{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:49:51Z","timestamp":1785890991040,"version":"3.56.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472176"],"award-info":[{"award-number":["82472176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172118"],"award-info":[{"award-number":["82172118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["LC2019ZD014"],"award-info":[{"award-number":["LC2019ZD014"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["yzjj2022qn29"],"award-info":[{"award-number":["yzjj2022qn29"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program Key Projects","doi-asserted-by":"publisher","award":["2025A04J3775"],"award-info":[{"award-number":["2025A04J3775"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118152","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:04:49Z","timestamp":1781049889000},"page":"118152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["\u03b2-Hydroxybutyric acid impairs host antimicrobial defense by targeting the CEACAM1-NADPH-ROS axis to disrupt macrophage bactericidal activity"],"prefix":"10.1016","volume":"251","author":[{"given":"Tao","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntian","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-3080","authenticated-orcid":false,"given":"Zhanguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bcp.2026.118152_b0005","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/PCC.0000000000002304","article-title":"Updating the epidemiology of severe bacterial infections reveals old truths: vaccination saves life and limb","volume":"21","author":"Fitzgerald","year":"2020","journal-title":"Pediatr. Crit. Care Med."},{"issue":"10219","key":"10.1016\/j.bcp.2026.118152_b0010","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.bcp.2026.118152_b0015","article-title":"Immunomodulatory biomaterials against bacterial infections: progress, challenges, and future perspectives","volume":"4","author":"Zhang","year":"2023","journal-title":"Innovation (Camb)"},{"issue":"10","key":"10.1016\/j.bcp.2026.118152_b0020","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/s41423-023-01070-5","article-title":"A metabolite from commensal candida albicans enhances the bactericidal activity of macrophages and protects against sepsis","volume":"20","author":"Gu","year":"2023","journal-title":"Cell. Mol. Immunol."},{"issue":"8","key":"10.1016\/j.bcp.2026.118152_b0025","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.chom.2021.06.002","article-title":"Uncoupling of il-6 signaling and lc3-associated phagocytosis drives immunoparalysis during sepsis","volume":"29","author":"Akoumianaki","year":"2021","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.bcp.2026.118152_b0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cmet.2013.06.018","article-title":"Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating \u03b2-oxidation-dependent mitochondrial ros production","volume":"18","author":"Hall","year":"2013","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.bcp.2026.118152_b0035","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02021-2017","article-title":"Mesenchymal stem cells enhance nox2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis","volume":"51","author":"Rabani","year":"2018","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.bcp.2026.118152_b0040","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1152\/ajpendo.00266.2013","article-title":"Ceacam1 deletion causes vascular alterations in large vessels","volume":"305","author":"Najjar","year":"2013","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"10.1016\/j.bcp.2026.118152_b0045","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.molmet.2018.01.009","article-title":"Liver-specific rescuing of ceacam1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of ceacam1 gene","volume":"9","author":"Russo","year":"2018","journal-title":"Mol. Metab."},{"issue":"5","key":"10.1016\/j.bcp.2026.118152_b0050","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1172\/JCI133142","article-title":"Hepatic ceacam1 expression indicates donor liver quality and prevents early transplantation injury","volume":"130","author":"Nakamura","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"7444","key":"10.1016\/j.bcp.2026.118152_b0055","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces il-1\u03b2 through hif-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2026.118152_b0060","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2021.12.039","article-title":"Magnesium sensing via lfa-1 regulates cd8(+) tcell effector function","volume":"185","author":"L\u00f6tscher","year":"2022","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bcp.2026.118152_b0065","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s11011-022-01146-7","article-title":"D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and bv-2 cells","volume":"38","author":"Zhang","year":"2023","journal-title":"Metab. Brain Dis."},{"issue":"6116","key":"10.1016\/j.bcp.2026.118152_b0070","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.1227166","article-title":"Suppression of oxidative stress by \u03b2-hydroxybutyrate, an endogenous histone deacetylase inhibitor","volume":"339","author":"Shimazu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.118152_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.925900","article-title":"\u0392-hydroxybutyrate impairs monocyte function via the ros-nlr family pyrin domain-containing three inflammasome (nlrp3) pathway in ketotic cows","volume":"9","author":"Dong","year":"2022","journal-title":"Front. Vet. