{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:52:07Z","timestamp":1791910327296,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020450","name":"Soochow University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020450","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bcp.2026.118282","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:01:48Z","timestamp":1784991708000},"page":"118282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Pharmacological inhibition of neddylation by MLN4924 protects against Coxsackievirus B3-induced myocarditis"],"prefix":"10.1016","volume":"253","author":[{"given":"Wenwen","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-9129","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118282_b0005","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1149911","article-title":"Roles of inflammasomes in viral myocarditis","volume":"13","author":"Xu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bcp.2026.118282_b0010","article-title":"Advances in cell death mechanisms involved in viral myocarditis","volume":"9","author":"Yang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bcp.2026.118282_b0015","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrcardio.2015.108","article-title":"Viral myocarditis\u2014diagnosis, treatment options, and current controversies","volume":"12","author":"Pollack","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bcp.2026.118282_b0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fcvm.2019.00064","article-title":"Myocarditis in humans and in experimental animal models","volume":"6","author":"B\u0142yszczuk","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bcp.2026.118282_b0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-319-57613-8_10","article-title":"Cardiac autoimmunity: myocarditis","volume":"1003","author":"Bracamonte-Baran","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bcp.2026.118282_b0030","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ymeth.2006.07.009","article-title":"Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity","volume":"41","author":"Fairweather","year":"2007","journal-title":"Methods"},{"key":"10.1016\/j.bcp.2026.118282_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02479","article-title":"TRIM21 restricts Coxsackievirus B3 replication, cardiac and pancreatic injury via interacting with MAVS and positively regulating IRF3-mediated Type-I interferon production","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118282_b0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/JVI.77.1.115-122.2003","article-title":"Impaired binding of standard initiation factors mediates poliovirus translation attenuation","volume":"77","author":"Ochs","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2026.118282_b0045","doi-asserted-by":"crossref","first-page":"33011","DOI":"10.1074\/jbc.M305352200","article-title":"Overexpression of interferon-\u03b3-inducible GTPase inhibits Coxsackievirus B3-induced apoptosis through the activation of the phosphatidylinositol 3-kinase\/akt pathway and inhibition of viral replication","volume":"278","author":"Zhang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118282_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013443","article-title":"The multifaceted role of the viral 2A protease in enterovirus replication and antagonism of host antiviral responses","volume":"21","author":"Schipper","year":"2025","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bcp.2026.118282_b0055","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3390\/v14071360","article-title":"Proteolytic activities of enterovirus 2A do not depend on its interaction with SETD3","volume":"14","author":"Yang","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.bcp.2026.118282_b0060","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41573-021-00195-4","article-title":"Kinase drug discovery 20 years after imatinib: progress and future directions","volume":"20","author":"Cohen","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bcp.2026.118282_b0065","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cell.2018.04.033","article-title":"Time-resolved analysis reveals rapid dynamics and broad scope of the CBP\/p300 acetylome","volume":"174","author":"Weinert","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118282_b0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in parkinson\u2019s disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bcp.2026.118282_b0075","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in cancer: mechanisms and clinical implications","volume":"15","author":"Pinho","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bcp.2026.118282_b0080","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1038\/ncomms11482","article-title":"The RanBP2\/RanGAP1*SUMO1\/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes","volume":"7","author":"Ritterhoff","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118282_b0085","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41392-024-01800-9","article-title":"Protein neddylation and its role in health and diseases","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2026.118282_b0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13045-021-01070-w","article-title":"Targeting neddylation E2s: a novel therapeutic strategy in cancer","volume":"14","author":"Zheng","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bcp.2026.118282_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.890121","article-title":"Association between neddylation and immune response","volume":"10","author":"Zhu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118282_b0100","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41419-021-03549-3","article-title":"Neddylation pathway alleviates chronic pancreatitis by reducing HIF1\u03b1-CCL5-dependent macrophage infiltration","volume":"12","author":"Lin","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.118282_b0105","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3389\/fimmu.2019.01432","article-title":"Neddylation Facilitates the Antiviral Response in