{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:38:52Z","timestamp":1793407132746,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["SPF201809006985"],"award-info":[{"award-number":["SPF201809006985"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004593","name":"Universidad Aut\u00f3noma de Madrid","doi-asserted-by":"publisher","award":["SFPI\/2016\\u201300981"],"award-info":[{"award-number":["SFPI\/2016\\u201300981"]}],"id":[{"id":"10.13039\/501100004593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004593","name":"Universidad Aut\u00f3noma de Madrid","doi-asserted-by":"publisher","award":["PEJ-2023-AI\/SAL-GL-28347"],"award-info":[{"award-number":["PEJ-2023-AI\/SAL-GL-28347"]}],"id":[{"id":"10.13039\/501100004593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004593","name":"Universidad Aut\u00f3noma de Madrid","doi-asserted-by":"publisher","award":["SFPI\/2020\\u201300053"],"award-info":[{"award-number":["SFPI\/2020\\u201300053"]}],"id":[{"id":"10.13039\/501100004593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004593","name":"Universidad Aut\u00f3noma de Madrid","doi-asserted-by":"publisher","award":["PEJ-2023-AI\/SAL-GL-28071"],"award-info":[{"award-number":["PEJ-2023-AI\/SAL-GL-28071"]}],"id":[{"id":"10.13039\/501100004593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD24\/00217"],"award-info":[{"award-number":["CD24\/00217"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD22\/00101"],"award-info":[{"award-number":["CD22\/00101"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003100","name":"F\u00e9d\u00e9ration Fran\u00e7aise de Cardiologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003043","name":"EMBO","doi-asserted-by":"publisher","award":["9053"],"award-info":[{"award-number":["9053"]}],"id":[{"id":"10.13039\/501100003043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bcp.2026.118180","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:55:12Z","timestamp":1781826912000},"page":"118180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P2","title":["Anakinra prevents high glucose-mediated potentiation of IL-1\u03b2-induced NLRP3 inflammasome activation, small extracellular vesicle release and vascular inflammation"],"prefix":"10.1016","volume":"251","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6741-8554","authenticated-orcid":false,"given":"In\u00e9s","family":"Valencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Vidal-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"San Hip\u00f3lito-Luengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Villacampa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Shamoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cuadrado-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Berlanas-Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"de la Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Moncada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge F.","family":"Gomez-Cerezo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos F.","family":"S\u00e1nchez-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramaroson","family":"Andriantsitohaina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9690-7816","authenticated-orcid":false,"given":"Concepci\u00f3n","family":"Peir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118180_b0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25020804","article-title":"Diabetic Vasculopathy: Molecular Mechanisms and Clinical Insights","volume":"25","author":"Jia","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118180_b0010","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118180_b0015","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.118180_b0020","article-title":"IL-1\u03b2 Inhibition in Cardiovascular Complications Associated to Diabetes Mellitus","volume":"13","author":"Peir\u00f3","year":"2017","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.bcp.2026.118180_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2017.10.003","article-title":"Inflammageing and metaflammation: the yin and yang of type 2 diabetes","volume":"41","author":"Prattichizzo","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bcp.2026.118180_b0030","article-title":"NLRP3 Inflammasome in Vascular Disease: a Recurrent Villain to Combat Pharmacologically","volume":"11","author":"Gonz\u00e1lez-Moro","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bcp.2026.118180_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1690443","article-title":"Inflammasomes as the molecular hub of cardiovascular-metabolic-immune comorbidity networks","volume":"16","author":"Qian","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118180_b0040","doi-asserted-by":"crossref","first-page":"284","DOI":"10.14336\/AD.2021.0617","article-title":"Pharmacological Blockade of NLRP3 Inflammasome\/IL-1\u03b2-positive Loop Mitigates Endothelial Cell Senescence and Dysfunction","volume":"13","author":"Romero","year":"2022","journal-title":"Aging Dis."},{"key":"10.1016\/j.bcp.2026.118180_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9081812","article-title":"The Inflammasome in Chronic Complications of Diabetes and Related Metabolic Disorders","volume":"9","author":"Menini","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118180_b0050","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1161\/HYPERTENSIONAHA.121.18477","article-title":"DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2-COX-2-TP Axis and NLRP3 Inflammasome Activation","volume":"79","author":"Valencia","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.bcp.2026.118180_b0055","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118180_b0060","article-title":"Cell-cell communication: new insights and clinical implications","volume":"9","author":"Su","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2026.118180_b0065","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s13105-024-01026-x","article-title":"The role of exosome derived miRNAs in inter-cell crosstalk among insulin-related organs in type 2 diabetes mellitus","volume":"80","author":"Lu","year":"2024","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.118180_b0070","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicles."},{"key":"10.1016\/j.bcp.2026.118180_b0075","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12964-023-01304-z","article-title":"Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential","volume":"21","author":"Liu","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bcp.2026.118180_b0080","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2353\/ajpath.2008.080228","article-title":"Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome","volume":"173","author":"Agouni","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bcp.2026.118180_b0085","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1161\/CIRCRESAHA.117.309419","article-title":"Extracellular vesicles in metabolic syndrome","volume":"120","author":"Mart\u00ednez","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2026.118180_b0090","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00125-019-05014-5","article-title":"Extracellular vesicles in metabolic disease","volume":"62","author":"Akbar","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.bcp.2026.118180_b0095","first-page":"1870","article-title":"Biotherapeutic approaches against cardio-metabolic dysfunctions based on extracellular vesicles","author":"Marchal","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bcp.2026.118180_b0100","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/HJH.0b013e3282f331fb","article-title":"The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning","volume":"26","author":"Lafuente","year":"2008","journal-title":"J. Hypertens."},{"key":"10.1016\/j.bcp.2026.118180_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010091","article-title":"Inflammation Determines the Pro-Adhesive Properties of High Extracellular D-Glucose in Human Endothelial Cells In Vitro and Rat Microvessels In Vivo","volume":"5","author":"Azcutia","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118180_b0110","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-016-0397-2","article-title":"Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway","volume":"15","author":"Peir\u00f3","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bcp.2026.118180_b0115","unstructured":"Kineret | European Medicines Agency (EMA). https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/kineret. Accessed 24 Mar 2026."},{"key":"10.1016\/j.bcp.2026.118180_b0120","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/CIRCRESAHA.115.304437","article-title":"Moderate hypoxia potentiates interleukin-1\u03b2 production in activated human macrophages","volume":"115","author":"Folco","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2026.118180_b0125","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13280","article-title":"PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation","volume":"7","author":"Xie","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118180_b0130","doi-asserted-by":"crossref","first-page":"e581","DOI":"10.1002\/iid3.581","article-title":"Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis","volume":"10","author":"Yu","year":"2021","journal-title":"Immun Inflamm Dis."},{"key":"10.1016\/j.bcp.2026.118180_b0135","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2026.118180_b0140","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1002\/j.2040-4603.2023.tb00279.x","article-title":"Energetic Stress-Induced Metabolic Regulation by Extracellular Vesicles","volume":"13","author":"Crewe","year":"2023","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.bcp.2026.118180_b0145","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-023-01103-6","article-title":"A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication","volume":"21","author":"Liu","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bcp.2026.118180_b0150","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2026.118180_b0155","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/cvr\/cvab010","article-title":"NLRP3 inflammasome as a key driver of vascular disease","volume":"118","author":"Takahashi","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2026.118180_b0160","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1414266","article-title":"Follow-up of glycemic control and cardiovascular outcomes in type 2 diabetes","volume":"372","author":"Hayward","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.118180_b0165","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bcp.2009.04.029","article-title":"Inflammatory cytokines in vascular dysfunction and vascular disease","volume":"78","author":"Sprague","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118180_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051168","article-title":"Inflammatory Mechanisms of Diabetes and its Vascular Complications","volume":"10","author":"Nedosugova","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bcp.2026.118180_b0175","doi-asserted-by":"crossref","unstructured":"American Diabetes Association Professional Practice Committee. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2024. Diabetes Care. 2024;47 Suppl 1:S158\u201378. doi: 10.2337\/dc24-S009.","DOI":"10.2337\/dc24-S009"},{"key":"10.1016\/j.bcp.2026.118180_b0180","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00536.2019","article-title":"Extracellular vesicles as signaling mediators in type 2 diabetes mellitus","volume":"318","author":"Noren Hooten","year":"2020","journal-title":"Am J Physiol Cell Physiol."},{"key":"10.1016\/j.bcp.2026.118180_b0185","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00424-016-1926-2","article-title":"Glucose and angiotensin II-derived endothelial extracellular vesicles regulate endothelial dysfunction via ERK1\/2 activation","volume":"469","author":"Taguchi","year":"2017","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bcp.2026.118180_b0190","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s00125-017-4331-2","article-title":"High glucose increases the formation and pro-oxidative activity of endothelial microparticles","volume":"60","author":"Burger","year":"2017","journal-title":"Diabetologia."},{"key":"10.1016\/j.bcp.2026.118180_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102847","article-title":"High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis","volume":"24","author":"Bouchareychas","year":"2021","journal-title":"iScience."