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2026.118152_b0080","first-page":"478","article-title":"Neutrophil phagocytosis and killing in insulin-dependent diabetes","volume":"63","author":"Wilson","year":"1986","journal-title":"Clin. Exp. Immunol."},{"issue":"8","key":"10.1016\/j.bcp.2026.118152_b0085","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.bcp.2026.118152_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109451","article-title":"\u0392-hydroxybutyrate alleviates pyroptosis in mpp(+)\/mptp-induced parkinson's disease models via inhibiting stat3\/nlrp3\/gsdmd pathway","volume":"113","author":"Jiang","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118152_b0095","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/osp4.432","article-title":"Urine dipsticks are not accurate for detecting mild ketosis during a severely energy restricted diet","volume":"6","author":"Gibson","year":"2020","journal-title":"Obes. Sci. Pract."},{"issue":"1","key":"10.1016\/j.bcp.2026.118152_b0100","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/obr.12230","article-title":"Do ketogenic diets really suppress appetite? a systematic review and meta-analysis","volume":"16","author":"Gibson","year":"2015","journal-title":"Obes. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2026.118152_b0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bcp.2026.118152_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111870","article-title":"Magnesium alleviates extracellular histone-induced apoptosis and defective bacterial phagocytosis in macrophages by regulating intracellular calcium signal","volume":"132","author":"Zhong","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118152_b0115","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/shk.0b013e31804d41dd","article-title":"Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia","volume":"28","author":"Kadl","year":"2007","journal-title":"Shock"},{"issue":"7","key":"10.1016\/j.bcp.2026.118152_b0120","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1016\/j.apsb.2024.03.025","article-title":"Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating slc12a4 and protects against sepsis in mice","volume":"14","author":"Li","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.bcp.2026.118152_b0125","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa079","article-title":"Therapeutic targets and signaling mechanisms of vitamin c activity against sepsis: a bioinformatics study","volume":"22","author":"Li","year":"2021","journal-title":"Brief. Bioinform."},{"issue":"1","key":"10.1016\/j.bcp.2026.118152_b0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.chom.2023.11.006","article-title":"Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism","volume":"32","author":"Li","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"9","key":"10.1016\/j.bcp.2026.118152_b0135","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.bcp.2026.118152_b0140","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/SHK.0000000000002263","article-title":"Magnesium sulfate ameliorates histone-induced coagulation dysfunction and lung damage in mice","volume":"61","author":"Zhong","year":"2024","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.bcp.2026.118152_b0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/imcb.12241","article-title":"Neutrophil-macrophage cooperation and its impact on tissue repair","volume":"97","author":"Bouchery","year":"2019","journal-title":"Immunol. Cell Biol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118152_b0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bcp.2026.118152_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176959","article-title":"\u0392-hydroxybutyrate alleviates brain aging through the mta1 pathway in d-galactose injured mice","volume":"983","author":"Wang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118152_b0160","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1189\/jlb.0109037","article-title":"Pivotal advance: ceacam1 is a negative coreceptor for the b cell receptor and promotes cd19-mediated adhesion of b cells in a pi3k-dependent manner","volume":"86","author":"Lobo","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bcp.2026.118152_b0165","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000001003","article-title":"Hepatic gdp-fucose transporter slc35c1 attenuates cholestatic liver injury and inflammation by inducing ceacam1 n153 fucosylation","author":"Zhang","year":"2024","journal-title":"Hepatology"},{"issue":"14","key":"10.1016\/j.bcp.2026.118152_b0170","doi-asserted-by":"crossref","DOI":"10.1172\/JCI184653","article-title":"Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice","volume":"135","author":"Li","year":"2025","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2026.118152_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114798","article-title":"Drug affinity responsive target stability (darts) accelerated small molecules target discovery: principles and application","volume":"194","author":"Ren","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118152_b0180","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-010715-103715","article-title":"The