{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:00:41Z","timestamp":1785074441635,"version":"3.55.0"},"reference-count":131,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital of Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118170","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:10:42Z","timestamp":1781651442000},"page":"118170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease"],"prefix":"10.1016","volume":"251","author":[{"given":"Lin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-cheng","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3279-2788","authenticated-orcid":false,"given":"Jiang-nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bcp.2026.118170_b0005","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2023.02.012","article-title":"Determinants and outcomes of mitochondrial dynamics","volume":"83","author":"Quintana-Cabrera","year":"2023","journal-title":"Mol. Cell"},{"issue":"25","key":"10.1016\/j.bcp.2026.118170_b0010","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1016\/j.cell.2025.11.002","article-title":"Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis","volume":"188","author":"Wang","year":"2025","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bcp.2026.118170_b0015","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010008","article-title":"Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma","volume":"12","author":"Zhang","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"25","key":"10.1016\/j.bcp.2026.118170_b0020","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1093\/eurheartj\/ehaf130","article-title":"SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis","volume":"46","author":"Tu","year":"2025","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/med.21929","article-title":"Mitochondrial quality control proteases and their modulation for cancer therapy","volume":"43","author":"Zhang","year":"2023","journal-title":"Med. Res. Rev."},{"issue":"6701","key":"10.1016\/j.bcp.2026.118170_b0030","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk5382","article-title":"Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction","volume":"384","author":"Liu","year":"2024","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bcp.2026.118170_b0035","doi-asserted-by":"crossref","unstructured":"K. Zhao, X. Huang, W. Zhao, B. Lu, Z. Yang, LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development, Development (Cambridge, England) 149(6) (2022).","DOI":"10.1242\/dev.200458"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0040","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s41467-022-28557-5","article-title":"Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength","volume":"13","author":"Xu","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2026.118170_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101134","article-title":"Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation","volume":"297","author":"Pollecker","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bcp.2026.118170_b0050","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1080\/15548627.2025.2472586","article-title":"Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion","volume":"21","author":"Fogo","year":"2025","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.bcp.2026.118170_b0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10048-020-00609-2","article-title":"Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease","volume":"21","author":"Key","year":"2020","journal-title":"Neurogenetics"},{"issue":"3","key":"10.1016\/j.bcp.2026.118170_b0060","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/2211-5463.13108","article-title":"NEK5 interacts with LonP1 and its kinase activity is essential for the regulation of mitochondrial functions and mtDNA maintenance","volume":"11","author":"Ferezin","year":"2021","journal-title":"FEBS Open Bio"},{"issue":"43","key":"10.1016\/j.bcp.2026.118170_b0065","doi-asserted-by":"crossref","first-page":"18410","DOI":"10.1073\/pnas.1008924107","article-title":"Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor a (TFAM)","volume":"107","author":"Matsushima","year":"2010","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.bcp.2026.118170_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.111264","article-title":"Molecular mechanisms of mitochondrial AAA+ proteases","volume":"302","author":"Currie","year":"2026","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0075","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/hmg\/ddy351","article-title":"Bi-allelic mutations of LONP1 encoding the mitochondrial LonP1 protease cause pyruvate dehydrogenase deficiency and profound neurodegeneration with progressive cerebellar atrophy","volume":"28","author":"Nimmo","year":"2019","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0080","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202216581","article-title":"LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease","volume":"15","author":"Bai","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bcp.2026.118170_b0085","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.canlet.2020.01.019","article-title":"Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis","volume":"474","author":"Kuo","year":"2020","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.bcp.2026.118170_b0090","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.molcel.2025.01.006","article-title":"The