{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:00:28Z","timestamp":1785074428143,"version":"3.55.0"},"reference-count":347,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"European Commission Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009243","name":"Direction G\u00e9n\u00e9rale de l\u2019offre de Soins","doi-asserted-by":"publisher","award":["HORIZON-MSCA-2021-DN-01"],"award-info":[{"award-number":["HORIZON-MSCA-2021-DN-01"]}],"id":[{"id":"10.13039\/501100009243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009243","name":"Direction G\u00e9n\u00e9rale de l\u2019offre de Soins","doi-asserted-by":"publisher","award":["101072462"],"award-info":[{"award-number":["101072462"]}],"id":[{"id":"10.13039\/501100009243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"French National Cancer Institute","doi-asserted-by":"publisher","award":["INCa_20115"],"award-info":[{"award-number":["INCa_20115"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118157","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:55:05Z","timestamp":1781135705000},"page":"118157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Tetraploidy in cancer: Diagnostic and therapeutic perspectives"],"prefix":"10.1016","volume":"251","author":[{"given":"Aline","family":"Lessa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Levergeois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mu\u00f1oz-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Mountford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge William","family":"Vargas-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Cochonneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle","family":"Renodon-Corni\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Fran\u00e7oise","family":"Heymann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Giurgea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Heymann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6274-6981","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"L\u00e9zot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118157_b0005","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2340\/00015555-1114","article-title":"Molecular markers associated with clinical response to bexarotene therapy in cutaneous T-cell lymphoma","volume":"91","author":"Ranki","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.bcp.2026.118157_b0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.bmt.1703902","article-title":"Tetraploid myeloid cells in donors of peripheral blood stem cells treated with rhG-CSF","volume":"32","author":"Kaplinsky","year":"2003","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.bcp.2026.118157_b0015","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1146\/annurev-cellbio-092910-154234","article-title":"The causes and consequences of polyploidy in normal development and cancer","volume":"27","author":"Davoli","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118157_b0020","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1091\/mbc.E18-02-0141","article-title":"A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation","volume":"29","author":"Vittoria","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bcp.2026.118157_b0025","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14399","article-title":"Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics","volume":"24","author":"Al-Naggar","year":"2025","journal-title":"Aging Cell"},{"key":"10.1016\/j.bcp.2026.118157_b0030","first-page":"6487","article-title":"Inverse regulation of cyclin B1 by c-Myc and p53 and induction of tetraploidy by cyclin B1 overexpression","volume":"61","author":"Yin","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118157_b0035","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1038\/sj.emboj.7601127","article-title":"Apoptosis regulation in tetraploid cancer cells","volume":"25","author":"Castedo","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.118157_b0040","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.4161\/cc.5.14.2925","article-title":"Overexpression of the anaphase promoting complex\/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells","volume":"5","author":"Lehman","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2026.118157_b0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1083\/jcb.200610099","article-title":"Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis","volume":"176","author":"Dikovskaya","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118157_b0050","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/modpathol.3801022","article-title":"Emi1 protein accumulation implicates misregulation of the anaphase promoting complex\/cyclosome pathway in ovarian clear cell carcinoma","volume":"21","author":"G\u00fctgemann","year":"2008","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0055","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ejca.2008.09.024","article-title":"The expression of the DeltaNp73beta isoform of p73 leads to tetraploidy","volume":"45","author":"Marrazzo","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0060","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.onc.1207216","article-title":"Enhanced expression of MYCN leads to centrosome hyperamplification after DNA damage in neuroblastoma cells","volume":"23","author":"Sugihara","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b0065","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ajh.26382","article-title":"Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6","volume":"97","author":"Renella","year":"2022","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b0070","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.bbmt.2010.07.014","article-title":"Graft-versus-host disease: role of inflammation in the development of chromosomal abnormalities of keratinocytes","volume":"16","author":"Sloand","year":"2010","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.bcp.2026.118157_b0075","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1111\/cas.13717","article-title":"Tetraploidy in cancer and its possible link to aging","volume":"109","author":"Tanaka","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bcp.2026.118157_b0080","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10577-021-09664-3","article-title":"Communal living: the role of polyploidy and syncytia in tissue biology","volume":"29","author":"Peterson","year":"2021","journal-title":"Chromosome Res."},{"key":"10.1016\/j.bcp.2026.118157_b0085","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mrgentox.2007.10.016","article-title":"Survival of aneuploid, micronucleated and\/or polyploid cells: crosstalk between ploidy control and apoptosis","volume":"651","author":"Decordier","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bcp.2026.118157_b0090","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/adt.2006.4.421","article-title":"Quantitative characterization of mitosis-blocked tetraploid cells using high content analysis","volume":"4","author":"Grove","year":"2006","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.bcp.2026.118157_b0095","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-022-04578-4","article-title":"Genetic instability from a single S phase after whole-genome duplication","volume":"604","author":"Gemble","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118157_b0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jmcb\/mjq052","article-title":"Prevention of DNA re-replication in eukaryotic cells","volume":"3","author":"Truong","year":"2011","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118157_b0105","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1101\/gad.1508907","article-title":"Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells","volume":"21","author":"Arias","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bcp.2026.118157_b0110","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cell.2010.01.031","article-title":"Persistent telomere damage induces bypass of mitosis and tetraploidy","volume":"141","author":"Davoli","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118157_b0115","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ccr.2012.03.044","article-title":"Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells","volume":"21","author":"Davoli","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.118157_b0120","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.ccr.2012.05.033","article-title":"\u201cTwo\u201d much of a good thing: telomere damage-induced genome doubling drives tumorigenesis","volume":"21","author":"Varetti","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.118157_b0125","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/cells9020271","article-title":"Cytokinesis in Eukaryotic Cells: the Furrow Complexity at a Glance","volume":"9","author":"Fraschini","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118157_b0130","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.gde.2007.02.011","article-title":"Tetraploidy, aneuploidy and cancer","volume":"17","author":"Ganem","year":"2007","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bcp.2026.118157_b0135","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cdd.2010.145","article-title":"Illicit survival of cancer cells during polyploidization and depolyploidization","volume":"18","author":"Vitale","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2026.118157_b0140","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1158\/0008-5472.CAN-09-0825","article-title":"The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55","volume":"69","author":"van der Horst","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118157_b0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41568-018-0084-6","article-title":"Cytokinesis defects and cancer","volume":"19","author":"Lens","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0150","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2217\/14796694.2.1.43","article-title":"BRCA2 in mitotic exit: a new role in regulating genomic stability","volume":"2","author":"Wang","year":"2006","journal-title":"Future Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b0155","doi-asserted-by":"crossref","unstructured":"B.A.A. Weaver, A.D. Silk, D.W. Cleveland, Cell biology: nondisjunction, aneuploidy and tetraploidy, Nature 442 (2006) E9-10; discussion E10. https:\/\/doi.org\/10.1038\/nature05139.","DOI":"10.1038\/nature05139"},{"key":"10.1016\/j.bcp.2026.118157_b0160","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/MCB.18.2.1055","article-title":"Characterization of the p53-dependent postmitotic checkpoint following spindle disruption","volume":"18","author":"Lanni","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118157_b0165","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2007.10.024","article-title":"Limiting the proliferation of polyploid cells","volume":"131","author":"Ganem","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118157_b0170","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.molonc.2011.07.007","article-title":"p53: guardian of ploidy","volume":"5","author":"Aylon","year":"2011","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b0175","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/excr.1999.4554","article-title":"p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells","volume":"250","author":"Casenghi","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bcp.2026.118157_b0180","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ccr.2005.10.017","article-title":"Tetraploidy and tumor development","volume":"8","author":"Margolis","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.118157_b0185","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1002\/ijc.26309","article-title":"Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells","volume":"130","author":"Yu","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0190","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1089\/dna.2010.1128","article-title":"Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3\u03b2 signaling, and its knockdown results in deregulated G2\/M transition in prostate cells","volume":"30","author":"Varisli","year":"2011","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bcp.2026.118157_b0195","doi-asserted-by":"crossref","DOI":"10.1080\/19420889.2018.1526605","article-title":"Tetraploidy-associated centrosome overduplication in mouse early embryos","volume":"11","author":"Yaguchi","year":"2018","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.bcp.2026.118157_b0200","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54565","article-title":"Asymmetric clustering of centrosomes defines the early evolution of tetraploid cells","volume":"9","author":"Baudoin","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.bcp.2026.118157_b0205","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jss.2007.01.039","article-title":"Cyclooxygenase-2 expression induces genomic instability in MCF10A breast epithelial cells","volume":"140","author":"Singh","year":"2007","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bcp.2026.118157_b0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0165-4608(03)00003-7","article-title":"Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy","volume":"143","author":"Fabarius","year":"2003","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0215","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.tig.2023.08.004","article-title":"Whole-genome doubling in tissues and tumors","volume":"39","author":"Vittoria","year":"2023","journal-title":"Trends Genet."