{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:44:59Z","timestamp":1785883499123,"version":"3.56.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020QH256"],"award-info":[{"award-number":["ZR2020QH256"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005420","name":"Dezhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005420","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118163","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:45:10Z","timestamp":1781307910000},"page":"118163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Targeting neuropilin-1 attenuates 4-hydroxytamoxifen-induced stemness and sensitizes ER\u03b1-re-expressing TNBC to tamoxifen"],"prefix":"10.1016","volume":"251","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-2130","authenticated-orcid":false,"given":"Qinglong","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2026.118163_b0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13058-020-01296-5","article-title":"Triple-negative breast cancer molecular subtyping and treatment progress","volume":"22","author":"Yin","year":"2020","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.bcp.2026.118163_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101312","article-title":"HDAC inhibitors: Targets for tumor therapy, immune modulation and lung diseases","volume":"16","author":"Shanmugam","year":"2022","journal-title":"Transl Oncol"},{"key":"10.1016\/j.bcp.2026.118163_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114193","article-title":"HDAC inhibitors and IBD: Charting new approaches in disease management","volume":"148","author":"Du","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"12","key":"10.1016\/j.bcp.2026.118163_b0020","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1158\/0008-5472.CAN-06-0402","article-title":"Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes","volume":"66","author":"Sharma","year":"2006","journal-title":"Cancer Res"},{"issue":"19","key":"10.1016\/j.bcp.2026.118163_b0025","first-page":"7025","article-title":"Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells","volume":"61","author":"Yang","year":"2001","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.bcp.2026.118163_b0030","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.7150\/thno.38973","article-title":"Sensitizing Triple Negative Breast Cancer to Tamoxifen Chemotherapy via a Redox-Responsive Vorinostat-containing Polymeric Prodrug Nanocarrier","volume":"10","author":"Ma","year":"2020","journal-title":"Theranostics"},{"issue":"58","key":"10.1016\/j.bcp.2026.118163_b0035","first-page":"7597","article-title":"Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas\/BCAR1","volume":"25","author":"Cowell","year":"2006","journal-title":"FAK and Src, via an adhesion-dependent pathway, Oncogene"},{"issue":"9","key":"10.1016\/j.bcp.2026.118163_b0040","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.molonc.2015.05.008","article-title":"Tamoxifen induces a pluripotency signature in breast cancer cells and human tumors","volume":"9","author":"Notas","year":"2015","journal-title":"Mol Oncol"},{"key":"10.1016\/j.bcp.2026.118163_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.563165","article-title":"Continuous Exposure of Breast Cancer Cells to Tamoxifen Upregulates GPER-1 and Increases Cell Proliferation","volume":"11","author":"Molina","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bcp.2026.118163_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2022.101386","article-title":"Acetyl-CoA synthetases ACSS1 and ACSS2 are 4-hydroxytamoxifen responsive factors that promote survival in tamoxifen treated and estrogen deprived cells","volume":"19","author":"Calhoun","year":"2022","journal-title":"Transl Oncol"},{"issue":"21","key":"10.1016\/j.bcp.2026.118163_b0055","doi-asserted-by":"crossref","first-page":"12285","DOI":"10.1111\/jcmm.15591","article-title":"miR-30b Promotes spinal cord sensory function recovery via the Sema3A\/NRP-1\/PlexinA1\/RhoA\/ROCK Pathway","volume":"24","author":"Wang","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.bcp.2026.118163_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107259","article-title":"Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis","volume":"205","author":"Chen","year":"2024","journal-title":"Pharmacol Res"},{"issue":"5","key":"10.1016\/j.bcp.2026.118163_b0065","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1158\/0008-5472.CAN-24-2223","article-title":"SEMA3G-NRP1 Signaling Functions as an Immune Checkpoint That Enables Tumor Immune Evasion by Impairing T-cell Cytotoxicity","volume":"85","author":"Chi","year":"2025","journal-title":"Cancer Res"},{"issue":"14","key":"10.1016\/j.bcp.2026.118163_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14143455","article-title":"Neuropilin-1 as a Potential Biomarker of Prognosis and Invasive-Related Parameters in Liver and