.2009.00722.x","article-title":"Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels","volume":"13","author":"Nguyen","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0325","article-title":"Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin","volume":"118","author":"Wijshake","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2026.118114_b0330","doi-asserted-by":"crossref","first-page":"12079","DOI":"10.3390\/ijms222112079","article-title":"AMBRA1 negatively regulates the function of ALDH1B1, a cancer stem cell marker, by controlling its ubiquitination","volume":"22","author":"Baek","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0335","first-page":"89","article-title":"Altered serum levels of autophagy proteins Beclin-1 and mTOR in patients with exudative age-related macular degeneration","volume":"7","author":"Kubicka-Trzaska","year":"2021","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118114_b0340","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/emboj.2013.123","article-title":"Autolysosomal \u03b2-catenin degradation regulates Wnt-autophagy-p62 crosstalk","volume":"32","author":"Petherick","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.118114_b0345","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/cancers12010007","article-title":"Overexpression of p62\/IMP2 can promote cell migration in hepatocellular carcinoma via activation of the Wnt\/\u03b2-catenin pathway","volume":"12","author":"Xing","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bcp.2026.118114_b0350","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/15548627.2017.1423439","article-title":"Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers","volume":"14","author":"N\u00e0ger","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2026.118114_b0355","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/jcb.29394","article-title":"LRP6 regulates Rab7-mediated autophagy through the Wnt\/\u03b2-catenin pathway to modulate trophoblast cell migration and invasion","volume":"121","author":"Li","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2026.118114_b0360","first-page":"503","article-title":"Maturation of autophagosomes and endosomes: a key role for Rab7","volume":"2013","author":"Hyttinen","year":"1833","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2026.118114_b0365","doi-asserted-by":"crossref","first-page":"328","DOI":"10.20892\/j.issn.2095-3941.2019.0229","article-title":"CDK11 negatively regulates Wnt\/\u03b2-catenin signaling in the endosomal compartment by affecting microtubule stability","volume":"17","author":"Ou","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0370","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1080\/15548627.2022.2034131","article-title":"Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E)","volume":"18","author":"Vessey","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2026.118114_b0375","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1111\/febs.13066","article-title":"miR-184 regulates ezrin, LAMP-1 expression, affects phagocytosis in human retinal pigment epithelium and is downregulated in age-related macular degeneration","volume":"281","author":"Murad","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.bcp.2026.118114_b0380","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/aos.17558","article-title":"Secretory autophagy and epithelial-to-mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression","volume":"104","author":"Gurubaran","year":"2025","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0385","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4161\/15548627.2014.984273","article-title":"Identification of secreted proteins that reflect autophagy dynamics within tumor cells","volume":"11","author":"Kraya","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2026.118114_b0390","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.3390\/ijms20225800","article-title":"The regulation of NFE2L2 (NRF2) signalling and epithelial-to-mesenchymal transition ion age-related macular degeneration pathology","volume":"20","author":"Hyttinen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0395","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.3390\/ijms21124271","article-title":"EMT and EndMT: Emerging roles in age-related macular degeneration","volume":"21","author":"Shu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0400","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-023-05099-7","article-title":"Wnt\/\u03b2-catenin-driven EMT regulation in human cancers","volume":"81","author":"Xue","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0405","article-title":"E-cadherin\/\u03b2-catenin complex and the epithelial barrier","volume":"2011","author":"Tian","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.bcp.2026.118114_b0410","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1089\/scd.2010.0188","article-title":"Wnt signaling regulates Snai1 expression and cellular localization in the mouse intestinal epithelial stem cell niche","volume":"20","author":"Horvay","year":"2011","journal-title":"Stem. Cells Dev."