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Hakonarson, Common variants at five new loci associated with early-onset inflammatory bowel disease, Nat. Genet. 41 (2009) 1335\u20131340. doi: 10.1038\/ng.489.","DOI":"10.1038\/ng.489"},{"key":"10.1016\/j.bcp.2026.118226_b0245","doi-asserted-by":"crossref","unstructured":"T.I.I.G.C. (IIBDGC), L. Jostins, S. Ripke, R.K. Weersma, R.H. Duerr, D.P. McGovern, K.Y. Hui, J.C. Lee, L.P. Schumm, Y. Sharma, C.A. Anderson, J. Essers, M. Mitrovic, K. Ning, I. Cleynen, E. Theatre, S.L. Spain, S. Raychaudhuri, P. Goyette, Z. Wei, C. Abraham, J.-P. Achkar, T. Ahmad, L. Amininejad, A.N. Ananthakrishnan, V. Andersen, J.M. Andrews, L. Baidoo, T. Balschun, P.A. Bampton, A. Bitton, G. Boucher, S. Brand, C. B\u00fcning, A. Cohain, S. Cichon, M. D\u2019Amato, D.D. Jong, K.L. Devaney, M. Dubinsky, C. Edwards, D. Ellinghaus, L.R. Ferguson, D. Franchimont, K. Fransen, R. Gearry, M. Georges, C. Gieger, J. Glas, T. Haritunians, A. Hart, C. Hawkey, M. Hedl, X. Hu, T.H. Karlsen, L. Kupcinskas, S. Kugathasan, A. Latiano, D. Laukens, I.C. Lawrance, C.W. Lees, E. Louis, G. Mahy, J. Mansfield, A.R. Morgan, C. Mowat, W. Newman, O. Palmieri, C.Y. Ponsioen, U. Potocnik, N.J. Prescott, M. Regueiro, J.I. Rotter, R.K. Russell, J.D. Sanderson, M. Sans, J. Satsangi, S. Schreiber, L.A. Simms, J. Sventoraityte, S.R. Targan, K.D. Taylor, M. Tremelling, H.W. Verspaget, M.D. Vos, C. Wijmenga, D.C. Wilson, J. Winkelmann, R.J. Xavier, S. Zeissig, B. Zhang, C.K. Zhang, H. Zhao, M.S. Silverberg, V. Annese, H. Hakonarson, S.R. Brant, G. Radford-Smith, C.G. Mathew, J.D. Rioux, E.E. Schadt, M.J. Daly, A. Franke, M. Parkes, S. Vermeire, J.C. Barrett, J.H. Cho, Host\u2013microbe interactions have shaped the genetic architecture of inflammatory bowel disease, Nature 491 (2012) 119\u2013124. doi: 10.1038\/nature11582.","DOI":"10.1038\/nature11582"},{"key":"10.1016\/j.bcp.2026.118226_b0250","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1007\/s10620-018-5216-z","article-title":"Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in mice","volume":"63","author":"Farooq","year":"2018","journal-title":"Dig. Dis. 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Sci."},{"key":"10.1016\/j.bcp.2026.118226_b0270","first-page":"103","article-title":"Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease","volume":"16","author":"Andoh","year":"2006","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bcp.2026.118226_b0275","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1046\/j.1365-2249.2000.01094.x","article-title":"Development of dextran sulphate sodium-induced experimental colitis is suppressed in genetically mast cell-deficient Ws\/Ws rats","volume":"119","author":"Araki","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bcp.2026.118226_b0280","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/ncomms2023","article-title":"Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors","volume":"3","author":"Kurashima","year":"2012","journal-title":"Nat. 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Pharmacol."},{"key":"10.1016\/j.bcp.2026.118226_b0295","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gut.22.1.55","article-title":"Disodium cromoglycate in the treatment of ulcerative colitis and Crohn\u2019s disease","volume":"22","author":"Binder","year":"1981","journal-title":"Gut"},{"key":"10.1016\/j.bcp.2026.118226_b0300","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/gut.28.1.88","article-title":"Comparative trial of sodium cromoglycate enemas with prednisolone enemas in the treatment of ulcerative colitis","volume":"28","author":"Grace","year":"1987","journal-title":"Gut"},{"key":"10.1016\/j.bcp.2026.118226_b0305","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1365-2222.1991.tb00848.x","article-title":"Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance","volume":"21","author":"Lunardi","year":"1991","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.bcp.2026.118226_b0310","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1023\/A:1013204612762","article-title":"Physical and Psychological stress in Rats Enhances Colonic Epithelial Permeability via Peripheral CRH","volume":"47","author":"Saunders","year":"2002","journal-title":"Dig. 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Sci."},{"key":"10.1016\/j.bcp.2026.118226_b0315","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1053\/gast.2002.36019","article-title":"Chronic stress induces mast cell\u2013dependent bacterial adherence and initiates mucosal inflammation in rat intestine","volume":"123","author":"S\u00f6derholm","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bcp.2026.118226_b0320","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1136\/gutjnl-2013-305690","article-title":"Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism","volume":"63","author":"Vanuytsel","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.bcp.2026.118226_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.108035","article-title":"Biased constitutive signaling of the G protein-coupled receptor GPR35 suppresses gut barrier permeability","volume":"301","author":"Quon","year":"2025","journal-title":"J. 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