{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:11:13Z","timestamp":1792008673815,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32121004"],"award-info":[{"award-number":["32121004"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972823"],"award-info":[{"award-number":["81972823"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372788"],"award-info":[{"award-number":["82372788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bcp.2026.118207","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:38:43Z","timestamp":1782887923000},"page":"118207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["4-DMB, a diclofenac derivative, alleviates DSS-induced ulcerative colitis in mice by binding TNFR1 to inhibit inflammation"],"prefix":"10.1016","volume":"252","author":[{"given":"Wei","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Jin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Dan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Zhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0005","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bcp.2026.118207_b0010","article-title":"Patient-specific electro-anatomical modeling of cochlear implants using deep neural networks","volume":"12034","author":"Ziteng","year":"2022","journal-title":"SPIE Medical Imaging"},{"issue":"3","key":"10.1016\/j.bcp.2026.118207_b0015","first-page":"1224","article-title":"Tumor necrosis factor-\u03b1 acts reciprocally with solute carrier family 26, member 3, (downregulated-in-adenoma) and reduces its expression, leading to intestinal inflammation","volume":"41","author":"Ding","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.118207_b0020","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41419-024-06559-z","article-title":"Cellular heterogeneity in TNF\/TNFR1 signalling: live cell imaging of cell fate decisions in single cells","volume":"15","author":"Preedy","year":"2024","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.bcp.2026.118207_b0025","doi-asserted-by":"crossref","first-page":"G612","DOI":"10.1152\/ajpgi.90576.2008","article-title":"Infliximab and the TNF-alpha system","volume":"296","author":"Ebert","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bcp.2026.118207_b0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cytogfr.2020.03.002","article-title":"Selective inhibition of Tumor necrosis factor receptor-1 (TNFR1) for the treatment of autoimmune diseases","volume":"55","author":"Zhang","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bcp.2026.118207_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118671","article-title":"Mesua assamica (King & Prain) kosterm. bark ethanolic extract attenuates rheumatoid arthritis via down-regulating TLR4\/NF-\u03baB\/COX-2\/iNOS and activation of Nrf2\/HO-1 pathways: a comprehensive study on in-vitro and in-vivo models","volume":"335","author":"Puppala","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12967-025-06122-0","article-title":"Exploring TNFR1: from discovery to targeted therapy development","volume":"23","author":"Li","year":"2025","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.118207_b0045","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1021\/acsbiomedchemau.2c00048","article-title":"Zafirlukast is a promising scaffold for selectively inhibiting TNFR1 signaling","volume":"3","author":"Vunnam","year":"2023","journal-title":"ACS Bio Med Chem Au"},{"issue":"11","key":"10.1016\/j.bcp.2026.118207_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113411","article-title":"A molecular biophysical approach to diclofenac topical gastrointestinal damage","volume":"19","author":"Fernandes","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt A","key":"10.1016\/j.bcp.2026.118207_b0055","article-title":"Design, synthesis, and pharmacological evaluation of hydrazide-imine diclofenac derivatives with dual anti-inflammatory and anticancer potential","volume":"198","author":"Hruaitluangi","year":"2025","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.bcp.2026.118207_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115669","article-title":"Diclofenac and eugenol hybrid with enhanced anti-inflammatory activity through activating HO-1 and inhibiting NF-\u03baB pathway in vitro and in vivo","volume":"259","author":"Wang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2026.118207_b0065","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2174\/1385272823666191021124443","article-title":"Molecular hybridization as a tool in the design of multi-target directed drug candidates for neurodegenerative diseases","volume":"18","author":"Gontijo","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118207_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031230","article-title":"Indomethacin and diclofenac hybrids with oleanolic acid oximes modulate key signaling pathways in pancreatic cancer cells","volume":"23","author":"Naro\u017cna","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118207_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115489","article-title":"Aesculetin exhibited anti-inflammatory activities through inhibiting NF-\u043aB and MAPKs pathway in vitro and in vivo","volume":"296","author":"Wang","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0080","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1968257","article-title":"Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease","volume":"13","author":"Li","year":"2021","journal-title":"Gut Microbes"},{"issue":"2","key":"10.1016\/j.bcp.2026.118207_b0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0014-2999(01)01446-7","article-title":"Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats","volume":"431","author":"S\u00fcmen","year":"2001","journal-title":"Eur. J. Pharmacol."},{"issue":"23","key":"10.1016\/j.bcp.2026.118207_b0090","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404908","article-title":"Colon-targeted natural polysaccharide-berberine armored hydrogel for the treatment of colitis","volume":"14","author":"Guo","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bcp.2026.118207_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173573","article-title":"Ameliorating and protective effects mesalazine on ethanol-induced gastric ulcers in experimental rats","volume":"888","author":"Beiranvand","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118207_b0100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nprot.2007.41","article-title":"Chemically induced mouse models of intestinal inflammation","volume":"2","author":"Wirtz","year":"2007","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.bcp.2026.118207_b0105","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1007\/s13346-023-01313-y","article-title":"Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids","volume":"13","author":"Klitgaard","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"issue":"7","key":"10.1016\/j.bcp.2026.118207_b0110","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1039\/D0FO01162B","article-title":"Ficus carica polysaccharide attenuates DSS-induced ulcerative colitis in C57BL\/6 