},{"key":"10.1016\/j.bcp.2026.118114_b0415","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1349-7006.2011.01861.x","article-title":"Matrix metalloproteinase-9 cooperates with transcription factor Snail to induce epithelial-mesenchymal transition","volume":"102","author":"Lin","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116685","article-title":"Wnt\/\u03b2-catenin signalling, epithelial-mesenchymal transition and crosslink signalling in colorectal cancer cells","volume":"175","author":"Sun","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118114_b0425","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5483\/BMBRep.2015.48.9.140","article-title":"Wnt5a attenuates the pathogenic effects of the Wnt\/\u03b2-catenin pathway in human retinal pigment epithelial cells via down-regulating \u03b2-catenin and Snail","volume":"48","author":"Kim","year":"2015","journal-title":"BMB Rep."},{"issue":"Suppl 5","key":"10.1016\/j.bcp.2026.118114_b0430","doi-asserted-by":"crossref","first-page":"S411","DOI":"10.1513\/AnnalsATS.201608-586AW","article-title":"Wnt signaling in lung aging and disease","volume":"13","author":"Lehmann","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.bcp.2026.118114_b0435","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s11658-025-00732-8","article-title":"Potential of autophagy in subretinal fibrosis in neovascular age-related macular degeneration","volume":"30","author":"Blasiak","year":"2025","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.bcp.2026.118114_b0440","doi-asserted-by":"crossref","first-page":"e1153","DOI":"10.1111\/aos.15051","article-title":"Epithelial-mesenchymal transition-related serum markers ET-1, IL-8 and TGF-\u03b22 are elevated in a Finnish wet age-related macular degeneration cohort","volume":"100","author":"Liukkonen","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0445","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/jcmm.14848","article-title":"IL-8 promotes cell migration through regulating EMT by activating the Wnt\/\u03b2-catenin pathway in ovarian cancer","volume":"24","author":"Wen","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0450","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ceb.2008.06.001","article-title":"The role of integrin binding sites in fibronectin matrix assembly in vivo","volume":"20","author":"Leiss","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1535370216675245","article-title":"Minireview: Fibronectin in retinal disease","volume":"242","author":"Miller","year":"2017","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.bcp.2026.118114_b0460","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1167\/iovs.66.3.10","article-title":"Fibronectin mediates endothelial-to-mesenchymal transition in retina angiogenesis","volume":"66","author":"Liu","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0465","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.1128\/MCB.19.8.5576","article-title":"The Wnt\/Wg signal transducer beta-catenin controls fibronectin expression","volume":"19","author":"Gradl","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.109880","article-title":"Fibronectin binds integrin \u03b15\u03b21 to regulate macular neovascularization through the Wnt\/\u03b2-catenin signaling pathway","volume":"242","author":"Zhao","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bcp.2026.118114_b0475","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00109-015-1289-8","article-title":"Attenuation of EMT in RPE cells and subretinal fibrosis by an RAR-\u03b3 agonist","volume":"93","author":"Kimura","year":"2015","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.bcp.2026.118114_b0480","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-\u03b2-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118114_b0485","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10456-018-9614-9","article-title":"SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization","volume":"21","author":"Sun","year":"2018","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bcp.2026.118114_b0490","first-page":"748","article-title":"Wnt signaling through Snail1 and Zeb1 regulates bone metastasis in lung cancer","volume":"5","author":"Yang","year":"2015","journal-title":"Am. J. Cancer Res."},{"issue":"2012","key":"10.1016\/j.bcp.2026.118114_b0495","doi-asserted-by":"crossref","first-page":"16654","DOI":"10.1073\/pnas.1205822109","article-title":"Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression","volume":"109","author":"Wu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2026.118114_b0500","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/sj.onc.1208237","article-title":"beta-Catenin activates the growth factor endothelin-1 in colon cancer cells","volume":"24","author":"Kim","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118114_b0505","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003888","article-title":"Endothelin-1 drives epithelial-mesenchymal transition in hypertensive nephroangiosclerosis","volume":"5","author":"Seccia","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bcp.2026.118114_b0510","article-title":"Endothelin-1 in neovascular