{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:05:21Z","timestamp":1790067921138,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["CYYY-BSYJSCXXM-202309"],"award-info":[{"award-number":["CYYY-BSYJSCXXM-202309"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171456"],"award-info":[{"award-number":["82171456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971229"],"award-info":[{"award-number":["81971229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118130","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:18:30Z","timestamp":1780589910000},"page":"118130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Vitamin B12 drives reparative fibroblast remodeling and functional recovery after ischemic stroke via epigenetic activation of RUNX2"],"prefix":"10.1016","volume":"251","author":[{"given":"Hongwei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuliang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3301-1279","authenticated-orcid":false,"given":"Jun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bcp.2026.118130_b0005","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/jama.2022.1420","article-title":"What is Acute Ischemic Stroke?","volume":"327","author":"Walter","year":"2022","journal-title":"JAMA"},{"issue":"389","key":"10.1016\/j.bcp.2026.118130_b0010","article-title":"Advances in treatments for acute ischemic stroke","volume":"7","author":"Sharma","year":"2025","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.bcp.2026.118130_b0015","doi-asserted-by":"crossref","first-page":"8178","DOI":"10.1038\/s41467-024-52556-3","article-title":"Nutritional vitamin B12 regulates RAS\/MAPK-mediated cell fate decisions through one-carbon metabolism","volume":"15","author":"Laranjeira","year":"2024","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bcp.2026.118130_b0020","article-title":"The Neurological Sequelae of Vitamin B12 Deficiency: a Systematic Review and Randomized Controlled Trial","volume":"17","author":"Hamza Ali","year":"2025","journal-title":"Cureus"},{"issue":"5","key":"10.1016\/j.bcp.2026.118130_b0025","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/s41433-021-01589-9","article-title":"Patients with unexplained neurological symptoms and signs should be screened for vitamin B12 deficiency regardless of haemoglobin levels","volume":"36","author":"Maghsoudlou","year":"2022","journal-title":"Eye (Lond.)"},{"issue":"22","key":"10.1016\/j.bcp.2026.118130_b0030","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.3390\/nu17223535","article-title":"Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women","volume":"17","author":"Ramirez-Villalobos","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.bcp.2026.118130_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103676","article-title":"Vitamin B12 and gut-brain homeostasis in the pathophysiology of ischemic stroke","volume":"73","author":"Roth","year":"2021","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.bcp.2026.118130_b0040","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12937-024-00977-7","article-title":"Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study","volume":"23","author":"Zhou","year":"2024","journal-title":"Nutr. J."},{"key":"10.1016\/j.bcp.2026.118130_b0045","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jocn.2023.09.024","article-title":"Low vitamin B12 levels may predict the risk of ischemic stroke: a cross-sectional study","volume":"117","author":"Zhou","year":"2023","journal-title":"J. Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.bcp.2026.118130_b0050","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1186\/s12967-025-06736-4","article-title":"Remodeling and repair of the damaged brain: the potential and challenges of organoids for ischaemic stroke","volume":"23","author":"Hao","year":"2025","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.118130_b0055","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.7150\/thno.48761","article-title":"M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124\/STAT3 pathway after ischemic stroke in mice","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2026.118130_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.115131","article-title":"Astrogliosis and glial scar in ischemic stroke - focused on mechanism and treatment","volume":"385","author":"Chen","year":"2025","journal-title":"Exp. Neurol."},{"issue":"Pt B","key":"10.1016\/j.bcp.2026.118130_b0065","article-title":"Echinacoside targets the HIF-1\u03b1\/LDHA axis to modulate A1\/A2 astrocyte differentiation and promote glial scar repair following ischemic stroke","volume":"353","author":"Liao","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"8086","key":"10.1016\/j.bcp.2026.118130_b0070","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41586-025-09449-2","article-title":"Dynamic fibroblast-immune interactions shape recovery after brain injury","volume":"646","author":"Ewing-Crystal","year":"2025","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bcp.2026.118130_b0075","doi-asserted-by":"crossref","first-page":"756","DOI":"10.4103\/NRR.NRR-D-24-00999","article-title":"Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction","volume":"21","author":"Wen","year":"2026","journal-title":"Neural Regen. Res."},{"issue":"15","key":"10.1016\/j.bcp.2026.118130_b0080","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.3390\/cells11152371","article-title":"Fibrotic Scar in CNS Injuries: from the Cellular Origins of Fibroblasts to the Molecular Processes of Fibrotic Scar Formation","volume":"11","author":"Ayazi","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118130_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2024.105862","article-title":"Shh regulates M2 microglial polarization and fibrotic scar formation after ischemic stroke","volume":"180","author":"Yang","year":"2024","journal-title":"Neurochem. Int."},{"issue":"10","key":"10.1016\/j.bcp.2026.118130_b0090","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.4103\/1673-5374.368299","article-title":"M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats","volume":"18","author":"Huang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bcp.2026.118130_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2023.07.003","article-title":"Glycolytic reprogramming in organ fibrosis: New dynamics of the epigenetic landscape","volume":"207","author":"Liu","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bcp.2026.118130_b0100","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1165\/rcmb.2024-0255OC","article-title":"Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis","volume":"72","author":"Hong","year":"2025","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"8057","key":"10.1016\/j.bcp.2026.118130_b0105","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41586-024-08542-2","article-title":"RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition","volume":"640","author":"Fang","year":"2025","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bcp.2026.118130_b0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00441-023-03791-5","article-title":"The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation","volume":"393","author":"Chen","year":"2023","journal-title":"Cell Tissue Res."