},{"key":"10.1016\/j.bcp.2026.118157_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrgentox.2024.503764","article-title":"Tetraploidy as a metastable state towards malignant cell transformation within a systemic approach of cancer development","volume":"896","author":"Kirsch-Volders","year":"2024","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.bcp.2026.118157_b0225","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nature04217","article-title":"Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells","volume":"437","author":"Fujiwara","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118157_b0230","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/ejh.13905","article-title":"Amp(1q) and tetraploidy are commonly acquired chromosomal abnormalities in relapsed multiple myeloma","volume":"110","author":"Locher","year":"2023","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.bcp.2026.118157_b0235","doi-asserted-by":"crossref","first-page":"E117","DOI":"10.1002\/ajh.25420","article-title":"Tetraploidy is associated with poor prognosis at diagnosis in multiple myeloma","volume":"94","author":"Sidana","year":"2019","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b0240","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-219274","article-title":"Tetraploidy acute myeloid leukaemia after chromosome 16 inversion","author":"Vilches","year":"2017","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.bcp.2026.118157_b0245","first-page":"30","article-title":"Is 5q deletion in de novo Acute Myelogenous Leukemia (AML) with excess blasts a surrogate marker for the cryptic t(7;21)(p22;q22)?","volume":"262\u2013263","author":"Johnston","year":"2022","journal-title":"A Case Report and Review of Literature, Cancer Genet"},{"key":"10.1016\/j.bcp.2026.118157_b0250","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s00277-014-2057-5","article-title":"Korean Multiple Myeloma Working Party (KMMWP), Chromosome 13 deletion and hypodiploidy on conventional cytogenetics are robust prognostic factors in Korean multiple myeloma patients: web-based multicenter registry study","volume":"93","author":"Oh","year":"2014","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b0255","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-018-0003-x","article-title":"Ewing sarcoma","volume":"4","author":"Gr\u00fcnewald","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bcp.2026.118157_b0260","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1210983","article-title":"The fate of extra centrosomes in newly formed tetraploid cells: should I stay, or should I go?","volume":"11","author":"Bloomfield","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118157_b0265","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1242\/jcs.039537","article-title":"The consequences of tetraploidy and aneuploidy","volume":"121","author":"Storchova","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bcp.2026.118157_b0270","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5483\/BMBRep.2017.50.7.185","article-title":"Survivin protects fused cancer cells from cell death","volume":"50","author":"Do","year":"2017","journal-title":"BMB Rep."},{"key":"10.1016\/j.bcp.2026.118157_b0275","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s13402-021-00654-5","article-title":"Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling","volume":"45","author":"Bernhard","year":"2022","journal-title":"Cell. Oncol. (Dordr.)"},{"key":"10.1016\/j.bcp.2026.118157_b0280","doi-asserted-by":"crossref","first-page":"446","DOI":"10.48095\/cccg2023446","article-title":"DNA analysis of partial hydatidiform mole revealing triandric monogynic tetraploidy","volume":"88","author":"Gergely","year":"2023","journal-title":"Ceska Gynekol."},{"key":"10.1016\/j.bcp.2026.118157_b0285","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tig.2007.03.016","article-title":"More is not always better: the genetic constraints of polyploidy","volume":"23","author":"Thorpe","year":"2007","journal-title":"Trends Genet."},{"key":"10.1016\/j.bcp.2026.118157_b0290","first-page":"569","article-title":"Clinicopathologic study of tetraploid hydropic villous tissues","volume":"120","author":"Fukunaga","year":"1996","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.bcp.2026.118157_b0295","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1091\/mbc.E15-01-0003","article-title":"Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition","volume":"26","author":"Sadaie","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bcp.2026.118157_b0300","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1155\/1999\/658189","article-title":"DNA aneuploidy in ulcerative colitis and in colorectal carcinoma\u2013a comparative study","volume":"18","author":"Stenling","year":"1999","journal-title":"Anal. Cell. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0305","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0165-4608(90)90080-T","article-title":"Cytogenetic studies in tuberous sclerosis","volume":"45","author":"Dietrich","year":"1990","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0310","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00412-025-00829-1","article-title":"Tetraploidy in normal tissues and diseases: mechanisms and consequences","volume":"134","author":"Kirsch-Volders","year":"2025","journal-title":"Chromosoma"},{"key":"10.1016\/j.bcp.2026.118157_b0315","first-page":"925","article-title":"Global genomic changes induced by two-stage carcinogen exposure are precancerous alterations in non-transformed human liver epithelial THLE-3 cells","volume":"27","author":"Inomata","year":"2005","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b0320","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0090-4295(00)00568-9","article-title":"Relationship between flow cytometric DNA ploidy and nuclear grade with endocrine dysfunction in adrenal cortical adenomas","volume":"56","author":"Shono","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.bcp.2026.118157_b0325","first-page":"11","article-title":"Flow cytometric DNA analysis of normal adrenal tissues and adrenal tumors","volume":"80","author":"Nakai","year":"1989","journal-title":"Nihon Hinyokika Gakkai Zasshi"},{"key":"10.1016\/j.bcp.2026.118157_b0330","first-page":"188","article-title":"Pheochromocytoma nuclear pattern analysis by flow cytometry","volume":"16","author":"Huang","year":"1993","journal-title":"Changgeng Yi Xue Za Zhi"},{"key":"10.1016\/j.bcp.2026.118157_b0335","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3349\/ymj.1992.33.3.249","article-title":"DNA flow cytometry in pheochromocytoma and paraganglioma","volume":"33","author":"Jung","year":"1992","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.bcp.2026.118157_b0340","first-page":"942","article-title":"Gene amplification in bladder tumors","volume":"21","author":"Pinto","year":"1997","journal-title":"Actas Urol. Esp."},{"key":"10.1016\/j.bcp.2026.118157_b0345","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0022-5347(01)64322-2","article-title":"Deoxyribonucleic acid ploidy enhances the cytological prediction of recurrent transitional cell carcinoma of the bladder","volume":"158","author":"Slaton","year":"1997","journal-title":"J. Urol."},{"key":"10.1016\/j.bcp.2026.118157_b0350","first-page":"651","article-title":"Cytogenetic analysis of transitional cell carcinoma of the bladder, stage B (pT2-3a\/pN0)","volume":"18","author":"Angulo","year":"1994","journal-title":"Actas Urol. Esp."},{"key":"10.1016\/j.bcp.2026.118157_b0355","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0360-3016(89)90137-5","article-title":"T2\/T3 bladder carcinomas treated with definitive radiotherapy with emphasis on flow cytometric DNA ploidy values","volume":"17","author":"Jacobsen","year":"1989","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bcp.2026.118157_b0360","first-page":"619","article-title":"DNA content in human cancer","volume":"113","author":"Seckinger","year":"1989","journal-title":"Application in Pathology and Clinical Medicine, Arch Pathol Lab Med"},{"key":"10.1016\/j.bcp.2026.118157_b0365","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0145-2126(87)90021-X","article-title":"Multiple chromosome abnormalities in a drug resistant TdT positive B-cell leukemia","volume":"11","author":"Secker-Walker","year":"1987","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcp.2026.118157_b0370","doi-asserted-by":"crossref","unstructured":"H. Mkrtchyan, D.R. Garcia Ney, E.S. de Ventura, T. Liehr, G.R. Felix, T. de J. Marques-Salles, E. Abdelhay, M.L. Macedo Silva, Molecular cytogenetic studies characterize a near-triploid complex karyotype in a child with acute lymphoblastic leukemia, Cancer Genet Cytogenet 197 (2010) 71\u201374. https:\/\/doi.org\/10.1016\/j.cancergencyto.2009.09.019.","DOI":"10.1016\/j.cancergencyto.2009.09.019"},{"key":"10.1016\/j.bcp.2026.118157_b0375","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.leu.2400930","article-title":"Detection of hyperdiploid karyotypes (\\textgreater50 chromosomes) in childhood acute lymphoblastic leukemia (ALL) using fluorescence in situ hybridization (FISH)","volume":"12","author":"Ritterbach","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2026.118157_b0380","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/bjc.1989.80","article-title":"Cell kinetics in acute lymphoblastic leukaemia: comparative analysis between adults and children","volume":"59","author":"Ffrench","year":"1989","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0385","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.7314\/APJCP.2014.15.9.3907","article-title":"Chromosomal abnormalities in Pakistani children with acute lymphoblastic leukemia","volume":"15","author":"Shaikh","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.bcp.2026.118157_b0390","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000285281","article-title":"Frequency and type of chromosomal abnormalities in childhood acute lymphoblastic leukemia patients in Kuwait: a six-year retrospective study","volume":"19","author":"Al-Bahar","year":"2010","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.bcp.2026.118157_b0395","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.cancergen.2025.02.009","article-title":"A case of T-cell acute lymphoblastic leukemia with co-occurrence of NUP214-ABL1 fusion and tetraploidy: a T-ALL case with NUP214-ABL1 fusion and tetraploidy","volume":"292\u2013293","author":"Zhu","year":"2025","journal-title":"Cancer Genet."},{"key":"10.1016\/j.bcp.2026.118157_b0400","first-page":"502","article-title":"Acute granulocytic leukemia with near-tetraploid chromosome constitution appearing in the late stage of the disease with survival of almost 9 years","volume":"30","author":"Oguma","year":"1989","journal-title":"Rinsho Ketsueki"},{"key":"10.1016\/j.bcp.2026.118157_b0405","first-page":"413","article-title":"Tetraploidy or near-tetraploidy clones with double 8;21 translocation: a non-random additional anomaly of acute myeloid leukemia with t(8;21)(q22;q22)","volume":"90","author":"Xiao","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.bcp.2026.118157_b0410","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02981981","article-title":"Philadelphia chromosome-positive acute myeloid leukemia with tetraploidy","volume":"75","author":"Yamaguchi","year":"2002","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b0415","first-page":"359","article-title":"Secondary near-pentaploidy and\/or near-tetraploidy characterized by the duplication of 8;21 translocation in the M2 subtype of acute myeloid leukemia","volume":"71","author":"Xue","year":"2000","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b0420","unstructured":"L.M. Isakova, N.N. Tretiak, V.N. Khromiak, A.I. Gordienko, A.S. Zverkova, A.M. Vakul\u2019chuk, [The immunophenotypic and cytogenetic characteristics of the blast cells in subvariants of acute myeloid leukemia], Tsitol Genet 34 (2000) 48\u201356."