AMD","volume":"118","author":"Sakai","year":"2011","journal-title":"Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0515","first-page":"1097","article-title":"Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: A crucial target for anti- and pro-angiogenic therapies, Genes","volume":"2","author":"Shibuya","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2026.118114_b0520","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1684\/ecn.2009.0170","article-title":"VEGF-A: a critical regulator of blood vessel growth","volume":"20","author":"Ferrara","year":"2009","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.bcp.2026.118114_b0525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2013.11.002","article-title":"Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning","volume":"25","author":"Vempati","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bcp.2026.118114_b0530","article-title":"Elevated tumor necrosis factor alpha and vascular endothelial growth factor in intermediate age-related macular degeneration and geographic atrophy","volume":"4","author":"Rajeswaren","year":"2024","journal-title":"Front. Ophthalmol. (Lausanne)"},{"key":"10.1016\/j.bcp.2026.118114_b0535","first-page":"6050","article-title":"Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia","volume":"61","author":"Zhang","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118114_b0540","article-title":"Wnt\/frizzled signaling in endothelium: A major player in blood-retinal- and blood-brain-barrier integrity","volume":"12","author":"Bats","year":"2022","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0545","first-page":"17","article-title":"The role of the Wnt pathway in VEGF\/anti-VEGF-dependent control of the endothelial cell barrier","volume":"62","author":"Li","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0550","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41433-020-0896-y","article-title":"Neurodegeneration, gliosis, and resolution of haemorrhage in neovascular age-related macular degeneration, a clinicopathologic correlation","volume":"35","author":"Li","year":"2021","journal-title":"Eye (Lond.)"},{"key":"10.1016\/j.bcp.2026.118114_b0555","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/hep.22084","article-title":"Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway","volume":"47","author":"Klein","year":"2008","journal-title":"Hepatol."},{"key":"10.1016\/j.bcp.2026.118114_b0560","doi-asserted-by":"crossref","first-page":"7529","DOI":"10.1158\/1078-0432.CCR-09-0336","article-title":"Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant \u03b2-catenin activation in colon cancer","volume":"15","author":"Naik","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.118114_b0565","first-page":"131","article-title":"The role of Wnt signalling in angiogenesis","volume":"38","author":"Olsen","year":"2017","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.bcp.2026.118114_b0570","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.15252\/embj.201488598","article-title":"Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer","volume":"33","author":"Pate","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.118114_b0575","first-page":"3145","article-title":"beta-Catenin regulates vascular endothelial growth factor expression in colon cancer","volume":"63","author":"Easwaran","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118114_b0580","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/cvr\/cvu133","article-title":"Frizzled7 controls vascular permeability through the Wnt-canonical pathway and cross-talk with endothelial cell junction complexes","volume":"103","author":"Ferreira Tojais","year":"2014","journal-title":"Cardiovasc."},{"key":"10.1016\/j.bcp.2026.118114_b0585","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.devcel.2015.12.015","article-title":"Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT\/Ca(2+)\/NFAT signaling","volume":"36","author":"Scholz","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0590","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1091\/mbc.e06-04-0320","article-title":"Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2","volume":"17","author":"Masckauch\u00e1n","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0595","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.exer.2018.05.033","article-title":"WNT7A\/B promote choroidal neovascularization","volume":"174","author":"Lin","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bcp.2026.118114_b0600","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0006-291X(03)00313-9","article-title":"PECAM-1 promotes beta-catenin accumulation and stimulates endothelial cell proliferation","volume":"303","author":"Biswas","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.118114_b0605","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.7150\/jca.46429","article-title":"VEGF promotes migration and invasion by regulating EMT and MMPs in nasopharyngeal carcinoma","volume":"11","author":"Chen","year":"2020","journal-title":"J. Cancer"},{"key":"10.1016\/j.bcp.2026.118114_b0610","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1167\/iovs.09-4278","article-title":"The pathogenic role of the canonical Wnt pathway in