Colorectal Cancer: A Systematic Review and Meta-Analysis of Human Studies","volume":"14","author":"Fernandez-Palanca","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.bcp.2026.118163_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/curroncol32040203","article-title":"Neuropilin-1: A Multifaceted Target for Cancer Therapy","volume":"32","author":"Varanasi","year":"2025","journal-title":"Curr Oncol"},{"key":"10.1016\/j.bcp.2026.118163_b0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-1-4615-0119-0_3","article-title":"The role of neuropilin in vascular and tumor biology","volume":"515","author":"Klagsbrun","year":"2002","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.bcp.2026.118163_b0085","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10456-024-09963-3","article-title":"Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions","volume":"28","author":"Pal","year":"2024","journal-title":"Angiogenesis"},{"issue":"4","key":"10.1016\/j.bcp.2026.118163_b0090","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/cncr.11560","article-title":"Expression and regulation of the novel vascular endothelial growth factor receptor neuropilin-1 by epidermal growth factor in human pancreatic carcinoma","volume":"98","author":"Parikh","year":"2003","journal-title":"Cancer"},{"issue":"16","key":"10.1016\/j.bcp.2026.118163_b0095","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1158\/0008-5472.CAN-11-3907","article-title":"Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment","volume":"72","author":"Yaqoob","year":"2012","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.bcp.2026.118163_b0100","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/imm.70072","article-title":"Targeting Neuropilin-1 to Enhance Immunotherapy in Melanoma: Reducing Peripheral Treg-Mediated Immunosuppression and Tumour Progression","volume":"177","author":"Khamaru","year":"2026","journal-title":"Immunology"},{"issue":"21","key":"10.1016\/j.bcp.2026.118163_b0105","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167049","article-title":"The semaphorin 3A\/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-beta signaling","volume":"8","author":"Jeon","year":"2023","journal-title":"JCI Insight"},{"issue":"12","key":"10.1016\/j.bcp.2026.118163_b0110","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.7150\/jca.52851","article-title":"Neuropilin-1 predicts poor prognosis and promotes tumor metastasis through epithelial-mesenchymal transition in gastric cancer","volume":"12","author":"Jin","year":"2021","journal-title":"J Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2026.118163_b0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13058-022-01501-7","article-title":"Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS\/MAPK pathway activation","volume":"24","author":"Tang","year":"2022","journal-title":"Breast Cancer Res"},{"issue":"2","key":"10.1016\/j.bcp.2026.118163_b0120","doi-asserted-by":"crossref","DOI":"10.1093\/jpp\/rgag007","article-title":"4-hydroxytamoxifen enhances stemness through the neuropilin-1\/estrogen-related receptor alpha pathway to enhance breast cancer cell paclitaxel resistance and metastasis","volume":"78","author":"Lv","year":"2026","journal-title":"J Pharm Pharmacol"},{"issue":"12","key":"10.1016\/j.bcp.2026.118163_b0125","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1158\/0008-5472.CAN-21-0184","article-title":"EPHB2 Activates beta-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma","volume":"81","author":"Leung","year":"2021","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.bcp.2026.118163_b0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/14728222.2022.2047178","article-title":"Calpain as a therapeutic target in cancer","volume":"26","author":"Shapovalov","year":"2022","journal-title":"Expert Opin Ther Targets"},{"issue":"5","key":"10.1016\/j.bcp.2026.118163_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2023.130345","article-title":"Functions and distribution of calpain-calpastatin system components in brain during mammal ontogeny","volume":"1867","author":"Kotova","year":"2023","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"5","key":"10.1016\/j.bcp.2026.118163_b0140","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41419-019-1572-7","article-title":"Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis"},{"issue":"27","key":"10.1016\/j.bcp.2026.118163_b0145","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1038\/s41388-022-02367-x","article-title":"Identification of a novel Calpain-2-SRC feed-back loop as necessity for beta-Catenin accumulation and signaling activation in hepatocellular carcinoma","volume":"41","author":"Ma","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.bcp.2026.118163_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115577","article-title":"Enhanced binding of beta-catenin and beta-TrCP mediates