},{"key":"10.1016\/j.bcp.2026.118157_b0425","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s002770050006","article-title":"Near-tetraploid minimally differentiated acute myeloid leukemia with extensive erythrophagocytosis by leukemic blasts","volume":"79","author":"Yeh","year":"2000","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b0430","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/10428199809057623","article-title":"Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma","volume":"31","author":"Kaplan","year":"1998","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bcp.2026.118157_b0435","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-4608(97)00315-4","article-title":"Two new cases of near-tetraploidy in adult acute myeloid leukemia","volume":"102","author":"Espinet","year":"1998","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0440","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3109\/10428199709039048","article-title":"De novo acute myeloid leukemia with near-pentaploidy: diploid karyotype and lymphoblastic phenotype at relapse","volume":"25","author":"Rund","year":"1997","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bcp.2026.118157_b0445","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0165-4608(96)00112-4","article-title":"Tetraploid or near-tetraploid clones characterized by two 8;21 translocations and other chromosomal abnormalities in two patients with acute myeloblastic leukemia","volume":"92","author":"Xue","year":"1996","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0450","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0165-4608(95)00184-0","article-title":"Near-tetraploidy in adult acute myelogenous leukemia","volume":"86","author":"Clarke","year":"1996","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0455","first-page":"45","article-title":"Giant neutrophils derived from tetraploid leukemic clone in an acute myeloblastic leukemia: cytofluorometric study","volume":"84","author":"Fujita","year":"1990","journal-title":"Acta Haematol."},{"key":"10.1016\/j.bcp.2026.118157_b0460","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MPH.0b013e3181b794b2","article-title":"Enlarged and prominent nucleus may be indicative of tetraploidy: a laboratory study of a rare near-tetraploidy in a child patient with acute myelogenous leukemia AML-M4","volume":"32","author":"Zhang","year":"2010","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b0465","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cancergencyto.2005.04.012","article-title":"Myeloid\/natural killer cell precursor acute leukemia with tetraploidy","volume":"163","author":"Din\u00e7ol","year":"2005","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0470","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/10428194.2020.1817435","article-title":"The prognostic implications of tetraploidy\/near-tetraploidy in acute myeloid leukemia: a case series and systematic review of the literature","volume":"62","author":"Xie","year":"2021","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bcp.2026.118157_b0475","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-0609.2011.01630.x","article-title":"AML associated with extensive erythrophagocytosis and tetraploidy","volume":"87","author":"Sharma","year":"2011","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.bcp.2026.118157_b0480","first-page":"124","article-title":"Successful treatment with reduced-intensity cord blood transplantation for acute myeloid leukemia with complete tetraploidy (92, XXXX)","volume":"52","author":"Iwasaki","year":"2011","journal-title":"Rinsho Ketsueki"},{"key":"10.1016\/j.bcp.2026.118157_b0485","first-page":"159","article-title":"Flow cytometric characterization of phenotype, DNA indices and p53 gene expression in 55 cases of acute leukemia","volume":"24","author":"Powari","year":"2002","journal-title":"Anal. Quant. Cytol. Histol."},{"key":"10.1016\/j.bcp.2026.118157_b0490","first-page":"233","article-title":"Cytogenetic examination of children with acute leukemia","volume":"22","author":"Ochocka","year":"1991","journal-title":"Acta Haematol. Pol."},{"key":"10.1016\/j.bcp.2026.118157_b0495","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1365-2141.1989.tb07681.x","article-title":"Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down\u2019s syndrome patient with acute megakaryoblastic leukaemia","volume":"72","author":"Sato","year":"1989","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcp.2026.118157_b0500","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0165-4608(88)90028-3","article-title":"Tetraploidy and Y chromosome loss in acute mixed-lineage leukemia","volume":"33","author":"Harth","year":"1988","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0505","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/j.leukres.2011.01.028","article-title":"Acute promyelocytic leukemia with tetraploid karyotype: first report in the Western hemisphere and update of previous reports","volume":"35","author":"Ravella","year":"2011","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcp.2026.118157_b0510","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/PAT.0b013e32835c772c","article-title":"Tetraploidy with double t(15;17)(q22;q21) in acute promyelocytic leukaemia","volume":"45","author":"Mohamed","year":"2013","journal-title":"Pathology"},{"key":"10.1016\/j.bcp.2026.118157_b0515","first-page":"127","article-title":"Tetraploid\/near-tetraploid acute promyelocytic leukaemia with double (15;17) translocation","volume":"42","author":"Tay Za","year":"2020","journal-title":"Malays. J. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0520","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1532\/IJH97.04104","article-title":"CD2+ tetraploid acute promyelocytic leukemia variant with double (15;17) translocations","volume":"81","author":"Kaito","year":"2005","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b0525","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1182\/blood.V70.4.1151.1151","article-title":"HL-T, a new cell line derived from HL-60 promyelocytic leukemia cell cultures expressing terminal transferase and secreting suppressor activity","volume":"70","author":"Paietta","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2026.118157_b0530","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cancergencyto.2010.01.018","article-title":"Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation","volume":"199","author":"Oshikawa","year":"2010","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0535","doi-asserted-by":"crossref","unstructured":"J.P. Meza Espinoza, V. Judith Picos C\u00e1rdenas, M. Guti\u00e9rrez-Angulo, J.R. Gonz\u00e1lez Garc\u00eda, Secondary chromosomal changes in 34 Philadelphia-chromosome-positive chronic myelocytic leukemia patients from the Mexican West, Cancer Genet Cytogenet 148 (2004) 166\u2013169. https:\/\/doi.org\/10.1016\/s0165-4608(03)00283-8.","DOI":"10.1016\/S0165-4608(03)00283-8"},{"key":"10.1016\/j.bcp.2026.118157_b0540","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1182\/blood.V76.3.578.578","article-title":"Establishment and characterization of a granulocyte-macrophage colony-stimulating factor-dependent human myeloid cell line","volume":"76","author":"Oez","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2026.118157_b0545","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-4608(90)90241-2","article-title":"Cytogenetic features of erythroleukemia (EL). a study of 11 cases","volume":"50","author":"Kadam","year":"1990","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0550","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1158\/1078-0432.CCR-05-2135","article-title":"Diffuse large B-cell lymphoma with overexpression of cyclin e substantiates poor standard treatment response and inferior outcome","volume":"12","author":"Tzankov","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.118157_b0555","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-4608(99)00102-8","article-title":"Chromosomal doubling: the significance of polyploidization in the development of human tumors: possibly relevant findings on a lymphoma","volume":"116","author":"Atkin","year":"2000","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0560","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0030-4220(93)90298-I","article-title":"Intraoral presentation of anaplastic large-cell Ki-1 lymphoma in association with HIV infection","volume":"76","author":"Hicks","year":"1993","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0565","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/modpathol.2010.63","article-title":"Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCR","volume":"23","author":"Rizzo","year":"2010","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0570","first-page":"627","article-title":"Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma, Trends","volume":"6","author":"Mahadevan","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0575","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/dc.10298","article-title":"Flow cytometric S-phase fraction as a complementary biological parameter for the cytological grading of non-Hodgkin\u2019s lymphoma","volume":"29","author":"Pinto","year":"2003","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.bcp.2026.118157_b0580","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jclinpath-2020-206573","article-title":"Cytogenetic complexity and heterogeneity in intravascular lymphoma","volume":"74","author":"Fujikura","year":"2021","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0585","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1046\/j.1365-2141.2003.04221.x","article-title":"A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differences","volume":"120","author":"Nilsson","year":"2003","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bcp.2026.118157_b0590","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/gcc.2870070305","article-title":"Use of fluorescence in situ hybridization for retrospective detection of aneuploidy in multiple myeloma","volume":"7","author":"Lee","year":"1993","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0595","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1182\/blood-2003-02-0493","article-title":"The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma","volume":"102","author":"Fonseca","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2026.118157_b0600","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/gcc.22895","article-title":"Poorly differentiated chordoma with whole-genome doubling evolving from a SMARCB1-deficient conventional chordoma: a case report","volume":"60","author":"Curcio","year":"2021","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0605","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1055\/s-2008-1026887","article-title":"Fluorescence cytophotometric DNA studies of Ewing and osteosarcomas","volume":"198","author":"Frohn","year":"1986","journal-title":"Klin. Padiatr."},{"key":"10.1016\/j.bcp.2026.118157_b0610","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cancergencyto.2007.11.002","article-title":"Complex rearrangement of chromosomes 19, 21, and 22 in Ewing sarcoma involving a novel reciprocal inversion-insertion mechanism of EWS-ERG fusion gene formation: a case analysis and literature review","volume":"181","author":"Maire","year":"2008","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0615","first-page":"56","article-title":"Flow and image cytometric DNA analysis in Ewing\u2019s sarcoma","volume":"5","author":"Kowal-Vern","year":"1992","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0620","first-page":"1047","article-title":"Cytogenetics in pediatric solid tumors","volume":"38","author":"Kaneko","year":"1990","journal-title":"Rinsho Byori"},{"key":"10.1016\/j.bcp.2026.118157_b0625","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/dc.1050","article-title":"Role of immunocytochemistry and DNA flow cytometry in the fine-needle aspiration diagnosis of malignant small round-cell tumors","volume":"24","author":"Brahmi","year":"2001","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.bcp.2026.118157_b0630","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00000421-199904000-00009","article-title":"Low-grade fibromyxoid sarcoma: clinicopathologic case report with review of the literature","volume":"22","author":"Shidham","year":"1999","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b0635","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/01.MP.0000083648.45923.2B","article-title":"Loss of 13q14-q21 and gain of 5p14-pter in the progression of leiomyosarcoma","volume":"16","author":"Wang","year":"2003","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0640","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0025-6196(12)61904-1","article-title":"Leiomyosarcomas and benign smooth muscle tumors of the stomach: nuclear DNA patterns studied by flow cytometry","volume":"62","author":"Tsushima","year":"1987","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.bcp.2026.118157_b0645","first-page":"169","article-title":"Flow cytometric studies of human osteosarcoma","author":"Mankin","year":"1991","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bcp.2026.118157_b0650","first-page":"96","article-title":"Ploidy and morphology in osteosarcoma","volume":"11","author":"Bauer","year":"1989","journal-title":"Anal. Quant. Cytol. Histol."