age-related macular degeneration","volume":"51","author":"Zhou","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0615","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1186\/s12967-025-06447-w","article-title":"Matrix metalloproteinase-driven epithelial-mesenchymal transition: implications in health and disease","volume":"23","author":"Khalili-Tanha","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0620","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/310183","article-title":"The Wnt\/\u03b2-catenin signaling pathway controls the inflammatory response in infections caused by pathogenic bacteria","volume":"2014","author":"Silva-Garc\u00eda","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bcp.2026.118114_b0625","article-title":"The changes of irisin and inflammatory cytokines in the age-related macular degeneration and retinal vein occlusion","volume":"13","author":"Li","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bcp.2026.118114_b0630","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.survophthal.2024.07.009","article-title":"The role of immune modulators in age-related macular degeneration","volume":"69","author":"Schloesser","year":"2024","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0635","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.3390\/cells8111372","article-title":"Wnt-3a induces cytokine release in human mast cells","volume":"8","author":"Tebroke","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118114_b0640","doi-asserted-by":"crossref","first-page":"14044","DOI":"10.1002\/jcb.28679","article-title":"Oxidative stress upregulates Wnt signaling in human retinal microvascular endothelial cells through activation of disheveled","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2026.118114_b0645","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/ars.2017.7084","article-title":"Oxidative stress induces an interactive decline in Wnt and Nrf2 signaling in degenerating retinal pigment epithelium","volume":"29","author":"Ebrahimi","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2026.118114_b0650","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.3390\/ijms21165934","article-title":"Matrix metalloproteinases in age-related macular degeneration (AMD)","volume":"21","author":"Garc\u00eda-Onrubia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0655","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00417-007-0749-4","article-title":"Are low inflammatory reactions involved in exudative age-related macular degeneration? Morphological and immunhistochemical analysis of AMD associated with basal deposits","volume":"246","author":"Lommatzsch","year":"2008","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0660","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1349-7006.2010.01815.x","article-title":"Wnt-5a signaling is correlated with infiltrative activity in human glioma by inducing cellular migration and MMP-2","volume":"102","author":"Kamino","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0665","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/jop.12761","article-title":"Elevated hydrostatic pressure promotes ameloblastoma cell invasion through upregulation of MMP-2 and MMP-9 expression via Wnt\/\u03b2-catenin signalling","volume":"47","author":"Yang","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0670","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.oooo.2013.03.005","article-title":"A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis","volume":"115","author":"Kibe","year":"2013","journal-title":"Oral Surg. Oral Med Oral Pathol. Oral Radiol."},{"key":"10.1016\/j.bcp.2026.118114_b0675","doi-asserted-by":"crossref","first-page":"17649","DOI":"10.1074\/jbc.M111.229427","article-title":"Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels","volume":"286","author":"Ingraham","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118114_b0680","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.exer.2009.06.014","article-title":"(Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling","volume":"89","author":"Alcazar","year":"2009","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.bcp.2026.118114_b0685","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/bjd.15079","article-title":"Beta-catenin causes fibrotic changes in the extracellular matrix via upregulation of collagen I transcription","volume":"177","author":"Roh","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bcp.2026.118114_b0690","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1167\/iovs.66.1.52","article-title":"Mechanical strain of corneal epithelium influences the expression of genes implicated in keratoconus","volume":"66","author":"Moon","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0695","first-page":"1003","article-title":"Age-related macular degeneration and changes in the extracellular matrix","volume":"20","author":"Nita","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bcp.2026.118114_b0700","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/jcb.25837","article-title":"Serum levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-negative AMD