cellular thermal shift assay: a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies","volume":"56","author":"Martinez","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118152_b0185","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13054-019-2506-6","article-title":"Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones","volume":"23","author":"Goossens","year":"2019","journal-title":"Crit. Care"},{"issue":"7","key":"10.1016\/j.bcp.2026.118152_b0190","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0022-3468(95)90321-6","article-title":"Weanling and adult rats differ in fatty acid and carnitine metabolism during sepsis","volume":"30","author":"Linz","year":"1995","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.bcp.2026.118152_b0195","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cytogfr.2019.05.008","article-title":"Carcinoembryonic antigen (ceacam) family members and inflammatory bowel disease","volume":"47","author":"Kelleher","year":"2019","journal-title":"Cytokine Growth Factor Rev."},{"issue":"6","key":"10.1016\/j.bcp.2026.118152_b0200","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nri1864","article-title":"Ceacam1: contact-dependent control of immunity","volume":"6","author":"Gray-Owen","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"51","key":"10.1016\/j.bcp.2026.118152_b0205","doi-asserted-by":"crossref","first-page":"39179","DOI":"10.1074\/jbc.M608864200","article-title":"Ceacam1 (cd66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and akt-dependent pathway","volume":"281","author":"Yu","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.bcp.2026.118152_b0210","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103230","article-title":"A selective \u03b2-catenin-metadherin\/ceacam1-ccl3 axis mediates metastatic heterogeneity upon tumor-macrophage interaction","volume":"9","author":"To","year":"2022","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2026.118152_b0215","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/gutjnl-2020-323636","article-title":"Autoimmune susceptibility gene ptpn2 is required for clearance of adherent-invasive escherichia coli by integrating bacterial uptake and lysosomal defence","volume":"71","author":"Spalinger","year":"2022","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.bcp.2026.118152_b0220","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/cr.2015.63","article-title":"Park7 interacts with p47(phox) to direct nadph oxidase-dependent ros production and protect against sepsis","volume":"25","author":"Liu","year":"2015","journal-title":"Cell Res."},{"issue":"8","key":"10.1016\/j.bcp.2026.118152_b0225","article-title":"Malarial hemozoin activates the nlrp3 inflammasome through lyn and syk kinases","volume":"5","author":"Shio","year":"2009","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.bcp.2026.118152_b0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002597","article-title":"Ceacam1 negatively regulates il-1\u03b2 production in lps activated neutrophils by recruiting shp-1 to a syk-tlr4-ceacam1 complex","volume":"8","author":"Lu","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bcp.2026.118152_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115632","article-title":"3-hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of gpr109\u03b1 in macrophages","volume":"213","author":"Huang","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118152_b0240","doi-asserted-by":"crossref","first-page":"8915","DOI":"10.1007\/s11033-023-08713-w","article-title":"\u0392-hydroxybutyrate ameliorates sepsis-induced acute kidney injury","volume":"50","author":"Kim","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bcp.2026.118152_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2026.01.002","article-title":"Fasting impairs humoral immunological memory by \u03b2-hydroxybutyrate-mediated depletion of plasma cells","author":"Zhu","year":"2026","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bcp.2026.118152_b0250","first-page":"14","article-title":"Effects of beta-hydroxybutyric acid on bovine milk leukocytes function in vitro","volume":"26","author":"Cerone","year":"2007","journal-title":"Gen. Physiol. Biophys."},{"issue":"1","key":"10.1016\/j.bcp.2026.118152_b0255","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12916-025-03920-7","article-title":"Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury","volume":"23","author":"Huang","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.bcp.2026.118152_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217808","article-title":"Ketogenesis instigates immune suppression in enzalutamide resistant prostate cancer via otud7b \u03b2-hydroxybutyrylation","volume":"625","author":"Jiang","year":"2025","journal-title":"Cancer Lett."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:58:15Z","timestamp":1785887895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226004880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":52,"alternative-id":["S0006295226004880"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118152","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b2-Hydroxybutyric acid impairs host antimicrobial defense by targeting the CEACAM1-NADPH-ROS axis to disrupt macrophage bactericidal activity","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118152"}}