},{"key":"10.1016\/j.bcp.2026.118157_b0655","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0165-4608(96)00306-8","article-title":"Cytogenetic findings in 73 osteosarcoma specimens and a review of the literature","volume":"95","author":"Bridge","year":"1997","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0660","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/ijc.2910550109","article-title":"Cytogenetic findings in 33 osteosarcomas","volume":"55","author":"Mertens","year":"1993","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0665","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.3390\/molecules23092121","article-title":"JNK Inactivation Induces Polyploidy and Drug-Resistance in Coronarin D-Treated Osteosarcoma Cells","volume":"23","author":"Hsu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2026.118157_b0670","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/1097-0142(19941015)74:8<2268::AID-CNCR2820740810>3.0.CO;2-5","article-title":"Cytogenetic findings in 19 malignant bone tumors","volume":"74","author":"Ozisik","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0675","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10616-012-9487-5","article-title":"Establishment and cytogenetic characterization of a cell line from a pulmonary metastasis of osteosarcoma","volume":"65","author":"Salinas-Souza","year":"2013","journal-title":"Cytotechnology"},{"key":"10.1016\/j.bcp.2026.118157_b0680","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/j.1582-4934.2008.00362.x","article-title":"U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint","volume":"13","author":"Carrassa","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2026.118157_b0685","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3109\/15513819009064703","article-title":"Comparison of chromosome analysis to DNA content by flow cytometry for pediatric tumors","volume":"10","author":"Sheng","year":"1990","journal-title":"Pediatr. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0690","first-page":"189","article-title":"Cytogenetic changes in low grade central osteosarcomas","volume":"82","author":"Werner","year":"1998","journal-title":"Verh. Dtsch. Ges. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0695","first-page":"57","article-title":"DNA-RNA cytofluorometric analysis of a case of osteosarcoma in relation to histological characteristics","volume":"31","author":"Takeshita","year":"1985","journal-title":"Gan No Rinsho"},{"key":"10.1016\/j.bcp.2026.118157_b0700","first-page":"374","article-title":"Two cases of orbital embryonal rhabdomyosarcoma with chromosome aberration","volume":"114","author":"Tsuchisaka","year":"2010","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"10.1016\/j.bcp.2026.118157_b0705","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1593\/neo.05829","article-title":"Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors","volume":"8","author":"Goldstein","year":"2006","journal-title":"Neoplasia"},{"key":"10.1016\/j.bcp.2026.118157_b0710","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1200\/JCO.1991.9.1.159","article-title":"Relationship of tumor-cell ploidy to histologic subtype and treatment outcome in children and adolescents with unresectable rhabdomyosarcoma","volume":"9","author":"Shapiro","year":"1991","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b0715","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/gcc.2870110402","article-title":"Chromosome analysis of brain tumors in childhood","volume":"11","author":"Fujii","year":"1994","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0720","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/gcc.2870030204","article-title":"Interphase cytogenetics of brain tumors","volume":"3","author":"Arnoldus","year":"1991","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0725","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/B:NEON.0000013493.31107.20","article-title":"Inverse correlation between genetic aberrations and malignancy grade in ependymal tumors: a paradox?","volume":"66","author":"Gilhuis","year":"2004","journal-title":"J. Neurooncol"},{"key":"10.1016\/j.bcp.2026.118157_b0730","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/00005072-199709000-00005","article-title":"Detection of p16 gene deletions in gliomas: a comparison of fluorescence in situ hybridization (FISH) versus quantitative PCR","volume":"56","author":"Perry","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bcp.2026.118157_b0735","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0165-4608(95)00092-5","article-title":"Cytogenetics of malignant gliomas. II. the sex chromosomes with reference to X isodisomy and the role of numerical X\/Y changes","volume":"84","author":"Hecht","year":"1995","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0740","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bbrc.2006.09.148","article-title":"Dominant negative pleiotrophin induces tetraploidy and aneuploidy in U87MG human glioblastoma cells","volume":"351","author":"Chang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.118157_b0745","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00383-009-2446-3","article-title":"Cytogenetic evaluation of neuroblastoma using fine needle aspiration cultures","volume":"25","author":"Moorthy","year":"2009","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.bcp.2026.118157_b0750","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/sj.bjc.6600938","article-title":"Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas","volume":"88","author":"Ikematsu","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0755","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0165-4608(02)00677-5","article-title":"MYCN gain and MYCN amplification in a stage 4S neuroblastoma","volume":"140","author":"Noguera","year":"2003","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0760","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/1096-911X(20010101)36:1<83::AID-MPO1020>3.0.CO;2-9","article-title":"Prognostic significance of DNA di-tetraploidy in neuroblastoma","volume":"36","author":"Ladenstein","year":"2001","journal-title":"Med. Pediatr. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b0765","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/02724939992202","article-title":"Neuroblastoma in southern Africa: epidemiological features, prognostic factors and outcome","volume":"19","author":"Hesseling","year":"1999","journal-title":"Ann. Trop. Paediatr."},{"key":"10.1016\/j.bcp.2026.118157_b0770","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0959-8049(98)00135-X","article-title":"10 years\u2019 neuroblastoma screening in Europe: preliminary results of a clinical and biological review from the Study Group for Evaluation of neuroblastoma Screening in Europe (SENSE)","volume":"34","author":"Erttmann","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0775","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0959-8049(97)00282-7","article-title":"Gain of chromosome arm 17q predicts unfavourable outcome in neuroblastoma patients. U.K. Children\u2019s Cancer Study Group and the U.K. Cancer Cytogenetics Group","volume":"33","author":"Lastowska","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0780","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1055\/s-2008-1046476","article-title":"Value of prognostic factors in the Austrian A-NB87 neuroblastoma Study","volume":"208","author":"Ladenstein","year":"1996","journal-title":"Klin. Padiatr."},{"key":"10.1016\/j.bcp.2026.118157_b0785","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/1097-0142(19950815)76:4<695::AID-CNCR2820760425>3.0.CO;2-O","article-title":"Unfavorable DNA ploidy and Ha-ras p21 findings in neuroblastomas detected through mass screening","volume":"76","author":"Kusafuka","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0790","first-page":"87","article-title":"Flow cytometric DNA analysis of neuroblastoma\u2013clinical significance of DNA tetraploidy","volume":"385","author":"Naito","year":"1994","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.bcp.2026.118157_b0795","first-page":"2763","article-title":"Combined determination of N-myc oncogene amplification and DNA ploidy in neuroblastoma","volume":"72","author":"Muraji","year":"1993","journal-title":"Complementary Prognostic Indicators, Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0800","first-page":"467","article-title":"Establishment of a new cell line, VA-N-BR, from a primitive neuroblastoma tumor of the abdomen","volume":"12","author":"Helson","year":"1992","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bcp.2026.118157_b0805","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-4608(88)90265-8","article-title":"Identical chromosome 1p breakpoint abnormality in both the tumor and the constitutional karyotype of a patient with neuroblastoma","volume":"34","author":"Lampert","year":"1988","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0810","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11060-009-0108-x","article-title":"A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature","volume":"99","author":"Aschero","year":"2010","journal-title":"J. Neurooncol"},{"key":"10.1016\/j.bcp.2026.118157_b0815","first-page":"317","article-title":"DNA evaluation in growth hormone producing pituitary adenomas: flow cytometry versus single cell analysis","volume":"121","author":"Hulting","year":"1989","journal-title":"Acta Endocrinol (copenh)"},{"key":"10.1016\/j.bcp.2026.118157_b0820","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3171\/jns.1991.75.4.0583","article-title":"Symptomatic subependymoma: a clinicopathological and flow cytometric study","volume":"75","author":"Lombardi","year":"1991","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.bcp.2026.118157_b0825","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1290\/0505033.1","article-title":"Establishment of three human breast epithelial cell lines derived from carriers of the 999del5 BRCA2 Icelandic founder mutation","volume":"41","author":"Rubner Fridriksdottir","year":"2005","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.bcp.2026.118157_b0830","first-page":"556","article-title":"DNA ploidy and S-phase fraction by image and flow cytometry in breast cancer fine-needle cytopunctures","volume":"10","author":"Spyratos","year":"1997","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0835","first-page":"321","article-title":"Transplantation of human primary in-situ and invasive breast carcinoma in nude mice","volume":"18","author":"He","year":"1996","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"10.1016\/j.bcp.2026.118157_b0840","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/ajcp\/99.6.708","article-title":"Comparison of nuclear grade and DNA cytometry in breast carcinoma aspirates to histologic grade in excised cancers","volume":"99","author":"Davey","year":"1993","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0845","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF01831474","article-title":"Proliferative activity of breast cancers increases in the course of genetic evolution as defined by cytogenetic analysis","volume":"23","author":"Remvikos","year":"1992","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.bcp.2026.118157_b0850","first-page":"61","article-title":"DNA ploidy, proliferation, and neu-oncogene protein overexpression in breast carcinoma","volume":"5","author":"Lee","year":"1992","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0855","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/ajcp\/95.5.623","article-title":"Carcinomas with metaplasia and sarcomas of the breast","volume":"95","author":"Pitts","year":"1991","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0860","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ijc.2910450108","article-title":"Prognostic significance of DNA-ploidy in a series of 690 primary breast cancer patients","volume":"45","author":"Beerman","year":"1990","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0865","doi-asserted-by":"crossref","first-page":"10170","DOI":"10.1073\/pnas.95.17.10170","article-title":"Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting","volume":"95","author":"Malkhosyan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2026.118157_b0870","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1699-0463.1998.tb01396.x","article-title":"Overexpression of ras is an independent prognostic factor in colorectal adenocarcinoma","volume":"106","author":"Sun","year":"1998","journal-title":"APMIS"},{"key":"10.1016\/j.bcp.2026.118157_b0875","doi-asserted-by":"crossref","unstructured":"C. Galofr\u00e9, \u00d6. G\u00f6n\u00fcl Geyik, E. Asensio, D. Wangsa, D. Hirsch, C. Parra, J. Saez, M. Moll\u00e0, Z. Y\u00fcce, A. Castells, T. Ried, J. Camps, Tetraploidy-Associated Genetic Heterogeneity Confers Chemo-Radiotherapy Resistance to Colorectal Cancer Cells, Cancers (Basel) 12 (2020) 1118. https:\/\/doi.org\/10.3390\/cancers12051118.","DOI":"10.3390\/cancers12051118"},{"key":"10.1016\/j.bcp.2026.118157_b0880","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0165-4608(90)90247-8","article-title":"Correlation between in vitro tetraploidy in skin fibroblasts and development of sporadic colorectal carcinomas","volume":"50","author":"Svendsen","year":"1990","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0885","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1158\/1940-6207.CAPR-10-0108","article-title":"A comprehensive survey of clonal diversity measures in Barrett\u2019s esophagus as biomarkers of progression to esophageal adenocarcinoma","volume":"3","author":"Merlo","year":"2010","journal-title":"Cancer Prev. Res. (Phila.)"