LMPt's anti-CSCs activity in colorectal cancer","volume":"212","author":"Wang","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bcp.2026.118163_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107377","article-title":"Inhibition of extracellular signal-regulated kinase\/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest","volume":"93","author":"Wang","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bcp.2026.118163_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112466","article-title":"Dose-dependent effects of Hedyotis diffusa extract on the pharmacokinetics of tamoxifen, 4-hydroxytamoxifen, and N-desmethyltamoxifen","volume":"145","author":"Cheng","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"10.1016\/j.bcp.2026.118163_b0165","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1038\/s41467-023-38097-1","article-title":"KK-LC-1 as a therapeutic target to eliminate ALDH(+) stem cells in triple negative breast cancer","volume":"14","author":"Bu","year":"2023","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.bcp.2026.118163_b0170","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/his.14129","article-title":"The prognostic significance of ALDH1A1 expression in early invasive breast cancer","volume":"77","author":"Althobiti","year":"2020","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/j.bcp.2026.118163_b0175","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/cr.2018.15","article-title":"Tamoxifen enhances stemness and promotes metastasis of ERalpha36(+) breast cancer by upregulating ALDH1A1 in cancer cells","volume":"28","author":"Wang","year":"2018","journal-title":"Cell Res"},{"key":"10.1016\/j.bcp.2026.118163_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114619","article-title":"Plasma endoxifen and 4-hydroxytamoxifen levels in CYP2D6(C100T) carrying breast cancer patients and association with serum cholesterol","volume":"378","author":"Chao","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"issue":"Suppl 1","key":"10.1016\/j.bcp.2026.118163_b0185","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40360-019-0358-y","article-title":"Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients","volume":"20","author":"Ximenez","year":"2019","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.bcp.2026.118163_b0190","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.canlet.2021.10.034","article-title":"Wnt signaling pathway in cancer immunotherapy","volume":"525","author":"Zhou","year":"2022","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.bcp.2026.118163_b0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/beta-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"18","key":"10.1016\/j.bcp.2026.118163_b0200","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1038\/onc.2014.178","article-title":"beta-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids","volume":"34","author":"Condello","year":"2015","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.bcp.2026.118163_b0205","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s12272-020-01281-8","article-title":"Ubiquitin-proteasome system (UPS) as a target for anticancer treatment","volume":"43","author":"Park","year":"2020","journal-title":"Arch Pharm Res"},{"issue":"3","key":"10.1016\/j.bcp.2026.118163_b0210","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.apsb.2025.01.010","article-title":"The ubiquitin-proteasome system: A potential target for the MASLD","volume":"15","author":"Liu","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bcp.2026.118163_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123377","article-title":"Biological functions and molecular interactions of Wnt\/beta-catenin in breast cancer: Revisiting signaling networks","volume":"232","author":"Hashemi","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.bcp.2026.118163_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2022.116920","article-title":"Targeting the interaction of beta-catenin and TCF\/LEF transcription factors to inhibit oncogenic Wnt signaling","volume":"70","author":"Koelman","year":"2022","journal-title":"Bioorg Med Chem"},{"issue":"6","key":"10.1016\/j.bcp.2026.118163_b0225","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12709","article-title":"SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3beta\/beta\u2011catenin\/TCF\/LEF signaling pathway","volume":"25","author":"Cai","year":"2022","journal-title":"Mol Med Rep"},{"issue":"2","key":"10.1016\/j.bcp.2026.118163_b0230","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12588","article-title":"MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated beta-catenin signaling repression","volume":"67","author":"Liu","year":"2019","journal-title":"J Pineal Res"},{"issue":"3","key":"10.1016\/j.bcp.2026.118163_b0235","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/brv.12686","article-title":"Calpain-calpastatin