mitochondrial DNAJC co-chaperone TCAIM reduces \u03b1-ketoglutarate dehydrogenase protein levels to regulate metabolism","volume":"85","author":"Jiahui","year":"2025","journal-title":"Mol. Cell"},{"issue":"42","key":"10.1016\/j.bcp.2026.118170_b0095","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2415153122","article-title":"Substrate-dependent activation of LONP1 informs on proteolytic regulation and ATPase motor function","volume":"122","author":"Mindrebo","year":"2025","journal-title":"PNAS"},{"key":"10.1016\/j.bcp.2026.118170_b0100","doi-asserted-by":"crossref","unstructured":"I. Mohammed, K.A. Schmitz, N. Schenck, D. Balasopoulos, A. Topitsch, T. Maier, J.P. Abrahams, Catalytic cycling of human mitochondrial Lon protease, Structure (London, England : 1993) 30(9) (2022) 1254-1268.e7.","DOI":"10.1016\/j.str.2022.06.006"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0105","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1038\/s41467-021-23495-0","article-title":"Structures of the human LONP1 protease reveal regulatory steps involved in protease activation","volume":"12","author":"Shin","year":"2021","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.bcp.2026.118170_b0110","doi-asserted-by":"crossref","first-page":"7128","DOI":"10.1111\/febs.15964","article-title":"Mitochondrial matrix proteases: quality control and beyond","volume":"289","author":"Szczepanowska","year":"2022","journal-title":"FEBS J."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118170_b0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/14728222.2023.2298358","article-title":"Powering down the mitochondrial LonP1 protease: a novel strategy for anticancer therapeutics","volume":"28","author":"Shetty","year":"2024","journal-title":"Expert Opin. Ther. Targets"},{"issue":"5","key":"10.1016\/j.bcp.2026.118170_b0120","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/pro.376","article-title":"Structure of the catalytic domain of the human mitochondrial Lon protease: proposed relation of oligomer formation and activity","volume":"19","author":"Garc\u00eda-Nafr\u00eda","year":"2010","journal-title":"Protein Sci."},{"issue":"23","key":"10.1016\/j.bcp.2026.118170_b0125","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233940","article-title":"Differential Expression of Lonp1 Isoforms in Cancer Cells","volume":"11","author":"Zanini","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0130","doi-asserted-by":"crossref","first-page":"10877","DOI":"10.1038\/s41598-022-14860-0","article-title":"Evidence for mitochondrial Lonp1 expression in the nucleus","volume":"12","author":"Gibellini","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118170_b0135","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fonc.2018.00254","article-title":"LonP1 differently modulates mitochondrial function and bioenergetics of primary versus metastatic colon cancer cells","volume":"8","author":"Gibellini","year":"2018","journal-title":"Front. Oncol."},{"issue":"43","key":"10.1016\/j.bcp.2026.118170_b0140","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1038\/s41388-019-0939-7","article-title":"Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits","volume":"38","author":"Ghosh","year":"2019","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0145","article-title":"Mitochondrial kinases and the role of mitochondrial protein phosphorylation in health and disease","volume":"11","author":"Kotrasov\u00e1","year":"2021","journal-title":"Life (Basel Switzerland)"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12967-023-03925-x","article-title":"Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination","volume":"21","author":"Wu","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0155","doi-asserted-by":"crossref","first-page":"40887","DOI":"10.1038\/s41598-025-24766-2","article-title":"Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging","volume":"15","author":"Llanquinao-Sandoval","year":"2025","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.bcp.2026.118170_b0160","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1159\/000547549","article-title":"Mechanisms of SIRT3 regulation of aging and aging-related diseases and advances in drug therapy","volume":"71","author":"Yang","year":"2025","journal-title":"Gerontology"},{"issue":"5","key":"10.1016\/j.bcp.2026.118170_b0165","doi-asserted-by":"crossref","first-page":"e396","DOI":"10.1002\/mco2.396","article-title":"Down-regulation of Lon protease 1 lysine crotonylation aggravates mitochondrial dysfunction in polycystic ovary syndrome","volume":"4","author":"Xie","year":"2023","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0170","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s13048-025-01837-6","article-title":"Single-cell transcriptomics uncovering a critical AKT-LONP1-STAR axis in ovarian hyperandrogenism of PCOS","volume":"18","author":"Zhang","year":"2025","journal-title":"J. Ovarian Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.118170_b0175","article-title":"The Role of Lonp1 on Mitochondrial Functions during Cardiovascular and Muscular Diseases","volume":"12","author":"Zanini","year":"2023","journal-title":"Antioxidants (Basel