},{"key":"10.1016\/j.bcp.2026.118180_b0200","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00125-024-06288-0","article-title":"Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance","volume":"68","author":"Ali","year":"2025","journal-title":"Diabetologia."},{"key":"10.1016\/j.bcp.2026.118180_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111263","article-title":"The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype","volume":"189","author":"Wallis","year":"2020","journal-title":"Mech Ageing Dev."},{"key":"10.1016\/j.bcp.2026.118180_b0210","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-025-02296-8","article-title":"NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development","volume":"23","author":"Vidal-G\u00f3mez","year":"2025","journal-title":"Cell Commun Signal."},{"key":"10.1016\/j.bcp.2026.118180_b0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007140","article-title":"Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1","volume":"4","author":"Sarkar","year":"2009","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2026.118180_b0220","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00951-22","article-title":"Circulatory Exosomes from COVID-19 patients Trigger NLRP3 Inflammasome in Endothelial Cells","volume":"13","author":"Sur","year":"2022","journal-title":"mBio."},{"key":"10.1016\/j.bcp.2026.118180_b0225","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260691","article-title":"Inflammatory macrophage to hepatocyte signals can be prevented by extracellular vesicle reprogramming","volume":"136","author":"Ghosh","year":"2023","journal-title":"J Cell Sci."},{"key":"10.1016\/j.bcp.2026.118180_b0230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/intimm\/dxx018","article-title":"Mechanisms governing inflammasome activation, assembly and pyroptosis induction","volume":"29","author":"Kesavardhana","year":"2017","journal-title":"Int Immunol."},{"key":"10.1016\/j.bcp.2026.118180_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010331","article-title":"Extracellular Vesicles Mediate Communication between Endothelial and Vascular Smooth Muscle Cells","volume":"23","author":"Fontaine","year":"2021","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.bcp.2026.118180_b0240","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/19336896.2017.1306162","article-title":"Prions on the run: how extracellular vesicles serve as delivery vehicles for self-templating protein aggregates","volume":"11","author":"Liu","year":"2017","journal-title":"Prion."},{"key":"10.1016\/j.bcp.2026.118180_b0245","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-023-01018-w","article-title":"The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches","volume":"118","author":"Chen","year":"2023","journal-title":"Basic Res Cardiol."},{"key":"10.1016\/j.bcp.2026.118180_b0250","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118180_b0255","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.atherosclerosis.2016.08.011","article-title":"Endothelial cell metabolism: a novel player in atherosclerosis? Basic principles and therapeutic opportunities","volume":"253","author":"Pircher","year":"2016","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.bcp.2026.118180_b0260","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/CIRCRESAHA.120.318805","article-title":"Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism","volume":"129","author":"Xiao","year":"2021","journal-title":"Circ Res."},{"key":"10.1016\/j.bcp.2026.118180_b0265","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.freeradbiomed.2025.12.046","article-title":"Age-dependent reprogramming of vascular metabolism compromises endothelial resilience to inflammation-induced endothelial dysfunction","volume":"245","author":"Kara\u015b","year":"2026","journal-title":"Free Radic Biol Med."},{"key":"10.1016\/j.bcp.2026.118180_b0270","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1089\/ars.2023.0476","article-title":"Metabolic responses to Redox stress in Vascular Cells","volume":"41","author":"Xiao","year":"2024","journal-title":"Antioxid Redox Signal."},{"key":"10.1016\/j.bcp.2026.118180_b0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203745","article-title":"PKM2 and HIF-1\u03b1 regulation in prostate cancer cell lines","volume":"13","author":"Hasan","year":"2018","journal-title":"PLoS One."},{"key":"10.1016\/j.bcp.2026.118180_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213902","article-title":"Oncometabolism: A Paradigm for the Metabolic Remodeling of the Failing Heart","volume":"23","author":"Kuhn","year":"2022","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.bcp.2026.118180_b0285","doi-asserted-by":"crossref","first-page":"14041","DOI":"10.1038\/ncomms14041","article-title":"Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23","volume":"8","author":"Wei","year":"2017","journal-title":"Nat Commun."},{"key":"10.1016\/j.bcp.2026.118180_b0290","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s00125-003-1056-1","article-title":"Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature","volume":"46","author":"Rodr\u00edguez-Ma\u00f1as","year":"2003","journal-title":"Diabetologia."},{"key":"10.1016\/j.bcp.2026.118180_b0295","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-014-0158-z","article-title":"The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats","volume":"13","author":"Vallejo","year":"2014","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.bcp.2026.118180_b0300","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1161\/CIRCRESAHA.120.315937","article-title":"Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease","volume":"126","author":"Abbate","year":"2020","journal-title":"Circ Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226005198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226005198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:13:31Z","timestamp":1785071611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226005198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":60,"alternative-id":["S0006295226005198"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118180","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anakinra prevents high glucose-mediated potentiation of IL-1\u03b2-induced NLRP3 inflammasome activation, small extracellular vesicle release and vascular inflammation","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118180"}}