},{"key":"10.1016\/j.bcp.2026.118157_b0890","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1158\/0008-5472.CAN-04-1738","article-title":"The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma","volume":"64","author":"Maley","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118157_b0895","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0165-4608(01)00580-5","article-title":"Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines","volume":"135","author":"Hu","year":"2002","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0900","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0002-9394(14)73592-5","article-title":"Deoxyribonucleic acid ploidy studies in choroidal melanomas","volume":"115","author":"Coleman","year":"1993","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.bcp.2026.118157_b0905","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0959-8049(95)00626-5","article-title":"N-MYC amplification, loss of heterozygosity on the short arm of chromosome 1 and DNA ploidy in retinoblastoma","volume":"32A","author":"Doz","year":"1996","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0910","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0165-4608(89)90129-5","article-title":"First cytogenetic evidence of homozygosity for the retinoblastoma deletion in chromosome 13","volume":"43","author":"Lemieux","year":"1989","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0915","first-page":"1951","article-title":"Establishment and characterization of three novel cell lines - P-STS, L-STS, H-STS - derived from a human metastatic midgut carcinoid","volume":"29","author":"Pfragner","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bcp.2026.118157_b0920","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0360-3016(97)00564-6","article-title":"Prognostic significance of cell proliferation markers and DNA-ploidy in head and neck tumors","volume":"40","author":"Struikmans","year":"1998","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.bcp.2026.118157_b0925","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/019459988709600402","article-title":"DNA flow cytometry as a prognostic indicator in head and neck cancer","volume":"96","author":"Goldsmith","year":"1987","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.bcp.2026.118157_b0930","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0165-4608(87)90060-4","article-title":"Evidence for genetic predisposition for some nasopharyngeal cancers by in vitro hyperdiploidy in human dermal fibroblasts","volume":"26","author":"Danes","year":"1987","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0935","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1365-2559.2011.03863.x","article-title":"High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: an international collaborative study","volume":"58","author":"Santos-Silva","year":"2011","journal-title":"Histopathology"},{"key":"10.1016\/j.bcp.2026.118157_b0940","first-page":"191","article-title":"Chromosome abnormalities in squamous cell carcinoma of the human oral cavity","volume":"37","author":"Ravindran","year":"1990","journal-title":"Neoplasma"},{"key":"10.1016\/j.bcp.2026.118157_b0945","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/jpsu.2002.32880","article-title":"Cytogenetic and histologic findings in Wilms\u2019 tumor","volume":"37","author":"Gow","year":"2002","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.bcp.2026.118157_b0950","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/emm.2007.56","article-title":"Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma","volume":"39","author":"Yun","year":"2007","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bcp.2026.118157_b0955","doi-asserted-by":"crossref","unstructured":"A.P. Ferragut Cardoso, A.N. Nail, M. Banerjee, S.S. Wise, J.C. States, miR-186 induces tetraploidy in arsenic exposed human keratinocytes, Ecotoxicol Environ Saf 256 (2023) 114823. https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114823.","DOI":"10.1016\/j.ecoenv.2023.114823"},{"key":"10.1016\/j.bcp.2026.118157_b0960","first-page":"53","article-title":"Aneuploidy and Tetraploidy as Distinct patterns during Melanomagenesis","volume":"29","author":"Escandon","year":"2016","journal-title":"Surg. Technol. Int."},{"key":"10.1016\/j.bcp.2026.118157_b0965","first-page":"707","article-title":"High frequency of tetraploidy detected in malignant melanoma of Japanese patients by fluorescence in situ hybridization","volume":"17","author":"Satoh","year":"2000","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b0970","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0165-4608(87)90112-9","article-title":"Cytogenetics in hereditary malignant melanoma and dysplastic nevus syndrome: is dysplastic nevus syndrome a chromosome instability disorder?","volume":"24","author":"Caporaso","year":"1987","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b0975","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/modpathol.3800627","article-title":"Expression and possible role of hPTTG1\/securin in cutaneous malignant melanoma","volume":"19","author":"Winnepenninckx","year":"2006","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b0980","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/1097-0142(19930401)71:7<2261::AID-CNCR2820710716>3.0.CO;2-T","article-title":"Ovarian carcinoma heterogeneity as demonstrated by DNA ploidy","volume":"71","author":"Zangwill","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0985","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ijc.2910520115","article-title":"Morphological, immunohistochemical and biochemical characterization of 6 newly established human ovarian carcinoma cell lines","volume":"52","author":"M\u00f6bus","year":"1992","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b0990","first-page":"635","article-title":"Genetics and biology of human ovarian teratomas. I. Cytogenetic analysis and mechanism of origin","volume":"47","author":"Surti","year":"1990","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bcp.2026.118157_b0995","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0022-5347(17)44104-8","article-title":"Characterization of a human chorionic gonadotropin-producing testicular choriocarcinoma cell line","volume":"137","author":"Yamazaki","year":"1987","journal-title":"J. Urol."},{"key":"10.1016\/j.bcp.2026.118157_b1000","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.4161\/cbt.7.9.6428","article-title":"Heat shock induces chromosomal instability in near-tetraploid embryonal carcinoma cells","volume":"7","author":"Gupta","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bcp.2026.118157_b1005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/00365529209011164","article-title":"DNA ploidy, S-phase fraction, and G2 fraction as prognostic determinants in human pancreatic cancer","volume":"27","author":"Eskelinen","year":"1992","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bcp.2026.118157_b1010","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00006676-198709000-00015","article-title":"In vitro evidence for genetic predisposition in some human pancreatic adenocarcinoma","volume":"2","author":"Danes","year":"1987","journal-title":"Pancreas"},{"key":"10.1016\/j.bcp.2026.118157_b1015","doi-asserted-by":"crossref","unstructured":"J.T. Chryssochoos, C.J. Weber, C. Cohen, J. Moore, P.B. DeRose, M. Hagler, R. Bray, L. Stempora, M. Mainiero, W.C. McGarity, DNA index and ploidy distinguish normal human parathyroids from parathyroid adenomas and primary hyperplastic parathyroids, Surgery 118 (1995) 1041\u20131049; discussion 1049-1050. https:\/\/doi.org\/10.1016\/s0039-6060(05)80112-6.","DOI":"10.1016\/S0039-6060(05)80112-6"},{"key":"10.1016\/j.bcp.2026.118157_b1020","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1667\/RR3454.1","article-title":"Cell death mechanisms associated with G2 radiosensitivity in patients with prostate cancer and benign prostatic hyperplasia","volume":"164","author":"Howe","year":"2005","journal-title":"Radiat. Res."},{"key":"10.1016\/j.bcp.2026.118157_b1025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.onc.1201554","article-title":"Identification of two distinct deleted regions on chromosome 13 in prostate cancer","volume":"16","author":"Li","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b1030","first-page":"4035","article-title":"Genotypic characterization of prostatic carcinomas: a combined cytogenetic, flow cytometry, and in situ DNA hybridization study","volume":"53","author":"Breitkreuz","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118157_b1035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0022-5347(17)35412-5","article-title":"Use of fluorescent in situ hybridization for deoxyribonucleic acid ploidy analysis of prostatic adenocarcinoma","volume":"150","author":"Persons","year":"1993","journal-title":"J. Urol."},{"key":"10.1016\/j.bcp.2026.118157_b1040","first-page":"348","article-title":"Cytogenetic and ploidy analysis of prostatic adenocarcinoma","volume":"6","author":"Perlman","year":"1993","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1045","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0022-5347(17)37960-0","article-title":"Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1)","volume":"146","author":"Gingrich","year":"1991","journal-title":"J. Urol."},{"key":"10.1016\/j.bcp.2026.118157_b1050","first-page":"4475","article-title":"Allelic imbalance and microsatellite instability in prostatic adenocarcinoma","volume":"56","author":"Cunningham","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118157_b1055","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/0046-8177(94)90119-8","article-title":"Frequency and distribution of numerical chromosomal aberrations in prostatic cancer","volume":"25","author":"Henke","year":"1994","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1060","first-page":"201","article-title":"Flow cytometric DNA content in Kaposi\u2019s sarcoma by histologic stage","volume":"13","author":"Dictor","year":"1991","journal-title":"Comparison with Angiosarcoma, Anal Quant Cytol Histol"},{"key":"10.1016\/j.bcp.2026.118157_b1065","first-page":"416","article-title":"Analysis of nuclear DNA histograms in thymomas","volume":"89","author":"Okada","year":"1988","journal-title":"Nihon Geka Gakkai Zasshi"},{"key":"10.1016\/j.bcp.2026.118157_b1070","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/carcin\/bgi218","article-title":"Tetraploidy and chromosomal instability are early events during cervical carcinogenesis","volume":"27","author":"Olaharski","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2026.118157_b1075","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/em.20418","article-title":"Chromosome aberrations in peripheral blood lymphocytes of high-risk HPV-infected women with HGSIL","volume":"49","author":"Alvarez-Rosero","year":"2008","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.bcp.2026.118157_b1080","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/ijc.2910570121","article-title":"Androgen responsiveness of the new human endometrial cancer cell line MFE-296","volume":"57","author":"Hackenberg","year":"1994","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b1085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bcp.2026.118157_b1090","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.200358","article-title":"Hallmarks of cancer-the new testament","volume":"11","author":"Senga","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1095","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118157_b1100","doi-asserted-by":"crossref","first-page":"10320","DOI":"10.18632\/oncotarget.3583","article-title":"HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity","volume":"6","author":"Valente","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.118157_b1105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.tig.2022.04.005","article-title":"Catastrophic DNA replication in unscheduled tetraploid cells","volume":"38","author":"Manic","year":"2022","journal-title":"Trends Genet."