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Sci."},{"key":"10.1016\/j.bcp.2026.118149_b0490","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2147\/DDDT.S149264","article-title":"Lysosomal Acid Lipase Deficiency: Therapeutic Options","volume":"14","author":"Pastores","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bcp.2026.118149_b0495","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1021\/bi052104y","article-title":"D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol alters cellular cholesterol homeostasis by modulating the endosome lipid domains","volume":"45","author":"Makino","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2026.118149_b0500","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF02531203","article-title":"Accumulation of a glycerolphospholipid in classical niemann\u2010pick disease","volume":"3","author":"Rouser","year":"1968","journal-title":"Lipids"},{"key":"10.1016\/j.bcp.2026.118149_b0505","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF02532899","article-title":"Low and moderate concentrations of lysobisphosphatidic acid in brain and liver of patients affected by some storage diseases","volume":"11","author":"Kahma","year":"1976","journal-title":"Lipids"},{"key":"10.1016\/j.bcp.2026.118149_b0510","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ana.410010410","article-title":"Niemann\u2010pick disease type D: Lipid analyses and studies on sphingomyelinases","volume":"1","author":"Rao","year":"1977","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bcp.2026.118149_b0515","first-page":"178","article-title":"Biochemical studies in niemann-pick disease I. Major sphingolipids of liver and spleen","volume":"750","author":"Vanier","year":"1983"},{"key":"10.1016\/j.bcp.2026.118149_b0520","first-page":"199","article-title":"Studies on lipids from liver and spleen of a child (O.L.) with Niemann-Pick\u2019s disease type C","volume":"22","author":"Harder","year":"1984","journal-title":"J. Clin. Chem. Clin. Biochem."},{"key":"10.1016\/j.bcp.2026.118149_b0525","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF01813904","article-title":"Enzyme activities and phospholipid storage patterns in brain and spleen samples from niemann\u2010pick disease variants: a comparison of neuropathic and non\u2010neuropathic forms","volume":"9","author":"Besley","year":"1986","journal-title":"J. Inher. Metab. 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