cases","volume":"118","author":"Sharma","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bcp.2026.118114_b0705","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/cells9010039","article-title":"The diverse roles of TIMP-3: insights into degenerative diseases of the senescent retina and brain","volume":"9","author":"Dewing","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118114_b0710","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1093\/hmg\/ddr270","article-title":"Common variants near FRK\/COL10A1 and VEGFA are associated with advanced age-related macular degeneration","volume":"20","author":"Yu","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bcp.2026.118114_b0715","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167087","article-title":"TIMP3\/Wnt axis regulates gliosis of M\u00fcller glia","volume":"1870","author":"Hung","year":"2024","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"10.1016\/j.bcp.2026.118114_b0720","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1136\/bjo.87.9.1159","article-title":"Differential expression of GFAP in early v late AMD: a quantitative analysis","volume":"87","author":"Wu","year":"2003","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0725","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1681\/ASN.2016070811","article-title":"(Pro)renin receptor is an amplifier of Wnt\/\u03b2-catenin signaling in kidney injury and fibrosis","volume":"28","author":"Li","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bcp.2026.118114_b0730","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00417-018-04230-w","article-title":"Increased soluble urokinase plasminogen activator receptor (suPAR) levels in neovascular age-related macular degeneration: a role for inflammation in the pathogenesis of the disease?","volume":"257","author":"Scotti","year":"2019","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0735","doi-asserted-by":"crossref","first-page":"20576","DOI":"10.1074\/jbc.M112.348888","article-title":"Urokinase-type plasminogen activator receptor (uPAR)-mediated regulation of WNT\/\u03b2-catenin signaling is enhanced in irradiated medulloblastoma cells","volume":"287","author":"Asuthkar","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118114_b0740","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s40942-022-00431-y","article-title":"C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration","volume":"8","author":"Yednock","year":"2022","journal-title":"Int. J. Retina Vitreous."},{"key":"10.1016\/j.bcp.2026.118114_b0745","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2012.03.047","article-title":"Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes","volume":"149","author":"Naito","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0750","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1167\/iovs.17-21672","article-title":"Retinal macrophages synthesize C3 and activate complement in AMD and in models of focal retinal degeneration","volume":"58","author":"Natoli","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0755","doi-asserted-by":"crossref","unstructured":"L. Zhuang, Q. Li, W. You, S. Wen, T. Chen, J. Su, et al., Complement C3 promotes islet \u03b2-cell dedifferentiation by activating Wnt\/\u03b2-catenin pathway, iScience 27 (2024) 111064. https:\/\/doi.org\/10.1016\/j.isci.2024.111064.","DOI":"10.1016\/j.isci.2024.111064"},{"key":"10.1016\/j.bcp.2026.118114_b0760","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11010-013-1654-2","article-title":"Kallistatin antagonizes Wnt\/\u03b2-catenin signaling and cancer cell motility via binding to low-density lipoprotein receptor-related protein 6","volume":"379","author":"Zhang","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bcp.2026.118114_b0765","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/ATVBAHA.114.304627","article-title":"Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization","volume":"35","author":"Wang","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0770","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1167\/iovs.08-1724","article-title":"Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction","volume":"50","author":"Glenn","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0775","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12964-024-01566-1","article-title":"Endothelial \u03b2-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR\/HDAC9","volume":"22","author":"Chen","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bcp.2026.118114_b0780","doi-asserted-by":"crossref","first-page":"14925","DOI":"10.1038\/s41598-017-14015-6","article-title":"Advanced glycation end products promote VEGF expression and thus choroidal neovascularization via Cyr61-PI3K\/AKT signaling pathway","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118114_b0785","doi-asserted-by":"crossref","first-page":"31655","DOI":"10.18632\/oncotarget.15877","article-title":"Wnt5a \/ planar cell polarity signaling pathway in urothelial carcinoma, a potential prognostic biomarker","volume":"8","author":"Saling","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.118114_b0790","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101169","article-title":"A