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Lett."},{"issue":"3","key":"10.1016\/j.bcp.2026.118210_b0740","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/sj.jes.7500589","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin in maternal breast milk and newborn head circumference","volume":"18","author":"Nishijo","year":"2008","journal-title":"J. Eposure Sci. Environ. Epidemiol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118210_b0745","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neulet.2005.12.087","article-title":"Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin suppresses contextual fear conditioning-accompanied activation of cyclic AMP response element-binding protein in the hippocampal CA1 region of male rats","volume":"398","author":"Mitsui","year":"2006","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.bcp.2026.118210_b0750","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.fct.2011.03.008","article-title":"Perinatal TCDD exposure alters developmental neuroendocrine system","volume":"49","author":"Ahmed","year":"2011","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118210_b0755","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-069X-8-24","article-title":"Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study","volume":"8","author":"Akahoshi","year":"2009","journal-title":"Environ. 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