Switzerland)"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0180","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s42003-021-02498-z","article-title":"Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix","volume":"4","author":"Matsushima","year":"2021","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0185","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf1390","article-title":"Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number","volume":"54","author":"Schrott","year":"2026","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0200","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1074\/jbc.M116.754127","article-title":"Regulation of pyruvate dehydrogenase kinase 4 in the heart through degradation by the lon protease in response to mitochondrial substrate availability","volume":"292","author":"Crewe","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bcp.2026.118170_b0205","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11121876","article-title":"HMGCS2 mediates ketone production and regulates the proliferation and metastasis of hepatocellular carcinoma","volume":"11","author":"Wang","year":"2019","journal-title":"Cancers"},{"issue":"9","key":"10.1016\/j.bcp.2026.118170_b0210","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ncb836","article-title":"Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism","volume":"4","author":"Bota","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118170_b0215","doi-asserted-by":"crossref","unstructured":"Y. Zhong, L. Wu, Z. Peng, W. Mao, T. Wang, B. Wu, Z. Yu, X. Li, E. Chen, LONP1 Promotes Hepatocarcinogenesis by Degrading ACO2 to Alleviate Ferroptosis, Frontiers in bioscience (Landmark edition) 30(8) (2025) 41226.","DOI":"10.31083\/FBL41226"},{"issue":"24","key":"10.1016\/j.bcp.2026.118170_b0220","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1007\/s00018-015-2039-3","article-title":"Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer","volume":"72","author":"Pinti","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.bcp.2026.118170_b0225","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1210\/me.2005-0458","article-title":"Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors","volume":"21","author":"Granot","year":"2007","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0230","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11033-025-10500-8","article-title":"The mitochondrial LONP1 protease: molecular targets and role in pathophysiology","volume":"52","author":"Tang","year":"2025","journal-title":"Mol. Biol. Rep."},{"issue":"7","key":"10.1016\/j.bcp.2026.118170_b0235","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.devcel.2024.12.011","article-title":"HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis","volume":"60","author":"Peng","year":"2025","journal-title":"Dev. Cell"},{"issue":"8","key":"10.1016\/j.bcp.2026.118170_b0240","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/s42255-025-01333-7","article-title":"LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes","volume":"7","author":"Li","year":"2025","journal-title":"Nat. Metabol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0245","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41389-021-00306-1","article-title":"LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival","volume":"10","author":"Lee","year":"2021","journal-title":"Oncogenesis"},{"issue":"18","key":"10.1016\/j.bcp.2026.118170_b0250","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25189950","article-title":"Mitochondrial aconitase and its contribution to the pathogenesis of neurodegenerative diseases","volume":"25","author":"Padalko","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0255","doi-asserted-by":"crossref","first-page":"42957","DOI":"10.1038\/s41598-025-25560-w","article-title":"Critical role of mitochondrial aconitase in skeletal muscle maturation","volume":"15","author":"Fukawa","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118170_b0260","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuro.2024.11.001","article-title":"ATF5-mediated mitochondrial unfolded protein response protects against Pb-induced mitochondria damage in SH-SY5Y cell","volume":"105","author":"Xu","year":"2024","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0265","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41467-024-44808-z","article-title":"NAD(+) dependent UPR(mt) activation underlies intestinal aging caused by mitochondrial DNA mutations","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0270","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13045-024-01615-9","article-title":"Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis","volume":"17","author":"Liu","year":"2024","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0275","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molcel.2012.10.023","article-title":"Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease","volume":"49","author":"Lu","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2026.118170_b0280","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/bs.ircmb.2024.01.006","article-title":"Mitochondria driven innate immune signaling and inflammation in cancer growth, immune evasion, and therapeutic resistance","volume":"386","author":"Pandey","year":"2024","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"21","key":"10.1016\/j.bcp.2026.118170_b0285","doi-asserted-by":"crossref","first-page":"11813","DOI":"10.1093\/nar\/gkad849","article-title":"Two mitochondrial HMG-box proteins, Cim1 and Abf2, antagonistically regulate mtDNA copy number in Saccharomyces cerevisiae","volume":"51","author":"Schrott","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0290","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.apsb.2021.05.011","article-title":"The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy","volume":"12","author":"Oduro","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"6378","key":"10.1016\/j.bcp.2026.118170_b0295","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science (New York, N.Y.)"