Zebrafish","volume":"10","author":"Yu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118282_b0110","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/jcmm.16137","article-title":"Neddylation inhibitor MLN4924 has anti\u2010HBV activity via modulating the ERK\u2010HNF1\u03b1\u2010C\/EBP\u03b1\u2010HNF4\u03b1 axis","volume":"25","author":"Xie","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2026.118282_b0115","article-title":"NEDDylation is essential for Kaposi\u2019s Sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target","volume":"11","author":"Fr\u00fch","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bcp.2026.118282_b0120","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00598-22","article-title":"Neddylation of enterovirus 71 VP2 protein reduces its stability and restricts viral replication","volume":"96","author":"Wang","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2026.118282_b0125","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01535-25","article-title":"The neddylation of the RNA-dependent RNA polymerase 3D of Coxsackievirus B3 promotes viral replication","volume":"99","author":"Li","year":"2025","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2026.118282_b0130","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nature07884","article-title":"An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer","volume":"458","author":"Soucy","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118282_b0135","doi-asserted-by":"crossref","first-page":"0179","DOI":"10.34133\/bmr.0179","article-title":"Myofibroblast-targeting extracellular vesicles: a promising platform for cardiac fibrosis drug delivery","volume":"29","author":"Wang","year":"2025","journal-title":"Biomater. Res."},{"key":"10.1016\/j.bcp.2026.118282_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102114","article-title":"Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia-reperfusion injury by Sirt1","volume":"46","author":"Zhang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.118282_b0145","doi-asserted-by":"crossref","first-page":"E4101","DOI":"10.1073\/pnas.1719309115","article-title":"Neddylation mediates ventricular chamber maturation through repression of Hippo signaling","volume":"115","author":"Zou","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bcp.2026.118282_b0150","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.7150\/thno.78876","article-title":"Targeting cullin neddylation for cancer and fibrotic diseases","volume":"13","author":"He","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2026.118282_b0155","doi-asserted-by":"crossref","unstructured":"Li, L. et al. Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer. JNCI: Journal of the National Cancer Institute 106, dju083, doi:10.1093\/jnci\/dju083 (2014).","DOI":"10.1093\/jnci\/dju083"},{"key":"10.1016\/j.bcp.2026.118282_b0160","doi-asserted-by":"crossref","unstructured":"Souii, A., M\u2019hadheb-Gharbi, M. B., Aouni, M. & Gharbi, J. In Vitro Molecular Characterization of RNA\u2013Proteins Interactions During Initiation of Translation of a Wild-Type and a Mutant Coxsackievirus B3 RNAs. Molecular Biotechnology 54, 515-527, doi:10.1007\/s12033-012-9592-x (2012).","DOI":"10.1007\/s12033-012-9592-x"},{"key":"10.1016\/j.bcp.2026.118282_b0165","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/JVI.73.1.718-727.1999","article-title":"Cleavage of poly(a)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro","volume":"73","author":"Joachims","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2026.118282_b0170","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1158\/0008-5472.CAN-14-2789","article-title":"Targeting the eIF4F translation initiation complex: a critical nexus for cancer development","volume":"75","author":"Pelletier","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118282_b0175","doi-asserted-by":"crossref","first-page":"10556","DOI":"10.1128\/MCB.25.23.10556-10565.2005","article-title":"Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation","volume":"25","author":"Svitkin","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118282_b0180","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12935-019-0947-2","article-title":"Eukaryotic translation Initiation factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?","volume":"19","author":"Jaiswal","year":"2019","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bcp.2026.118282_b0185","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/2211-5463.13400","article-title":"Picornavirus translation strategies","volume":"12","author":"Francisco-Velilla","year":"2022","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bcp.2026.118282_b0190","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.3390\/ijms14034400","article-title":"Ribosomal Initiation complex assembly within the Wild-Strain of Coxsackievirus B3 and live-attenuated sabin3-like IRESes during the initiation of translation","volume":"14","author":"Souii","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118282_b0195","doi-asserted-by":"crossref","first-page":"9611","DOI":"10.1073\/pnas.1704390114","article-title":"Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation","volume":"114","author":"Avanzino","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2026.118282_b0200","doi-asserted-by":"crossref","first-page":"19977","DOI":"10.1038\/srep19977","article-title":"Broad and potent antiviral activity of the NAE inhibitor MLN4924","volume":"6","author":"Le-Trilling","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226006210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226006210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:26:46Z","timestamp":1791908806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226006210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":40,"alternative-id":["S0006295226006210"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118282","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological inhibition of neddylation by MLN4924 protects against Coxsackievirus B3-induced myocarditis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118282"}}