},{"key":"10.1016\/j.bcp.2026.118157_b1110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/gcc.21921","article-title":"Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances","volume":"51","author":"Padilla-Nash","year":"2012","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b1115","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10555-013-9436-6","article-title":"Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos","volume":"32","author":"Potapova","year":"2013","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bcp.2026.118157_b1120","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1038\/s41388-019-0859-6","article-title":"Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumors","volume":"38","author":"Delespaul","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b1125","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13052-018-0541-6","article-title":"ETV6\/RUNX1-positive childhood acute lymphoblastic leukemia in China: excellent prognosis with improved BFM protocol","volume":"44","author":"Wang","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.bcp.2026.118157_b1130","first-page":"5363","article-title":"Tetraploidy acute promyelocytic leuemia with double t(15;17)\/PML-RARA, a case report with review of literature","volume":"7","author":"Dalia","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-4608(03)00035-9","article-title":"Tetraploid acute promyelocytic leukemia with double t(15;17) and PML\/RARA rearrangements detected by fluorescence in situ hybridization analysis","volume":"145","author":"Oh","year":"2003","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b1140","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.oooo.2011.08.011","article-title":"Tetraploidy with double t(11;18) of recurrent MALT lymphoma in buccal mucosa: a case report, Oral Surg Oral Med Oral Pathol","volume":"113","author":"Tanaka","year":"2012","journal-title":"Oral Radiol."},{"key":"10.1016\/j.bcp.2026.118157_b1145","first-page":"510","article-title":"Near-tetraploidy acute myeloid leukemia with RUNX1-RUNX1T1 rearrangement due to cryptic t(8;21)","volume":"29","author":"Im","year":"2009","journal-title":"Korean J. Lab. Med."},{"key":"10.1016\/j.bcp.2026.118157_b1150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/10428194.2011.603447","article-title":"Cytogenetic analysis of acute myeloid leukemia with t(8;21) from a tertiary care center in India with correlation between clinicopathologic characteristics and molecular analysis","volume":"53","author":"Parihar","year":"2012","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bcp.2026.118157_b1155","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF02982067","article-title":"CD7+ near-tetraploid acute myeloblastic leukemia M2 with double t(8;21)(q22;q22) translocations and Aml1\/ETO rearrangements detected by fluorescence in situ hybridization analysis","volume":"74","author":"Yamamoto","year":"2001","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b1160","first-page":"207","article-title":"Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia","volume":"23","author":"Drexler","year":"1999","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcp.2026.118157_b1165","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1530\/ERC-15-0086","article-title":"Copy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors","volume":"22","author":"Nielsen","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b1170","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cancergencyto.2008.01.022","article-title":"Tetraploidy and 5q deletion in myelodysplastic syndrome: a case report","volume":"183","author":"Znoyko","year":"2008","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b1175","doi-asserted-by":"crossref","first-page":"19874","DOI":"10.1038\/srep19874","article-title":"The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1","volume":"6","author":"Gao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118157_b1180","first-page":"167","article-title":"Nuclear DNA content and proliferative potential of human carcinoma in situ cells in testes of intersex children","volume":"39","author":"S\u0142owikowska-Hilczer","year":"2001","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.bcp.2026.118157_b1185","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/0016-5085(93)90958-F","article-title":"DNA mapping of colorectal neoplasms: a flow cytometric study of DNA abnormalities and proliferation","volume":"105","author":"Fischbach","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcp.2026.118157_b1190","first-page":"496","article-title":"Granulosa cell tumor of the ovary","volume":"114","author":"Suh","year":"1990","journal-title":"Histopathologic and Flow Cytometric Analysis with Clinical Correlation, Arch Pathol Lab Med"},{"key":"10.1016\/j.bcp.2026.118157_b1195","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3109\/00365528909093118","article-title":"Association between tumor DNA aneuploidy and in vitro tetraploidy of skin fibroblasts in patients with colorectal neoplasms","volume":"24","author":"Svendsen","year":"1989","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bcp.2026.118157_b1200","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.canlet.2012.11.028","article-title":"MYCN-mediated overexpression of mitotic spindle regulatory genes and loss of p53-p21 function jointly support the survival of tetraploid neuroblastoma cells","volume":"331","author":"Gogolin","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2026.118157_b1205","first-page":"203","article-title":"PAUF\/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt\/\u03b2-catenin pathway","volume":"41","author":"Escudero-Paniagua","year":"2020","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bcp.2026.118157_b1210","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1593\/neo.08356","article-title":"Notch activation is associated with tetraploidy and enhanced chromosomal instability in meningiomas","volume":"10","author":"Baia","year":"2008","journal-title":"Neoplasia"},{"key":"10.1016\/j.bcp.2026.118157_b1215","article-title":"The c-Myc target glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cells","volume":"5","author":"Wu","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118157_b1220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002679","article-title":"Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells","volume":"8","author":"Pampalona","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bcp.2026.118157_b1225","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4161\/cc.23720","article-title":"Immortality of cancers: a consequence of inherent karyotypic variations and selections for autonomy","volume":"12","author":"Duesberg","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2026.118157_b1230","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1038\/sj.onc.1209399","article-title":"Effects of hTERT on metal ion-induced genomic instability","volume":"25","author":"Glaviano","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b1235","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1743-8977-10-63","article-title":"Cell cycle alterations induced by urban PM2.5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved","volume":"10","author":"Longhin","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.bcp.2026.118157_b1240","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/annonc\/mdw612","article-title":"Cyclin D mediates tolerance of genome-doubling in cancers with functional p53","volume":"28","author":"Crockford","year":"2017","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b1245","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.4161\/cc.19944","article-title":"Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells","volume":"11","author":"Wilsker","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2026.118157_b1250","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/onc.2010.440","article-title":"Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy","volume":"30","author":"Tommasi","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b1255","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1038\/sj.onc.1209276","article-title":"Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6","volume":"25","author":"Incassati","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b1260","doi-asserted-by":"crossref","first-page":"28238","DOI":"10.18632\/oncotarget.4958","article-title":"Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress","volume":"6","author":"Dom\u00ednguez","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.118157_b1265","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1038\/onc.2008.77","article-title":"Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy","volume":"27","author":"Finkin","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b1270","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.4161\/cc.21801","article-title":"Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0\/1 phase","volume":"11","author":"Karakaya","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2026.118157_b1275","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/nyas.12072","article-title":"Immunological control of cell cycle aberrations for the avoidance of oncogenesis: the case of tetraploidy","volume":"1284","author":"Senovilla","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bcp.2026.118157_b1280","article-title":"A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response","volume":"e138829","author":"Li","year":"2020","journal-title":"JCI Insight 5"},{"key":"10.1016\/j.bcp.2026.118157_b1285","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/path.5372","article-title":"Interpretation of somatic POLE mutations in endometrial carcinoma","volume":"250","author":"Le\u00f3n-Castillo","year":"2020","journal-title":"J. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1290","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s13577-023-00990-8","article-title":"Tracking circulating PD-L1-positive cells to monitor the outcome of patients with gastric cancer receiving anti-HER2 plus anti-PD-1 therapy","volume":"37","author":"Chong","year":"2024","journal-title":"Hum. Cell"},{"key":"10.1016\/j.bcp.2026.118157_b1295","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1182\/blood.V76.3.590.590","article-title":"Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood","volume":"76","author":"Pui","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.bcp.2026.118157_b1300","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cancergencyto.2003.07.009","article-title":"Secondary near-tetraploidy with double der(15)t(15;17) in acute promyelocytic leukemia in relapse","volume":"149","author":"Morita","year":"2004","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b1305","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04321-3","article-title":"Paradoxical implication of BAX\/BAK in the persistence of tetraploid cells","volume":"12","author":"Deng","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.118157_b1310","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.leukres.2010.01.013","article-title":"Near-tetraploidy clone can evolve from a hyperdiploidy clone and cause resistance to lenalidomide and bortezomib in a multiple myeloma patient","volume":"34","author":"Yuan","year":"2010","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcp.2026.118157_b1315","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.leukres.2011.09.011","article-title":"Bortezomib resistance in a myeloma cell line is associated to PSM\u03b25 overexpression and polyploidy","volume":"36","author":"Balsas","year":"2012","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcp.2026.118157_b1320","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1038\/sj.onc.1207686","article-title":"Make WARTS, not cancer!","volume":"23","author":"Edwards","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b1325","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0165-4608(98)00144-7","article-title":"Jumping translocation of homogeneously staining region and tetraploidy with double minutes in acute myelomonocytic leukemia","volume":"109","author":"Yoshida","year":"1999","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b1330","doi-asserted-by":"crossref","unstructured":"C. Wang, Y. He, X. Fang, D. Zhang, J. Huang, S. Zhao, L. Li, G. Li, METTL1-modulated LSM14A facilitates proliferation and migration in glioblastoma via the stabilization of DDX5, iScience 27 (2024) 110225. https:\/\/doi.org\/10.1016\/j.isci.2024.110225.","DOI":"10.1016\/j.isci.2024.110225"},{"key":"10.1016\/j.bcp.2026.118157_b1335","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.ccell.2025.05.015","article-title":"Senescence in cancer","volume":"43","author":"Colucci","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.118157_b1340","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrc3038","article-title":"Otto Warburg\u2019s contributions to current concepts of cancer metabolism","volume":"11","author":"Koppenol","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b1345","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/1871520616666161031143301","article-title":"The Warburg effect and the Hallmarks of Cancer","volume":"17","author":"Schwartz","year":"2017","journal-title":"Anticancer Agents Med Chem."},{"key":"10.1016\/j.bcp.2026.118157_b1350","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.3390\/ijms13056492","article-title":"The quiescent cellular state is Arf\/p53-dependent and associated with H2AX downregulation and genome stability","volume":"13","author":"Yoshioka","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118157_b1355","first-page":"181","article-title":"Mitochondrial Adaptations underlying Tetraploidization in Human Cancer, Fungal, and yeast Models","volume":"15","author":"Jema\u00e0","year":"2026","journal-title":"Biology (basel)"},{"key":"10.1016\/j.bcp.2026.118157_b1360","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41591-019-0377-7","article-title":"The microbiome, cancer, and cancer therapy","volume":"25","author":"Helmink","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2026.118157_b1365","doi-asserted-by":"crossref","first-page":"13926","DOI":"10.3390\/ijms241813926","article-title":"Tetraploidization increases the Motility and Invasiveness of Cancer Cells","volume":"24","author":"Jema\u00e0","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118157_b1370","doi-asserted-by":"crossref","first-page":"16669","DOI":"10.18632\/oncotarget.14291","article-title":"Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells","volume":"8","author":"Jema\u00e0","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bcp.2026.118157_b1375","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1096\/fj.201700247RR","article-title":"Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit enhanced invasiveness","volume":"32","author":"Wangsa","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2026.118157_b1380","doi-asserted-by":"crossref","first-page":"e1028","DOI":"10.1038\/cddis.2013.535","article-title":"GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis","volume":"5","author":"Pantazi","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.118157_b1385","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1097\/00000478-199912000-00002","article-title":"Clear cell sarcoma of kidney in an adolescent and in young adults: a report of four cases with ultrastructural, immunohistochemical, and DNA flow cytometric analysis","volume":"23","author":"Amin","year":"1999","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1390","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.cell.2026.03.016","article-title":"Targeting angiogenesis: Lessons from 25 years of normalizing tumor vasculature","volume":"189","author":"Subudhi","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118157_b1395","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.leukres.2016.11.016","article-title":"Tetraploidy\/near-tetraploidy acute myeloid leukemia","volume":"53","author":"Huang","year":"2017","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bcp.2026.118157_b1400","first-page":"3311","article-title":"The angiogenic growth factors HGF and VEGF in serum and plasma from neuroblastoma patients","volume":"29","author":"Sk\u00f6ldenberg","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bcp.2026.118157_b1405","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00428-018-2497-8","article-title":"Donor-derived hepatocytes in human hematopoietic cell transplant recipients: evidence of fusion","volume":"474","author":"Myerson","year":"2019","journal-title":"Virchows Arch."},{"key":"10.1016\/j.bcp.2026.118157_b1410","first-page":"512","article-title":"Clinical and biological characteristics in childhood acute myeloid leukemia with 8;21 translocation","volume":"21","author":"He","year":"2004","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"10.1016\/j.bcp.2026.118157_b1415","doi-asserted-by":"crossref","first-page":"367","DOI":"10.6004\/jnccn.2006.0031","article-title":"Barrett\u2019s esophagus and its progression to adenocarcinoma","volume":"4","author":"Maley","year":"2006","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"10.1016\/j.bcp.2026.118157_b1420","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/01635580701586762","article-title":"Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective study","volume":"60","author":"Dong","year":"2008","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b1425","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1158\/1055-9965.EPI-05-0246","article-title":"Genetic mechanisms of TP53 loss of heterozygosity in Barrett\u2019s esophagus: implications for biomarker validation","volume":"15","author":"Wongsurawat","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.bcp.2026.118157_b1430","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S1470-2045(05)70431-9","article-title":"Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett\u2019s oesophagus: a prospective study","volume":"6","author":"Vaughan","year":"2005","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b1435","first-page":"129","article-title":"DNA tetraploidy in Feulgen-stained bladder washings assessed by image cytometry","volume":"17","author":"Kline","year":"1995","journal-title":"Anal. Quant. Cytol. Histol."},{"key":"10.1016\/j.bcp.2026.118157_b1440","first-page":"904","article-title":"A model of DNA aneuploidization and evolution in colorectal cancer","volume":"71","author":"Giaretti","year":"1994","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bcp.2026.118157_b1445","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3109\/00365528809090190","article-title":"Prognostic significance of hereditary predisposition on the outcome of colorectal cancer as expressed by increased in vitro tetraploidy","volume":"23","author":"Svendsen","year":"1988","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bcp.2026.118157_b1450","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/1066896912445923","article-title":"Fluorescence in situ hybridization (FISH) analysis of melanocytic nevi and melanomas: sensitivity, specificity, and lack of association with sentinel node status","volume":"20","author":"Fang","year":"2012","journal-title":"Int. J. Surg. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1455","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/DAD.0000000000000440","article-title":"Clinical follow-up of Atypical Spitzoid Tumors Analyzed by Fluorescence In Situ Hybridization","volume":"38","author":"Egnatios","year":"2016","journal-title":"Am. J. Dermatopathol."},{"key":"10.1016\/j.bcp.2026.118157_b1460","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cancergencyto.2006.11.015","volume":"174","author":"Christensen","year":"2007","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b1465","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3346\/jkms.1996.11.5.402","article-title":"Interphase cytogenetics of non-Hodgkin\u2019s lymphoma using non-fluorescent in situ hybridization in paraffin embedded tissue","volume":"11","author":"Choi","year":"1996","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.bcp.2026.118157_b1470","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00006676-199510000-00001","article-title":"Inactivation of p53 and the development of tetraploidy in the elastase-SV40 T antigen transgenic mouse pancreas","volume":"11","author":"Ramel","year":"1995","journal-title":"Pancreas"},{"key":"10.1016\/j.bcp.2026.118157_b1475","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.jpedsurg.2011.09.005","article-title":"Correlation between the number of segmental chromosome aberrations and the age at diagnosis of diploid neuroblastomas without MYCN amplification","volume":"46","author":"Souzaki","year":"2011","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.bcp.2026.118157_b1480","first-page":"106","article-title":"In vitro tetraploidy in patients with non-hereditary colorectal adenoma and carcinoma","volume":"22","author":"Svendsen","year":"1987","journal-title":"Support for a Genetic Influence on the Pathogenesis of Colorectal Carcinoma, Scand J Gastroenterol"},{"key":"10.1016\/j.bcp.2026.118157_b1485","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4161\/cc.23046","article-title":"Transgenerational cell fate profiling: a method for the graphical presentation of complex cell cycle alterations","volume":"12","author":"Jema\u00e0","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2026.118157_b1490","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/cyto.990080609","article-title":"Hyperdiploidy of cultured dermal fibroblasts from patients with aerodigestive squamous carcinoma","volume":"8","author":"Danes","year":"1987","journal-title":"Cytometry"},{"key":"10.1016\/j.bcp.2026.118157_b1495","first-page":"1348","article-title":"Dysplasia and aneuploidy as markers of malignant degeneration in Barrett\u2019s oesophagus","volume":"35","author":"Menke-Pluymers","year":"1994","journal-title":"The Rotterdam Oesophageal Tumour Study Group, Gut"},{"key":"10.1016\/j.bcp.2026.118157_b1500","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/1097-0142(19950401)75:7<1694::AID-CNCR2820750721>3.0.CO;2-Z","article-title":"Morphologic and molecular cytogenetics in neuroblastoma","volume":"75","author":"Avet-Loiseau","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b1505","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/dc.21831","article-title":"Exclusion of the uniform tetraploid cells significantly improves specificity of the urine FISH assay","volume":"41","author":"Moatamed","year":"2013","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.bcp.2026.118157_b1510","first-page":"243","article-title":"Flow cytometry of transitional cell carcinoma of the urinary bladder: influence of prior local therapy","volume":"4","author":"T\u00eatu","year":"1987","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1515","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/modpathol.3880137","article-title":"Image analysis and flow cytometric DNA studies of benign and malignant body cavity fluids: reappraisal of the role of current methods in the differential diagnosis of reactive versus malignant conditions","volume":"13","author":"Lazcano","year":"2000","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1520","first-page":"363","article-title":"Application of comparative genomic hybridization to hyperdiploid acute lymphoblastic leukemia","volume":"19","author":"Cao","year":"1998","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"10.1016\/j.bcp.2026.118157_b1525","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-61779-182-6_3","article-title":"Cytofluorometric purification of diploid and tetraploid cancer cells","volume":"761","author":"Castedo","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1530","doi-asserted-by":"crossref","unstructured":"N. Gupta, M. Parihar, S. Banerjee, S. Brahma, R. Pawar, A. Rath, S. Shewale, M. Singh, A. Sasikumaran Nair Remani, S. Krishnan, A. Bhatacharyya, A. Das, J. Kumar, S. Bhave, V. Radhakrishnan, R. Nair, M. Chandy, D. Mishra, N. Arora, FxCycleTM