},{"issue":"3","key":"10.1016\/j.bcp.2026.118170_b0300","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s12276-023-00965-7","article-title":"Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bcp.2026.118170_b0305","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-biochem-032620-104401","article-title":"Mitochondrial DNA release in innate immune signaling","volume":"92","author":"Newman","year":"2023","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.bcp.2026.118170_b0310","doi-asserted-by":"crossref","unstructured":"J. Kim, R. Gupta, L.P. Blanco, S. Yang, A. Shteinfer-Kuzmine, K. Wang, J. Zhu, H.E. Yoon, X. Wang, M. Kerkhofs, H. Kang, A.L. Brown, S.J. Park, X. Xu, E. Zandee van Rilland, M.K. Kim, J.I. Cohen, M.J. Kaplan, V. Shoshan-Barmatz, J.H. Chung, VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease, Science (New York, N.Y.) 366(6472) (2019) 1531\u20131536.","DOI":"10.1126\/science.aav4011"},{"issue":"7548","key":"10.1016\/j.bcp.2026.118170_b0315","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bcp.2026.118170_b0320","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.7150\/thno.101298","article-title":"Acylglycerol kinase inhibits macrophage anti-tumor activity via limiting mtDNA release and cGAS-STING-type I IFN response","volume":"15","author":"Du","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2026.118170_b0325","article-title":"Targeting the cGAS STING pathway for therapeutic gain in autoimmune inflammatory cutaneous diseases with a focus on systemic lupus erythematosus and systemic sclerosis","author":"O'Reilly","year":"2025","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bcp.2026.118170_b0330","doi-asserted-by":"crossref","unstructured":"J. Zhang, H. Ji, M. Liu, M. Zheng, Z. Wen, H. Shen, Mitochondrial DNA Programs Lactylation of cGAS to Induce IFN Responses in Patients with Systemic Lupus Erythematosus, Journal of immunology (Baltimore, Md. : 1950) 213(6) (2024) 795-807.","DOI":"10.4049\/jimmunol.2300758"},{"key":"10.1016\/j.bcp.2026.118170_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103929","article-title":"Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination","volume":"88","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0340","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12929-022-00859-2","article-title":"Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?","volume":"29","author":"Kuo","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bcp.2026.118170_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2023.10.003","article-title":"Mitochondrial dysfunction and inflammasome activation in neurodegenerative diseases: Mechanisms and therapeutic implications","author":"Hamzeh","year":"2023","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bcp.2026.118170_b0350","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yjmcc.2018.12.017","article-title":"Mitochondrial LonP1 protects cardiomyocytes from ischemia\/reperfusion injury in vivo","volume":"128","author":"Venkatesh","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0355","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2022.12.008","article-title":"Microenvironment-driven metabolic adaptations guiding CD8(+) T cell anti-tumor immunity","volume":"56","author":"Park","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2026.118170_b0360","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1729690","article-title":"Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease","volume":"16","author":"Getachew","year":"2025","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118170_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112583","article-title":"Pyruvate metabolism controls chromatin remodeling during CD4(+) T cell activation","volume":"42","author":"Mocholi","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.bcp.2026.118170_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108411","article-title":"Lipid metabolism in Th17 cell function","volume":"245","author":"Kanno","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0375","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cmet.2015.12.005","article-title":"Disease-causing SDHAF1 mutations impair transfer of Fe-S clusters to SDHB","volume":"23","author":"Maio","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2026.118170_b0380","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol."},{"issue":"15","key":"10.1016\/j.bcp.2026.118170_b0385","first-page":"7794","article-title":"Hmgcs2 regulates M2 polarization of macrophages to repair myocardial injury induced by sepsis","volume":"15","author":"Zou","year":"2023","journal-title":"Aging"},{"issue":"5","key":"10.1016\/j.bcp.2026.118170_b0390","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.cell.2019.07.048","article-title":"Ketone body signaling mediates intestinal stem cell homeostasis and adaptation to diet","volume":"178","author":"Cheng","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0395","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12916-022-02352-x","article-title":"Ketone body \u03b2-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway","volume":"20","author":"Huang","year":"2022","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0400","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-023-01478-6","article-title":"Metabolism, metabolites, and macrophages in cancer","volume":"16","author":"Li","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118170_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101719","article-title":"Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives","volume":"298","author":"Lee","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0410","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1038\/s41598-020-63482-x","article-title":"CDDO-Me alters the tumor microenvironment in estrogen receptor negative breast cancer","volume":"10","author":"Ball","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149600","article-title":"CDDO-Me redirects activation of breast tumor associated macrophages","volume":"11","author":"Ball","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0430","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41419-025-07449-8","article-title":"Lon protease 1-mediated metabolic reprogramming promotes the progression of prostate cancer","volume":"16","author":"Yao","year":"2025","journal-title":"Cell Death Dis."},{"issue":"47","key":"10.1016\/j.bcp.2026.118170_b0435","doi-asserted-by":"crossref","first-page":"77457","DOI":"10.18632\/oncotarget.12681","article-title":"Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of lon as a therapeutic target in glioma","volume":"7","author":"Di","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.bcp.2026.118170_b0440","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s42255-022-00582-0","article-title":"Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix","volume":"4","author":"Kay","year":"2022","journal-title":"Nat. Metabol."},{"key":"10.1016\/j.bcp.2026.118170_b0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2023.103011","article-title":"Proline metabolism shapes the tumor microenvironment: from collagen deposition to immune evasion","volume":"84","author":"Kay","year":"2023","journal-title":"Curr. Opin. Biotechnol."},{"issue":"9","key":"10.1016\/j.bcp.2026.118170_b0450","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.it.2024.07.009","article-title":"The extracellular matrix in solid tumor immunotherapy","volume":"45","author":"Cho","year":"2024","journal-title":"Trends Immunol."},{"issue":"8","key":"10.1016\/j.bcp.2026.118170_b0455","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1158\/0008-5472.CAN-21-2778","article-title":"Ketogenesis attenuates KLF5-dependent production of CXCL12 to overcome the immunosuppressive tumor microenvironment in colorectal cancer","volume":"82","author":"Wei","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118170_b0460","doi-asserted-by":"crossref","unstructured":"Z. Li, X. Lai, S. Fu, L. Ren, H. Cai, H. Zhang, Z. Gu, X. Ma, K. Luo, Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency, Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9(22) (2022) e2201734.","DOI":"10.1002\/advs.202201734"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0465","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00018-024-05191-6","article-title":"cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors","volume":"81","author":"Li","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bcp.2026.118170_b0470","article-title":"Ferroptosis in cancer toward molecular insights and clinical translation in pancreatic cancer","author":"Chen","year":"2026","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0475","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41416-022-01998-x","article-title":"Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy","volume":"128","author":"Ajoolabady","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118170_b0480","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trsl.2018.07.014","article-title":"Mitochondria in innate immune signaling","volume":"202","author":"Banoth","year":"2018","journal-title":"Trans. Res."},{"issue":"5","key":"10.1016\/j.bcp.2026.118170_b0485","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1007\/s11357-024-01165-5","article-title":"Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches","volume":"46","author":"Molnar","year":"2024","journal-title":"GeroScience"},{"issue":"19","key":"10.1016\/j.bcp.2026.118170_b0490","doi-asserted-by":"crossref","DOI":"10.3390\/cells11192969","article-title":"NSP4 and ORF9b of SARS-CoV-2 induce pro-inflammatory mitochondrial DNA release in inner membrane-derived vesicles","volume":"11","author":"Faizan","year":"2022","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.bcp.2026.118170_b0495","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098034","article-title":"Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0500","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12974-025-03363-0","article-title":"Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders","volume":"22","author":"Zhang","year":"2025","journal-title":"J. Neuroinflamm."