},{"issue":"10","key":"10.1016\/j.bcp.2026.118130_b0115","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s12264-020-00534-2","article-title":"Guidelines for Acute Ischemic Stroke Treatment","volume":"36","author":"Qiu","year":"2020","journal-title":"Neurosci. Bull."},{"issue":"11","key":"10.1016\/j.bcp.2026.118130_b0120","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1177\/0271678X17709185","article-title":"The IMPROVE guidelines (Ischaemia Models: Procedural Refinements of in Vivo Experiments)","volume":"37","author":"Percie du Sert","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"16","key":"10.1016\/j.bcp.2026.118130_b0125","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1111\/bph.15193","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"177","author":"Percie du Sert","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118130_b0130","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1038\/s42255-023-00916-6","article-title":"Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair","volume":"5","author":"Kovatcheva","year":"2023","journal-title":"Nat Metab."},{"issue":"22","key":"10.1016\/j.bcp.2026.118130_b0135","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112012","article-title":"CBP\/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos","volume":"41","author":"Wang","year":"2022","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.bcp.2026.118130_b0140","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1038\/s42255-025-01379-7","article-title":"Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke","volume":"7","author":"Zhao","year":"2025","journal-title":"Nat Metab."},{"issue":"1","key":"10.1016\/j.bcp.2026.118130_b0145","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12933-025-02854-x","article-title":"Association of novel triglyceride-glucose-related indices with incident stroke in early-stage cardiovascular-kidney-metabolic syndrome","volume":"24","author":"Yue","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118130_b0150","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s12933-025-02932-0","article-title":"Association between metabolic score for insulin resistance and future stroke risk in patients with cardiovascular-kidney-metabolic syndrome stages 0-3: a longitudinal analysis based on CHARLS","volume":"24","author":"Wu","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"issue":"15","key":"10.1016\/j.bcp.2026.118130_b0155","article-title":"Fibrotic Scar after Spinal Cord Injury: Crosstalk with Other Cells, Cellular Origin, Function, and Mechanism","volume":"26","author":"Li","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"10","key":"10.1016\/j.bcp.2026.118130_b0160","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1007\/s10787-025-01952-2","article-title":"The neuroinflammatory triumvirate: NF-\u03baB, NLRP3, and mTOR in spinal cord injury","volume":"33","author":"Darabniya","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"10","key":"10.1016\/j.bcp.2026.118130_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111315","article-title":"Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages","volume":"40","author":"Hojo","year":"2022","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.bcp.2026.118130_b0170","article-title":"RUNX2 phase Separation Mediates Long-Range Regulation between Osteoporosis-Susceptibility Variant and XCR1 to Promote Osteoblast Differentiation","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci (weinh)."},{"issue":"1","key":"10.1016\/j.bcp.2026.118130_b0175","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-024-00394-w","article-title":"Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2","volume":"13","author":"Dong","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.bcp.2026.118130_b0180","article-title":"RUNX2 Activation in Fibro\/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy","volume":"22","author":"Wu","year":"2025","journal-title":"Adv Sci (weinh)."},{"issue":"7","key":"10.1016\/j.bcp.2026.118130_b0185","doi-asserted-by":"crossref","first-page":"e1316","DOI":"10.1002\/ctm2.1316","article-title":"Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating Itgav expression","volume":"13","author":"Zhong","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bcp.2026.118130_b0190","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skae202","article-title":"One-carbon metabolite supplementation increases vitamin B12, folate, and methionine cycle metabolites in beef heifers and fetuses in an energy dependent manner at day 63 of gestation","author":"Syring","year":"2024","journal-title":"J. Anim. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2026.118130_b0195","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/ars.2011.4368","article-title":"Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls","volume":"17","author":"Copped\u00e8","year":"2012","journal-title":"Antioxid. Redox Signal."},{"issue":"476","key":"10.1016\/j.bcp.2026.118130_b0200","article-title":"Folate, vitamin B12, one carbon metabolism and the nervous system: Excess folic acid is potentially harmful","volume":"15","author":"Reynolds","year":"2025","journal-title":"J. Neurol. Sci."}],"updated-by":[{"DOI":"10.1016\/j.bcp.2026.118473","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000}}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600465X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600465X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:15:26Z","timestamp":1785071726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522600465X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":40,"alternative-id":["S000629522600465X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118130","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin B12 drives reparative fibroblast remodeling and functional recovery after ischemic stroke via epigenetic activation of RUNX2","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118130"}}