guide to understanding endoplasmic reticulum stress in metabolic disorders","volume":"47","author":"Lemmer","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bcp.2026.118114_b0795","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1039\/C4MT00058G","article-title":"Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration","volume":"6","author":"Flinn","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.bcp.2026.118114_b0800","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104770","article-title":"Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients","volume":"299","author":"Karema-Jokinen","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118114_b0805","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1039\/D1CB00063B","article-title":"Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine","volume":"2","author":"Bonnet","year":"2021","journal-title":"RSC Chem. Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0810","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tips.2023.03.008","article-title":"Modulation of Wnt-\u03b2-catenin signaling with antibodies: therapeutic opportunities and challenges","volume":"44","author":"O'Brien","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0815","doi-asserted-by":"crossref","first-page":"43736","DOI":"10.1038\/srep43736","article-title":"Inhibition of proliferation and epithelial mesenchymal transition in retinal pigment epithelial cells by heavy chain-hyaluronan\/pentraxin 3","volume":"7","author":"He","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118114_b0820","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.580884","article-title":"Fenofibrate inhibits subretinal fibrosis through suppressing TGF-\u03b2-Smad2\/3 signaling and Wnt signaling in neovascular age-related macular degeneration","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118114_b0825","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1167\/iovs.08-2475","article-title":"Fibrocontractive M\u00fcller cell phenotypes in proliferative diabetic retinopathy","volume":"50","author":"Guidry","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0830","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1001\/jamaophthalmol.2024.4400","article-title":"Curcuma-based nutritional supplements and risk of age-related macular degeneration","volume":"142","author":"Alsoudi","year":"2024","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0835","first-page":"1791","article-title":"Suppression of corneal neovascularization by curcumin via inhibition of Wnt\/\u03b2-catenin pathway activation","volume":"10","author":"Zhang","year":"2017","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0840","first-page":"603","article-title":"Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway","volume":"38","author":"Teiten","year":"2011","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bcp.2026.118114_b0845","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.3390\/nu14142974","article-title":"The role of resveratrol in eye diseases - a review of the literature","volume":"14","author":"Bryl","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bcp.2026.118114_b0850","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.3390\/ijms23084092","article-title":"Resveratrol inhibition of the WNT\/\u03b2-catenin pathway following discogenic low back pain","volume":"23","author":"Genovese","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0855","article-title":"Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt\/\u03b2-catenin signaling pathway","volume":"9","author":"Fu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118114_b0860","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbrc.2004.12.151","article-title":"Quercetin, a potent inhibitor against beta-catenin\/Tcf signaling in SW480 colon cancer cells","volume":"328","author":"Park","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.118114_b0865","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111371","article-title":"The therapeutic use of quercetin in ophthalmology: recent applications","volume":"137","author":"Zhao","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118114_b0870","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.exer.2015.02.001","article-title":"Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells","volume":"132","author":"Hytti","year":"2015","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.bcp.2026.118114_b0875","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1007\/s10753-024-01997-5","article-title":"Quercetin regulates microglia M1\/M2 polarization and alleviates retinal inflammation via ERK\/STAT3 pathway","volume":"47","author":"Zou","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.bcp.2026.118114_b0880","doi-asserted-by":"crossref","first-page":"10439","DOI":"10.1038\/s41598-023-37619-7","article-title":"A novel retinoic acid drug, EYE-502, inhibits choroidal neovascularization by targeting endothelial cells and pericytes","volume":"13","author":"Shen","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118114_b0885","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/iovs.65.2.23","article-title":"5-Aza-2'-deoxycytidine