Based Ploidy Correlates with Cytogenetic Ploidy in B-Cell Acute Lymphoblastic Leukemia and Is Able to Detect the Aneuploid Minimal Residual Disease Clone, Cytometry B Clin Cytom 96 (2019) 359\u2013367. https:\/\/doi.org\/10.1002\/cyto.b.21765.","DOI":"10.1002\/cyto.b.21765"},{"key":"10.1016\/j.bcp.2026.118157_b1535","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/cncr.20259","article-title":"Elevated levels of tetraploid cervical cells in human papillomavirus-positive Papanicolaou smears diagnosed as atypical squamous cells of undetermined significance","volume":"102","author":"Olaharski","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b1540","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejca.2022.08.013","article-title":"Near-tetraploid T-cell acute lymphoblastic leukaemia in childhood: results of the AIEOP-BFM ALL studies","volume":"175","author":"Ceppi","year":"2022","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118157_b1545","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cancergencyto.2006.04.006","article-title":"Near-triploidy and near-tetraploidy in childhood acute lymphoblastic leukemia: association with B-lineage blast cells carrying the ETV6-RUNX1 fusion, T-lineage immunophenotype, and favorable outcome","volume":"169","author":"Raimondi","year":"2006","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.bcp.2026.118157_b1550","first-page":"601","article-title":"Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA","volume":"96","author":"Secker-Walker","year":"1997","journal-title":"MRC Adult Leukaemia Working Party, Br J Haematol"},{"key":"10.1016\/j.bcp.2026.118157_b1555","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1159\/000217955","article-title":"Flow cytometric nuclear DNA content analysis of renal tumors in children: prognostic significance of nuclear DNA ploidy","volume":"16","author":"Li","year":"1995","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1560","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5507\/bp.2023.046","article-title":"Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia","volume":"169","author":"Jashiashvili","year":"2025","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub."},{"key":"10.1016\/j.bcp.2026.118157_b1565","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.4161\/cc.6.16.4585","article-title":"Mitotic bypass via an occult cell cycle phase following DNA topoisomerase II inhibition in p53 functional human tumor cells","volume":"6","author":"Smith","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2026.118157_b1570","doi-asserted-by":"crossref","first-page":"e1337","DOI":"10.1371\/journal.pone.0001337","article-title":"Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway","volume":"2","author":"Vitale","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118157_b1575","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/01.COC.0000020960.98562.84","article-title":"Translocation (11;15;19): a highly specific chromosome rearrangement associated with poorly differentiated thymic carcinoma in young patients","volume":"26","author":"Toretsky","year":"2003","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b1580","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000471663","article-title":"DNA ploidy, S phase fraction and G2 fraction as prognostic determinants in prostatic adenocarcinoma","volume":"20","author":"Eskelinen","year":"1991","journal-title":"Eur. Urol."},{"key":"10.1016\/j.bcp.2026.118157_b1585","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/s44319-024-00089-7","article-title":"Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors","volume":"25","author":"Aubert","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bcp.2026.118157_b1590","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/excr.2001.5349","article-title":"A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines","volume":"270","author":"Blajeski","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bcp.2026.118157_b1595","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1158\/1535-7163.MCT-10-0095","article-title":"Sensitivity of cancer cells to Plk1 inhibitor GSK461364A is associated with loss of p53 function and chromosome instability","volume":"9","author":"Degenhardt","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bcp.2026.118157_b1600","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1080\/15384101.2015.1021518","article-title":"Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase a","volume":"14","author":"Kobayashi","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bcp.2026.118157_b1605","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13073-018-0520-y","article-title":"NSAID use and somatic exomic mutations in Barrett\u2019s esophagus","volume":"10","author":"Galipeau","year":"2018","journal-title":"Genome Med."},{"key":"10.1016\/j.bcp.2026.118157_b1610","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1073\/pnas.1318440111","article-title":"Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention","volume":"111","author":"Lissa","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2026.118157_b1615","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038612","article-title":"Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett\u2019s esophagus: results from biomarkers and genetic variants","volume":"7","author":"Takata","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118157_b1620","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ebiom.2018.01.017","article-title":"Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization","volume":"28","author":"Yeung","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bcp.2026.118157_b1625","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26031209","article-title":"JNK Inhibition Overcomes Resistance of Metastatic Tetraploid Cancer Cells to Irradiation-Induced Apoptosis","volume":"26","author":"Jema\u00e0","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118157_b1630","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3390\/ijms21041308","article-title":"Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence","volume":"21","author":"Mirzayans","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118157_b1635","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10555-023-10082-6","article-title":"Insights into the role of senescence in tumor dormancy: mechanisms and applications","volume":"42","author":"DeLuca","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bcp.2026.118157_b1640","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.semcancer.2021.10.005","article-title":"The life cycle of polyploid giant cancer cells and dormancy in cancer: Opportunities for novel therapeutic interventions","volume":"81","author":"Liu","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1645","doi-asserted-by":"crossref","first-page":"26756","DOI":"10.1073\/pnas.2011912117","article-title":"Vimentin filaments drive migratory persistence in polyploidal cancer cells","volume":"117","author":"Xuan","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2026.118157_b1650","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-1-0716-3946-7_16","article-title":"Generation of Polyploid Giant Cancer Cells (PGCCs) from Hey Ovarian Cancer Cells and Analysis of Embryonic Properties","volume":"2825","author":"Niu","year":"2024","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1655","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217998","article-title":"Polyploid giant cancer cells: Unveiling a latent axis of resistance and tumor evolution in HER2-targeted therapy","volume":"631","author":"Krishnan","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2026.118157_b1660","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1017588","article-title":"Polyploid giant cancer cells and cancer progression","volume":"10","author":"Zhou","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1665","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2025.104802","article-title":"Polyploid giant cancer cells: underlying mechanisms, signaling pathways, and therapeutic strategies","volume":"213","author":"Temaj","year":"2025","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bcp.2026.118157_b1670","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1410637","article-title":"Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation","volume":"12","author":"Liu","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1675","article-title":"Polyploid giant cancer cells and tumor budding: translation from basic research to clinical application","volume":"15","author":"Huang","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2026.118157_b1680","article-title":"Polyploid giant cancer cells: a novel target in future cancer therapy","volume":"105","author":"Wang","year":"2026","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1685","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.semcancer.2021.03.017","article-title":"Polyploid giant cancer cell characterization: New frontiers in predicting response to chemotherapy in breast cancer","volume":"81","author":"Saini","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bcp.2026.118157_b1690","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bcp.2018.11.004","article-title":"Dormant, quiescent, tolerant and persister cells: four synonyms for the same target in cancer","volume":"162","author":"Vallette","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118157_b1695","doi-asserted-by":"crossref","first-page":"e1567","DOI":"10.1002\/ctm2.1567","article-title":"Dormant cancer cells and polyploid giant cancer cells: the roots of cancer recurrence and metastasis","volume":"14","author":"Jiao","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bcp.2026.118157_b1700","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.3390\/ijms23094922","article-title":"CD44+ and CD133+ Non-Small Cell Lung Cancer Cells exhibit DNA damage Response Pathways and Dormant Polyploid Giant Cancer Cell Enrichment Relating to their p53 Status","volume":"23","author":"Pustovalova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118157_b1705","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/onc.2013.96","article-title":"Generation of cancer stem-like cells through the formation of polyploid giant cancer cells","volume":"33","author":"Zhang","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118157_b1710","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2020.151505","article-title":"Are polyploid giant cancer cells in high grade serous carcinoma of the ovary blastomere-like cancer stem cells?","volume":"46","author":"Salem","year":"2020","journal-title":"Ann. Diagn. Pathol."},{"key":"10.1016\/j.bcp.2026.118157_b1715","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12935-025-04079-0","article-title":"Etiology of polyploid giant cancer cells: a new frontier in cancer biology","volume":"26","author":"Manickasamy","year":"2026","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bcp.2026.118157_b1720","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/1568009618666180703154233","article-title":"Polyploid Giant Cancer Cells (PGCCs): the Evil Roots of Cancer","volume":"19","author":"Chen","year":"2019","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.bcp.2026.118157_b1725","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216843","article-title":"Recent advancement of autophagy in polyploid giant cancer cells and its interconnection with senescence and stemness for therapeutic opportunities","volume":"590","author":"Patra","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2026.118157_b1730","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1475-2867-6-25","article-title":"Stem cells, senescence, neosis and self-renewal in cancer","volume":"6","author":"Rajaraman","year":"2006","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bcp.2026.118157_b1735","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/bs.acr.2020.03.001","article-title":"Giants and monsters: Unexpected characters in the story of cancer recurrence","volume":"148","author":"White-Gilbertson","year":"2020","journal-title":"Adv. Cancer Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226004946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:15:16Z","timestamp":1785071716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226004946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":347,"alternative-id":["S0006295226004946"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118157","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetraploidy in cancer: Diagnostic and therapeutic perspectives","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118157"}}