system and cancer progression","volume":"96","author":"Nian","year":"2021","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"12","key":"10.1016\/j.bcp.2026.118163_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122698","article-title":"Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118163_b0245","doi-asserted-by":"crossref","unstructured":"V. Te Boekhorst, L. Jiang, M. Mahlen, M. Meerlo, G. Dunkel, F.C. Durst, Y. Yang, H. Levine, B.M.T. Burgering, P. Friedl, Calpain-2 regulates hypoxia\/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis, Curr Biol 32 (2) (2022) 412-427 e418, http:\/\/doi.org\/10.1016\/j.cub.2021.11.040.","DOI":"10.1016\/j.cub.2021.11.040"},{"issue":"9","key":"10.1016\/j.bcp.2026.118163_b0250","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/pros.23512","article-title":"Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-kappaB\/DNMT1 signaling pathway","volume":"78","author":"Gao","year":"2018","journal-title":"Prostate"},{"issue":"9","key":"10.1016\/j.bcp.2026.118163_b0255","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1093\/annonc\/mds176","article-title":"Calpain system protein expression in basal-like and triple-negative invasive breast cancer","volume":"23","author":"Storr","year":"2012","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.bcp.2026.118163_b0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0298184","article-title":"17beta-Estradiol promotes metastasis in triple-negative breast cancer through the Calpain\/YAP\/beta-catenin signaling axis","volume":"19","author":"Niu","year":"2024","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bcp.2026.118163_b0265","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s12035-018-1135-4","article-title":"The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-gamma1\/PKC\/ERK Signaling and Microglial Polarization","volume":"56","author":"Mohanraj","year":"2019","journal-title":"Mol Neurobiol"},{"issue":"6","key":"10.1016\/j.bcp.2026.118163_b0270","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.micpath.2011.02.007","article-title":"Involvement of Ca(2)+ signaling in intracellular invasion of non-phagocytic host cells by Orientia tsutsugamushi","volume":"50","author":"Ko","year":"2011","journal-title":"Microb Pathog"},{"key":"10.1016\/j.bcp.2026.118163_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175290","article-title":"Inhibition of neuropilin-1 enhances the therapeutic effects of lenvatinib in suppressing cholangiocarcinoma cells via the c-Met pathway","volume":"935","author":"Zheng","year":"2022","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"10.1016\/j.bcp.2026.118163_b0280","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1039\/D4TB02222J","article-title":"Co-delivery of dasatinib and miR-30a by liposomes targeting neuropilin-1 receptors for triple-negative breast cancer therapy","volume":"13","author":"Soghrati","year":"2025","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.bcp.2026.118163_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117183","article-title":"Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the NRP1-ZFX axis","volume":"241","author":"Zhai","year":"2025","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"10.1016\/j.bcp.2026.118163_b0290","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1097\/HEP.0000000000000320","article-title":"Targeting neuropilin-1 abolishes anti-PD-1-upregulated regulatory T cells and synergizes with 4-1BB agonist for liver cancer treatment","volume":"78","author":"Wu","year":"2023","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.bcp.2026.118163_b0295","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s10549-011-1901-8","article-title":"GPER mediates the Egr-1 expression induced by 17beta-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells","volume":"133","author":"Vivacqua","year":"2012","journal-title":"Breast Cancer Res Treat"},{"issue":"26","key":"10.1016\/j.bcp.2026.118163_b0300","doi-asserted-by":"crossref","first-page":"9908","DOI":"10.1073\/pnas.0510596103","article-title":"A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta","volume":"103","author":"Wang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226005009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226005009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:53:56Z","timestamp":1785880436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226005009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":60,"alternative-id":["S0006295226005009"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118163","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting neuropilin-1 attenuates 4-hydroxytamoxifen-induced stemness and sensitizes ER\u03b1-re-expressing TNBC to tamoxifen","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118163","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118163"}}