ameliorates choroidal neovascularization by inhibiting the Wnt\/\u03b2-catenin signaling pathway","volume":"65","author":"Wu","year":"2024","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0890","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1158\/0008-5472.CAN-06-2726","article-title":"An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth","volume":"67","author":"Fujii","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118114_b0895","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nchembio.453","article-title":"Small-molecule inhibition of Wnt signaling through activation of casein kinase 1\u03b1","volume":"6","author":"Thorne","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0900","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1158\/1078-0432.CCR-18-1319","article-title":"A CK1\u03b1 activator penetrates the brain and shows efficacy against drug-resistant metastatic medulloblastoma","volume":"25","author":"Rodriguez-Blanco","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.118114_b0905","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/ijc.24810","article-title":"Small molecule antagonists of Tcf4\/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo","volume":"126","author":"Wei","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118114_b0910","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1021\/jm901370m","article-title":"Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin\/T-cell transcriptional factor 4 pathway inhibition","volume":"53","author":"Dehnhardt","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2026.118114_b0915","doi-asserted-by":"crossref","unstructured":"L.F. Leal, A.C. Bueno, D.C. Gomes, R. Abduch, M. de Castro, S.R. Antonini, Inhibition of the Tcf\/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis, Oncotarget 6 (2015) 43016\u201343032,doi: 10.18632\/oncotarget.5513.","DOI":"10.18632\/oncotarget.5513"},{"key":"10.1016\/j.bcp.2026.118114_b0920","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41416-020-01162-3","article-title":"Pharmacological blockage of transforming growth factor-\u03b2 signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846","volume":"124","author":"Sugano","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118114_b0925","doi-asserted-by":"crossref","DOI":"10.1177\/1758835920913798","article-title":"Inhibition of the Wnt\/\u03b2-catenin pathway enhances antitumor immunity in ovarian cancer","volume":"12","author":"Doo","year":"2020","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.bcp.2026.118114_b0930","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1038\/onc.2015.280","article-title":"Wnt addiction of genetically defined cancers reversed by PORCN inhibition","volume":"35","author":"Madan","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118114_b0935","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.1158\/1078-0432.CCR-17-2157","article-title":"A first-in-human phase I study of the anticancer stem cell agent Ipafricept (OMP-54F28), a decoy receptor for Wnt ligands, in patients with advanced solid tumors","volume":"23","author":"Jimeno","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.118114_b0940","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/mc.22937","article-title":"Wnt signaling dynamics in head and neck squamous cell cancer tumor-stroma interactions","volume":"58","author":"Le","year":"2018","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bcp.2026.118114_b0945","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s43018-022-00359-0","article-title":"Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR \u00d7 LGR5 bispecific antibody with efficacy in epithelial tumors","volume":"3","author":"Herpers","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.bcp.2026.118114_b0950","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ccell.2020.05.014","article-title":"Targeting RSPO3-LGR4 signaling for leukemia stem cell eradication in acute myeloid leukemia","volume":"38","author":"Salik","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.118114_b0955","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/hep.26996","article-title":"Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy","volume":"60","author":"Gao","year":"2014","journal-title":"Hepatol."},{"key":"10.1016\/j.bcp.2026.118114_b0960","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/sctm.20-0211","article-title":"Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function","volume":"9","author":"Cerniauskas","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bcp.2026.118114_b0965","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ajo.2025.04.016","article-title":"Pegcetacoplan treatment for geographic atrophy in age-related macular degeneration over 36 months: Data from OAKS, DERBY, and GALE","volume":"276","author":"Wykoff","year":"2025","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b0970","first-page":"82","article-title":"Geographic atrophy in age-related macular degeneration","volume":"122","author":"Liakopoulos","year":"2025","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.bcp.2026.118114_b0975","doi-asserted-by":"crossref","first-page":"11877","DOI":"10.3390\/ijms222111877","article-title":"Wnt signaling in inner blood-retinal barrier maintenance","volume":"22","author":"Yemanyi","year":"2021","journal-title":"Int. J. Mol."