mice","volume":"11","author":"Zou","year":"2020","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.bcp.2026.118207_b0115","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1038\/s41596-020-0310-z","article-title":"Cellular thermal shift assay for the identification of drug\u2013target interactions in the Plasmodium falciparum proteome","volume":"15","author":"Dziekan","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bcp.2026.118207_b0120","first-page":"0188","article-title":"Mulberry biomass-derived nanomedicines mitigate colitis through improved inflamed mucosa accumulation and intestinal microenvironment modulation","volume":"6","author":"Yang","year":"2023","journal-title":"Research (wash D c)"},{"issue":"9","key":"10.1016\/j.bcp.2026.118207_b0125","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ja.2017.74","article-title":"Allantopyrone a interferes with multiple components of the TNF receptor 1 complex and blocks RIP1 modifications in the TNF-\u03b1-induced signaling pathway","volume":"70","author":"Quach","year":"2017","journal-title":"J. Antibiot. (Tokyo)"},{"issue":"12","key":"10.1016\/j.bcp.2026.118207_b0130","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1097\/MIB.0000000000000165","article-title":"Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: pathophysiology and clinical associations","volume":"20","author":"Habib","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"10.1016\/j.bcp.2026.118207_b0135","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.apsb.2019.08.006","article-title":"Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions","volume":"10","author":"Li","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bcp.2026.118207_b0140","doi-asserted-by":"crossref","unstructured":"V. Sojitra, P.R. Naradasu, K.M. Patel, R. Patel, S. Patel, H.D. Desai, Evolving burden of inflammatory bowel disease in women from 1990-2019: global, regional, national variations, age dynamics, and implications for global health, Inflammatory Bowel Diseases, 30 (Supplement_1) (2024) S30-S31.","DOI":"10.1093\/ibd\/izae020.068"},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40168-021-01028-7","article-title":"Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPAR\u03b3 signaling activation","volume":"9","author":"Li","year":"2021","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0150","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s40168-021-01115-9","article-title":"Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis","volume":"9","author":"Wu","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.bcp.2026.118207_b0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13020-020-0296-z","article-title":"Targeting NF-\u03baB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines","volume":"15","author":"Lu","year":"2020","journal-title":"Chin. Med."},{"issue":"45","key":"10.1016\/j.bcp.2026.118207_b0160","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1021\/bi301039t","article-title":"Binding efficiency of protein-protein complexes","volume":"51","author":"Day","year":"2012","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0165","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1038\/s41467-025-61271-6","article-title":"Highly ordered clustering of TNF\u03b1 and BAFF ligand-receptor-intracellular adaptor complexes on a lipid membrane","volume":"16","author":"Lim","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0170","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41467-020-20828-3","article-title":"Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF","volume":"12","author":"McMillan","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bcp.2026.118207_b0175","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1742-4658.2011.08015.x","article-title":"TNFR1-induced activation of the classical NF-\u03baB pathway","volume":"278","author":"Wajant","year":"2011","journal-title":"FEBS J."},{"issue":"18","key":"10.1016\/j.bcp.2026.118207_b0180","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.3748\/wjg.v29.i18.2733","article-title":"Study of tumor necrosis factor receptor in the inflammatory bowel disease","volume":"29","author":"Souza","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.bcp.2026.118207_b0185","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00018-015-1850-1","article-title":"Species differential regulation of COX2 can be described by an NF\u03baB-dependent logic AND gate","volume":"72","author":"Nguyen","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"issue":"57","key":"10.1016\/j.bcp.2026.118207_b0190","doi-asserted-by":"crossref","first-page":"9247","DOI":"10.1038\/sj.onc.1208169","article-title":"Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation","volume":"23","author":"Takada","year":"2004","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.bcp.2026.118207_b0195","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1445-2197.2005.03596.x","article-title":"Aspirin induces apoptosis in oesophageal cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2","volume":"75","author":"Liu","year":"2005","journal-title":"ANZ J. Surg."},{"issue":"2","key":"10.1016\/j.bcp.2026.118207_b0200","doi-asserted-by":"crossref","first-page":"L184","DOI":"10.1152\/ajplung.00303.2009","article-title":"Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema","volume":"299","author":"Roh","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bcp.2026.118207_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117420","article-title":"A TNF-\u03b1 blocking peptide that reduces NF-\u03baB and MAPK activity for attenuating inflammation","volume":"92","author":"Wang","year":"2023","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0210","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/s13287-022-03178-3","article-title":"TNF\u03b1 and IFN\u03b3 rapidly activate PI3K-AKT signaling to drive glycolysis that confers mesenchymal stem cells enhanced anti-inflammatory property","volume":"13","author":"Xu","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0215","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41419-025-07609-w","article-title":"Inflammation and cancer cell survival: TRAF2 as a key player","volume":"16","author":"Albini","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.118207_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2024.184394","article-title":"TNF receptors: structure-function relationships and therapeutic targeting strategies","volume":"1867","author":"Lo","year":"2025","journal-title":"Biochim. Biophys. Acta Biomembr."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226005460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226005460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:13:58Z","timestamp":1786652038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226005460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"alternative-id":["S0006295226005460"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118207","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"4-DMB, a diclofenac derivative, alleviates DSS-induced ulcerative colitis in mice by binding TNFR1 to inhibit inflammation","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118207"}}