},{"issue":"9","key":"10.1016\/j.bcp.2026.118170_b0505","doi-asserted-by":"crossref","DOI":"10.3390\/biom15091339","article-title":"Mitochondrial reactive oxygen species: a unifying mechanism in long COVID and spike protein-associated injury: a narrative review","volume":"15","author":"Lee","year":"2025","journal-title":"Biomolecules"},{"issue":"Pt 1","key":"10.1016\/j.bcp.2026.118170_b0510","article-title":"N6-methyladenosine (m(6)A) modification regulates LONP1 to inhibit coxsackievirus B3 replication by suppressing virus-induced ferroptosis","volume":"335","author":"Wang","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.bcp.2026.118170_b0515","doi-asserted-by":"crossref","DOI":"10.3390\/v16091448","article-title":"N6-methyladenosine positively regulates coxsackievirus B3 replication","volume":"16","author":"Zhao","year":"2024","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0520","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13567-024-01284-z","article-title":"Non-cytopathic bovine viral diarrhea virus (BVDV) inhibits innate immune responses via induction of mitophagy","volume":"55","author":"Li","year":"2024","journal-title":"Vet. Res."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0525","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01880-23","article-title":"Mitochondria-mediated ferroptosis contributes to the inflammatory responses of bovine viral diarrhea virus (BVDV) in vitro","volume":"98","author":"Li","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2026.118170_b0530","first-page":"1","article-title":"The biology of Lonp1: more than a mitochondrial protease","volume":"354","author":"Gibellini","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118170_b0535","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/15548627.2020.1725375","article-title":"Influenza a virus protein PB1-F2 impairs innate immunity by inducing mitophagy","volume":"17","author":"Wang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bcp.2026.118170_b0540","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1038\/ncomms5713","article-title":"Influenza a virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity","volume":"5","author":"Yoshizumi","year":"2014","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.bcp.2026.118170_b0545","doi-asserted-by":"crossref","DOI":"10.3390\/v12040409","article-title":"Influenza PB1-F2 inhibits avian MAVS signaling","volume":"12","author":"Xiao","year":"2020","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.bcp.2026.118170_b0550","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.02310-24","article-title":"Peste des petits ruminants virus (PPRV) induces ferroptosis via LONP1-mediated mitochondrial GPX4 degradation in cell culture","volume":"99","author":"Hou","year":"2025","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.bcp.2026.118170_b0555","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1189\/jlb.4MR0616-288R","article-title":"Hero turned villain: NLRP3 inflammasome-induced inflammation during influenza a virus infection","volume":"101","author":"Ong","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118170_b0560","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.stem.2024.08.001","article-title":"Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells","volume":"31","author":"Xu","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bcp.2026.118170_b0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121666","article-title":"Mitochondrion: a bridge linking aging and degenerative diseases","volume":"322","author":"Zhang","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2026.118170_b0570","doi-asserted-by":"crossref","unstructured":"W. Wang, X. Ma, S. Bhatta, C. Shao, F. Zhao, H. Fujioka, S. Torres, F. Wu, X. Zhu, Intraneuronal \u03b2-amyloid impaired mitochondrial proteostasis through the impact on LONP1, Proceedings of the National Academy of Sciences of the United States of America 120(51) (2023) e2316823120.","DOI":"10.1073\/pnas.2316823120"},{"issue":"5","key":"10.1016\/j.bcp.2026.118170_b0575","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13603","article-title":"Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration","volume":"21","author":"Rai","year":"2022","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0580","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1038\/s41598-021-86847-2","article-title":"Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1\/PARK 7 missense mutants","volume":"11","author":"S\u00e1nchez-Lanzas","year":"2021","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.bcp.2026.118170_b0585","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70090","article-title":"LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis","volume":"28","author":"Zhang","year":"2024","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0590","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12964-025-02308-7","article-title":"Mitochondrial dysfunction in the regulation of aging and aging-related diseases","volume":"23","author":"Zhang","year":"2025","journal-title":"Cell Commun. Signal"},{"issue":"5","key":"10.1016\/j.bcp.2026.118170_b0595","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.17305\/bb.2024.10429","article-title":"Aging of alveolar type 2 cells induced by Lonp1 deficiency exacerbates pulmonary fibrosis","volume":"24","author":"Zhu","year":"2024","journal-title":"Biomol. Biomed."