},{"key":"10.1016\/j.bcp.2026.118114_b0980","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1167\/iovs.10-7146","article-title":"Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier","volume":"52","author":"Paes","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b0985","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1161\/ATVBAHA.118.311689","article-title":"Endothelial cell-specific inactivation of TSPAN12 (Tetraspanin 12) reveals pathological consequences of barrier defects in an otherwise intact vasculature","volume":"38","author":"Zhang","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2026.118114_b0990","article-title":"Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bcp.2026.118114_b0995","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1523\/JNEUROSCI.21-13-04761.2001","article-title":"Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene","volume":"21","author":"Wang","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bcp.2026.118114_b1000","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1136\/bjo.2010.190116","article-title":"The role of Frizzled-4 mutations in familial exudative vitreoretinopathy and Coats disease","volume":"95","author":"Robitaille","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118114_b1005","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.preteyeres.2018.11.008","article-title":"Wnt signaling in vascular eye diseases","volume":"70","author":"Wang","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bcp.2026.118114_b1010","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.4103\/1673-5374.303010","article-title":"The neuroprotective role of Wnt signaling in the retina","volume":"16","author":"Kassumeh","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bcp.2026.118114_b1015","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.64.5.28","article-title":"Mechanisms of Acquired Resistance to Anti-VEGF Therapy for Neovascular Eye Diseases","volume":"64","author":"Sharma","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bcp.2026.118114_b1020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41433-024-03373-x","article-title":"Exploring new horizons in neovascular age-related macular degeneration: novel mechanisms of action and future therapeutic avenues","volume":"39","author":"Shirian","year":"2025","journal-title":"Eye"},{"key":"10.1016\/j.bcp.2026.118114_b1025","doi-asserted-by":"crossref","unstructured":"R. Chidiac, M. Abedin, G. Macleod, A. Yang, P.E. Thibeault, L.L. Blazer, et al., A Norrin\/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy, EMBO Mol. Med. 13 (2021) e13977, doi: 10.15252\/emmm.202113977.","DOI":"10.15252\/emmm.202113977"},{"key":"10.1016\/j.bcp.2026.118114_b1030","unstructured":"Www-reference: https:\/\/db.antibodysociety.org\/db0\/619\/ (consulted in May 2026)."},{"key":"10.1016\/j.bcp.2026.118114_b1035","unstructured":"Www-reference: https:\/\/clinicaltrials.gov\/study\/NCT05919693 (visited in May 2026)."},{"key":"10.1016\/j.bcp.2026.118114_b1040","unstructured":"Www-reference: https:\/\/clinicaltrials.gov\/study\/NCT07205887?intr=restoret&rank=1 (consulted in May 2026)."},{"key":"10.1016\/j.bcp.2026.118114_b1045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0226928","article-title":"Surrogate R-spondins for tissue-specific potentiation of Wnt signaling","volume":"15","author":"Luca","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118114_b1050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/tvst.11.9.19","article-title":"SZN-413, a FZD4 agonist, as a potential novel therapeutic for the treatment of diabetic retinopathy","volume":"11","author":"Nguyen","year":"2022","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.bcp.2026.118114_b1055","unstructured":"S. Lee, Y. Fan, Y. Yang, N. Suen, J. Ye, H. Chen, C. et al., a Norrin mimetic and an anti-VEGF fusion molecule, as a novel candidate for retinopathy therapeutics, Invest. Ophthalmol. Vis. Sci. 66 (2025), 2635. Congress abstract."},{"key":"10.1016\/j.bcp.2026.118114_b1060","unstructured":"Www-reference: https:\/\/modernod.com\/news\/surrozen-discontinues-liver-program-shifts-focus-to-ophthalmology\/2482716\/ (www-page visited in May 2026)."},{"key":"10.1016\/j.bcp.2026.118114_b1065","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/aos.15801","article-title":"The roadmap to geographic atrophy treatment: a journey of trials and promise","volume":"101","author":"Trivizki","year":"2023","journal-title":"Acta Ophthalmol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:26:46Z","timestamp":1783920406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226004491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":213,"alternative-id":["S0006295226004491"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118114","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of Wnt signalling in the pathogenesis and therapy of age-related macular degeneration (AMD)","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118114"}}