},{"key":"10.1016\/j.bcp.2026.118170_b0600","article-title":"Mitochondrial dysfunction and alveolar type II epithelial cell senescence: the destroyer and rescuer of idiopathic pulmonary fibrosis","volume":"13","author":"Liu","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118170_b0605","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85415","article-title":"Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosis","volume":"12","author":"Liang","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.bcp.2026.118170_b0610","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.999600","article-title":"Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis","volume":"10","author":"Zhou","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118170_b0615","doi-asserted-by":"crossref","unstructured":"S. Wang, R. Wang, Q. He, Y. Ma, Y. Fang, J. Yang, H. Zhao, L. Fu, D. Chen, Cellular Senescence: A Pathogenic Driver for Pulmonary Fibrosis, Frontiers in bioscience (Landmark edition) 30(7) (2025) 37811.","DOI":"10.31083\/FBL37811"},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0620","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ajhg.2014.12.003","article-title":"CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease","volume":"96","author":"Strauss","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bcp.2026.118170_b0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108983","article-title":"A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease","volume":"710","author":"Sha","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"issue":"9","key":"10.1016\/j.bcp.2026.118170_b0665","first-page":"808","article-title":"Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis","volume":"22","author":"Xu","year":"2024","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0670","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jhep.2025.07.013","article-title":"Decreased LONP1 expression exacerbates MASH-induced liver fibrosis via elevated orotic acid levels","volume":"84","author":"Xu","year":"2026","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118170_b0675","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29010159","article-title":"In silico and in vivo pharmacokinetic evaluation of 84-B10, a novel drug candidate against acute kidney injury and chronic kidney disease","volume":"29","author":"Su","year":"2023","journal-title":"Molecules (Basel Switzerland)"},{"issue":"8","key":"10.1016\/j.bcp.2026.118170_b0650","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080833","article-title":"CDDO-Me selectively attenuates CA1 neuronal death induced by status epilepticus via facilitating mitochondrial fission independent of LONP1","volume":"8","author":"Kim","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118170_b0630","article-title":"Hypoxia-induced LONP1 overexpression and mtDNA damage may serve as biomarkers for death from mechanical asphyxia","volume":"80","author":"Wu","year":"2025","journal-title":"Leg. Med. (Tokyo)"},{"key":"10.1016\/j.bcp.2026.118170_b0635","doi-asserted-by":"crossref","DOI":"10.1007\/s00414-025-03703-y","article-title":"Postmortem interval estimation through skeletal muscle protein degradation: a comprehensive review","author":"Kori","year":"2026","journal-title":"Int. J. Leg. Med."},{"issue":"4","key":"10.1016\/j.bcp.2026.118170_b0640","doi-asserted-by":"crossref","DOI":"10.3390\/biom15040553","article-title":"Modulation of Lonp1 activity by Small Compounds","volume":"15","author":"Zanini","year":"2025","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.bcp.2026.118170_b0645","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1021\/acs.jmedchem.0c02152","article-title":"Structure-based Design of selective LONP1 inhibitors for probing in vitro biology","volume":"64","author":"Kingsley","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2026.118170_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107697","article-title":"Dual targeting of the mitochondrial Lon peptidase 1 and the chymotrypsin-like proteasome activity as a potential therapeutic strategy in malignant astrocytoma models","volume":"215","author":"Douglas","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.bcp.2026.118170_b0660","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1111\/j.1349-7006.2010.01701.x","article-title":"Obtusilactone a and (-)-sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints","volume":"101","author":"Wang","year":"2010","journal-title":"Cancer Sci."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226005083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226005083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:17:04Z","timestamp":1785071824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226005083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":131,"alternative-id":["S0006295226005083"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118170","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118170"}}